Professor Dion Morton OBE, MBChB, FRCS (Eng), MD

Dion Morton

Institute of Cancer and Genomic Sciences
Barling Professor of Surgery
Head of Surgery

Contact details

Address
Surgery
Institute of Cancer and Genomic Sciences
University of Birmingham Office
Heritage Building (Queen Elizabeth Hospital)
Mindelsohn Way
Edgbaston, Birmingham, B15 2TH

After Dion received his degree in Medicine from Bristol University in 1985, he took up an honorary consultant appointment at the University Hospitals Birmingham NHS Foundation Trust in 1996 and was appointed Professor of Surgery in 2006. In 2015, he became Barling Chair of Surgery. He is also Surgery Section Head at the Institute of Cancer and Genomics.

Dion was appointed Officer of the Order of the British Empire (OBE) in the 2020 Queen's Birthday Honours for services to innovation in the NHS.

Up to a third of all medical conditions are surgically treatable and under Dion’s inspirational leadership, surgery at the University of Birmingham is at the forefront of surgical research across the world.

Including:

ORCID ID: 0000-0001-6784-1689

Qualifications

  • MD, 1994, Bristol
  • FRCS (Eng), 1989, Bristol
  • MBChB 1985, Bristol

Biography

Dion is Director of the West Midlands Genomic Medicine Centre (WMGMC) which is a partnership of 18 NHS acute Trusts across the region, working collaboratively to help to deliver the NHS England innovative 100,000 Genomes Project. It is one of 13 similar centres, paving the way for the future of medical science - personalised medicine. Dion also leads the Pan Cancer Genomics England Clinical Interpretation Partnership (GeCIP) and is a member of the Colorectal Cancer GeCIP.

Since 2017, he has co-led the newly established NIHR Global Health Research Unit on Global Surgery.

He was Chair of the Research Committee of the European Society of Coloproctology (ESCP) 2011 to 2019 and initiated the expansion of the clinical research portfolio and growth in international collaboration within the European colorectal community. He is now Chair of the Global Reach Committee.

Dion led the Birmingham Experimental Cancer Medicine Centre between 2009 and 2019, leading the successful increased multi million pound refunding in 2012 and again in 2016. The Birmingham ECMC aims to improve the feasibility and quality of research in the areas of immunotherapy and gene therapy, translational genetics and biomarkers. It is UK government and Cancer Research UK funded and the largest centre in the UK.

Nationally he was Director of Clinical Research at the Royal College of Surgeons of England 2012-2019 and led the Clinical Research Initiative. The programme is now well established and has 7 Surgical Trials Units and 11 Surgical Specialty Leads (including Mr Simon Bach and BiSTC at the University). This initiative has led to the big rise in patients recruited to surgical trials and of surgical trials opened in the UK. 

He is Past President of the Society for Academic and Research Surgery.

The Professor Morton recognised the immense potential of surgical trainees in research, and championing the development of the UK’s first trainee-led research network, the West Midlands Research Collaborative (WMRC) which pioneered a UK wide network of 18 collaboratives.

Teaching

He is a popular lecturer with students and trainees and lectures on the postgraduate Genomics in Cancer Pathology course among others.

Postgraduate supervision

Theses Supervised  

Table of Research Students, Thesis Titles and Dates of Award

Name of Student and Thesis Title

 

Degree Award Date

Yvonne Wallis

Phenotype genotype correlation in FAP

 

PhD (Birmingham) 1996

Shaheen Chughtai

Studies of putative tumour suppressor genes on C8p

 

PhD (Birmingham) 1999

Michael Kuo

“Tumour suppressor gene studies in head and neck cancers”

 

PhD (Birmingham) 1999

Mohammed A Mohammed

Evaluating the process of care changes in Birmingham in the management of colorectal cancer

 

PhD (Birmingham) 2002

Robert Hardy

Cell adhesion control in colorectal tumourigenesis

 

PhD (Birmingham) 2003

Clare Adams

Molecular studies of colorectal neoplasia in screening

 

PhD (Birmingham) 2004

Nazzia Mirza

Identification of a novel tumour suppressor gene at 8p12

 

PhD (Birmingham) 2008

Mike Walker

The influence of parathyroid hormone on the gene expression in the colorectal epithelium

 

PhD (Birmingham) 2012

Katherina McEvoy

The role of desmosomal cadherins in colorectal tumourigenesis

 

MD (Birmingham) 2012

Kai Leong

Exploring novel epigenetic predictive markers in early rectal cancer.

 

PhD (Birmingham) 2013

Karina Rønlund

Identification of molecular targets for a non-invasive methylation based test for pre-symptomatic diagnosis of colorectal neoplasia

 

PhD (Denmark\Birmingham) 2014

Lorna Gilligan

Oestrogen Metabolism in Colorectal Cancer and its Effect on Prognosis

 

Commenced May 2012

Thomas Pinkney        

MD Developing and delivering clinical trials to prevent surgical wound infection

   

MD (Birmingham) 2017

Dmitri Nepogodiev

An evaluation of access to surgical treatment and methods by which it might be improved in low and middle income countries

   

PhD (Birmingham)

Commenced 2017

Toritseju Oluwafunmilayo Sillo                                  

The impact of inherited differences and of the clonality of antigenic neo-epitopes on the immune contexture in colorectal cancer

   

PhD (Birmingham)

Commenced Jan 2018

Mark Monahan

A health Economics analysis of wound infection following surgical care for patients in low and middle income countries

   

PhD (Birmingham)

Commenced 2018

Research

His research interests are predominantly in clinical and translational research in colorectal cancer, but also encompassing the development of clinical trials in surgery. 

