Thomas A, Perry T, Berhane S, Oldreive C, Zlatanou A, Williams LR, Weston VJ, Stankovic T, Kearns P, Pors K, Grand RJ, Stewart GS. (2014). The dual acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53. Oncogene. 34:3336-48.
Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP**, Stewart GS**, Bicknell LS. (2015). Mutations in the NHEJ component XRCC4 cause primordial dwarfism. Am J Hum Genet. 96:412-24. (** Corresponding author)
Higgs MR, Reynolds JJ, Winczura A, Blackford AN, Borel V, Miller ES, Zlatanou A, Nieminuszczy J, Ryan EL, Davies NJ, Stankovic T, Boulton SJ, Niedzwiedz W, Stewart GS. (2015). BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. Mol Cell. 59:462-77.
Zlatanou A, Sabbioneda S, Miller ES, Greenwalt A, Aggathanggelou A, Maurice MM, Lehmann AR, Stankovic T, Reverdy C, Colland F,Vaziri C, Stewart GS. (2016). USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. Oncogene. 35:965-76.
Harley ME, Murina O, Leitch A, Higgs MR, Bicknell LS, Yigit G, Blackford AN, Zlatanou A, Mackenzie K, Reddy K, Halachev M, McGlasson S, Reijns MAM, Fluteau A, Martin C-A, Sabbioneda S, Elcioglu NH, Altmüller J, Thiele H, Greenhalgh L, Chessa L, Maghnie M, Salim M, Bober MB, Nürnberg P, Jackson SP, Hurles ME, Wollnik B, Stewart GS**, Jackson AP**. (2016). The primordial dwarfism gene TRAIP promotes DNA damage response during genome replication. Nature Genet. 48:36-43(** Corresponding author)
Byrd PJ, Stewart GS, Smith A, Eaton C, Taylor AJ, Guy C, Eringyte I, Fooks P, Last JI, Horsely R, Oliver AW, Janic D, Dokmanovic L, Stankovic T, Taylor AMR. (2016). A hypomorphic PALB2 allele gives rise to an unusual form of FA-N associated with lymphoid tumour development. PLoS Genet. 12:e1005945
Guturi KKN, Bohgaki M, Bohgaki T, Srikumara T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Saad Eldin M, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. (2016). RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. Nature Comms. 7:12638
Clarke TL, Sanchez-Bailon MP, Chiang K, Reynolds JJ, Herrero-Ruiz J, Bandeiras TM, Matias PM, Maslen SL, Skehel JM, Stewart GS, Davies CC. (2017). PRMT5-mediated methylation of the TIP60 coactivator RUVBL1 is a key regulator of homologous recombination. Mol Cell. 65:900-916
Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaitė Ž, Wessel SR, Zlatanou A, Vernet A, Kriegsheim A, Mottram RMA, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Tala SA, Alswaid A, AhmedS, Al-Aama JY, Altmüller J, Balwi MA, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nürnberg P, Percin EF, Peron S, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, TomancakP, Yigit G, Taylor AMR, Reijns MAM, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS. (2017). Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Nature Genet. 49:537-549
Agathanggelou A, Smith E, Davies NJ, Kwok M, Zlatanou A, Oldreive CE, Mao J, Da Costa D, Yadollahi S, Perry T, Kearns P, Skowronska A, Yates E, Parry H, Pratt G, Moss P, Taylor AMR, Stewart GS**, Stankovic T.** (2017). USP7 inhibition alters homologous recombination repair and targets CLL cells independent of ATM/p53 functional status. Blood. 130:156-166 (** Corresponding author)
Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND. (2018). PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation. Nature Comms. 9:746
Higgs MR, Sato K, Reynolds JJ, Begum S, Bayley R, Goula A, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, Stewart GS. (2018). Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2. Mol Cell. 71:25-41
Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza D, Seavitt J, Jain M, Li X,Parry D, Raman V, Chitayat D, Chinn IK, Bertuch AA, Karaviti L, Schlesinger AE, Earl D, Bamshad M, Savarirayan R, Doddapaneni H, Muzny D, Jhangiani SN, Eng C, Gibbs RA, Bi W, Emrick L, Rosenfeld JA, Postlethwait J, Westerfield M, Dickinson M, Beaudet A, Ranza E, Huber C, Cormier-Daire V, Shen W, Mao R, Heaney JD, Orange JS, University of Washington Center for Mendelian Genomics, Undiagnosed Diseases Network, Bertola D, Yamamoto G, Baratela WAR, Butler MG, Ali A, Adeli M, Cohn DH, Krakow D, Jackson AP, Lees M, Offiah AC, Carlston CM, Carey JC, Stewart GS**, Bacino CA**, Campeau PM**, Lee B.** (2019). Biallelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Am J Hum Genet. 104:422-438 (** Senior author)
Daza-Martin M, Starowicz K, Jamshad M, Tye S, Ronson GE, MacKay HL, Chauhan AS, Walker AK, Stone HR, Beesley JFJ, Coles JL, Garvin AJ, Stewart GS, McCorvie T, Zhang X, Densham RM, Morris JR. (2019). Phosphorylation and isomerization regulation of BRCA1-BARD1 promotes replication fork protection. Nature 571:521-527
Zarrizi R, Higgs MR, Voßgröne K, Rossing M, Bertelsen B, Bose M, Nedergaard Kousholt A, Rösner H, The Complexo Network, Ejlertsen B, Stewart GS, Cilius Nielsen F, Sørensen CS (2020). Germline RBBP8 variants associated with early onset breast cancer compromise replication fork stability. J. Clin Invest 130:4069-4080
Zhang J, Bellani MA, James R, Pokharel D, Pratto F, Zhang Y, Reynolds JJ, McNee GS, Jackson AP, Camerini-Otero RD, Stewart GS, Seidman MM. (2020). DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain. Nat Comms 11:3951
Faramarz A, van Schie J, Balk J, Stewart GS, Oostra A, Rooimans M, Parish J, De Almedia Estéves C, Dumic K, Barisic I, Diderich K, Pisani F, Ameziane N, Wolthuis R, de Lange J. (2020) DDX11 helicase activity protects against G-quadraplex induced chromosomal breakage and concomitant loss of sister chromatid exchange. Nat Comms 11:4287
Baxley RM, Leung W, Schmit MM, Matson JP, Oram MK, Wang L, Yin L, Hedberg J, Rogers CB, Harvey AJ, Basu D, Hendrickson EA, Mace EM, Orange JS, Aihara H, Stewart GS, Blair E, Gowen Cook J, Bielinsky AK. (2020). Bi-allelic MCM10 mutations cause telomere shortening with immune dysfunction and cardiomyopathy. Nat Comms 12:1626
Blakemore D, Vilaplana N, Almaghrabi R, Gonzalez E, Moya M, Murphy G, Gambus A, Petermann E, Stewart GS**, Garcia P.** (2021) MYBL2 and ATM prevent replication stress in pluripotent stem cells. EMBO Reports 22:e51120 (** Senior author)
Sanchez-Bailon MP, Choi S-Y, Dufficy ER, Sharma K, McNee GS, Gunnell E, Chiang K, Sahay D, Maslen S, Stewart GS, Skehel JM, Davies CC. (2021). Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair. Nature Comms 12:6313
Scott WA, Dhanji EZ, Dyakov B, Dreseris ES, Asa JS, Grange LJ, Mirceta M, Pearson CE, Stewart GS, Gingras A-C, Campos EI. (2021). ATRX proximal protein associations boast roles beyond histone deposition. PLoS Genetics 17:e1009909
Lappin KM, Barros EM, Jhujh SS, Irwin G, Liberante F, Latimer C, Wilson M, Mills KI, Harkin DP, Stewart GS, Savage KI. (2022). The cancer associated SF3B1K700E mutation induces a BRCA-like cellular phenotype that is vulnerable to treatment with synthetically lethal small molecule inhibitors. Cancer Res 82:819-830
Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GMC, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan G-L, Roukos V, Harel T, Brosh Jr. RM, Stewart GS. (2022). RECON Syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1. J Clin Invest. 132:e147301
Bayley R, Borel V, Moss RJ, Sweatman E, Ruis P, Ormrod A, Goula A, Mottram RMA, Stanage T, Hewitt G, Saponaro M, Stewart GS**, Boulton SJ**, Higgs MR**. (2022). H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ. Mol CellIn press (** Corresponding author)
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