Professor Hisham Mehanna PhD, BMedSc, MBChB, FRCS, FRCS(ORL-HNS)

Professor Hisham Mehanna

Institute of Cancer and Genomic Sciences
Director, Institute for Global Innovation and the Institute for Advanced Studies
Chair, Head and Neck Surgery, Institute of Cancer and Genomic Sciences
Director, Institute of Head and Neck Studies and Education (InHANSE)

Contact details

Address
Institute of Head and Neck Studies and Education
Institute of Cancer and Genomic Sciences
Robert Aitken Building
Vincent Drive
University of Birmingham
Birmingham B15 2TT

Professor Mehanna is the Chair of Head and Neck Surgery and is the Director of the Institute of Head and Neck Studies and Education (InHANSE) at the Institute of Cancer and Genomic Sciences. Professor Mehanna is also the Director of the Institute for Global Innovation which undertakes multidisciplinary solution-focussed research on the challenges affecting the world on a global level. He is a head and neck and thyroid surgeon with clinical interests in recurrent head and neck cancer, carotid body surgery and thyroid and parathyroid surgery. 

Professor Mehanna has a keen interest in clinical research, especially in clinical trials evaluating the efficacy and effectiveness of new interventions, therapeutic agents and biomarkers in head and neck and thyroid cancer.   He runs a research team of over 20 members and holds over £12million in grants from the National Institute for Health Research Unit, Cancer Research UK, Macmillan Cancer Research and industry. Professor Mehanna has recently been appointed as an NIHR Senior Investigator.

Professor Mehanna is the current President of the British Association of Head and Neck Oncologists and is the past Chair of the UK’s National Cancer Research Institute Head and Neck Group. He is also the Secretary General of the Head and Neck Cancer International Group, an international collaborative of 20 clinical trials groups

Qualifications

  • PhD, Assessment of Quality of Life in Head and Neck Cancers.  Erasmus University 2010
  • FRCS (ORL-HNS) 2002
  • FRCS Glasgow 1998
  • MBChB (Hons)  University of Glasgow 1994
  • B.Med.Sc (Hons) University of Kuwait 1990 

Teaching

Professor Mehanna runs several post graduate courses and meetings, including the ‘Controversies in the management of head and neck cancer’ meeting. He also serves on the organising committee of several large international conferences, and has served on faculty of many conferences and courses. He is currently the Academic Chair for the British Academic Conference of Otorhinolaryngology-head and neck surgery (BACO International) 2020.

Postgraduate supervision

Hisham Mehanna is the Chair of Head and Neck Surgery and is the Director of the Institute of Head and Neck Studies and Education (InHANSE) at the Institute of Cancer and Genomic Sciences. He is a head and neck and thyroid surgeon with clinical interests in microvascular reconstructive surgery and endoscopic thyroid and parathyroid surgery. He has a keen interest in clinical research, especially in clinical trials evaluating the efficacy and effectiveness of new interventions, therapeutic agents and biomarkers in head and neck and thyroid cancer.

Professor Mehanna is also the Chair of the UK’s National Cancer Research Institute Head and Neck Group.He is also the Chair of the Research Committee of the British Association of Head Neck Oncologists. He serves on the Council of the Royal Society of Medicine, Laryngology Section, the Council of the International Association of Oral Oncology and was also past Secretary of the Otorhinolaryngological Research Society. He is happy to supervise doctoral research related to his research interests.

