Recent publications
Article
Blagden, SP, Billingham, L, Brown, LC, Buckland, SW, Cooper, AM, Ellis, S, Fisher, W, Hughes, H, Keatley, DA, Maignen, FM, Morozov, A, Navaie, W, Pearson, S, Shaaban, A, Wydenbach, K & Kearns, PR 2020, 'Effective delivery of Complex Innovative Design (CID) cancer trials—A consensus statement', British Journal of Cancer. https://doi.org/10.1038/s41416-019-0653-9
Jackson, RK, Liebich, M, Berry, P, Errington, J, Liu, J, Parker, C, Moppett, J, Samarasinghe, S, Hough, R, Rowntree, C, Goulden, NJ, Vora, A, Kearns, PR, Saha, V, Hempel, G, Irving, JAE & Veal, GJ 2019, 'Impact of dose and duration of therapy on dexamethasone pharmacokinetics in childhood acute lymphoblastic leukaemia: a report from the UKALL 2011 trial', European Journal of Cancer, vol. 120, pp. 75-85. https://doi.org/10.1016/j.ejca.2019.07.026
Janssens, GO, Timmermann, B, Laprie, A, Mandeville, H, Padovani, L, Chargari, C, Journy, N, Kameric, L, Kienesberger, A, Brunhofer, M, Kozhaeva, O, Gasparotto, C, Kearns, P, Boterberg, T, Lievens, Y & Vassal, G 2019, 'Recommendations for the organisation of care in paediatric radiation oncology across Europe: a SIOPE-ESTRO-PROS-CCI-Europe collaborative project in the framework of the JARC', European Journal of Cancer, vol. 114, pp. 47-54. https://doi.org/10.1016/j.ejca.2019.03.003
Pais, H, Ruggero, K, Zhang, J, Al-Assar, O, Bery, N, Bhuller, R, Weston, V, Kearns, PR, Mecucci, C, Miller, A & Rabbitts, TH 2019, 'Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model', Scientific Reports, vol. 9, no. 1, 5760. https://doi.org/10.1038/s41598-019-42214-w
Kearns, PR, European Neuroblastoma Study Group (ENSG) & Children's Cancer and Leukaemia Group (CCLG) 2019, 'Long-term analysis of children with metastatic neuroblastoma treated in the ENSG5 randomised clinical trial', Pediatric Blood & Cancer, vol. 66, no. 4, e27565. https://doi.org/10.1002/pbc.27565
Ferrari, A, Brecht, IB, Gatta, G, Schneider, DT, Orbach, D, Cecchetto, G, Godzinski, J, Reguerre, Y, Bien, E, Stachowicz-Stencel, T, Ost, M, Magni, C, Kearns, P, Vassal, G, Massimino, M, Biondi, A, Bisogno, G & Trama, A 2019, 'Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors', European Journal of Cancer, vol. 110, pp. 120-126. https://doi.org/10.1016/j.ejca.2018.12.031
Mussai, F, Wheat, R, Sarrou, E, Booth, S, Stavrou, V, Fultang, L, Perry, T, Kearns, P, Cheng, P, Keehsan, K, Craddock, C & De Santo, C 2018, 'Targeting the arginine metabolic brake enhances immunotherapy for leukaemia', International Journal of Cancer. https://doi.org/10.1002/ijc.32028
Stevens, S, Main, C, Bailey, S, Pizer, B, English, M, Phillips, B, Peet, A, Avula, S, Wilne, S, Wheatley, K, Kearns, P & Wilson, J 2018, 'The utility of routine surveillance screening with magnetic resonance imaging to detect tumour recurrence/progression in children with high-grade central nervous system tumours', Pediatric Blood & Cancer. https://doi.org/10.1002/pbc.27509
Stevens, SP, Main, C, Bailey, S, Pizer, B, English, M, Phillips, R, Peet, A, Avula, S, Wilne, S, Wheatley, K, Kearns, PR & Wilson, JS 2018, 'The utility of routine surveillance screening with magnetic resonance imaging (MRI) to detect tumour recurrence in children with low-grade central nervous system (CNS) tumours: a systematic review', Journal of Neuro-Oncology, vol. 139, no. 3, pp. 507-522. https://doi.org/10.1007/s11060-018-2901-x
Weston, VJ, Wei, W, Stankovic, T & Kearns, P 2018, 'Synergistic action of dual IGF1/R and MEK inhibition sensitizes childhood acute lymphoblastic leukaemia (ALL) cells to cytotoxic agents and involves down-regulation of STAT6 and PDAP1', Experimental Hematology, vol. 63, pp. 52-63.e5. https://doi.org/10.1016/j.exphem.2018.04.002
De Santo, C, Booth, S, Vardon, A, Cousins, A, Tubb, V, Perry, T, Noyvert, B, Beggs, A, Ng, M, Halsey, C, Kearns, P, Cheng, P & Mussai, F 2018, 'The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated-recombinant arginase I BCT-100', International Journal of Cancer, vol. 142, no. 7, pp. 1490-1502. https://doi.org/10.1002/ijc.31170
Comment/debate
Kearns, PR, Vassal, G, Ladenstein, R, Schrappe, M, Biondi, A, Blanc, P, Eggert, A, Kienesberger, A, Kozhaeva, O, Pieters, R & Schmiegelow, K 2019, 'A European paediatric cancer mission: aspiration or reality?', The Lancet Oncology, vol. 20, no. 9, pp. 1200-1202. https://doi.org/10.1016/S1470-2045(19)30487-5
Letter
Kearns, P, Zwaan, CM, Reinhardt, D, Gibson, B, Moreno, L, Nysom, K, Nakahara, S, Huang, F, Zhou, W, Parasrampuria, DA & Nemat, S 2019, 'Phase 1-2 safety, efficacy and pharmacokinetic study of decitabine in sequential administration with cytarabine in children with relapsed or refractory acute myeloid leukaemia', British Journal of Haematology, vol. 186, no. 3, pp. e7-e11. https://doi.org/10.1111/bjh.15847
Review article
Gatz, S, Aladowicz, E, Casanova, M, Chisholm, JC, Kearns, P, Fulda, S, geoerger, B, Schafer, B & Shipley, J 2019, 'A perspective on polo-like kinase-1 inhibition for the treatment of rhabdomyosarcoma', Frontiers in Oncology, vol. 9, 1271. https://doi.org/10.3389/fonc.2019.01271
Aldape, K, Brindle, KM, Chesler, L, Chopra, R, Gajjar, A, Gilbert, MR, Gottardo, N, Gutmann, DH, Hargrave, D, Holland, EC, Jones, DTW, Joyce, JA, Kearns, P, Kieran, MW, Mellinghoff, IK, Merchant, M, Pfister, SM, Pollard, SM, Ramaswamy, V, Rich, JN, Robinson, GW, Rowitch, DH, Sampson, JH, Taylor, MD, Workman, P & Gilbertson, RJ 2019, 'Challenges to curing primary brain tumours', Nature Reviews Clinical Oncology, vol. 16, pp. 509-520. https://doi.org/10.1038/s41571-019-0177-5, https://doi.org/10.1038/s41571-019-0177-5
View all publications in research portal