Mr Simon Bach BMedSci (Hons) MB BS MD FRCS (Gen.)

Institute of Cancer and Genomic Sciences
Clinical Lead D3B Early Phase Trials Unit, CRUK Clinical Trials Unit
Consultant Colorectal Surgeon, Queen Elizabeth Hospital Birmingham, Academy Department of Surgery

Contact details

Telephone: +44 (0) 121 6978449
Email: s.p.bach@bham.ac.uk

Address: Institute of Cancer and Genomic Sciences
Office 17, First Floor
Institute of Translational Medicine, Heritage Building
Mindelsohn Way
Edgbaston
Birmingham B15 2TH

Simon is a colorectal surgeon in Birmingham and chief investigator for the Cancer Research UK TREC and STAR-TREC studies evaluating rectal sparing treatment for early rectal cancer. I am Royal College of Surgeons of Eng Surgical Specialty Lead for colorectal surgery and have developed a national strategy for research prioritisation, collaborating closely with ACPGBI and stakeholder charities. This initiative has produced a number of exciting new studies including the HTA Prepare ABC (prehabillitaion), CIPER (parastomal hernia) an LEGO (resolution of postoperative ileus).

Simon works with the trainee collaboratives e.g. national audit of small bowel obstruction (NASBO) and with medical student collaboratives; STAR-SURG (http://starsurg.org)and EUROSURG (http://eurosurg.org) developing a training programme to teach recruitment techniques for randomised studies (GRANULE).

Simon is clinical lead for Birmingham’s early phase trials unit (Drugs, Diagnostics, Devices and Biomarkers -D3B) also chair the National Cancer Research Institute Colorectal Surgery subgroup, overseeing delivery of the UK’s colorectal cancer research portfolio.

Qualifications

Aug 2006 FRCS (General Surgery Intercollegiate Board)
Jan 2003 Doctor of Medicine (University of Manchester)
May 1997 FRCS (RCS England)
July 1992 MB BS (University of Newcastle upon Tyne)
June 1989 Bachelor of Medical Sciences (Hons)

Biography

POSITIONS HELD

1. Clinical lead D3B (drugs, devices, diagnostics and biomarkers) early phase clinical trials unit UHB/UoB

2. Deputy Director CRUK trials unit Birmingham.

3. Chair National Cancer Research Institute surgical subgroup colorectal cancer

4. Royal College of Surgeons (Eng) research lead for colorectal surgery

5. Chief investigator international STAR-TREC study.

6. TMG CRUK ARISTOTLE

7. DMEC MRC ICON 8 study & FP7 eSMART

8. Birmingham NIHR BRC operations group

9. Birmingham ECMC management group

10. Perioperative Medicine Clinical Trials Network working group

Publications

Association of Coloproctology of Great Britain and Ireland consensus exercise on surgical management of fistulating perianal Crohn's disease. ACPGBI Perianal Crohn’s Disease Group. Colorectal Disease 2017 May;19(5):418-429. doi: 10.1111/codi.13672

A national patient and public colorectal research agenda: Integration of consumer perspectives in bowel disease through early consultation. McNair AGK,Heywood N, Tiernan J, Verjee A, Bach SP, Fearnhead NS. On behalf of ORACLE Collaboration. Colorectal Disease 2017 Jan;19(1): O75-O85. doi: 10.1111/codi.13564.

Does HubBLe spell trouble for HAL? Bach SP and Fearnhead N. Lancet. 2016 Jul 23;388(10042):311-2.

Feasibility study from a randomised controlled trial of standard closure of stoma site versus biologic mesh reinforcement. On behalf of the Reinforcement of Closure of Stoma Site (ROCSS) Collaborative and the West Midlands Research Collaborative. Colorectal Disease 2016 Sep;18(9):889-96.

EuroSurg: a new European student-driven research network in surgery. EuroSurg Collaborative. Colorectal Disease 2016 Feb;18(2):214-5. doi: 10.1111/codi.13260.

Interventions in randomised controlled trials in surgery: issues to consider during trial design. Blencowe NS et al. Trials 2015 Sep 4;16:392.

Surgical excision: Submucosal or Transmural? Bach SP. EMJ Gastroenterology 2016. In press.

A multicentre study of short course preoperative radiotherapy and TEMS for early rectal cancer. Smart CJ, Korsgen S, Hill J, Speake D, Levy B, Steward M, Geh JI, Robinson J, Sebag-Montefiore D, Bach SP. BJS 2016 Jul;103(8):1069-75.

Early rectal cancer: the European Association for Endoscopic Surgery (EAES) clinical consensus conference. Morino M, Risio M, Bach S, Beets-Tan R, Bujko K, Panis Y, Quirke P, Rembacken B, Rullier E, Young-Fadok T, Allaix M. Surgical Endoscopy 2015.

Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas. Waage J, Leh S, Røsler C, Pfeffer F, Bach S, Flesland Havre R, Haldorsen IS, Ødegaard S, Baatrup G. Colorectal Disease 2015 Feb;17(2):124-31.

