Dr Archana Sharma-Oates PhD

Dr Archana Sharma-Oates

School of Biosciences
Assistant Professor

Contact details

Address
School of Biosciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Sharma-Oates is a Bioinformatics Assistant Professor specialising in multi-omics analysis to study cancer, musculoskeletal conditions, and ageing, with a focus on disease onset disparities in minority ethnic groups driven by genetics and environmental factors.

Qualifications

  • BSc, Biochemistry, University of Liverpool, UK
  • MRes (Distinction), Bioinformatics, University of Leeds, UK
  • PhD “Interpretation of C. elegans Genome Sequence Data through Gene Expression Patterns”, University of Leeds, UK

Biography

Following her undergraduate degree, Dr. Sharma-Oates spent a year working as a research assistant at Georgetown University, Washington DC, USA. She then returned to the UK to pursue an MRes in Bioinformatics at the University of Leeds, followed by a PhD, which included a three-month fellowship at the National Institute of Genetics in Mishima, Japan.

After completing her PhD, she worked for several years as a post-doctoral research fellow in various research areas, including cancer, animal development and disease, and COVID-19. In 2021, she began her current position as an Assistant Professor in Bioinformatics in the School of Biosciences at the University of Birmingham. Dr. Sharma-Oates is also affiliated with the institute of Data and AI, Centre for Environmental Research and Justice (CERJ) and the Department of Inflammation and Ageing.

Teaching

Program Lead of MSc Bioinformatics (Distance Learning)

Module Lead for Computational Biology for Complex Systems (Dubai)

Module Lead for Essentials for Complex Systems (Distance Learning)

Module Lead for Computational Biology for Complex Systems (Distance Learning)

Deputy Lead for Computational Biology for Complex Systems (Edgbaston)

Postgraduate supervision

Dr Sharma-Oates is currently supervising bioinformatics projects focused on:

  • Integrative analysis of genetic, proteomic, and clinical data to identify biomarkers of persistent pain in post-operative osteoarthritis patients.
  • Exploring mechanisms of platelet function using large datasets and employing machine learning and bioinformatics tools.
  • Restoring environmental justice with Next Generation Risk Assessment (NGRA) for diverse ethnic populations

Students interested in pursuing a PhD position are encouraged to contact Dr Sharma-Oates directly via email.

Research

Dr Sharma-Oates is an Assistant Professor in Bioinformatics with extensive experience in transcriptomic, whole genome/exome sequences and methylome data analysis applied to research in cancer, musculoskeletal and ageing.  She works with large-scale datasets such as UK Biobank to explore population-level insights and uncover disease mechanisms and biological pathways.

She is particularly interested in determining the underlying mechanisms behind the earlier onset of diseases in minority ethnic groups, focusing on the contributions of the environmental factors versus the genetics. Her expertise in bioinformatics enables her to contribute across a wide range of biomedical and translational research areas.

Other activities

She is a member of the Biosciences Equality Diversity and Inclusion (EDI) Committee and the British Society for Research on Ageing

Publications

Recent publications

Article

Sharma-Oates, A, Dunne, N, Raza, K, Padyukov, L, Rivera, N, van der Helm-van Mil, AHM, Pratt, AG, Duggal, N, Jones, S & Lord, J 2025, 'Ethnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis', GeroScience. https://doi.org/10.1007/s11357-025-01508-w

Raza, K, Sharma-Oates, A, Padyukov, L, van der Helm-van Mil, AHM, Pratt, AG, Jones, SW, Filer, A, Lord, JM & Duggal, NA 2025, 'Specific features of immune ageing are detected in the earliest stages in rheumatoid arthritis development', EBioMedicine, vol. 119, 105900. https://doi.org/10.1016/j.ebiom.2025.105900

PHOSP-COVID study collaborative group & ISARIC4C Investigators 2024, 'Accelerated immune ageing is associated with COVID-19 disease severity', Immunity & Ageing, vol. 21, no. 1, 6. https://doi.org/10.1186/s12979-023-00406-z

Conway, J, De Jong, EN, White, AJ, Dugan, B, Paddison Rees, N, Parnell, SM, Lamberte, LE, Sharma‐Oates, A, Sullivan, J, Mauro, C, van Schaik, W, Anderson, G, Bowdish, DME & Duggal, NA 2024, 'Age‐related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing', Aging Cell. https://doi.org/10.1111/acel.14401

