Dr Vasileios Panagiotis Lenis PhD, FHEA

Dr Vasileios Lenis

Department of Cancer and Genomic Sciences
Associate Professor in Bioinformatics and Health Data Science Education

Contact details

Address
Department of Cancer and Genomic Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

I am an Associate Professor in Bioinformatics and Health Data Science Education in the Department of Cancer and Genomic Sciences at the University of Birmingham. I serve as Programme Director for the MSc Health Data Science at the Edgbaston campus and as Deputy PGR Training Lead in the School of Medical Sciences.

My academic interests span bioinformatics, computational biology, health data science and the application of statistical and machine learning methods to biomedical research. My research involves the analysis and integration of complex biological and clinical datasets, particularly high-throughput omics data, to better understand disease mechanisms and support the development of more personalised approaches to healthcare.

Alongside my research and teaching, I am actively involved in developing and delivering bioinformatics and data science training through national and international initiatives, including ELIXIR-UK, The Carpentries and Bioconductor.

Qualifications

  • PgCert Learning and Teaching in Higher Education (LTHPGC), Teesside University, UK.
  • PhD in Bioinformatics, Aberystwyth University, UK.
  • M.Sc. in Applied Informatics, University of Macedonia, Greece.
  • B.Sc. in Computer Science, Hellenic Open University, Greece.

Biography

I am an Associate Professor in Bioinformatics and Health Data Science Education at the University of Birmingham. I hold a PhD in Bioinformatics from Aberystwyth University and have previously held academic and research positions at Aberystwyth, Plymouth and Teesside universities.

My academic work combines research in computational biology and bioinformatics with teaching, curriculum development and postgraduate programme leadership. As Programme Director for the MSc Health Data Science at the University's Edgbaston campus, I contribute to the development and delivery of interdisciplinary education at the interface of computing, statistics, biomedical sciences and healthcare.

I am also actively involved in research software and data science training, contributing to national and international training communities and initiatives that promote open, reproducible and accessible computational research.

Teaching

Programme Leadership

  • Programme Director, MSc Health Data Science (Edgbaston campus)
  • Deputy PGR Training Lead, School of Medical Sciences

MSc Health Data Science – Edgbaston

Teaching and module leadership contributions across:

  • Foundations of Computing Practices in Health Data Science
  • Epidemiology and Health Informatics
  • Data Analytics and Statistical Machine Learning for Health Data Science
  • Integrative Multimodal Data Analytics
  • Health Data Science Challenges
  • Health Data Analytics
  • Interdisciplinary Health Data Research Project

MSc Health Data Science – Dubai

Teaching and module leadership contributions to:

  • Foundations of Computing Practices in Health Data Science
  • Interdisciplinary Health Data Research Project

My teaching focuses on computational approaches to biomedical and healthcare data, including programming, statistical analysis, machine learning, bioinformatics, reproducible research and the interpretation of complex biological datasets.

Postgraduate supervision

I am always looking for interested and motivated PhD students within my preferred research areas. Please contact me directly via email. 

Research

My research interests lie at the intersection of bioinformatics, computational biology and health data science, with a particular focus on applying computational and statistical approaches to understand complex biological systems and human disease.

My work includes the analysis and integration of high-throughput omics datasets, including genomics, transcriptomics and other molecular data, alongside the application of machine learning and systems biology approaches to biomedical research.

I am particularly interested in cancer biology, molecular mechanisms of disease, biomarker discovery and the integration of heterogeneous biological and clinical data to support translational research and precision medicine. I also have a broader interest in reproducible computational workflows, research data management and FAIR data practices.

Other activities

I am actively involved in national and international bioinformatics and data science training initiatives, with a particular interest in building computational research skills and promoting reproducible, open science practices.

  • ELIXIR-UK: ELIXIR-UK Fellow and contributor to training, research data management and FAIR data stewardship initiatives, including activities supporting the development and sharing of bioinformatics training resources.
  • The Carpentries: Certified Instructor and Instructor Trainer, contributing to the delivery of Software Carpentry and Data Carpentry workshops, as well as the training of new instructors in evidence-based approaches to computational skills teaching.
  • Bioconductor: Instructor contributing to training in the analysis of high-throughput biological data using R and Bioconductor.

Through these activities, I contribute to the development and delivery of workshops and training resources for researchers and students in the UK and internationally, promoting accessible, reproducible and sustainable computational research practices.

