Our mission is to understand how cancer cells adapt to and exploit aneuploidy.
We combine cutting edge functional genomics, bioinformatics and machine learning to develop diagnostic and therapeutic strategies to deliver the next generation of precision oncology based on large-scale alterations of cancer genomes.
Please visit our website: www.continolab.org
Establish models of aneuploidy in gastrointestinal cancers and in particular of Barrett’s oesophagus and oesophageal adenocarcinoma
Our lab is investigating the evolutionary routes that cancer genome follows during their accumulation of large-scale chromosomal rearrangements. We aim to understand what the molecular mechanisms of initiation and dependency of aneuploidy in cancer cells are. We combine developing cutting edge functional genomics and bioinformatic approaches to model aneuploidy in vitro and in large cohorts of cancer genomes.
Copy Number and Structural Variation based cancer genome-wide association studies
We are developing methods to unveil the heritability of Cancer Genome due to Copy Number and Structural Variation in germline genomes. We are developing a pan cancer pipeline leveraging on our collaboration with Genomics England and UK Biobank.
Novel Aneuploidy-Based Biomarkers
We are developing novel sequencing methods to identify and track aneuploidy for prevention and treatment of oesophageal cancer from Cytosponge, biopsies and blood.
Increase diversity in Cancer Genomes Repositories
We are investigating germline risk variants and somatic genomic features of cancer associated with different ethinic background. We are collaborating with institutions world-wide and with UK genomic services to improve our understanding of diverse genomes.