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Article
Menne, T, Slade, D, Savage, J, Johnson, S, Irving, J, Kearns, P, Plummer, R, Shenton, G, Veal, GJ, Vormoor, B, Vormoor, J & Billingham, L 2022, 'Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial', BMJ open, vol. 12, no. 3, e059872. https://doi.org/10.1136/bmjopen-2021-059872
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P, Gates, S & CATALYST Trial Investigators 2021, 'CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults', BMJ open, vol. 11, no. 11, e050202. https://doi.org/10.1136/bmjopen-2021-050202
Millen, GC, Arnold, R, Cazier, J-B, Curley, H, Feltbower, R, Gamble, A, Glaser, A, Grundy, RG, Kirton, L, Lee, LYW, McCabe, MG, Palles, C, Phillips, B, Stiller, CA, Varnai, C & Kearns, P 2021, 'COVID-19 in children with haematological malignancies', Archives of Disease in Childhood. https://doi.org/10.1136/archdischild-2021-322062
de Rojas, T, Pearson, AJ, Scobie, N, Knox, L, Wariabharaj, D, Kearns, P, Vassal, G & Reaman, G 2021, 'Intercontinental collaboration in clinical trials for children and adolescents with cancer—a systematic review by ACCELERATE', Cancer Medicine, vol. 10, no. 23, pp. 8462-8474. https://doi.org/10.1002/cam4.4356
CATALYST investigators, Fisher, B, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, M, Cooke, G, Morley, N, Gabriel, Z, Wise, M, Porter, J, McShane, H, Ho, L-P, Newsome, P, Rowe, A, Sharpe, R, Thickett, D, Bion, J, Gates, S, Richards, D & Kearns, P 2021, 'Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial', The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(21)00460-4
Moreira, DC, Millen, GC, Sands, S, Kearns, PR & Hawkins, DS 2021, 'The care of children with cancer during the COVID-19 pandemic', American Society of Clinical Oncology educational book / ASCO. American Society of Clinical Oncology. Meeting, vol. 41, pp. e305-e314. https://doi.org/10.1200/EDBK_321497
Moreira, DC, Sniderman, E, Mukkada, S, Chantada, G, Bhakta, N, Foster, W, Avula, M, Homsi, MR, Faughan, L, Happ, B, Andujar, A, Sonnenfelt, J, Dalvi, R, Frazier, AL, Hessissen, L, Kearns, P, Luna-Fineman, S, Moreno, A, Khan, MS, Sullivan, M, Devidas, M, Santana, V, Caniza, M, Pritchard-Jones, K & Rodriguez-Galindo, C 2021, 'The global COVID-19 observatory and resource center for childhood cancer: a response for the pediatric oncology community by SIOP and St. Jude Global', Pediatric Blood & Cancer, vol. 68, no. 5, e28962. https://doi.org/10.1002/pbc.28962
Syrimi, E, Fennell, E, Richter, A, Vrljicak, P, Stark, R, Ott, S, Murray, PG, Al-Abadi, E, Chikermane, A, Dawson, P, Hackett, S, Jyothish, D, Kanthimathinathan, HK, Monaghan, S, Nagakumar, P, Scholefield, BR, Welch, S, Khan, N, Faustini, S, Davies, K, Zelek, WM, Kearns, P & Taylor, GS 2021, 'The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery', iScience, vol. 24, no. 11, 103215. https://doi.org/10.1016/j.isci.2021.103215
Pritchard-Jones, K, de C. V. Abib, A, Esiashvili, N, Kaspers, GJL, Rosser, J, Van Doorninck, JA, Braganca, JML, Hoffman, RI, Rodriguez-Galindo, C, Adams, C, Connor, SR, Abdelhafeez, AH, Bouffet, E, Howard, SC, Challinor, JM, Hessissen, L, Dalvi, RB, Kearns, P, Chantada, GL, Frazier, LA, Sullivan, MJ, Schulte, FSM, Morrissey, LK, Kozhaeva, O, Luna-Fineman, S & Khan, MS 2021, 'The threat of the COVID-19 pandemic on reversing global life-saving gains in the survival of childhood cancer: a call for collaborative action from SIOP, IPSO, PROS, WCC, CCI, St Jude Global, UICC and WHPCA', Ecancermedicalscience, vol. 15, 1187. https://doi.org/10.3332/ecancer.2021.1187
Vassal, G, Kozhaeva, O, Griskjane, S, Arnold, F, Nysom, K, Basset, L, Kameric, L, Kienesberger, A, Kamal, S, Cherny, N, Bricalli, G, Latino, N & Kearns, P 2020, 'Access to essential anticancer medicines for children and adolescents in Europe', Annals of oncology : official journal of the European Society for Medical Oncology. https://doi.org/10.1016/j.annonc.2020.12.015
Syrimi, E, Lewison, G, Sullivan, R & Kearns, P 2020, 'Analysis of Global Pediatric Cancer Research and Publications', JCO Global Oncology, no. 6, pp. 9-18. https://doi.org/10.1200/JGO.19.00227
Comment/debate
Pritchard-Jones, K, Challinor, JM, Hunger, SP, Sung, L, Davidson, A, Morrissey, LK, Khan, MS, Dalvi, RB, Sullivan, MJ, Hessissen, L, Chantada, GL, Kearns, P, Frazier, AL, Wollaert, S & Laub, T 2022, 'SIOP Strategy 2021-2025: cure for more, care for all', Pediatric Blood & Cancer, vol. 69, no. 6, e29577. https://doi.org/10.1002/pbc.29577
Preprint
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P & Gates, S 2021 'CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults' medRxiv, pp. 1-15. https://doi.org/10.1101/2021.02.10.21251478
Fisher, BA, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, MS, Cooke, G, Morley, N, Gabriel, Z, Wise, MP, Porter, J, McShane, H, Ho, L-P, Newsome, PN, Rowe, A, Sharpe, R, Thickett, DR, Bion, J, Gates, S, Richards, D & Kearns, P 2021 'Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial' medRxiv, pp. 1-26. https://doi.org/10.1101/2021.06.02.21258204
Menne, T, Slade, D, Savage, J, Johnson, S, Irving, JAE, Kearns, PR, Plummer, R, Shenton, G, Veal, GJ, Vormoor, B, Vormoor, J & Billingham, L 2021 'Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial' medRxiv. https://doi.org/10.1101/2021.10.22.21265327
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