Dr Pavlovic’s research is focused on 4 major themes:
- Regulation of the Cardiac Sodium Pump
Our laboratory has, over the years, significantly contributed to the understanding of how intracellular sodium is regulated in the heart. Our work has focused on the sodium pump, the primary regulator of intracellular sodium in the heart, and has demonstrated how its accessory protein phospholemman regulates its activity in health and disease. Current research is focused on identifying novel how these regulatory pathways are modified in disease and on identifying and developing novel therapeutics to target these mechanisms.
- The role of Steroids in the Heart
Pavlovic laboratory investigates the effect of a number of steroids on the heart function, including cardiotonic steroids and sex steroids. More recently we have also started focusing on the role of fibroblast growth factor 23. Primary focus of the lab is to investigate the role of cardiotonic steroids. Read some of the press coverage by following these links, BHF article, BHF Blog, BHF blog 2, Phoenix paper.
- Optical Mapping
Optical mapping allows us to visualise electrical activity across the heart using fluorescent dyes. This technique has revolutionised cardiac electrophysiology and we are among the leading groups in this exciting new research area. Our recent work on the optical mapping software ElectroMap has been extensively covered in the international press, including Science Daily, India Times, Equities.com, News Medical and many others.
- Causes of Atrial Fibrillation
Atrial fibrillation is the most common sustained arrhythmia. Electrical and structural remodelling of the myocardium are the two main causes of atrial fibrillation development. Current research is focused on identifying the differences in sodium regulation between the atria and the ventricles and how commonly used antiarrhythmic drugs affect their respective functions.
Research Group and Centres