Mrs Natalie Rowland (née Ives) BSc (Hons), MSc

Mrs Natalie Rowland

Institute of Applied Health Research
Reader in Clinical Trials, BCTU Director of Statistics and Research Strategy

Contact details

Address
Birmingham Clinical Trials Unit (BCTU)
College of Medical and Dental Sciences
Public Health Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Natalie Rowland (née Ives) is a Reader in Clinical Trials. She is the Director of Statistics & Research Strategy, and a member of the Senior Management Team at the Birmingham Clinical Trials Unit (BCTU) in the Institute of Applied Health Research

Natalie is interested in the design, conduct and analysis of large scale late phase randomised controlled clinical trials.  She is the Lead Methodologist and Senior Statistician on a substantial and diverse portfolio of high quality clinical trials in the areas of Neuroscience and Parkinson’s Disease, Renal Disease, Coloproctology, Critical Care, Trauma and Primary Care assessing medical, surgical and complex interventions in both adults and children. 

Her research has been published in various high impact scientific journals (NEJM, Lancet, BMJ) and she is a co-applicant on a number of grants funded by the National Institute for Health Research (NIHR) funding streams (HTA, EME and RfPB). 

Qualifications

  • MSc in Statistics, University of Sheffield, 1997
  • BSc (Hons) in Mathematics (1st), University of Leicester, 1995

Teaching

Teaching Programmes

Other activities

  • Member of the NIHR Incubator for Methodology (2020-present), and lead for the Incubator Awareness Raising Workstream
  • Member of the UKCRC Statistics Operational Group committee (2019-present). Deputy Chair since 2021.
  • Reviewer for various scientific journals
  • Statistical reviewer for the National Institute for Health Research (HTA, EME, RfPB) 
  • Independent statistician on several Trial Steering and Data Monitoring Committees contributing to the oversight and direction of externally run clinical trials

Publications

Recent publications

Article

Bilateral Remote Ischemic Conditioning in Children Trial Investigators, Drury, NE, Doorn, CV, Woolley, RL, Amos-Hirst, RJ, Bi, R, Spencer, CM, Morris, KP, Montgomerie, J, Stickley, J, Crucean, A, Gill, A, Hill, M, Weber, RJM, Najdekr, L, Jankevics, A, Southam, AD, Lloyd, GR, Jaber, O, Kassai, I, Pelella, G, Khan, NE, Botha, P, Barron, DJ, Madhani, M, Dunn, WB, Ives, NJ, Kirchhof, P & Jones, TJ 2024, 'Bilateral Remote Ischemic Conditioning in Children: a two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgery', The Journal of Thoracic and Cardiovascular Surgery. https://doi.org/10.1016/j.xjon.2024.02.018

Bhandari, S, Mehta, S, Khawaja, A, Cleland, JGF, Rowland, N & Cockwell, P 2024, 'Evaluation of the stopping angiotensin converting enzyme inhibitor compared to angiotensin receptor blocker (STOP ACEi trial) in advanced and progressive chronic kidney disease', Kidney International, vol. 105, no. 1, pp. 200-208. https://doi.org/10.1016/j.kint.2023.09.012

Sackley, CM, Rick, C, Brady, MC, Woolley, R, Burton, C, Patel, S, Masterson-Algar, P, Nicoll, A, Smith, CH, Jowett, S, Ives, N, Beaton, G, Dickson, S, Ottridge, R, Sharp, L, Nankervis, H, Clarke, CE & PD COMM Collaborative Group 2024, 'Lee Silverman Voice Treatment versus NHS Speech and Language Therapy versus control for dysarthria in Parkinson’s disease (PD COMM): a UK, multicentre, pragmatic, randomised controlled trial', BMJ.

Krouwel, M, Greenfield, SM, Chalkley, A, Sanders, JP, Parretti, HM, Gokal, K, Jolly, K, Skrybant, M, Biddle, SJH, Greaves, C, Maddison, R, Mutrie, N, Ives, N, Esliger, DW, Sherar, L, Edwardson, CL, Yates, T, Frew, E, Tearne, S, Daley, AJ & Kwaghe, AV (ed.) 2023, 'Promoting participation in physical activity through Snacktivity: A qualitative mixed methods study', PLOS One, vol. 18, no. 9, e0291040. https://doi.org/10.1371/journal.pone.0291040

Daley, AJ, Griffin, RA, Moakes, CA, Sanders, JP, Skrybant, M, Ives, N, Maylor, B, Greenfield, SM, Gokal, K, Parretti, HM, Biddle, SJH, Greaves, C, Maddison, R, Mutrie, N, Esliger, DW, Sherar, L, Edwardson, CL, Yates, T, Frew, E, Tearne, S & Jolly, K 2023, 'Snacktivity™ to promote physical activity and reduce future risk of disease in the population: protocol for a feasibility randomised controlled trial and nested qualitative study', Pilot and Feasibility Studies, vol. 9, no. 1, 45. https://doi.org/10.1186/s40814-023-01272-8

