Recent publications
Article
Bhaskaran, D, Savage, J, Patel, A, Collinson, F, Mant, R, Boele, F, Brazil, L, Meade, S, Buckle, P, Lax, S, Billingham, L & Short, S 2024, 'A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): Protocol for a multi-centre, double-blind, placebo-controlled trial', BMC Cancer, vol. 24, 83. https://doi.org/10.1186/s12885-023-11792-4
Kong, A, Kirkham, AJ, Savage, JS, Mant, R, Lax, S, Good, J, Forster, MD, Sacco, JJ, Schipani, S, Harrington, KJ, Yap, C & Mehanna, H 2024, 'Results and lessons learnt from the WISTERIA phase I trial combining AZD1775 with cisplatin pre- or post-operatively in head and neck cancer', BJC Reports, vol. 2, no. 1, 6. https://doi.org/10.1038/s44276-023-00026-6
Hirschfield, G, Arndtz, K, Kirkham, A, Chen, Y-Y, Fox, R, Rowe, A, Douglas-Pugh, J, Thorburn, D, Barnes, E, Aithal, GP, Hull, D, Bhandal, K, Olsen, K, Woodward, P, Lax, S, Newsome, P, Smith, D, Kallio, A, Adams, D, Homer, V & Weston, C 2024, 'Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: open-label, multi-centre, single arm, phase II trial', Hepatology Communications.
Fernando, IN, Lax, S, Bowden, SJ, Ahmed, I, Steven, JH, Churn, M, Brunt, AM, Agrawal, RK, Canney, P, Stevens, A & Rea, DW 2023, 'Detailed Sub-study Analysis of the SECRAB Trial: Quality of Life, Cosmesis and Chemotherapy Dose Intensity', Clinical Oncology, vol. 35, no. 6, pp. 397-407. https://doi.org/10.1016/j.clon.2023.03.007
Stapley, R, Smith, C, Haining, E, Bacon, A, Lax, S, Pisareva, V, Pisarev, A, Watson, S, Khan, A & Morgan, N 2021, 'Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment: SLFN14 mediates lineage commitment in mice', Blood Advances, vol. 5, no. 2, pp. 377–390. https://doi.org/10.1182/bloodadvances.2020002404
Haining, E, Lowe, K, Wichaiyo, S, Kataru, RP, Nagy, Z, Kavanagh, D, Lax, S, Di, Y, Nieswandt, B, Ho-Tin-Noé, B, Mehrara, BJ, Senis, Y, Rayes, J & Watson, S 2021, 'Lymphatic blood filling in CLEC-2-deficient mouse models', Platelets, vol. 32, no. 3, pp. 352-367. https://doi.org/10.1080/09537104.2020.1734784
Chimen, M, Evryviadou, A, Box, CL, Harrison, MJ, Hazeldine, J, Dib, LH, Kuravi, SJ, Payne, H, Price, JMJ, Kavanagh, D, Iqbal, AJ, Lax, S, Kalia, N, Brill, A, Thomas, SG, Belli, A, Crombie, N, Adams, RA, Evans, S-A, Deckmyn, H, Lord, JM, Harrison, P, Watson, SP, Nash, GB & Rainger, GE 2020, 'Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation', Haematologica, vol. 105, no. 5, pp. 1248-1261. https://doi.org/10.3324/haematol.2018.215145
Wichaiyo, S, Lax-Williams, S, Montague, S, Li, Z, Grygielska, B, Pike, J, Haining, E, Brill, A, Watson, S & Rayes, J 2019, 'Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice', Haematologica, vol. 104, no. 8, pp. 1648-1660. https://doi.org/10.3324/haematol.2018.208363
Lax, S, Rayes, J, Thickett, DR & Watson, SP 2017, 'Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice', BMJ Open Respiratory Research, vol. 4, no. 1, e000257. https://doi.org/10.1136/bmjresp-2017-000257
Lax, S, Rayes, J, Wichaiyo, S, Haining, EJ, Lowe, K, Grygielska, B, Laloo, R, Flodby, P, Borok, Z, Crandall, ED, Thickett, DR & Watson, SP 2017, 'Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse', American journal of physiology. Lung cellular and molecular physiology, vol. 313, no. 6, pp. L1016-L1029. https://doi.org/10.1152/ajplung.00023.2017
Rayes, J, Lax, S, Wichaiyo, S, Watson, S, Di, Y, Lombard, S, Grygielska, B, Smith, S, Skordilis, K & Watson, S 2017, 'The podoplanin-CLEC-2 axis inhibits inflammation in sepsis', Nature Communications, vol. 8, 2239. https://doi.org/10.1038/s41467-017-02402-6
Parekh, D, Patel, JM, Scott, A, Lax, S, Dancer, RCA, D'Souza, V, Greenwood, H, Fraser, WD, Gao, F, Sapey, E, Perkins, GD & Thickett, DR 2017, 'Vitamin D deficiency in human and murine sepsis', Critical care medicine, vol. 45, no. 2, pp. 282-289. https://doi.org/10.1097/CCM.0000000000002095
Hitchcock, JR, Cook, CN, Bobat, S, Ross, EA, Flores-Langarica, A, Lowe, KL, Khan, M, Dominguez Medina, C, Lax, S, Carvalho-Gaspar, M, Hubscher, S, Rainger, G, Cobbold, M, Buckley, CD, Mitchell, TJ, Mitchell, A, Jones, N, Van Rooijen, N, Kirchhofer, D, Henderson, IR, Adams, DH, Watson, SP & Cunningham, AF 2015, 'Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets', Journal of Clinical Investigation, vol. 125, no. 12, pp. 4429–4446. https://doi.org/10.1172/JCI79070
Letter
Fernando, IN, Lax, S & Ahmed, I 2020, 'Response to Gultekin et al. regarding SECRAB trial toxicity', Radiotherapy and Oncology, vol. 147, pp. 233. https://doi.org/10.1016/j.radonc.2020.01.019
Rayes, J, Jadoui, S, Lax, S, Gros, A, Wichaiyo, S, Ollivier, V, Denis, CV, Ware, J, Nieswandt, B, Jandrot-Perrus, M, Watson, SP & Ho-Tin-Noé, B 2018, 'The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent', Haematologica, vol. 103, no. 6, pp. e256-e258. https://doi.org/10.3324/haematol.2017.182162
View all publications in research portal