Dr Alice Sitch PhD, MSc, BSc (Hons), PCAP, CStat, FHEA

Dr Alice Sitch

Institute of Applied Health Research
Senior Lecturer in Biostatistics

Contact details

Public Health Building
Institute of Applied Health Research
College of Medical and Dental Sciences
University of Birmingham
B15 2TT

Alice Sitch is a Senior Lecturer working in the Institute of Applied Health Research and a member of the Biostatistics, Evidence Synthesis and Test Evaluation (BESaTE) research group.

Since joining the University in 2009, Alice has become involved in many exciting projects allowing her to collaborate with others in the BESaTE team and many other researchers at the University of Birmingham and beyond.

Alice’s main research interests are in the area of designing and evaluating monitoring tests and studies of biological variability. Alice is the deputy lead for the cross-cutting diagnostics and biomarkers theme of the Birmingham NIHR Biomedical Research Centre.


  • PhD in Medical Statistics, University of Birmingham, 2019
  • Post-graduate certificate in Academic Practice, University of Birmingham, 2017
  • MSc in Statistics, University of Sheffield, 2009
  • BSc (Hons) in Mathematics, University of Sheffield, 2008
  • Royal Statistical Society Chartered Statistician
  • Fellow of Higher Education Academy


Alice began working with the Biostatistics group within the Institute of Applied Health Research at the University of Birmingham as a Research Fellow in October 2009 and later became a Lecturer in Medical Statistics.  

Alice is involved with many exciting research projects. Her work is diverse, covering methodological problems, test research and a variety of public health issues.  The focus of her research is test evaluation, specifically the use of tests to monitor progressive and recurrent disease and studies of biological variability. 

Alice enjoys teaching and interacting with students, with her responsibilities spanning many courses. Predominately, her teaching duties involve communicating statistical ideas to a non-statistical audience. Alice is involved with teaching both undergraduate and postgraduate students and leads the statistics module on the Medicine and Surgery (MBChB) Graduate Entry Course (GEC).



The focus of Alice’s research is the use of repeated testing to monitor disease progression or recurrence and the use of biological variability studies to provide evidence to guide the use of monitoring tests.

Her work in the area of monitoring stems from her involvement in the methodology work stream of the NIHR programme grant Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease. Alice is also involved in a primary study (eGFR-C) looking at estimation using creatinine and cystatin C for monitoring disease progression in patients with stage 3 chronic kidney disease.  

In other test evaluation work, Alice is the study statistician for the NIHR HTA study Prognostic Value of Interferon Gamma Release Assays in predicting active tuberculosis among individuals with, or at risk of, latent tuberculosis infection (PREDICT); the Wellcome Trust Innovation Challenge Fund supported study Real-time Adaptive Predictive Indicator of Deterioration (RAPID) which uses Formula One technology to monitor children in intensive care in real time; and, two NIHR Research for Patient Benefit funded pilot studies investigating home monitoring of cystic fibrosis and an alert system for the early detection of acute kidney injury

Through collaboration with other academics and clinicians, Alice has been part of many research projects.  These include the NIHR global project in COPD Breathe Well, a MRC funded project Pathfinder, and a NIHR PHR funded project ABA.


Recent publications


Webb, S, Sitch, A & MacArthur, C 2020, 'The impact of mode of subsequent birth after obstetric anal sphincter injury on bowel function and related quality of life: a cohort study', International Urogynecology Journal. https://doi.org/10.1007/s00192-020-04234-3

Keene , SJ, Adab, P, de Vries, F, Franssen, FME, Sitch, A, Martin, J, Marshall, T & Jordan, R 2020, 'The stability of the ADO score among UK COPD patients from The Health Improvement Network', ERJ Open Research.

Adab, P, Jordan, R, Fitzmaurice, D, Ayres, J, Cheng, KK, Cooper, B, Daley, A, Dickens, A, Enocson, A, Greenfield, S, Haroon, S, Jolly, K, Jowett, S, Lambe, T, Martin, J, Miller, M, Rai, K, Riley, RD, Sadhra, S, Sitch, A, Siebert, S, Stockley, RA & Turner, A 2020, 'Chronic Obstructive Pulmonary Disease in primary care; from case finding to improving patient outcomes: the Birmingham Lung Improvement Studies (BLISS) research programme', ERO .

Jones, R, Barratt, J, Brettell, E, Cockwell, P, Dalton, RN, Deeks, J, Eaglestone, G, Pellatt-Higgins, T, Kalra, P, Khunti, K, Morris, F, Ottridge, R, Sitch, A, Stevens, PE, Sharpe, CC, Sutton, A, Taal, MW & Lamb, EJ 2020, 'Biological variation of cardiac troponins in chronic kidney disease', Annals of Clinical Biochemistry.

