Dr Siân Lax BSc (Hons), PhD

Dr Siân Lax

Institute of Cancer and Genomic Sciences
Clinical Trial Facilitator

Contact details

Address
Cancer Research UK Clinical Trials Unit (CRCTU)
Institute of Cancer and Genomic Sciences
Sir Robert Aitken Building
College of Medical and Dental Sciences
Edgbaston
Birmingham B15 2TT

Siân Lax’s current role is within the Cancer Research UK Clinical Trials Unit (CRCTU) where she acts as the first point of contact for clinical investigators wishing to work with the CRCTU.

Qualifications

  • PhD in Biochemistry, 2004
  • BSc (Hons) in Molecular and Cellular Biochemistry, 2001

Biography

As the Clinical Trial Facilitator, Siân, manages the CRCTU New Business process and provides assistance in obtaining research grants and contributes to writing clinical trial essential documents, publications and reports.

Before working at the CRCTU, Siân was a post-doctoral research fellow working in Professor Steve Watson’s Platelet Group, understanding the role of the platelet receptor CLEC-2 in regulating the severity of acute lung injury using in vivo models of lung inflammation and injury. Her previous post-doctoral work involved elucidating the in vivo role of hormones in lung injury and the role of mesenchymal stromal cells in lymphoid tissues following infection. Siân obtained her PhD from University of Birmingham in 2004 researching the function of Rho-kinase II in regulated keratinocyte differentiation.

Publications

Recent publications

Article

Haining, E, Lowe, K, Wichaiyo, S, Kataru, RP, Nagy, Z, Kavanagh, D, Lax, S, Di, Y, Nieswandt, B, Ho-Tin-Noé, B, Mehrara, BJ, Senis, Y, Rayes, J & Watson, S 2020, 'Lymphatic blood filling in CLEC-2-deficient mouse models', Platelets. https://doi.org/10.1080/09537104.2020.1734784

Fernando, IN, Lax, S & Ahmed, I 2020, 'Response to Gultekin et al. regarding SECRAB trial toxicity', Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2020.01.019

Chimen, M, Evryviadou, A, Box, CL, Harrison, MJ, Hazeldine, J, Dib, LH, Kuravi, SJ, Payne, H, Price, JMJ, Kavanagh, D, Iqbal, AJ, Lax, S, Kalia, N, Brill, A, Thomas, SG, Belli, A, Crombie, N, Adams, RA, Evans, S-A, Deckmyn, H, Lord, JM, Harrison, P, Watson, SP, Nash, GB & Rainger, GE 2019, 'Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation', Haematologica. https://doi.org/10.3324/haematol.2018.215145

Wichaiyo, S, Lax-Williams, S, Montague, S, Li, Z, Grygielska, B, Pike, J, Haining, E, Brill, A, Watson, S & Rayes, J 2019, 'Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice', Haematologica, vol. 104, no. 8, pp. 1648-1660. https://doi.org/10.3324/haematol.2018.208363

Rayes, J, Lax, S, Wichaiyo, S, Watson, S, Di, Y, Lombard, S, Grygielska, B, Smith, S, Skordilis, K & Watson, S 2017, 'The podoplanin-CLEC-2 axis inhibits inflammation in sepsis', Nature Communications, vol. 8, 2239. https://doi.org/10.1038/s41467-017-02402-6

Lax, S, Rayes, J, Wichaiyo, S, Haining, EJ, Lowe, K, Grygielska, B, Laloo, R, Flodby, P, Borok, Z, Crandall, ED, Thickett, DR & Watson, SP 2017, 'Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse', American journal of physiology. Lung cellular and molecular physiology, vol. 313, no. 6, pp. L1016-L1029. https://doi.org/10.1152/ajplung.00023.2017

Lax, S, Rayes, J, Thickett, DR & Watson, SP 2017, 'Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice', BMJ Open Respiratory Research, vol. 4, no. 1, e000257. https://doi.org/10.1136/bmjresp-2017-000257

Parekh, D, Patel, JM, Scott, A, Lax, S, Dancer, RCA, D'Souza, V, Greenwood, H, Fraser, WD, Gao, F, Sapey, E, Perkins, GD & Thickett, DR 2017, 'Vitamin D deficiency in human and murine sepsis', Critical care medicine, vol. 45, no. 2, pp. 282-289. https://doi.org/10.1097/CCM.0000000000002095

Hitchcock, JR, Cook, CN, Bobat, S, Ross, EA, Flores-Langarica, A, Lowe, KL, Khan, M, Dominguez Medina, C, Lax, S, Carvalho-Gaspar, M, Hubscher, S, Rainger, G, Cobbold, M, Buckley, CD, Mitchell, TJ, Mitchell, A, Jones, N, Van Rooijen, N, Kirchhofer, D, Henderson, IR, Adams, DH, Watson, SP & Cunningham, AF 2015, 'Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets', Journal of Clinical Investigation, vol. 125, no. 12, pp. 4429–4446. https://doi.org/10.1172/JCI79070

Dancer, RCA, Parekh, D, Lax, S, D'souza, V, Zheng, S, Bassford, CR, Park, D, Bartis, DG, Mahida, R, Turner, A, Sapey, E, Wei, W, Naidu, B, Stewart, PM, Fraser, WD, Christopher, KB, Cooper, MS, Gao, F, Sansom, DM, Martineau, AR, Perkins, GD & Thickett, DR 2015, 'Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)', Thorax, vol. 70, no. 7, pp. 617-624. https://doi.org/10.1136/thoraxjnl-2014-206680

Parekh, D, Lax, S, Dancer, R, Perkins, G & Thickett, D 2014, 'Vitamin D deficiency and bacterial load in a murine model of sepsis-induced lung injury', The Lancet, vol. 383, pp. S15. https://doi.org/10.1016/S0140-6736(14)60278-6

Lax, S, Wilson, MR, Takata, M & Thickett, DR 2014, 'Using a non-invasive assessment of lung injury in a murine model of acute lung injury', BMJ Open Respiratory Research, vol. 1, no. 1, e000014. https://doi.org/10.1136/bmjresp-2013-000014

Parekh, D, Dancer, RC, Lax, S, Cooper, MS, Martineau, AR, Fraser, WD, Tucker, O, Alderson, D, Perkins, GD & Gao-Smith, F 2013, 'Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO) : study protocol for a randomised placebo controlled trial', Trials, vol. 14, no. 1, 100, pp. 100. https://doi.org/10.1186/1745-6215-14-100

Ross, EA, Coughlan, RE, Flores-Langarica, A, Lax, S, Nicholson, J, Desanti, GE, Marshall, JL, Bobat, S, Hitchcock, J, White, A, Jenkinson, WE, Khan, M, Henderson, IR, Lavery, GG, Buckley, CD, Anderson, G & Cunningham, AF 2012, 'Thymic function is maintained during Salmonella-induced atrophy and recovery', Journal of Immunology, vol. 189, no. 9, pp. 4266-4274. https://doi.org/10.4049/jimmunol.1200070

Buckley, C & Lax, S 2012, 'Pericytes promote selective vessel regression to regulate vascular patterning', Blood, vol. 120, no. 7, pp. 1516-1527. https://doi.org/10.1182/blood-2011-01-332338

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