Recent publications
Article
Piberger, L, Bowry, A, Kelly, R, Walker, A, Gonzalez-Acosta, D, Bailey, L, Doherty, A, Mendez, J, Morris, J, Bryant, HE & Petermann, E 2020, 'PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts', Nature Communications, vol. 11, no. 1, 5863. https://doi.org/10.1038/s41467-020-19570-7
Daza-martin, M, Densham, RM & Morris, JR 2019, 'BRCA1-BARD1: the importance of being in shape', Molecular and Cellular Oncology, vol. 6, no. 6, e1656500. https://doi.org/10.1080/23723556.2019.1656500
Daza-Martin, M, Starowicz, K, Jamshad, M, Tye, S, Ronson, GE, MacKay, HL, Chauhan, AS, Walker, AK, Stone, HR, Beesley, JFJ, Coles, JL, Garvin, AJ, Stewart, GS, McCorvie, TJ, Zhang, X, Densham, RM & Morris, JR 2019, 'Isomerization of BRCA1-BARD1 promotes replication fork protection', Nature, vol. 571, no. 7766, pp. 521-527. https://doi.org/10.1038/s41586-019-1363-4
Garvin, AJ, Walker, AK, Densham, RM, Chauhan, AS, Stone, HR, Mackay, HL, Jamshad, M, Starowicz, K, Daza-Martin, M, Ronson, GE, Lanz, AJ, Beesley, JF & Morris, JR 2019, 'The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms', Genes & Development, vol. 33, no. 5-6, pp. 333-347. https://doi.org/10.1101/gad.321125.118
Spiliotopoulos, A, Blokpoel Ferreras, L, Densham, RM, Caulton, SG, Maddison, BC, Morris, JR, Dixon, JE, Gough, KC & Dreveny, I 2018, 'Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11', Journal of Biological Chemistry. https://doi.org/10.1074/jbc.RA118.004469
Uckelmann, M, Densham, RM, Baas, R, Winterwerp, HHK, Fish, A, Sixma, TK & Morris, JR 2018, 'USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A', Nature Communications, vol. 9, no. 1, 229. https://doi.org/10.1038/s41467-017-02653-3
Morris, JR & Garvin, AJ 2017, 'SUMO in the DNA Double-Stranded Break Response: Similarities, Differences, and Cooperation with Ubiquitin', Journal of Molecular Biology, vol. 429, no. 22, pp. 3376-3387. https://doi.org/10.1016/j.jmb.2017.05.012
Densham, RM & Morris, JR 2017, 'The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair', Nucleus (Austin), vol. 8, pp. 116-125. https://doi.org/10.1080/19491034.2016.1267092
Densham, RM, Garvin, AJ, Stone, HR, Strachan, J, Baldock, RA, Daza-Martin, M, Fletcher, A, Blair-Reid, S, Beesley, J, Johal, B, Pearl, LH, Neely, R, Keep, NH, Watts, FZ & Morris, JR 2016, 'Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection', Nature Structural and Molecular Biology, vol. 23, no. 7, pp. 647-655. https://doi.org/10.1038/nsmb.3236
Flower, KJ, Shenker, NS, El-Bahrawy, M, Goldgar, DE, Parsons, MT, Spurdle, AB, Morris, JR, Brown, R & Flanagan, JM 2015, 'DNA methylation profiling to assess pathogenicity of BRCA1 unclassified variants in breast cancer', Epigenetics : official journal of the DNA Methylation Society, vol. 10, no. 12, pp. 1121-1132. https://doi.org/10.1080/15592294.2015.1111504
Samuels, JM, Ahmadian, M, Barkan, C, Connell, D, Gertler, J, Graab, D, Harrison, J, Hendrickson, C, Holt, EK, Jack, A, La Guardia, E, Lynch, C, McCarthy, R, Nicholson, T, Nowak, A, Reimer, B, Stem, JA, Verna, V, Morris, JR & Kortum, K 2015, 'Evaluation of the federal railroad administration research and development program', Transportation Research Board - Special Report, no. 316, pp. 1-71.
Preprint
Faulkner, EL, Pike, JA, Densham, RM, Garlick, E, Thomas, SG, Neely, RK & Morris, JR 2021 'Imaging nanoscale nuclear structures with expansion microscopy' bioRxiv. https://doi.org/10.1101/2021.05.04.442164
Review article
Tye, S, Ronson, G & Morris, J 2021, 'A fork in the road: Where homologous recombination and stalled replication fork protection part ways', Seminars in Cell and Developmental Biology, vol. 113, pp. 14-26. https://doi.org/10.1016/j.semcdb.2020.07.004
Densham, RM & Morris, JR 2019, 'Moving Mountains-The BRCA1 Promotion of DNA Resection', Frontiers in Molecular Bioscience, vol. 6, 79. https://doi.org/10.3389/fmolb.2019.00079
Garvin, AJ & Morris, JR 2017, 'SUMO, a small, but powerful, regulator of double-strand break repair', Royal Society of London. Proceedings B. Biological Sciences, vol. 372, no. 1731, 20160281. https://doi.org/10.1098/rstb.2016.0281
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