Other activities

  • Council Member, University of Birmingham 2015 – 2019
  • President, British Association of Head Neck Oncologists, 2017-2019
  • Secretary, Head and Neck Cancer International Group (HNCIG) 2016 - present
  • Chair, UK’s National Cancer Research Institute Head and Neck Group 2012-2018

Publications

Recent publications

Article

Kong, A, Good, JS, Kirkham, A, Savage, J, Mant, R, Llewellyn, L, Parish, J, Spruce, R, Forster, M, Schipani, S, Harrington, K, Sacco, JJ, Murray, P, Middleton, G, Yap, C & Mehanna, H 2020, 'A phase I trial of WEE1 inhibition with chemotherapy and radiotherapy as adjuvant treatment, and a window of opportunity trial with cisplatin in patients with head and neck cancer: the WISTERIA trial protocol', BMJ open, vol. 10, no. 3, e033009. https://doi.org/10.1136/bmjopen-2019-033009

Wang, Z, Li, F, Rufo, J, Chen, C, Yang, S, Li, L, Zhang, J, Cheng, J, Kim, Y, Wu, M, Abemayor, E, Tu, M, Chia, D, Spruce, R, Mehanna, H, Wong, DTW & Huang, TJ 2020, 'Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus–associated oropharyngeal cancer detection', Journal of Molecular Diagnostics, vol. 22, no. 1, pp. 50-59. https://doi.org/10.1016/j.jmoldx.2019.08.004

the Head and Neck International Group (HNCIG) & Mehanna, H 2020, 'Adapting head and neck cancer management in the time of COVID-19', International Journal of Radiation: Oncology - Biology - Physics , vol. 107, no. 4, pp. 628-630. https://doi.org/10.1016/j.ijrobp.2020.04.017

Jones, D, Mistry, P, Dalby, M, Fulton-Lieuw, T, Kong, A, Dunn, J, Mehanna, H & Gray, A 2020, 'Concurrent cisplatin or cetuximab with radiotherapy for HPV-positive oropharyngeal cancer: medical resource use, costs, and quality-adjusted survival from the De-ESCALaTE HPV trial', European Journal of Cancer, vol. 124, pp. 178-185. https://doi.org/10.1016/j.ejca.2019.10.025

Mehanna, H, Rischin, D, Wong, SJ, Gregoire, V, Ferris, R, Waldron, J, Le, Q-T, Forster, M, Gillison, M, Laskar, S, Tahara, M, Psyrri, A, Vermorken, J & Porceddu, S 2020, 'De-escalation after DE-ESCALATE and RTOG 1016: a head and neck cancer InterGroup framework for future de-escalation studies', Journal of Clinical Oncology , vol. 38, no. 22, pp. 2552-2557. https://doi.org/10.1200/JCO.20.00056, https://doi.org/10. 1200/JCO.20.00056, https://doi.org/10.1200/JCO.20.00056

Porceddu, SV, Daniels, C, Yom, SS, Liu, H, Waldron, J, Gregoire, V, Moore, A, Veness, M, Yao, M, Johansen, J, Mehanna, H, Rischin, D & Le, QT 2020, 'Head and Neck Cancer International Group (HNCIG) consensus guidelines for the delivery of postoperative radiation therapy in Complex Cutaneous Squamous Cell Carcinoma of the Head and Neck (cSCCHN)', International Journal of Radiation Oncology Biology Physics, vol. 107, no. 4, pp. 641-651. https://doi.org/10.1016/j.ijrobp.2020.03.024

Abreu, PM, Valle, IB, Damasceno, TCD, Có, ACG, Pansini, PF, Podestá, JRV, Souza, ED, Rocha, RM, Curado, MP, Mehanna, H & von Zeidler, SV 2020, 'Human Papillomavirus E6/E7 mRNA detection by in situ hybridization in oral cavity squamous cell carcinoma', Archives of Oral Biology, vol. 116, 104746. https://doi.org/10.1016/j.archoralbio.2020.104746