Dickens, A, Fitzmaurice, D, Adab, P, Sitch, A, Riley, RD, Enocson, A & Jordan, R 2020, 'Accuracy of Vitalograph lung monitor as a screening test for COPD in primary care', NPJ Primary Care Respiratory Medicine, vol. 30, no. 2, pp. 1-8. https://doi.org/10.1038/s41533-019-0158-2

Middleton, L & Sitch, A 2020, 'How to determine if a treatment works for some people but not for others? Testing for sub-group effects', BJOG: An International Journal of Obstetrics and Gynaecology. https://doi.org/10.1111/1471-0528.15852

Gupta, R, Lipman, M, Jackson, C, Sitch, A, Southern, J, Drobniewski, F, Deeks, J, Tsou, C-Y, Griffiths, C, Davidson, J, Campbell, C, Stirrup, O, Noursadeghi, M, Kunst, H, Haldar, P, Lalvani, A & Abubakar, I 2019, 'Quantitative interferon gamma release assay and tuberculin skin test results to predict incident tuberculosis: a prospective cohort study', American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201905-0969OC

Keene , SJ, Jordan, R, Franssen, FME, de Vries, F, Martin, J, Sitch, A, Turner, A, Dickens, A, Fitzmaurice, D & Adab, P 2019, 'External validation of the updated ADO score in COPD patients from the Birmingham COPD cohort', International journal of chronic obstructive pulmonary disease, vol. 14, pp. 2395—2407. https://doi.org/10.2147/COPD.S212381

Clarke, J, Ingram, J, Johnson , D, Tricky, H, Dombrowski, SU, Sitch, A, Dykes , F, Feltham, M, MacArthur, C, Roberts, T, Hoddinott, P & Jolly, K 2019, 'The Assets-based infant feeding help Before and After birth (ABA) intervention for improving breastfeeding initiation and continuation: feasibility study results', Maternal and Child Nutrition.

Thomas, ME, Abdelaziz, T, Perkins, G, Sitch, A, Baharani, J & Temple, R 2019, 'The acute kidney outreach to prevent deterioration and death – a large pilot study for a cluster randomised trial', Nephrology, Dialysis, Transplantation.

Lee, KC, Bamford, A, Gardiner, A, Agovino, A, Ter Horst, B, Bishop, J, Sitch, A, Grover, L, Logan, A & Moiemen, N 2019, 'Investigating the intra- and inter-rater reliability of a panel of subjective and objective burn scar measurement tools', Burns, vol. 45, no. 6, pp. 1311-1324. https://doi.org/10.1016/j.burns.2019.02.002

Rowe, C, Sitch, A, Barratt, J, Brettell, E, Cockwell, P, Dalton, N, Deeks, J, Eaglestone, G, Pellatt-Higgins, T, Kalra, PA, Khunti, K, Loud, F, Morris, F, Ottridge, R, Stevens, PE, Sharpe, CC, Sutton, A, Taal, MW, Lamb, EJ & eGFR-C study group 2019, 'Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease', Kidney International, vol. 96, no. 2, pp. 429-435. https://doi.org/10.1016/j.kint.2019.02.021

Lambe, T, Adab, P, Jordan, R, Sitch, A, Enocson, A, Jolly, K, Marsh, J, Riley, RD, Miller, M, Cooper, BG, Turner, A, Ayres, J, Stockley, RA, Greenfield, S, Siebert, S, Daley, A, Cheng, K, Fitzmaurice, D & Jowett, S 2019, 'Model-based evaluation of the long-term cost-effectiveness of systematic case-finding for COPD in primary care', Thorax, vol. 74, pp. 730-739. https://doi.org/10.1136/thoraxjnl-2018-212148

Chua, WWL, Easter, C, Guasch, E, Sitch, A, Casadei, B, Crijns, HJGM, Haase, D, Hatem, S, Kääb, S, Mont, L, Schotten, U, Sinner, MF, Hemming, K, Deeks, J, Kirchhof, P & Fabritz, L 2019, 'Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset', BMC Cardiovascular Disorders, vol. 19, no. 1, 120. https://doi.org/10.1186/s12872-019-1105-4


Sitch, A & Middleton, L 2020, 'Are these means really different? Statistical testing for continuous data', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 127, no. 6. https://doi.org/10.1111/1471-0528.15569

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