Dr Cameron Baines PhD, MRes, BSc (Hons)

School of Biosciences
Research Fellow

Contact details

Address
School of Biosciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Cameron Baines is a postdoctoral research fellow in Professor Helen Cooper’s research group, specialising in mass spectrometry. His research focuses on native mass spectrometry and mass spectrometry imaging to investigate proteins involved with amyotrophic lateral sclerosis.   

Qualifications

PhD in Chemistry, University of Nottingham, 2025

MRes in Molecular Microbiology, Nottingham Trent University, 2019

BSc (Hons) in Microbiology, Nottingham Trent University, 2018

Biography

Dr Cameron Baines completed his BSc in Microbiology at Nottingham Trent University under the supervision of Dr Gareth McVicker, with a research project focused on toxin-antitoxin plasmid maintenance systems in enteroinvasive Escherichia coli. This was followed by an MRes under Dr David Negus researching the therapeutic use of the predatory bacteria Bdellovibrio bacteriovorus to combat polymicrobial infections.

He achieved his PhD at the University of Nottingham under the guidance of Professor Neil Oldham in the field of structural and native mass spectrometry. He used covalent protein labelling to study the conformational dynamics of the bacterial protein EF-Tu when complexed with a range of antibiotics, alongside native and ion-mobility mass spectrometry to interrogate the stability of these complexes.

Cameron joined the Cooper group in November 2024 to work under the native ambient mass spectrometry (NAMS) project, with a focus of NAMS imaging. His research focuses on amyotrophic lateral sclerosis (ALS) where he uses nano desorption electrospray ionisation (nano-DESI) mass spectrometry imaging to characterise the spatial distributions of the causative misfolded SOD1 protein directly from brain tissue.   

Research

Native mass spectrometry, mass spectrometry imaging and top-down analysis of proteins.

Publications

Recent publications

Article

Ducker, C, Baines, C, Guy, J, Euzébio Goulart Santana, A, Pickett, JA & Oldham, NJ 2024, 'A diterpene synthase from the sandfly Lutzomyia longipalpis produces the pheromone sobralene', Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 12, e2322453121. https://doi.org/10.1073/pnas.2322453121

Baines, C, Sargeant, J, Fage, CD, Pugh, H, Alkhalaf, LM, Challis, GL & Oldham, NJ 2024, 'Native ESI-MS and Collision-Induced Unfolding (CIU) of the Complex between Bacterial Elongation Factor-Tu and the Antibiotic Enacyloxin IIa', Journal of the American Society for Mass Spectrometry, vol. 35, no. 7, pp. 1490-1496. https://doi.org/10.1021/jasms.4c00087

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