Recent publications
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Gatz, SA, Berlanga, P, Le Teuff, G, Valiev, I, Leruste, A, André, N, Bluteau, D, Corradini, N, Rubino, J, Thomas, F, Nebchi, S, Karamouza, E, Petit, J, Thebaud, E, Rubio-San-Simón, A, van Eijkelenburg, NKA, Marshall, LV, Raimbault, S, Canete, A, Ducassou, S, Makin, G, Casanova, M, De Carli, E, Petit, A, Cardon, M, Lacroix, L, Pierron, G, Schleiermacher, G, Hubank, MJF, Fernandez, AS, Langenberg, KPS, Castel, D, Adam-de Beaumais, T, Paoletti, X, Lukka, PB, Baldry, R, Mortimer, PGS, Nikolaev, SI, Geoerger, B & Lax, S 2026, 'Phase I/II study of the PARP inhibitor olaparib and irinotecan in children and young adults with recurrent/refractory malignancies: Arm D of the AcSé-ESMART trial', Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-25-3767
Brugha, R, Kirkham, A, Bate, J, Burke, GAA, Hughes, A, Magwaro, S, Pope, AM, Beesley, R, Lax, S, Kelly, E, Greenland, M, Minassian, AM, Liu, X, Billingham, L, McInnes, I, Goodyear, CS, Kearns, P, Wedderburn, LR & OCTAVE-Minor Collaborative Group 2026, 'SARS-CoV-2-Specific Immune Responses to Vaccination in Children and Adolescents with Suppressed Immune Systems: A Prospective, Observational Study', The Journal of pediatrics, vol. 289, 114873. https://doi.org/10.1016/j.jpeds.2025.114873
Moiemen, N, Homer, V, Nice, L, Brock, K, Jenkins, S, Altarrah, K, Imran, R, Tullie, S, Barton, D & Lax, S 2025, 'Efficacy and optimal dose of acetic acid for treating colonised burns wounds (AceticA): a double-blind, single Centre, randomised, controlled phase II trial', Journal of Burn Care and Research. https://doi.org/10.1093/jbcr/iraf228
McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF & Lax, S 2025, 'Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial', BMC Cancer, vol. 25, 56. https://doi.org/10.1186/s12885-024-13383-3
Dias, RP, Brock, K, Hu, K, Gupta, R, Martin, U, Peet, A, Wilson, M, Yu-Wai-Man, P, Wright, B, Mollan, S, Kulkarni, A, Meunier, I, Billingham, L, Nagy, Z, Rose, H, Koks, S, Zatyka, M, Astuti, D, Lynch, T, Morrison, KE, Barton, D, Cronier, S, Malpass, R, Evans, R, Malhi, A, Takhar, P, Lamb, A, Esteban-Bueno, G, Młynarski, W, Orssaud, C, Roubertie, A, Homer, V, Barrett, T & Lax, S 2025, 'Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind controlled trial', BMJ Open, vol. 15, no. 2, e091495. https://doi.org/10.1136/bmjopen-2024-091495
Bhaskaran, D, Savage, J, Patel, A, Collinson, F, Mant, R, Boele, F, Brazil, L, Meade, S, Buckle, P, Lax, S, Billingham, L & Short, S 2024, 'A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): Protocol for a multi-centre, double-blind, placebo-controlled trial', BMC Cancer, vol. 24, 83. https://doi.org/10.1186/s12885-023-11792-4
McIlroy, G, Lax, S, Gaskell, C, Jackson, A, Rhodes, M, Seale, T, Fox, S, Hopkins, L, Okosun, J, Barrington, SF, Ringshausen, I, Ramsay, AG, Calaminici, M, Linton, K & Bishton, M 2024, 'Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial', BMC Cancer, vol. 24, no. 1, 370. https://doi.org/10.1186/s12885-024-12112-0
Kong, A, Kirkham, AJ, Savage, JS, Mant, R, Lax, S, Good, J, Forster, MD, Sacco, JJ, Schipani, S, Harrington, KJ, Yap, C & Mehanna, H 2024, 'Results and lessons learnt from the WISTERIA phase I trial combining AZD1775 with cisplatin pre- or post-operatively in head and neck cancer', BJC Reports, vol. 2, no. 1, 6. https://doi.org/10.1038/s44276-023-00026-6
Hirschfield, G, Arndtz, K, Kirkham, A, Chen, Y-Y, Fox, R, Rowe, A, Douglas-Pugh, J, Thorburn, D, Barnes, E, Aithal, GP, Hull, D, Bhandal, K, Olsen, K, Woodward, P, Lax, S, Newsome, P, Smith, D, Kallio, A, Adams, D, Homer, V & Weston, C 2024, 'Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: open-label, multi-centre, single arm, phase II trial', Hepatology Communications, vol. 8, no. 5, e0426. https://doi.org/10.1097/HC9.0000000000000426
Fernando, IN, Lax, S, Bowden, SJ, Ahmed, I, Steven, JH, Churn, M, Brunt, AM, Agrawal, RK, Canney, P, Stevens, A & Rea, DW 2023, 'Detailed Sub-study Analysis of the SECRAB Trial: Quality of Life, Cosmesis and Chemotherapy Dose Intensity', Clinical Oncology, vol. 35, no. 6, pp. 397-407. https://doi.org/10.1016/j.clon.2023.03.007
Mahida, RY, Lax, S, Bassford, CR, Scott, A, Parekh, D, Hardy, RS, Naidu, B, Matthay, MA, Stewart, PM, Cooper, MC, Perkins, GD & Thickett, DR 2023, 'Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS', Frontiers in immunology, vol. 14, 1159831. https://doi.org/10.3389/fimmu.2023.1159831
Stapley, R, Smith, C, Haining, E, Bacon, A, Lax, S, Pisareva, V, Pisarev, A, Watson, S, Khan, A & Morgan, N 2021, 'Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment: SLFN14 mediates lineage commitment in mice', Blood Advances, vol. 5, no. 2, pp. 377–390. https://doi.org/10.1182/bloodadvances.2020002404
Haining, E, Lowe, K, Wichaiyo, S, Kataru, RP, Nagy, Z, Kavanagh, D, Lax, S, Di, Y, Nieswandt, B, Ho-Tin-Noé, B, Mehrara, BJ, Senis, Y, Rayes, J & Watson, S 2021, 'Lymphatic blood filling in CLEC-2-deficient mouse models', Platelets, vol. 32, no. 3, pp. 352-367. https://doi.org/10.1080/09537104.2020.1734784
Comment/debate
Gray, J, Weston, R, Gates, S, Moreno, L & Lax, S 2026, 'Reply to: Signal Worth Trusting—If We Can Reproduce It: Clarifying Overall Response Rate and Progression-Free Survival in BEACON Immuno', Journal of Clinical Oncology . https://doi.org/10.1200/JCO-26-00237
Letter
Hare, L, Hughes, J, Morgan, M, Burke, GAA, Trotman, J, Tarpey, P, Hatcher, H, Ford, SJ, Watkins, AJ, Hook, CE, Murray, MJ & Lax, S 2026, 'Novel Pediatric Aggressive Adipose Tumor With Pathogenic TERT Promoter Variant and an Initial Durable Response to Vincristine and Dactinomycin', Pediatric Blood & Cancer, vol. 73, no. 5, e70193. https://doi.org/10.1002/1545-5017.70193
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