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Moreno, L, DuBois, SG, Glade Bender, J, Mauguen, A, Bird, N, Buenger, V, Casanova, M, Doz, F, Fox, E, Gore, L, Hawkins, DS, Izraeli, S, Jones, DTW, Kearns, PR, Molenaar, JJ, Nysom, K, Pfister, S, Reaman, G, Smith, M, Weigel, B, Vassal, G, Zwaan, CM, Paoletti, X, Iasonos, A & Pearson, ADJ 2023, 'Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents', Journal of Clinical Oncology . https://doi.org/10.1200/JCO.22.02430
Millen, GC, Arnold, R, Cazier, J-B, Curley, H, Feltbower, R, Gamble, A, Glaser, A, Grundy, RG, Kirton, L, Lee, LYW, McCabe, MG, Palles, C, Phillips, B, Stiller, CA, Varnai, C & Kearns, P 2022, 'COVID-19 in children with haematological malignancies', Archives of Disease in Childhood, vol. 107, no. 2, pp. 186-188. https://doi.org/10.1136/archdischild-2021-322062
Retzer, A, Sivell, S, Scott, H, Nelson, A, Bulbeck, H, Seddon, K, Grant, R, Adams, R, Watts, C, Aiyegbusi, OL, Kearns, P, Cruz Rivera, S, Dirven, L, Baddeley, E, Calvert, M & Byrne, A 2022, 'Development of a core outcome set and identification of patient-reportable outcomes for primary brain tumour trials: protocol for the COBra study', BMJ open, vol. 12, no. 9, e057712, pp. e057712. https://doi.org/10.1136/bmjopen-2021-057712
CATALYST investigators, Fisher, B, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, M, Cooke, G, Morley, N, Gabriel, Z, Wise, M, Porter, J, McShane, H, Ho, L-P, Newsome, P, Rowe, A, Sharpe, R, Thickett, D, Bion, J, Gates, S, Richards, D, Kearns, P & Mussai, F 2022, 'Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial', The Lancet Respiratory Medicine, vol. 10, no. 3, pp. 255-266. https://doi.org/10.1016/S2213-2600(21)00460-4, https://doi.org/10.1016/s2213-2600(21)00460-4
the QUARTET Project and the SIOPE Radiation Oncology Working Group 2022, 'QUARTET: a SIOP Europe project for quality and excellence in radiotherapy and imaging for children and adolescents with cancer', European Journal of Cancer , vol. 172, pp. 209-220. https://doi.org/10.1016/j.ejca.2022.05.037
Menne, T, Slade, D, Savage, J, Johnson, S, Irving, J, Kearns, P, Plummer, R, Shenton, G, Veal, GJ, Vormoor, B, Vormoor, J & Billingham, L 2022, 'Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial', BMJ open, vol. 12, no. 3, e059872. https://doi.org/10.1136/bmjopen-2021-059872
De Wilde, B, Barry, E, Fox, E, Karres, D, Kieran, M, Manlay, J, Ludwinski, D, Reaman, G & Kearns, P 2022, 'The critical role of academic clinical trials in pediatric cancer drug approvals: design, conduct, and fit for purpose data for positive regulatory decisions', Journal of Clinical Oncology , vol. 40, no. 29, pp. 3456-3464. https://doi.org/10.1200/JCO.22.00033
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P, Gates, S & CATALYST Trial Investigators 2021, 'CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults', BMJ open, vol. 11, no. 11, e050202. https://doi.org/10.1136/bmjopen-2021-050202
de Rojas, T, Pearson, AJ, Scobie, N, Knox, L, Wariabharaj, D, Kearns, P, Vassal, G & Reaman, G 2021, 'Intercontinental collaboration in clinical trials for children and adolescents with cancer—a systematic review by ACCELERATE', Cancer Medicine, vol. 10, no. 23, pp. 8462-8474. https://doi.org/10.1002/cam4.4356
Millen, GC, Arnold, R, Cazier, J-B, Curley, H, Feltbower, RG, Gamble, A, Glaser, AW, Grundy, RG, Lee, LYW, McCabe, MG, Phillips, RS, Stiller, CA, Várnai, C & Kearns, PR 2021, 'Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project', British Journal of Cancer, vol. 124, pp. 754-759. https://doi.org/10.1038/s41416-020-01181-0
Comment/debate
Pritchard-Jones, K, Challinor, JM, Hunger, SP, Sung, L, Davidson, A, Morrissey, LK, Khan, MS, Dalvi, RB, Sullivan, MJ, Hessissen, L, Chantada, GL, Kearns, P, Frazier, AL, Wollaert, S & Laub, T 2022, 'SIOP Strategy 2021-2025: cure for more, care for all', Pediatric Blood & Cancer, vol. 69, no. 6, e29577. https://doi.org/10.1002/pbc.29577
Vassal, G, Lazarov, D, Rizzari, C, Szczepański, T, Ladenstein, R & Kearns, PR 2022, 'The impact of the EU General Data Protection Regulation on childhood cancer research in Europe', The Lancet Oncology, vol. 23, no. 8, pp. 974-975. https://doi.org/10.1016/S1470-2045(22)00287-X
Preprint
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P & Gates, S 2021 'CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults' medRxiv, pp. 1-15. https://doi.org/10.1101/2021.02.10.21251478
Fisher, BA, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, MS, Cooke, G, Morley, N, Gabriel, Z, Wise, MP, Porter, J, McShane, H, Ho, L-P, Newsome, PN, Rowe, A, Sharpe, R, Thickett, DR, Bion, J, Gates, S, Richards, D & Kearns, P 2021 'Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial' medRxiv, pp. 1-26. https://doi.org/10.1101/2021.06.02.21258204
Menne, T, Slade, D, Savage, J, Johnson, S, Irving, JAE, Kearns, PR, Plummer, R, Shenton, G, Veal, GJ, Vormoor, B, Vormoor, J & Billingham, L 2021 'Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial' medRxiv. https://doi.org/10.1101/2021.10.22.21265327
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