Dr Richard T. Bryan MBChB PhD MRCS FAcadTM

Dr Richard T. Bryan

Institute of Cancer and Genomic Sciences
Director of the Bladder Cancer Research Centre
Reader in Urothelial Cancer Research

Contact details

Telephone
+44 (0)121 414 7870
Email
r.t.bryan@bham.ac.uk
View my research portal
Address
Institute of Cancer and Genomic Sciences
Robert Aitken Institute for Clinical Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Rik Bryan is a former clinical urologist, and now a full-time bladder cancer research academic. He is the Chief Investigator of the Bladder Cancer Prognosis Programme (BCPP), the SELENIB clinical trial, and POUT-T. He is the Director of the Bladder Cancer Research Centre (BCRC) in the Institute of Cancer & Genomic Sciences. The BCRC has a particular interest in the proteomics, genomics and epigenomics of bladder cancer and related biomarkers, and novel agents, technologies and pathways.

Qualifications

  • Fellow of the Academy of Translational Medicine 2016
  • PhD in Medicine 2007
  • Membership of The Royal College of Surgeons of England 1999
  • MBChB 1995

Biography

Rik Bryan qualified in Medicine at the University of Birmingham and subsequently entered surgical training. After completing a PhD in bladder cancer biology he became a higher surgical trainee in Urology. After 4-years as a Specialist Registrar, Rik left clinical urology to assist with the set-up of the Bladder Cancer Prognosis Programme (BCPP) in the Department of Public Health, Epidemiology and Biostatistics at the University of Birmingham, and was then subsequently appointed as a Senior Research Fellow in the School of Cancer Sciences. Rik is now the Chief Investigator of BCPP, which incorporates the SELENIB clinical trial.

Rik has an interest in all aspects of bladder cancer research and directs the Bladder Cancer Research Centre (BCRC) with a focus on translation. The particular interests of the BCRC include cancer proteomics/genomics/epigenomics, urinary biomarkers, novel therapeutics/technologies/devices, and clinical and epidemiological research. Rik has a track record of publication in all of these areas.

The BCRC also has an interest in upper tract urothelial cancer, and Rik is the Chief Investigator of POUT-T, the translational study linked to the POUT trial.

Postgraduate supervision

  • Intercalated BMedSci
  • MRes
  • PhD

Research

  • Genomics and epigenomics, and associated biomarkers for non-invasive diagnosis and prognostication
  • Novel genomic platforms and approaches
  • Proteomics and urinary protein biomarkers
  • Novel therapeutics, technologies and devices and associated clinical trials
  • Tumour immunology and BCG mechanisms of action
  • Clinical, epidemiological and health economic research.

Aside from the research carried out at the University of Birmingham, the Bladder Cancer Group also has a number of important national and international collaborations with other bladder cancer investigators, including Professor Maurice Zeegers (Maastricht), Professor John Kelly (UCL), Professor Bart Kiemeney (Radboud), Professor Chris Probert (Liverpool), Dr Anne Kiltie (Oxford) and Professor Chas Bountra (Oxford).

Other activities

Aside from his bladder cancer research at the University of Birmingham, Rik also fulfils a number of other roles:

  • Member of the University of Birmingham’s Clinical Trials Oversight Committee (CTOC)
  • Member of the Bladder GeCIP, 100,000 Genomes Project
  • Trustee of the charity Action Bladder Cancer UK
  • Member of the T2 and Below Subgroup (TABS) of the NCRI Bladder & Renal Clinical Studies Group
  • Council Member and current Honorary Secretary of The Royal Society of Medicine Section of Urology
  • Member of the Trial Management Group of the Peri-Operative Chemotherapy versus Surveillance in Upper Tract Urothelial Cancer (POUT) trial
  • Member of the Trial Management Group of the Clinical Research Office of the Endourology Society (CROES) multicentre randomised trial of narrow band imaging-assisted transurethral resection (TURBT) versus conventional white light-assisted TURBT in primary non-muscle-invasive bladder cancer patients.

Publications

Recent publications

Article

Galesloot, TE, Grotenhuis, AJ, Kolev, D, Aben, KK, Bryan, RT, Catto, JWF, Cheng, KK, Conroy, S, Dyrskjøt, L, Fleshner, NE, James, ND, Lamy, P, Lindskrog, SV, Malats, N, Mengual, L, Verhaegh, G, Zeegers, MP, Kiemeney, LALM & Vermeulen, SH 2022, 'Genome-wide meta-analysis identifies novel genes associated with recurrence and progression in non-muscle-invasive bladder cancer', European Urology Oncology, vol. 5, no. 1, pp. 70-83. https://doi.org/10.1016/j.euo.2021.07.001

BladderPath Trial Management Group 2022, 'Highly sensitive and specific detection of bladder cancer via targeted ultra-deep sequencing of urinary DNA', European Urology Oncology. https://doi.org/10.1016/j.euo.2022.03.005

Gordon, N, Humayun-Zakaria, N, Goel, A, Abbotts, B, Zeegers, MP, Cheng, KK, Arnold, R, James, ND, Bryan, R & Ward, D 2022, 'STAG2 protein expression in non-muscle-invasive bladder cancer: associations with sex, genomic and transcriptomic changes, and clinical outcomes', European Urology Open Science, vol. 38, pp. 88-95. https://doi.org/10.1016/j.euros.2022.02.004

Iya, AM, Beyer, K, Kotecha, P, Kibaru, J, Abdullahi, M, Alhassan, SU, Mustapha, MI, Ahmad, A, Lawal, Y, Jalo, RI, Aminu, A, Abubakar, A, Saleh, A, Bryan, R, Van Hemelrijck, M & Russell, B 2022, 'Scoping review: bladder cancer in Nigeria - what are the gaps in clinical care and research?', BMJ open, vol. 12, no. 3, e049241, pp. 1-11. https://doi.org/10.1136/bmjopen-2021-049241

