Llorens-Agost M, Luessing J, van Beneden A, Eykelenboom J, O’Reilly D, Bicknell LS, Reynolds JJ, van Koegelenberg M, Hurles ME, Brady AF, Jackson AP, Stewart GS, Lowndes NF (2018). Analysis of novel missense ATR mutations reveals further evidence for splicing defects underlying Seckel Syndrome. Human Mutation. 39:1847-1853
Higgs MR, Sato K, Reynolds JJ, Begum S, Bayley R, Goula A, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, Stewart GS (2018). Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2. Mol Cell. 71:25-41
Ronson GE, Piberger AL, Higgs MR, Olsen AL, Stewart GS, McHugh PJ, Petermann E, Lakin ND. (2018). PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation. Nature Comms. 9:746
Agathanggelou A, Smith E, Davies NJ, Kwok M, Zlatanou A, Oldreive CE, Mao J, Da Costa D, Yadollahi S, Perry T, Kearns P, Skowronska A, Yates E, Parry H, Pratt G, Moss P, Taylor AMR, Stewart GS**, Stankovic T** (2017). USP7 inhibition laters homologous recombination repair and targets CLL cells independent of ATM/p53 functional status. Blood. 130:156-166 (** Corresponding author)
Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaitė Ž, Wessel SR, Zlatanou A, Vernet A, Kriegsheim A, Mottram RMA, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Tala SA, Alswaid A, AhmedS, Al-Aama JY, Altmüller J, Balwi MA, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nürnberg P, Percin EF, Peron S, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, TomancakP, Yigit G, Taylor AMR, Reijns MAM, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS. (2017). Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Nature Genet. 49:537-549
Clarke TL, Sanchez-Bailon MP, Chiang K, Reynolds JJ, Herrero-Ruiz J, Bandeiras TM, Matias PM, Maslen SL, Skehel JM, Stewart GS, Davies CC. (2017). PRMT5-mediated methylation of the TIP60 coactivator RUVBL1 is a key regulator of homologous recombination. Mol Cell. 65:900-916
Kumar NaiduGuturi K, Bohgaki M, Bohgaki T, Srikumara T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Saad Eldin M, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R. (2016). RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation. Nature Comms. 7:12638
Byrd PJ, Stewart GS, Smith A, Eaton C, Taylor AJ, Guy C, Eringyte I, Fooks P, Last JI, Horsely R, Oliver AW, Janic D, Dokmanovic L, Stankovic T, Taylor AMR. (2016). A hypomorphic PALB2 allele gives rise to an unusual form of FA-N associated with lymphoid tumour development. PLoS Genet. 12:e1005945
Kwok M, Davies N, Agathaggelou A, Smith E, Oldreive C, Petermann E, Stewart GS, Brown J, Lau A, PrattG, Parry H, Taylor AMR, Moss P, Hillmen P, Stankovic T. (2016). Synthetic Lethality in Chronic Lymphocytic Leukemia with DNA Damage Response Defects by Targeting ATR. Blood. 127:582-95.
Harley ME, Murina O, Leitch A, Higgs MR, Bicknell LS, Yigit G, Blackford AN, Zlatanou A, Mackenzie K, Reddy K, Halachev M, McGlasson S, Reijns MAM, Fluteau A, Martin C-A, Sabbioneda S, Elcioglu NH, Altmüller J, Thiele H, Greenhalgh L, Chessa L, Maghnie M, Salim M, Bober MB, Nürnberg P, Jackson SP, Hurles ME, Wollnik B, Stewart GS**, Jackson AP**. (2016). The primordial dwarfism gene TRAIP promotes DNA damage response during genome replication. Nature Genet. 48:36-43(** Corresponding author)
Zlatanou A, Sabbioneda S, Miller ES, Greenwalt A, Aggathanggelou A, Maurice MM, Lehmann AR, Stankovic T, Reverdy C, Colland F,Vaziri C, Stewart GS. (2016). USP7 is essential for maintaining Rad18 stability and DNA damage tolerance. Oncogene. 35:965-76.
Higgs MR, Reynolds JJ, Winczura A, Blackford AN, Borel V, Miller ES, Zlatanou A, Nieminuszczy J, Ryan EL, Davies NJ, Stankovic T, Boulton SJ, Niedzwiedz W, Stewart GS. (2015). BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks. Mol Cell. 59:462-77.
Agathanggelou A, Weston VJ, Perry T, Davies NJ, Skowronska A, Payne DT, Fossey JS, Oldreive CE, Wei W, Pratt G, Parry H, Oscier D, Coles SJ, Hole PS, Darley RL, McMahon M, Hayes JD, Moss P, Stewart GS, Taylor AMR, Stankovic T. (2015). Targeting the ATM-null phenotype in chronic lymphocytic leukemia with pro-oxidants. Haematologica. 100:1076-85.
Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, Faqeih EA, Graham GE, Ranza E, Blundell TL, Jackson AP**, Stewart GS**, Bicknell LS. (2015). Mutations in the NHEJ component XRCC4 cause primordial dwarfism. Am J Hum Genet. 96:412-24. (** Corresponding author)
Thomas A, Perry T, Berhane S, Oldreive C, Zlatanou A, Williams LR, Weston VJ, Stankovic T, Kearns P, Pors K, Grand RJ, Stewart GS. (2014). The dual acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53. Oncogene. 34:3336-48.
Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R. (2013). RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Proc Natl Acad Sci U S A. 110:20982-7
Tikoo S, Madhavan V, Miller ES, Arora P, Zlatanou A, Modi P, Townsend K, Stewart GS**, Sengupta S**. (2013). Ubiquitin-dependent recruitment of the Bloom syndrome helicase in response to replication stress is required to suppress homologous recombination. EMBO J. 32:1778-92 (** Corresponding author)
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