Mehanna, H, Hardman, JC, Shenson, JA, Abou-foul, AK, Topf, MC, Alfalasi, M, Chan, JYK, Chaturvedi, P, Chow, VLY, Dietz, A, Fagan, JJ, Godballe, C, Golusiński, W, Homma, A, Hosal, S, Iyer, NG, Kerawala, C, Koh, YW, Konney, A, Kowalski, LP, Kraus, D, Kuriakose, MA, Kyrodimos, E, Lai, SY, Leemans, CR, Lennon, P, Licitra, L, Lou, P, Lyons, B, Mirghani, H, Nichols, AC, Paleri, V, Panizza, BJ, Parente Arias, P, Patel, MR, Piazza, C, Rischin, D, Sanabria, A, Takes, RP, Thomson, DJ, Uppaluri, R, Wang, Y, Yom, SS, Zhu, Y, Porceddu, SV, De Almeida, JR, Simon, C & Holsinger, FC 2020, 'Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus', The Lancet Oncology, vol. 21, no. 7, pp. e350-e359. https://doi.org/10.1016/S1470-2045(20)30334-X

Malik, A, Nair, S, Singh, A, Lamba, K, Rane, S, Bal, M, Bhattacharjee, A, Mehanna, H & Chaturvedi, P 2020, 'Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: a matched pair analysis', Head and Neck. https://doi.org/10.1002/hed.26103

Hollows, R, Wei, W, Cazier, J-B, Mehanna, H, Parry, G, Halford, G & Murray, P 2019, 'Association between loss of Y chromosome and poor prognosis in male head and neck squamous cell carcinoma', Head & Neck, vol. 41, no. 4, pp. 993-1006. https://doi.org/10.1002/hed.25537

Lai, SL, Tan, ML, Hollows, RJ, Robinson, M, Ibrahim, M, Margielewska, S, Parkinson, EK, Ramanathan, A, Zain, RB, Mehanna, H, Spruce, RJ, Wei, W, Chung, I, Murray, PG, Yap, LF & Paterson, IC 2019, 'Collagen induces a more proliferative, migratory and chemoresistant phenotype in head and neck cancer via DDR1', Cancers, vol. 11, no. 11, 1766 , pp. 1-16. https://doi.org/10.3390/cancers11111766

Comment/debate

Sharma, N, Fagan, J, Wallace, M, Joubert, E, Greef, L, Konney, A, Simonds, H, Vanderpuye, V, Sewram, V, Young, T, Mehanna, H, ICOnIC Africa & Nankivell, P 2020, 'Prioritisation of research topics for head and neck cancer in Africa – Report of the International Collaboration On Improving Cancer outcomes in low and middle income countries – ICOnIC Africa', Oral Oncology, vol. 102, 104503. https://doi.org/10.1016/j.oraloncology.2019.104503

Editorial

Chaves, ALF, Castro, AF, Marta, GN, Junior, GC, Ferris, RL, Giglio, RE, Golusinski, W, Gorphe, P, Hosal, S, Leemans, CR, Magné, N, Mehanna, H, Mesía, R, Netto, E, Psyrri, A, Sacco, AG, Shah, J, Simon, C, Vermorken, JB & Kowalski, LP 2020, 'Emergency changes in international guidelines on treatment for head and neck cancer patients during the COVID-19 pandemic', Oral Oncology, vol. 107, 104734. https://doi.org/10.1016/j.oraloncology.2020.104734

Review article

Rohde, M, Rosenberg, T, Pareek, M, Nankivell, P, Sharma, N, Mehanna, H & Godballe, C 2020, 'Definition of locally recurrent head and neck squamous cell carcinoma: a systematic review and proposal for the Odense–Birmingham definition', European Archives of Oto-Rhino-Laryngology, vol. 277, no. 6, pp. 1593-1599. https://doi.org/10.1007/s00405-020-05953-5

Payne, K, Brooks, J, Spruce, R, Batis, N, Taylor, G, Nankivell, P & Mehanna, H 2019, 'Circulating tumour cell biomarkers in head and neck cancer: Current progress and future prospects', Cancers, vol. 11, no. 8, 1115. https://doi.org/10.3390/cancers11081115

View all publications in research portal

Expertise

  • Head and Neck Cancer
  • Global Development and Research