Combined endorectal ultrasonography and strain elastography for staging of early rectal cancer. Waage J, Bach SP, Pfeffer F, Leh S, Havre R, Ødegaard S, Baatrup G. Colorectal Disease 2015 Jan;17(1):50-6.

Biomarker based treatment selection in early stage rectal cancer to promote organ preservation. Leong KJ, Beggs A, James J, Morton DG, Matthews GM, Bach SP. BJS 2014. Sep;101(10):1299-309.

The cost effectiveness of wound edge protection devices compared to standard care in reducing surgical site infection after laparotomy: an economic evaluation alongside the ROSSINI trial. ROSSINI Trial Invesitgators. PLoS One 2014 Apr 18;9(4):e95595.

Commentry on Systematic review and meta-analysis of published trials comparing the effectiveness of transanal endoscopic microsurgery and radical resection in the management of early rectal cancer.Bach SP. Colorectal Dis. 2014 Jan;16(1):15-6.

Hypermethylation of SNAP91 as an alternative mechanism of epidermal growth factor signaling dysregulation: a genome-wide meta-analysis with validation of colorectal cancers. Beggs A, James J, Leong K, Caldwell G, Ronlund K, Bach SP, Kolvraa S, Morton DG, Matthews GM. Lancet Feb 2014, Vol 383, S25.

Indications for Transanal Endoscopic Microsurgery. Smart C, Cunningham C, Bach SP. Best practice & research. Clinical gastroenterology. Feb 2014; 28(1): 143-157.

Impact of tissue processing, archiving and enrichment techniques on DNA methylation yield in rectal carcinoma. Leong KJ, James J, Wen K, Taniere P, Morton DG, Bach SP, Matthews GM. Exp Mol Path 2013 Dec; 95(3): 349-9.

The impact of wound-edge protection devices on surgical site infection after laparotomy (ROSSINI Trial): a multicentre randomised controlled trial. West Midlands Research Collaborative and the ROSSINI Trial Investigators BMJ 2013;347:f4305

Is Tailoring Treatment of Rectal Cancer the Only True Benefit of Long-Course Neoadjuvant Chemoradiation? Bach SP. Diseases of The Colon and Rectum 2013 Feb;56(2):267-70.

A critical appraisal of ERUS, TEM and decision-making in early rectal cancer. Ashraff SQ, Hompes R, Slater A, Lindsey I, Bach S, Mortensen NJ and Cunningham C, on behalf of the ACPGBI TEM Collaboration. Colorectal Disease 2013.

Methylation profiling of rectal cancer identifies novel markers of early stage disease. Leong KJ, Wei W, Tannahill LA, Caldwell GM, Jones CE, Morton DG, Matthews GM and Bach SP. BJS 2011 May;98(5):724-34.

Severe Perineal Burns. D’Souza BB, Heriot A, Bach SP, Beer J. ANZ Journal of Surgery 2010

A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Bach SP, Hill J, Monson JRT, Simson JNL, Lane L, Merrie A, Warren B and Mortensen NJ on behalf of the ACPGBI TEM Collaboration. BJS 2009; 96(3): 280-290.

Developments in early rectal cancer treatment. Bach SP. European Journal of Cancer 2009; 45: 464-5.

A rare cause of the "acute abdomen" following proctocolectomy. Croagh D, Bach SP and Keck J. The American Journal of Surgery 2009; 197(4): 41-42.

Ileal pouch surgery for ulcerative colitis. Bach SP and Mortensen NJ. World Journal of Gastroenterology 2007. Jun 28;13(24):3288-300.

Regional Localisation of p53 Independent Apoptosis Determines Toxicity to 5-Fluorouracil and Pyrrolidinedithiocarbamate in the Murine Gut. Bach SP, Williamson SE, O'Dwyer ST, Potten CS and Watson AJM. British Journal of Cancer 2006; 95(1): 35-41.

Revolution and Evolution: 30 Years of Ileoanal Pouch Surgery. Bach SP and Mortensen NJ. Inflammatory Bowel Disease 2006; 12(2): 131-45.

The antioxidant N-acetylcysteine increases 5-fluorouracil activity against colorectal cancer xenografts in nude mice. Bach SP, Williamson SE, Marshman E, Kumar S, O'Dwyer ST, Potten CS and Watson AJM. Journal of Gastrointestinal Surgery 2001; 5(1): 91-97.

The Relevance of Apoptosis for Cellular Homeostasis and Tumorogenesis in the Intestine. Renehan AH, Bach SP and Potten CS. Canadian Journal of Gastroenterology 2001; 15(3): 166-76.

Pyrrolidinedithiocarbamate Increases the Therapeutic Index of 5-FU in a Mouse Model. Bach SP, Chinery R, O’Dwyer ST, Potten CS, Coffey RJ and Watson AJM. Gastroenterology 2000; 118 (1): 81-89.

Stem Cells - the intestinal stem cell as a paradigm. Bach SP, Renehan AH and Potten CS. Carcinogenesis 2000; 21: 469-476.