Dr Siân Lax BSc (Hons), PhD

Dr Siân Lax

Institute of Cancer and Genomic Sciences
Clinical Trial Facilitator

Contact details

Address
Cancer Research UK Clinical Trials Unit (CRCTU)
Institute of Cancer and Genomic Sciences
Sir Robert Aitken Building
College of Medical and Dental Sciences
Edgbaston
Birmingham B15 2TT

Siân Lax’s current role is within the Cancer Research UK Clinical Trials Unit (CRCTU) where she acts as the first point of contact for clinical investigators wishing to work with the CRCTU.

Qualifications

  • PhD in Biochemistry, 2004
  • BSc (Hons) in Molecular and Cellular Biochemistry, 2001

Biography

As the Clinical Trial Facilitator, Siân, manages the CRCTU New Business process and provides assistance in obtaining research grants and contributes to writing clinical trial essential documents, publications and reports.

Before working at the CRCTU, Siân was a post-doctoral research fellow working in Professor Steve Watson’s Platelet Group, understanding the role of the platelet receptor CLEC-2 in regulating the severity of acute lung injury using in vivo models of lung inflammation and injury. Her previous post-doctoral work involved elucidating the in vivo role of hormones in lung injury and the role of mesenchymal stromal cells in lymphoid tissues following infection. Siân obtained her Ph.D. from University of Birmingham in 2004 researching the function of Rho-kinase II in regulated keratinocyte differentiation.

Publications

Rayes J*, Jadoui S*, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B. (2018) The contribution of platelet glycoprotein receptors to bleeding prevention at sites of inflammation is stimulus and organ dependent. Haematologica: 103(6):e256-58  *Contributed equally

Rayes J, Lax S, Wichaiyo S, Watson SK, Di Y, Lombard S, Grygielska B, Smith SW, Skodilis K, Watson SP. (2017) The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. Nat Commun: 8:2239

Lax S, Rayes J, Thickett DR, Watson SP. (2017) Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice. BMJ Open Respir Res: 4:e000257

Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP. (2017) Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. Am J Physiol Lung Cell Mol Physiol: 313(6):L1016-29

Parekh D, Patel J, Scott A, Lax S, Dancer RCA, D’Souza V, Greenwood H, Fraser WD, Gao F, Sapey E, Perkins GD, Thickett DR. (2017) Vitamin D deficiency in human and murine sepsis. Crit Care Med: 45:282-89

Hitchcock JR, Cook CN, Bobat S, Ross EA, Flores-Langarica A, Lowe KL, Khan M, Dominguez-Medina CC, Lax S, Carvalho-Gaspar M, Hubscher S, Rainger E, Cobbold M, Buckley CD, Mitchell T, Mitchell A, Jones ND, Van Rooijen N, Kirchhofer D, Henderson IR, Adams DH, Watson SW, Cunnigham AF. (2015) Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. J Clin Invest; 125(12):4429-46

Dancer RCA, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, Park D, Turner AM, Sapey E, Naidu B, Stewart PM, Fraser WD, Cooper MS, Gao F, Martineau A, Perkins GD, Thickett DR. (2015) Vitamin D deficiency contributes directly to acute lung injury. Thorax; 70:617-24

Lax S, Wilson MR, Takata M, Thickett DR. (2014) Using a non-invasive assessment of lung injury in a murine model of acute lung injury. BMJ Open Resp Res;1:e000014

Parekh, D, Dancer R, Lax S, Cooper M, Martineau, Fraser W, Tucker O, Alderson D, Perkins GD, Gao-Smith F, Thickett DR. (2013) Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO) – a randomised placebo controlled trial. Trials, 14(1):100.

Ross EA, Coughlan RE, Flores-Langarica A, Lax S, Nicholson J, Desanti GE, Marshall JL, Bobat S, Hitchcock J, White A, Jenkinson WE, Khan M, Henderson IR, Lavery GG, Buckley CD, Anderson G, Cunningham AF. (2012) Thymic Function Is Maintained during Salmonella-Induced Atrophy and Recovery. J Immunol, 189:4266-74

Simonavicius N, Ashenden M, van Weverwijk A, Lax S, Huso DL, Buckley CD, Huijber IJ, Yarwood H, Isacke CM.(2012) Pericytes promote selective vessel regression to regulate vascular patterning. Blood, 120:1516-27

Lax S, Ross EA, White A, Marshall JL, Jenkinson WE, Isacke CM, Huso DL, Cunningham AF, Anderson G, Buckley CD. (2012) CD248 expression on mesenchymal stromal cells is required for post-natal and infection-dependent thymus remodelling and regeneration. FEBS open bio, 2:187-90.

Hardie DL, Baldwin MJ, Naylor A, Haworth OJ, Hou TZ, Lax S, Curnow SJ, Willcox N, MacFadyen J, Isacke CM, Buckley CD. (2011) The stromal cell antigen CD248 (endosialin) is expressed on naive CD8+ human T cells and regulates proliferation. Immunology, 133:288-95.

Lax S, Hardie DL, Wilson A, Douglas MR, Anderson G, Huso D, Isacke CM, Buckley CD. (2010) The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. Eur J Immunol, 40:11884-9

Flavell SJ, Hou TZ, Lax S, Filer AD, Salmon M, Buckley CD. (2008) Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol, 153:S241-6

Ross EA, Freeman S, Zhao Y, Dhanjal TS, Ross EJ, Lax S, Ahmed Z, Hou TZ, Kalia N, Egginton S, Nash G, Watson SP, Frampton J, Buckley CD. (2008) A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow. PLoS One, 3:e2338

Parsonage G, Filer A, Bik M, Hardie D, Lax S, Howlett K, Church LD, Raza K, Wong SH, Trebilcock E, Scheel-Toellner D, Salmon M, Lord JM, Buckley CD.(2008) Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha. Arthritis Res Ther, 10:R47

Lax S*, Hou TZ*, Jenkinson E, Salmon M, MacFadyen JR, Isacke CM, Anderson G, Cunningham AF, Buckley CD. (2007) CD248/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair. FEBS Lett, 581:3550-6   *Contributed equally

McMullan R, Lax S, Robertson VH, Radford DJ, Broad S, Watt FM, Rowles A, Croft DR, Olson MF, Hotchin NA. (2003) Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway. Curr Biol, 13:2185-9

Dawson J, Hotchin N, Lax S, Rumsby M. (2003) Lysophosphatidic acid induces process retraction in CG-4 line oligodendrocytes and oligodendrocyte precursor cells but not in differentiated oligodendrocytes. J Neurochem, 87:947-57

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