Professor Hisham Mehanna PhD, BMedSc, MBChB, FRCS, FRCS(ORL-HNS)

Professor Hisham Mehanna

Institute of Cancer and Genomic Sciences
Deputy Pro-Vice Chancellor (interdisciplinary research)
Director, Institute for Global Innovation and Institute for Advanced Studies
Director, Institute of Head and Neck Studies and Education (InHANSE)

Contact details

Address
Institute of Head and Neck Studies and Education
Institute of Cancer and Genomic Sciences
Robert Aitken Building
Vincent Drive
University of Birmingham
Birmingham B15 2TT

Professor Hisham Mehanna is the chair of head and neck surgery, and is the Director of the Institute of Head and Neck Studies and Education (InHANSE) at the Institute of Cancer and Genomic Sciences.

Hisham is a head and neck and thyroid surgeon with clinical interests in recurrence in thyroid and parathyroid surgery. He has a keen interest in clinical and translational research, heading a research team of 20 researchers, and holding over £15million in research grants. His research has changed clinical practice across the world. 

His experience of multi-disciplinary research in the field of cancer biology and treatment has made him a strong proponent of multi- and inter- disciplinary research, as the way to provide new insights and approaches to address intractable global challenges. 

As Deputy PVC, Hisham has responsibility for promoting interdisciplinary research across the University. Also as Director of the Institute for Global Innovation (IGI) and the Institute of Advanced Studies (IAS), Hisham strives to ensure that the Institutes inspire, support and deliver world-leading, multi- and inter-disciplinary research that seeks to address some of the world’s most pressing challenges, that affect humanity at a global level. The IGI’s research themes revolve around the factors that challenge, and sometimes threaten, the sustainability and resilience of individuals, communities, countries and the world as a whole. Themes include resilient cities, water challenges in a changing world, clean cooling, pollution solutions, antimicrobial resistance, ageing and frailty, gender inequality, artificial intelligence and 21st century transnational crime. 

Qualifications

  • PhD, Assessment of Quality of Life in Head and Neck Cancers. Erasmus University 2010
  • FRCS (ORL-HNS) 2002
  • FRCS Glasgow 1998
  • MBChB (Hons)  University of Glasgow 1994
  • B.Med.Sc (Hons) University of Kuwait 1990 

Teaching

Hisham runs several post graduate courses and meetings, including the international biennial ‘Controversies in the management of head and neck cancer’ meeting. He also serves on the organising committee of several large international conferences, and has served on faculty of many conferences and courses. He is currently the Academic Chair for the British Academic Conference of Otorhinolaryngology-head and neck surgery (BACO International) 2021.

Postgraduate supervision

Hisham supervises several PhD, Masters and intercalating BSc students, in topics ranging from translational research to bioinformatics to clinical research

Other activities

  • Chair, Head and Neck Cancer International Group, 2019-present 
  • Council Member, University of Birmingham, 2015-2019
  • President, British Association of Head Neck Oncologists, 2017-2019
  • Secretary, Head and Neck Cancer International Group (HNCIG), 2016-2020
  • Chair, UK’s National Cancer Research Institute Head and Neck Group, 2012-2018

Publications

Recent publications

Article

James, TW, Edwards, MJ, Nieto, H, Mehanna, H, Pracy, P, Jennings, C, Sharma, N & Nankivell, P 2022, 'An external validation of C-reactive protein reduction as a predictor of healing following laryngopharyngectomy', Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. https://doi.org/10.1111/coa.13966

Payne, K, Brooks, J, Batis, N, Taylor, G, Nankivell, P & Mehanna, H 2022, 'Characterising the epithelial-mesenchymal transition status of circulating tumour cells in head and neck squamous cell carcinoma', Head & Neck, pp. 1-10. https://doi.org/10.1002/hed.27167

Lorenc, A, Wells, M, Fulton-Lieuw, T, Nankivell, P, Mehanna, H, Jepson, M & PETNECK2 Research Team 2022, 'Clinicians’ views of patient-initiated follow-up in head and neck cancer: a qualitative study to inform the PETNECK2 trial', Clinical Oncology, vol. 34, no. 4, pp. 230-240. https://doi.org/10.1016/j.clon.2021.11.010

ICO International HPV in Head and Neck Cancer Study Group 2022, 'Concordance of p16INK4a and E6*I mRNA among HPV-DNA positive oropharyngeal, laryngeal and oral cavity carcinomas from the ICO international study', Cancers, vol. 14, no. 15, 3787. https://doi.org/10.3390/cancers14153787

PETNECK2 Research Team 2022, 'Exploring the views of patients' and their family about patient-initiated follow-up in head and neck cancer: a mixed methods study', European journal of cancer care. https://doi.org/10.1111/ecc.13641

Camuzi, D, Buexm, LA, Lourenço, SDQC, Grazziotin, R, Guaraldi, S, Valverde, P, Rapozo, D, Brooks, JM, Mehanna, H, Pinto, LFR & Soares-Lima, SC 2022, 'FBXL7 body hypomethylation is frequent in tumors from the digestive and respiratory tracts and is associated with risk-factor exposure', International Journal of Molecular Sciences, vol. 23, no. 14, 7801. https://doi.org/10.3390/ijms23147801