Advanced Colorectal Cancer Trials:

As the national NCRI lead for colon cancer surgical trials (2007-13),Dion had responsibility for the development of multicentre colorectal surgical trials and helped launch 7 new trials over that period.

FOxTROT Trial – Dion is CI for this international study of neoadjuvant chemotherapy for locally advanced colon cancer which is randomising 1050 patients over 100 centres in three countries (CTAAC). 

Dion is co-applicant and co-investigator for the following national multicentre RCTs; CReST, investigating the role of endoluminal stenting for obstructing CRC. TREC, investigating the role of organ preserving surgery for early rectal cancer. ARISTOTLE, investigating chemoradiotherapy in advanced rectal cancer.

TRIALS Management Committees:

TMG (Trial Management Group) member - ISAAC, CReST, TREC, FOxTROT (Chair), ROSSINI, ARISTOTLE, DREAMs

TSC (Trial Steering Committee) Member – UCL Lung and Gynae Trials, ICR-CTSU Breast Systemic Therapies, STARTREC (pan Europe trial)

DMEC (Data Monitoring Committee) Member SEAFOod Trial, Lead CONFIDeNT TRIAL, ENDCAP

Research Groups:

Other activities

The Queen Elizabeth Hospital Birmingham is recognised as one of the leading hospitals in Europe and Dion and the departmental team are all surgeons or trainees here and across the West Midlands region.

Dion heads up Surgery which includes Emeritus Professor of Surgery, Derek Alderson, from July 2017, President of the Royal College of Surgeons, Mr Simon Bach, Mr Thomas Pinkney, Andrew Beggs, Aneel Bhangu and Dmitri Nepogodiev ACF.

Dion is an advisor and trustee on several charities.

  1. Advisor Bobby Moore Foundation: 2008 – present
  2. Trustee Bowel Disease Research Foundation: Jul 2010 – Present
  3. Medical Advisory Board member Bowel Cancer UK: Sep 2010 – present

He is a member of the following societies:

  •  The Association of Coloproctology (Great Britain and Ireland)
  •  The Society of Academic & Research Surgeons
  •  The European Society of Coloproctology
  •  West Midlands Surgical Society
  •  British Society of Human Genetics
  •  The European Surgical Association

Publications

2020

Identifying a basket of surgical procedures to standardize global surgical metrics: an international Delphi study Maria Lisa Odland, Dion Morton, Justine Davies, 17 Nov 2020, In: Annals of surgery. Publish Ahead of Print, 00, p. 1-17. Research output: Contribution to journal › Article › peer-review

Delphi prioritization and development of global surgery guidelines for the prevention of surgical-site infection Thomas Pinkney, Aneel Bhangu & 86 others, , Peter Brocklehurst, Justine Davies, James Glasbey, Richard Lilford, Omar Omar, Thomas Pinkney, Martin Smith, Sudha Sundar, Aneel Bhangu, Peter Brocklehurst, Dion Morton, Thomas Pinkney, Martin Smith, 1 Jul 2020, In: British Journal of Surgery. 107, 8, p. 970-977 8 p. Research output: Contribution to journal › Article › peer-review

Surgical site infection and costs in low- and middle-income countries: a systematic review of the economic burden. Mark Monahan, Sue Jowett, Thomas Pinkney, Peter Brocklehurst, Dion Morton, Zainab Abdali & Tracy Roberts, 4 Jun 2020, In: PLoSONE. 15, 6, 21 p., e0232960. Research output: Contribution to journal › Article › peer-review

Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial. 8 Feb 2020, In: The Lancet. 395, 10222, p. 417-426 10 p. Research output: Contribution to journal › Article › peer-review

2019

Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3) Justine Davies, James Glasbey, Richard Lilford, Dion Morton & Aneel Bhangu, 24 May 2019, In: BMJ open. 9, 5, 6 p., e026646. Research output: Contribution to journal › Article › peer-review

Global burden of postoperative death 2 Feb 2019, In: The Lancet. 393, 10170, p. 401-401 1 p. Research output: Contribution to journal › Letter › peer-review

Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study Andrew Beggs, Samir Mehta, Jon Deeks, Germaine Caldwell, Jo Stockton, Daniel Blakeway, Valerie Somani, Tariq Iqbal, Glenn Matthews & Dion Morton, 1 Jan 2019, In: EBioMedicine. 39, p. 265-271 7 p. Research output: Contribution to journal › Article › peer-review

Prioritizing research for patients requiring surgery in low-and middle-income countries Jan 2019, In: British Journal of Surgery. 106, 2, p. e113-e120 Research output: Contribution to journal › Article › peer-review

View all publications in research portal