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Almaghrabi, R, Alyahyawi, Y, Keane, P, Mian, SA, Habel, K, Atkinson, A, Ward, C, Bayley, R, Sargas, C, Menendez, P, Murphy, GJ, Sobahy, T, Baghdadi, MA, Flemban, AF, Kabrah, SM, Torres-Ruiz, R, Papapetrou, EP, Akerman, I, Raghavan, M, Barragan, E, Bonnet, D, Bonifer, C & Garcia, P 2025, 'A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression', Nature Communications, vol. 16, no. 1, 5489. https://doi.org/10.1038/s41467-025-60192-8
Maytum, A, Edginton-White, B, Keane, P, Cockerill, PN, Cazier, J-B & Bonifer, C 2024, 'Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification', Life Science Alliance, vol. 7, no. 2, e202302363. https://doi.org/10.26508/lsa.202302363
Davies, N, Francis, T, Oldreive, C, Azam, M, Wilson, J, Byrd, PJ, Burley, M, Sharma-Oates, A, Keane, P, Alatawi, S, Higgs, MR, Rudzki, Z, Ibrahim, M, Perry, T, Agathanggelou, A, Hewitt, AM, Smith, E, Bonifer, C, O’Connor, M, Forment, JV, Murray, PG, Fennell, E, Kelly, G, Chang, C, Stewart, GS, Stankovic, T, Kwok, M & Taylor, AM 2024, 'Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma', Haematologica, vol. 109, no. 12, pp. 3989-4006. https://doi.org/10.3324/haematol.2023.284404
Kellaway, SG, Potluri, S, Keane, P, Blair, HJ, Ames, L, Worker, A, Chin, PS, Ptasinska, A, Derevyanko, PK, Adamo, A, Coleman, DJL, Khan, N, Assi, SA, Krippner-Heidenreich, A, Raghavan, M, Cockerill, PN, Heidenreich, O & Bonifer, C 2024, 'Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth', Nature Communications, vol. 15, no. 1, 1359. https://doi.org/10.1038/s41467-024-45691-4
Coleman, DJL, Keane, P, Chin, PS, Ames, L, Kellaway, S, Blair, H, Khan, N, Griffin, J, Holmes, E, Maytum, A, Potluri, S, Strate, L, Koscielniak, K, Raghavan, M, Bushweller, J, Heidenreich, O, Rabbitts, T, Cockerill, PN & Bonifer, C 2024, 'Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1', iScience, vol. 27, no. 4, 109576. https://doi.org/10.1016/j.isci.2024.109576
Edginton-White, B, Maytum, A, Kellaway, SG, Goode, DK, Keane, P, Pagnuco, I, Assi, SA, Ames, L, Clarke, M, Cockerill, PN, Göttgens, B, Cazier, JB & Bonifer, C 2023, 'A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification', Nature Communications, vol. 14, no. 1, 267. https://doi.org/10.1038/s41467-023-35910-9
Coleman, DJL, Keane, P, Luque-Martin, R, Chin, PS, Blair, H, Ames, L, Kellaway, SG, Griffin, J, Holmes, E, Potluri, S, Assi, SA, Bushweller, J, Heidenreich, O, Cockerill, PN & Bonifer, C 2023, 'Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth', Cell Reports, vol. 42, no. 12, 113568. https://doi.org/10.1016/j.celrep.2023.113568
Adamo, A, Chin, P, Keane, P, Assi, SA, Potluri, S, Kellaway, SG, Coleman, D, Ames, L, Ptasinska, A, Delwel, HR, Cockerill, PN & Bonifer, C 2023, 'Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia', Leukemia, vol. 37, no. 1, pp. 102-112. https://doi.org/10.1038/s41375-022-01744-5
Tirtakusuma, R, Bonifer, C, Ptasinska, A, Chin, PS, Cauchy, P, Keane, P, Assi, S, Kellaway, S, Imperato, M, Cockerill, P, Heidenreich, O & Bomken, S 2022, 'Epigenetic regulator genes direct lineage switching in MLL/AF4 leukaemia', Blood. https://doi.org/10.1182/blood.2021015036
Kellaway, S, Keane, P, Edginton-White, B, Regha, K, Kennett, E & Bonifer, C 2021, 'Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories', Life Science Alliance, vol. 4, no. 2, e202000864. https://doi.org/10.26508/lsa.202000864
Bevington, S, Fiancette, R, Gajdasik, D, Keane, P, Soley, J, Willis, C, Coleman, D, Withers, D & Cockerill, P 2021, 'Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo', Frontiers in immunology, vol. 12, 642807. https://doi.org/10.3389/fimmu.2021.642807
Bevington, SL, Ng, STH, Britton, GJ, Keane, P, Wraith, DC & Cockerill, PN 2020, 'Chromatin priming renders T cell tolerance-associated genes sensitive to activation below the signaling threshold for immune response genes', Cell Reports, vol. 31, no. 10, 107748. https://doi.org/10.1016/j.celrep.2020.107748
Nafria, M, Keane, P, Ng, ES, Stanley, EG, Elefanty, AG & Bonifer, C 2020, 'Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells', Cell Reports, vol. 31, no. 8, 107691. https://doi.org/10.1016/j.celrep.2020.107691
Bevington, SL, Keane, P, Soley, JK, Tauch, S, Gajdasik, DW, Fiancette, R, Matei-Rascu, V, Willis, CM, Withers, DR & Cockerill, PN 2020, 'IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors', The EMBO journal, vol. 39, no. 22, e105220. https://doi.org/10.15252/embj.2020105220
Letter
Potluri, S, Kellaway, SG, Coleman, DJL, Keane, P, Imperato, MR, Assi, SA, Cockerill, PN & Bonifer, C 2024, 'Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis', Leukemia, vol. 38, no. 2, pp. 403-407. https://doi.org/10.1038/s41375-023-02118-1
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