PREDNOS Collaborative Group, NIHR Medicines for Children Research Network Nephrology Clinical Studies Group, Afentou, N, Frew, E, Mehta, S, Rowland, N, Woolley, R, Brettell, E, Khan, A, Milford, D, Bockenhauer, D, Saleem , MA, Hall, AS, Koziell, A, Maxwell, H, Hegde , S, Finlay, ER, Gilbert, RD, Jones, C, McKeever, K, Cook, W, Webb, NJA & Christian, MT 2022, 'Economic evaluation of using daily prednisolone versus placebo at the time of an upper respiratory tract infection for the management of children with steroid-sensitive nephrotic syndrome: a model-based analysis', PharmacoEconomics, vol. 6, no. 4, pp. 605-617. https://doi.org/10.1007/s41669-022-00334-6

Jayne, D, Walsh, M, Merkel, PA, Peh, CA, Szpirt, W, Puéchal, X, Fujimoto, S, Hawley, C, Khalidi, N, Jones, R, Flossmann, O, Wald, R, Girard, L, Levin, A, Gregorini, G, Harper, L, Clark, W, Pagnoux, C, Specks, U, Smyth, L, Ito-Ihara, T, De zoysa, J, Brezina, B, Mazzetti, A, Mcalear, CA, Reidlinger, D, Mehta, S, Ives, N, Brettell, EA, Jarrett, H, Wheatley, K, Broadhurst, E, Casian, A & Pusey, CD 2022, 'Plasma exchange and glucocorticoids to delay death or end-stage renal disease in anti-neutrophil cytoplasm antibody-associated vasculitis: PEXIVAS non-inferiority factorial RCT', Health Technology Assessment, vol. 26, no. 38, pp. 1-60. https://doi.org/10.3310/PNXB5040

STOP ACEi Trial Investigators 2022, 'Renin-angiotensin system inhibition in advanced chronic kidney disease', The New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2210639

Kyte, D, Anderson, N, Bishop, J, Bissell, A, Brettell, E, Calvert, M, Chadburn, M, Cockwell, P, Dutton, M, Eddington, H, Forster, E, Hadley, G, Rowland, N, Jackson, L, O’Brien, S, Price, G, Sharpe, K, Stringer, S, Verdi, R, Waters, J & Wilcockson, A 2022, 'Results of a pilot feasibility randomised controlled trial exploring the use of an electronic patient-reported outcome measure in the management of UK patients with advanced chronic kidney disease', BMJ open, vol. 12, no. 3, e050610. https://doi.org/10.1136/bmjopen-2021-050610

RePHILL collaborative group 2022, 'Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial', The Lancet Haematology, vol. 9, no. 4, pp. e250-e261. https://doi.org/10.1016/S2352-3026(22)00040-0

Gokal, K, Amos-Hirst, R, Moakes, C, Sanders, JP, Esliger, DW, Sherar, LB, Ives, N, Biddle, SJH, Edwardson, C, Frew, E, Yates, T, Greaves, C, Rowland, N, Greenfield, S, Jolly, K, Skrybant, M, Maddison, R, Mutrie, N, Parretti, H & Daley, A 2022, 'Views of the public about Snacktivity™: A small changes approach to promoting physical activity and reducing sedentary behaviour', BMC Public Health, vol. 22, no. 618, 618. https://doi.org/10.1186/s12889-022-13050-x

The SUNRRISE Study Group on behalf of the Northwest Research Collaborative and the West Midlands Research Collaborative 2021, 'An international pragmatic randomised controlled trial to compare a single use negative pressure dressing versus a surgeon’s preference of dressing to reduce the incidence of surgical site infection following emergency laparotomy: the SUNRRISE Trial Protocol', Colorectal Disease, vol. 23, no. 4, pp. 989-1000. https://doi.org/10.1111/codi.15474

Abstract

Bhandari, S, Mehta, S, Ives, N & Cockwell, P 2024, 'WCN24-318: Utility of 2-year Kidney Failure Risk Equation for advanced chronic kidney disease: analysis from the STOP ACEi Trial', Kidney International Reports, vol. 9, no. 4, pp. S81-S82. https://doi.org/10.1016/j.ekir.2024.02.174

Spencer, S, Desborough, R, Mehta, S, Rowland, N & Bhandari, S 2024, 'WCN24-398: Report on STOP-ACEi trial: reviewing cystatin C levels in CKD patients', Kidney International Reports, vol. 9, no. 4, pp. S83-S83. https://doi.org/10.1016/j.ekir.2024.02.176

Letter

Bhandari, S, Mehta, S, Rowland, N & Cockwell, P 2023, 'Utility of 2-year kidney failure risk equation for advanced chronic kidney disease: analysis from the STOP-ACEi trial', Nephrology, Dialysis, Transplantation. https://doi.org/10.1093/ndt/gfad263

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