Spencer-Bowdage, S, Russell, B, Rigby, J, O'Kelly, J, Kelly, P, Page, M, Raw, C, Allchorne, P, Harper, P, Crew, J, Kockelbergh, R, Knight, A, Van Hemelrijck, M & Bryan, R 2022, 'The experience of UK patients with bladder cancer during the second wave of the COVID-19 pandemic', BJUI Compass. <https://bjui-journals.onlinelibrary.wiley.com/journal/26884526>

Gordon, NS, Baxter, LA, Goel, A, Arnold, R, Kaur, B, Liu, W, Pirrie, SJ, Hussain, S, Viney, R, Ford, D, Zarkar, A, Wood, MA, Mitin, T, Thompson, RF, James, ND, Ward, DG & Bryan, RT 2022, 'Urine DNA for monitoring chemoradiotherapy response in muscle-invasive bladder cancer: a pilot study', BJU International , vol. 129, no. 1, pp. 32-34. https://doi.org/10.1111/bju.15589

Veskimae, E, Subbarayan, S, Campi, R, Carron, D, Omar, MI, Yuan, C, Dimitropoulos, K, Van Hemelrijck, M, Bryan, R, N'Dow, J, Babjuk, M, Witjes, JA, Sylvester, R & MacLennan, S 2021, 'A systematic review of outcome reporting, definition and measurement heterogeneity in non-muscle invasive bladder cancer effectiveness trials of adjuvant, prophylactic treatment after transurethral resection', Bladder Cancer, vol. 7, no. 2, pp. 221-241. https://doi.org/10.3233/BLC-201510

Lindskrog, SV, Prip, FF, Lamy, P, Taber, A, Groeneveld, CS, Birkenkamp-Demtröder, K, Jensen, J, Strandgaard, T, Nordentoft, I, Christensen, E, Sokac, M, Birkbak, NJ, Maretty, L, Hermann, GG, Petersen, AC, Weyerer, V, Grimm, MO, Horstmann, M, Sjödahl, G, Höglund, M, Steiniche, T, Mogensen, K, de Reyniès, A, Nawroth, R, Jordan, B, Lin, X, Dragicevic, D, Ward, D, Goel, A, Hurst, CD, Raman, JD, Warrick, JI, Segersten, U, Sikic, D, van Kessel, KEM, Maurer, T, Meeks, JJ, DeGraff, DJ, Bryan, R, Knowles, MA, Simic, T, Hartmann, A, Zwarthoff, EC, Malmström, PU, Malats, N, Real, FX & Dyrskjøt, L 2021, 'An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer', Nature Communications, vol. 12, no. 1, 2301. https://doi.org/10.1038/s41467-021-22465-w

Bryan, R, Liu, W, Pirrie, S, Amir, R, Gallagher, J, Hughes, A, Jefferson, K, Knight, A, Nanton, V, Mintz, H, Pope, A, Catto, J, Patel, P & James, N 2021, 'Comparing an imaging-guided pathway with the standard pathway for staging muscle-invasive bladder cancer: preliminary data from the BladderPath study', European urology, vol. 80, no. 1, pp. 12-15. https://doi.org/10.1016/j.eururo.2021.02.021

Bessa, A, Bosco, C, Cahill, F, Russell, B, Fox, L, Moss, C, Wylie, H, Haire, A, Green, S, Enting, D, Khan, S, Nair, R, Thurairaja, R, Chatterton, K, Amery, S, Peat, N, Smith, S, Spear, S, Bryan, RT, Frodsham, L, Burke, D, Rigby, J, Makaroff, L, Kelly, P, Costin, M, Häggström, C & Van Hemelrijck, M 2021, 'Designing a pragmatic intervention to help improve the bladder cancer patient experience', Inquiry : a journal of medical care organization, provision and financing, vol. 58, 469580211030217. https://doi.org/10.1177/00469580211030217

Richters, A, Kiemeney, LALM, Mehra, N, Westgeest, HM, Birtle, A, Bryan, RT & Aben, KKH 2021, 'Evidence or prejudice? Critical re-analysis of randomized controlled trials comparing overall survival after cisplatin versus carboplatin-based regimens in advanced urothelial carcinoma', Clinical Genitourinary Cancer. https://doi.org/10.1016/j.clgc.2021.12.017

Dowell, A, Munford, H, Goel, A, Gordon, N, James, N, Cheng, KK, Zeegers, M, Ward, D & Bryan, R 2021, 'PD-L2 is constitutively expressed in normal and malignant urothelium', Frontiers in Oncology, vol. 11, 626748. https://doi.org/10.3389/fonc.2021.626748

Comment/debate

Bryan, RT, Arnold, R, Khanim, FL, Shepherd, DE, Patel, P & Ward, DG 2021, 'Establishing the Bladder Cancer Research Centre at the University of Birmingham', Nature Reviews Urology, vol. 18, no. 6, pp. 318-320. https://doi.org/10.1038/s41585-021-00448-2

BladderPath Trial Management Group 2021, 'Reply to Trey Durdin, Alvin Goh, and Eugene Pietzak. Can an imaging-guided pathway replace the current paradigm for muscle-invasive bladder cancer?', European urology, vol. 80, no. 1, pp. 18-19. https://doi.org/10.1016/j.eururo.2021.04.034

Review article

Unsworth-White, S, Kitchen, M & Bryan, R 2022, 'Immunotherapy for non-muscle invasive bladder cancer: from the origins of BCG to novel therapies', Future Oncology, vol. 18, no. 1, pp. 105-115. https://doi.org/10.2217/fon-2021-0781

View all publications in research portal

Expertise

Bladder Cancer