Dr Joanne Clark PhD, BSc (Hons)

Dr Joanne Clark

Institute of Cardiovascular Sciences
Postdoctoral Research Fellow

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Joanne Clark is a Postdoctoral Research Fellow within the Birmingham Platelet Group working with Professor Steve Watson. Her research focusses on investigating platelet glycoprotein receptors, CLEC-2 and GPVI organisation and activation using advanced microscopy. Joanne Clark is a Postdoctoral Research Fellow within the Birmingham Platelet Group working with Professor Steve Watson. Her research focusses on investigating platelet glycoprotein receptors, CLEC-2 and GPVI organisation and activation using advanced microscopy.

Qualifications

  • 2017-2021 - PhD, Institute of Cardiovascular Sciences, University of Birmingham
  • 2014-2017 - BSc (Hons) 1st Class Pharmacology, University of Portsmouth

Other activities

Society Memberships

  • The Platelet Society (2021-Present)
  • British Pharmacological Society (2017-Present)
  • Organiser: Lecture Series in Imaging and Technology Theme, ICVS (Jan 2022- September 2022)           

Publications

Recent publications

Article

Martin, E, Clark, J, Montague, S, Moran, LA, Di, Y, Bull, LJ, Whittle, L, Raka, F, Buka, R, Zafar, I, Kardeby, C, Slater, A & Watson, S 2024, 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand', Journal of Thrombosis and Haemostasis, vol. 22, no. 1, pp. 271-285. https://doi.org/10.1016/j.jtha.2023.09.026

Clark, JC, Martin, EM, Morán, LA, Di, Y, Wang, X, Zuidscherwoude, M, Brown, HC, Kavanagh, DM, Hummert, J, Eble, JA, Nieswandt, B, Stegner, D, Pollitt, AY, Herten, D, Tomlinson, MG, García, A & Watson, SP 2023, 'Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists', Communications Biology, vol. 6, no. 1, 376. https://doi.org/10.1038/s42003-023-04766-6

Clark, J, Watson, S & Owen, D 2023, 'Validation of agent-based models of surface receptor oligomerisation', Trends in Pharmacological Sciences, vol. 44, no. 10, pp. 643-646. https://doi.org/10.1016/j.tips.2023.07.002

Maqsood, Z, Clark, JC, Martin, EM, Cheung, YFH, Morán, LA, Watson, SET, Pike, JA, Di, Y, Poulter, NS, Slater, A, Lange, BMH, Nieswandt, B, Eble, JA, Tomlinson, MG, Owen, DM, Stegner, D, Bridge, LJ, Wierling, C & Watson, SP 2022, 'Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins', PLoS Computational Biology, vol. 18, no. 11, e1010708. https://doi.org/10.1371/journal.pcbi.1010708

Morán, LA, Di, Y, Sowa, MA, Hermida-Nogueira, L, Barrachina, MN, Martin, E, Clark, JC, Mize, TH, Eble, JA, Moreira, D, Pollitt, AY, Loza, MI, Domínguez, E, Watson, SP & García, Á 2022, 'Katacine is a new ligand of CLEC-2 that acts as a platelet agonist', Thrombosis and Haemostasis, vol. 122, no. 08, pp. 1361-1368. https://doi.org/10.1055/a-1772-1069

Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966

Billiald, P, Slater, A, Welin, M, Clark, J, Loyau, S, Pugnière, M, Jiacomini , IG, Rose, N, Lebozec, K, Toledano, E, François, D, Watson, S & Jandrot-Perrus, M 2022, 'Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition', Blood Advances. https://doi.org/10.1182/bloodadvances.2022007863

Clark, J, Neagoe, RAI, Zuidscherwoude, M, Kavanagh, D, Slater, A, Martin, E, Soave, M, Stegner, D, Nieswandt, B, Poulter, N, Hummert, J, Herten, D-P, Tomlinson, M, Hill, SJ & Watson, S 2021, 'Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation: GPVI dimerisation is not critical for ligand binding', Thrombosis and Haemostasis, vol. 2021, no. 00, pp. 1-26. https://doi.org/10.1055/a-1401-5014

Slater, A, Di, Y, Clark, J, Jooss, N, Martin, E, Alenazy, F, Thomas, MR, Ariëns, RAS, Herr, AB, Poulter, N, Emsley, J & Watson, S 2021, 'Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer', Blood, vol. 2021, no. 00, pp. 1-20. https://doi.org/10.1182/blood.2020009440

Clark, JC, Damaskinaki, F-N, Cheung, YFH, Slater, A & Watson, SP 2021, 'Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?', Platelets, vol. 32, no. 6, pp. 724-732. https://doi.org/10.1080/09537104.2021.1887469

Clark, J, Kavanagh, D, Watson, S, Pike, J, Andrews, R, Gardiner, EE, Poulter, N, Hill, SJ & Watson, S 2019, 'Adenosine and forskolin inhibit platelet aggregation by collagen but not the proximal signalling events', Thrombosis and Haemostasis, vol. 119, no. 07, pp. 1124-1137. https://doi.org/10.1055/s-0039-1688788

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