Sharma-Oates, A, Sullivan, J, Pestana, D, dos Santos, C, Binnie, A & Lord, J 2024, 'Association of Epigenetic Age and Outcome in Critically Ill Patients', Critical Care Explorations, vol. 6, no. 2, e1044. https://doi.org/10.1097/CCE.0000000000001044

Davies, N, Francis, T, Oldreive, C, Azam, M, Wilson, J, Byrd, PJ, Burley, M, Sharma-Oates, A, Keane, P, Alatawi, S, Higgs, MR, Rudzki, Z, Ibrahim, M, Perry, T, Agathanggelou, A, Hewitt, AM, Smith, E, Bonifer, C, O’Connor, M, Forment, JV, Murray, PG, Fennell, E, Kelly, G, Chang, C, Stewart, GS, Stankovic, T, Kwok, M & Taylor, AM 2024, 'Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma', Haematologica, vol. 109, no. 12, pp. 3989-4006. https://doi.org/10.3324/haematol.2023.284404

Chen, Y-Y, Sullivan, J, Hanley, S, Price, J, Tariq, M, McIlvenna, LC, Whitham, M, Sharma-Oates, A, Harrison, P, Lord, J & Hazeldine, J 2024, 'Impact of Senescent Cell-Derived Extracellular Vesicles on Innate Immune Cell Function', Advanced Biology. https://doi.org/10.1002/adbi.202400265

Wilson, DG, Sharma-Oates, A, Sheldon, J, Power, DF, Lord, J, Roberts, PR & Morgan, JM 2024, 'Predictors of death without prior appropriate therapy in ICD recipients: the comorbidities, frailty and functional status (COMFFORT study)', Open Heart, vol. 11, no. 2, e002574. https://doi.org/10.1136/openhrt-2023-002574

Wijesinghe, S, Badoume, A, Nanus, D, Sharma-Oates, A, Farah, H, Certo, M, Alnajjar, FAQ, Davis, E, Mauro, C, Lindsay, MA & Jones, S 2023, 'Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets', Clinical and Translational Medicine, vol. 13, no. 4, e1232. https://doi.org/10.1002/ctm2.1232

Sharma-Oates, A, Zemedikun, D, Kumar, K, Reynolds, J, Jain, A, Raza, K, Williams, J, Bravo Merodio, L, Roth Cardoso, V, Gkoutos, G, Nirantharakumar, K & Lord, J 2022, 'Early onset of immune-mediated diseases in minority ethnic groups in the UK', BMC medicine, vol. 20, no. 1, 346. https://doi.org/10.1186/s12916-022-02544-5

UKCCMP team 2022, 'Mortality among adults with cancer undergoing chemotherapy or immunotherapy and infected with COVID-19', JAMA network open, vol. 5, no. 2, e220130. https://doi.org/10.1001/jamanetworkopen.2022.0130

Parry, HM, Dowell, AC, Zuo, J, Verma, K, Kinsella, FAM, Begum, J, Croft, W, Sharma-Oates, A, Pratt, G & Moss, P 2021, 'PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity', PLoS pathogens, vol. 17, no. 3, e1009349. https://doi.org/10.1371/journal.ppat.1009349

Abstract

Wilson, DG, James, SX, Power, D, Sharma-Oates, A, Lord, J, Roberts, PR & Morgan, JM 2023, 'Do co-morbidities, frailty and functional status identify patients who may not benefit from ICD therapy?', EP Europace, vol. 25, no. Supplement_1, euad122.416. https://doi.org/10.1093/europace/euad122.416

Duggal, N, Raza, K, Sharma-Oates, A, Rivera, N, Padyukov, L, Pratt, A, Niemantsverdriet, E, Van der helm-Van mil, A, Jones, S & Lord, J 2022, 'AB0034 INVESTIGATING THE ROLE OF ACCELERATED IMMUNESENESCENCE IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS', Annals of the Rheumatic Diseases, vol. 81, no. Supplement 1, pp. 1152-1152. https://doi.org/10.1136/annrheumdis-2022-eular.4896

Sharma-Oates, A, Rivera, N, Duggal, N, Raza, K, Padyukov, L, Pratt, A, Niemantsverdriet, E, Van der helm-Van mil, A, Jones, S & Lord, J 2022, 'AB0091 INCREASED BIOLOGICAL AGE IN MALE PARTICIPANTS OF SWEDISH AND UK RHEUMATOID ARTHRITIS COHORTS IS NOT LINKED TO DISEASE', Annals of the Rheumatic Diseases, vol. 81, no. Supplement 1, pp. 1177-1177. https://doi.org/10.1136/annrheumdis-2022-eular.4502

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