Publications

Recent publications

Article

Bhat, N, Lenis, VP & Mohsin, S 2026, 'A Putative XIST–miRNA–ZNF662 ceRNA Axis with Diagnostic and Prognostic Potential in Oral Squamous Cell Carcinoma', International Journal of Molecular Sciences, vol. 27, no. 9, 3987. https://doi.org/10.3390/ijms27093987

Halldórsdóttir, HH, Williams, R, Greene, E, Lenis, VP & Taylor, G 2025, 'Determining the impact of elemental composition on the long-term survival of vegetable-tanned leather in archaeological environments', Archaeometry, vol. 67, no. 5, pp. 1394-1411. https://doi.org/10.1111/arcm.13101

Quesnel, A, Martin, LD, Tarzi, C, Lenis, VP, Coles, N, Islam, M, Angione, C, Outeiro, TF, Khundakar, AA & Filippou, PS 2024, 'Uncovering potential diagnostic and pathophysiological roles of α‐synuclein and DJ‐1 in melanoma', Cancer Medicine, vol. 13, no. 1, e6900. https://doi.org/10.1002/cam4.6900

Smulders-Srinivasan, TK, Jenkinson, SE, Brown, LJ, Lenis, VP & Bass, R 2023, 'PDIA6 and Maspin in Prostate Cancer', Anticancer research, vol. 43, no. 12, pp. 5331-5340. https://doi.org/10.21873/anticanres.16736

Tounsi, WA, Lenis, VP, Tammi, SM, Sainio, S, Haimila, K, Avent, ND & Madgett, TE 2022, 'Rh Blood Group D Antigen Genotyping Using a Portable Nanopore-based Sequencing Device: Proof of Principle', Clinical Chemistry, vol. 68, no. 9, pp. 1196–1201. https://doi.org/10.1093/clinchem/hvac075

Sweet-Jones, J, Lenis, VP, Yurchenko, AA, Yudin, NS, Swain, M & Larkin, DM 2021, 'Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits', Frontiers in Genetics, vol. 12, 612492. https://doi.org/10.3389/fgene.2021.612492

Craven, HM, Bonsignore, R, Lenis, VP, Santi, N, Berrar, D, Swain, M, Whiteland, H, Casini, A & Hoffmann, KF 2021, 'Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni', PLoS Neglected Tropical Diseases, vol. 15, no. 2, e0008770. https://doi.org/10.1371/journal.pntd.0008770

Dunn, J, Lenis, VP, Hilton, DA, Warta, R, Herold-Mende, C, Hanemann, CO & Futschik, M 2020, 'Integration and Comparison of Transcriptomic and Proteomic Data for Meningioma', Cancers. https://doi.org/10.3390/cancers12113270

Attardo, GM, Abd-Alla, AMM, Acosta-Serrano, A, Allen, JE, Bateta, R, Benoit, JB, Bourtzis, K, Caers, J, Caljon, G, Christensen, MB, Farrow, DW, Friedrich, M, Hua-Van, A, Jennings, EC, Larkin, DM, Lawson, D, Lehane, MJ, Lenis, VP, Lowy-Gallego, E, Macharia, RW, Malacrida, AR, Marco, HG, Masiga, D, Maslen, GL, Matetovici, I, Meisel, RP, Meki, I, Michalkova, V, Miller, WJ, Minx, P, Mireji, PO, Ometto, L, Parker, AG, Rio, R, Rose, C, Rosendale, AJ, Rota-Stabelli, O, Savini, G, Schoofs, L, Scolari, F, Swain, MT, Takáč, P, Tomlinson, C, Tsiamis, G, Van Den Abbeele, J, Vigneron, A, Wang, J, Warren, WC, Waterhouse, RM & Weirauch, MT 2019, 'Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes', Genome Biology, vol. 20, no. 1, 187. https://doi.org/10.1186/s13059-019-1768-2

Lenis, VPE, Swain, M & Larkin, DM 2018, 'G-Anchor: a novel approach for whole-genome comparative mapping utilizing evolutionary conserved DNA sequences', GigaScience. https://doi.org/10.1093/gigascience/giy017

Damas, J, O'Connor, R, Farré, M, Lenis, VPE, Martell, HJ, Mandawala, A, Fowler, K, Joseph, S, Swain, MT, Griffin, DK & Larkin, DM 2017, 'Upgrading short-read animal genome assemblies to chromosome level using comparative genomics and a universal probe set', Genome Research. https://doi.org/10.1101/gr.213660.116

Skujina, I, McMahon, R, Lenis, VE, Gkoutos, GV & Hegarty, M 2016, 'Duplication of the mitochondrial control region is associated with increased longevity in birds', Aging. https://doi.org/10.18632/aging.101012

View all publications in research portal