Recent publications
Article
Slater, A, Pan, H-Y, Ho, T-H, Martin, EM, Watson, SP, Pike, JA, Poulter, NS & Thomas, SG 2026, 'Nanobodies to GPVI as alternative reagents for platelet spreading', Platelets, vol. 37, no. 1, 2653068. https://doi.org/10.1080/09537104.2026.2653068
Clark, JC, Martin, EM, Slater, A, Calebiro, D, Koszegi, Z & Watson, SP 2026, 'Receptor homodimerisation significantly prolongs the lifetime of ligand-induced crosslinking of CLEC-2 but not GPVI', Blood vessels, thrombosis & hemostasis. https://doi.org/10.1016/j.bvth.2026.100160
Lamerton, R, Martin, EM, Perry, J, Cunningham, A, Watson, S & Frelinger III, AL 2025, 'A minimal valency of four is required for robust activation of platelets by multivalent nanobodies to GPVI, CLEC-2 and PEAR1', Research and Practice in Thrombosis and Haemostasis. https://doi.org/10.1016/j.rpth.2025.103196
Montague, SJ, Price, J, Pennycott, K, Pavey, NJ, Martin, EM, Thirlwell, I, Kemble, S, Monteiro, C, Redmond-Motteram, L, Lawson, N, Reynolds, K, Fratter, C, Bignell, P, Groenheide, A, Huskens, D, Laat, BD, Pike, JA, Poulter, NS, Thomas, SG, Lowe, GC, Lancashire, J, Harrison, P & Morgan, NV 2024, 'Comprehensive functional characterization of a novel ANO6 variant in a new patient with Scott syndrome', Journal of Thrombosis and Haemostasis, vol. 22, no. 8, pp. 2281-2293. https://doi.org/10.1016/j.jtha.2024.02.021
Martin, E, Clark, J, Montague, S, Moran, LA, Di, Y, Bull, LJ, Whittle, L, Raka, F, Buka, R, Zafar, I, Kardeby, C, Slater, A & Watson, S 2024, 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand', Journal of Thrombosis and Haemostasis, vol. 22, no. 1, pp. 271-285. https://doi.org/10.1016/j.jtha.2023.09.026
Damaskinaki, F-N, Jooss, NJ, Martin, EM, Clark, JC, Thomas, MR, Poulter, NS, Emsley, J, Kellam, B, Watson, SP & Slater, A 2023, 'Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 2, pp. 317-328. https://doi.org/10.1016/j.jtha.2022.11.002
Clark, JC, Martin, EM, Morán, LA, Di, Y, Wang, X, Zuidscherwoude, M, Brown, HC, Kavanagh, DM, Hummert, J, Eble, JA, Nieswandt, B, Stegner, D, Pollitt, AY, Herten, D, Tomlinson, MG, García, A & Watson, SP 2023, 'Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists', Communications Biology, vol. 6, no. 1, 376. https://doi.org/10.1038/s42003-023-04766-6
Kardeby, C, Evans, A, Campos, J, Al-Wahaibi, AM, Smith, C, Slater, A, Martin, E, Severin, S, Brill, A, Pejler, G, Sun, Y & Watson, S 2023, 'Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ', Journal of Thrombosis and Haemostasis, vol. 21, no. 1, pp. 101-116. https://doi.org/10.1016/j.jtha.2022.10.008
Buka, R, Montague, S, Moran, LA, Martin, E, Slater, A, Watson, S & Nicolson, P 2023, 'PF4 activates the c-Mpl-Jak2 pathway in platelets', Blood. https://doi.org/10.1182/blood.2023020872
Maqsood, Z, Clark, JC, Martin, EM, Cheung, YFH, Morán, LA, Watson, SET, Pike, JA, Di, Y, Poulter, NS, Slater, A, Lange, BMH, Nieswandt, B, Eble, JA, Tomlinson, MG, Owen, DM, Stegner, D, Bridge, LJ, Wierling, C & Watson, SP 2022, 'Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins', PLoS Computational Biology, vol. 18, no. 11, e1010708. https://doi.org/10.1371/journal.pcbi.1010708
Morán, LA, Di, Y, Sowa, MA, Hermida-Nogueira, L, Barrachina, MN, Martin, E, Clark, JC, Mize, TH, Eble, JA, Moreira, D, Pollitt, AY, Loza, MI, Domínguez, E, Watson, SP & García, Á 2022, 'Katacine is a new ligand of CLEC-2 that acts as a platelet agonist', Thrombosis and Haemostasis, vol. 122, no. 08, pp. 1361-1368. https://doi.org/10.1055/a-1772-1069
Clark, J, Neagoe, RAI, Zuidscherwoude, M, Kavanagh, D, Slater, A, Martin, E, Soave, M, Stegner, D, Nieswandt, B, Poulter, N, Hummert, J, Herten, D-P, Tomlinson, M, Hill, SJ & Watson, S 2021, 'Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation: GPVI dimerisation is not critical for ligand binding', Thrombosis and Haemostasis, vol. 2021, no. 00, pp. 1-26. https://doi.org/10.1055/a-1401-5014
Xu, R-G, Gauer, J, Baker, S, Slater, A, Martin, E, McPherson, H, Duval, C, Manfield, I, Bonna, A, Watson, S & Ariëns, RAS 2021, 'GPVI (Glycoprotein VI) interaction with fibrinogen is mediated by avidity and the fibrinogen αC-region', Arteriosclerosis Thrombosis and Vascular Biology, vol. 41, no. 3, pp. 1092-1104. https://doi.org/10.1161/ATVBAHA.120.315030
Montague, SJ, Patel, P, Martin, EM, Slater, A, Quintanilla, LG, Perrella, G, Kardeby, C, Nagy, M, Mezzano, D, Mendes, PM & Watson, SP 2021, 'Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors', Platelets, vol. 32, no. 8, pp. 1-13. https://doi.org/10.1080/09537104.2021.1945571
Letter
Bourne, J, Colicchia, M, Di, Y, Martin, E, Slater, A, Roumenina, LT, Dimitrov, JD, Watson, S & Rayes, J 2021, 'Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2', Haematologica, vol. 106, no. 2, pp. 626-629. https://doi.org/10.3324/haematol.2020.246488
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