Love, SB, Cafferty, F, Snowdon, C, Carty, K, Savage, J, Pallmann, P, McParland, L, Brown, L, Masters, L, Schiavone, F, Hague, D, Townsend, S, Amos, C, South, A, Sturgeon, K, Langley, R, Maughan, T, James, N, Hall, E, Kernaghan, S, Bliss, J, Turner, N, Tutt, A, Yap, C, Firth, C, Kong, A, Mehanna, H, Watts, C, Hills, R, Thomas, I, Copland, M, Bell, S, Sebag-Montefiore, D, Jones, R, Parmar, MKB & Sydes, MR 2022, 'Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units', Trials, vol. 23, no. 1, 757. https://doi.org/10.1186/s13063-022-06680-4

Rischin, D, Mehanna, H, Young, RJ, Bressel, M, Dunn, J, Corry, J, Soni, P, Fulton-lieuw, T, Iqbal, G, Kenny, L, Porceddu, S, Wratten, C, Robinson, M & Solomon, BJ 2022, 'Prognostic stratification of HPV associated oropharyngeal cancer based on CD103+ immune cell abundance in patients treated on TROG 12.01 and De-ESCALaTE randomised trials', Annals of Oncology. https://doi.org/10.1016/j.annonc.2022.04.074

ENT UK, BAHNO, INTEGRATE (The UK ENT Trainee Research Network) 2022, 'Symptom-based remote assessment in post treatment head and neck cancer surveillance: a prospective national study', Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. https://doi.org/10.1111/coa.13948

Fu, T, Scheffler, P, Forner, D, Noel, C, Huang, SH, Gilbert, R, Goldstein, D, O'Sullivan, B, Mehanna, H, Waldron, J & de Almeida, J 2021, 'A cost-utility analysis comparing CT surveillance, PET-CT surveillance, and planned postradiation neck dissection for advanced nodal HPV-positive oropharyngeal cancer', Cancer. https://doi.org/10.1002/cncr.33653

Shaban, M, Raza, SEA, Hassan, M, Jamshed, A, Mushtaq, S, Loya, A, Batis, N, Brooks, J, Nankivell, P, Sharma, N, Robinson, M, Mehanna, H, Khurram, SA & Rajpoot, N 2021, 'A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma', Journal of Pathology. https://doi.org/10.1002/path.5819

Bresadola, L, Weber, D, Ritzel, C, Lower, M, Bukur, V, Akilli-Öztürk, Ö, Becke, J, Mehanna, H, Schrörs, B, Vascotto, F, Sahin, U & Kong, A 2021, 'Comprehensive genomic and transcriptomic analysis of three synchronous primary tumours and a recurrence from a head and neck cancer patient', International Journal of Molecular Sciences, vol. 22, no. 14, 7583. https://doi.org/10.3390/ijms22147583

Mehanna, H, Mistry, P, Golusinski, P, Maio, PD, Nankivell, P, Snider, F, Ferrante, AMR, Montalto, N, Nicolai, P, Marcantoni, A, Grandi, C, Zavatta, M, Grego, F, Malec, K, Hosal, S, Suslu, N, Kuscu, O, Torrealba, I, Valdes, F, Sharma, N, Ayuk, J, Monksfield, P, Irving, R, Dunn, JA, Kay, M & Borsetto, D 2021, 'Development and validation of an improved classification and risk stratification system for carotid body tumors: a multinational collaborative cohort study', Head and Neck, vol. 43, no. 11, pp. 3448-3458. https://doi.org/10.1002/hed.26844

Preprint

Love, SB, Cafferty, F, Snowdon, C, Carty, K, Savage, J, Pallmann, P, McParland, L, Brown, LJ, Masters, L, Schiavone, F, Hague, D, Townsend, S, Amos, C, South, A, Sturgeon, K, Langley, RE, Maughan, TS, James, N, Hall, E, Kernaghan, S, Bliss, J, Turner, NC, Yap, C, Firth, C, Kong, A, Mehanna, H, Watts, C, Hills, R, Thomas, I, Copland, M, Bell, SE, Tutt, ANJ, Sebag-Montefiore, D, Jones, R, Parmar, MKB & Sydes, MR 2022 'Practical Guidance for Running Late-Phase Platform Protocols for Clinical Trials: Lessons From Experienced UK Clinical Trials Units' Research Square. https://doi.org/10.21203/rs.3.rs-1195468/v1

Shaban, M, Raza, SEA, Hassan, M, Jamshed, A, Mushtaq, S, Loya, A, Batis, N, Brooks, J, Nankivell, P, Sharma, N, Robinson, M, Mehanna, H, Khurram, SA & Rajpoot, N 2021 'A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma' arXiv. <https://arxiv.org/abs/2104.12862>

View all publications in research portal

Expertise

  • Head and Neck Cancer
  • Global Development and Research