Recent publications
Article
Noureddine, M, Mikolajek, H, Cowieson, N, Pinotsis, N, Robinson, P, Slater, A, Redwood, C, Loughna, S, Denning, C, Mohammed, F & Gehmlich, K 2026, 'Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy', Nature Communications, vol. 17, 6127. https://doi.org/10.1038/s41467-026-75392-z
Slater, A, Pan, H-Y, Ho, T-H, Martin, EM, Watson, SP, Pike, JA, Poulter, NS & Thomas, SG 2026, 'Nanobodies to GPVI as alternative reagents for platelet spreading', Platelets, vol. 37, no. 1, 2653068. https://doi.org/10.1080/09537104.2026.2653068
Clark, JC, Martin, EM, Slater, A, Calebiro, D, Koszegi, Z & Watson, SP 2026, 'Receptor homodimerisation significantly prolongs the lifetime of ligand-induced crosslinking of CLEC-2 but not GPVI', Blood vessels, thrombosis & hemostasis. https://doi.org/10.1016/j.bvth.2026.100160
Noureddine, M, Jones, BAI, Oliobi, OCM, Beckingham, R, Ehler, E, Mikolajek, H, Cowieson, N, Robinson, P, Redwood, C, Slater, A, Loughna, S, Denning, C, Myles, R, Coats, C, Mohammed, F & Gehmlich, K 2026, 'Structural, biophysical and cellular assessment of filamin C M82K: A test case for VUS interpretation in cardiomyopathy', Journal of Molecular and Cellular Cardiology. https://doi.org/10.1016/j.yjmcc.2026.06.009
Xu, R-G, Tiede, C, Calabrese, AN, Cheah, LT, Adams, TL, Gauer, JS, Hindle, MS, Webb, BA, Yates, DM, Slater, A, Duval, C, Naseem, KM, Herr, AB, Tomlinson, DC, Watson, SP & Ariëns, RAS 2024, 'Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer', Blood Advances, vol. 8, no. 15, pp. 3917-3928. https://doi.org/10.1182/bloodadvances.2024012689
Slater, A, Khattak, S & Thomas, MR 2024, 'GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease', European heart journal. Cardiovascular pharmacotherapy. https://doi.org/10.1093/ehjcvp/pvae018
Wang, X, Slater, A, Lee, SC, Harrison, N, Pollock, NL, Bakker, SE, Navarro, S, Nieswandt, B, Dafforn, TR, García, Á, Watson, SP & Tomlinson, MG 2024, 'Purification and characterisation of the platelet-activating GPVI/FcRγ complex in SMALPs', Archives of Biochemistry and Biophysics, vol. 754, 109944. https://doi.org/10.1016/j.abb.2024.109944
Martin, E, Clark, J, Montague, S, Moran, LA, Di, Y, Bull, LJ, Whittle, L, Raka, F, Buka, R, Zafar, I, Kardeby, C, Slater, A & Watson, S 2024, 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand', Journal of Thrombosis and Haemostasis, vol. 22, no. 1, pp. 271-285. https://doi.org/10.1016/j.jtha.2023.09.026
Alenazy, FO, Harbi, MH, Kavanagh, DP, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, PLR, Connolly, DL, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, SP & Thomas, MR 2023, 'Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 11, pp. 3236-3251. https://doi.org/10.1016/j.jtha.2023.07.018
Damaskinaki, F-N, Jooss, NJ, Martin, EM, Clark, JC, Thomas, MR, Poulter, NS, Emsley, J, Kellam, B, Watson, SP & Slater, A 2023, 'Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 2, pp. 317-328. https://doi.org/10.1016/j.jtha.2022.11.002
Kardeby, C, Evans, A, Campos, J, Al-Wahaibi, AM, Smith, C, Slater, A, Martin, E, Severin, S, Brill, A, Pejler, G, Sun, Y & Watson, S 2023, 'Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ', Journal of Thrombosis and Haemostasis, vol. 21, no. 1, pp. 101-116. https://doi.org/10.1016/j.jtha.2022.10.008
Buka, R, Montague, S, Moran, LA, Martin, E, Slater, A, Watson, S & Nicolson, P 2023, 'PF4 activates the c-Mpl-Jak2 pathway in platelets', Blood. https://doi.org/10.1182/blood.2023020872
Jooss, NJ, Smith, CW, Slater, A, Montague, SJ, Di, Y, O'shea, C, Thomas, MR, Henskens, YMC, Heemskerk, JWM, Watson, SP & Poulter, NS 2022, 'Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling and thrombus formation', Journal of Thrombosis and Haemostasis, vol. 20, no. 11, pp. 2617-2631. https://doi.org/10.1111/jth.15836
Maqsood, Z, Clark, JC, Martin, EM, Cheung, YFH, Morán, LA, Watson, SET, Pike, JA, Di, Y, Poulter, NS, Slater, A, Lange, BMH, Nieswandt, B, Eble, JA, Tomlinson, MG, Owen, DM, Stegner, D, Bridge, LJ, Wierling, C & Watson, SP 2022, 'Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins', PLoS Computational Biology, vol. 18, no. 11, e1010708. https://doi.org/10.1371/journal.pcbi.1010708
Comment/debate
Slater, A & Jandrot-Perrus, M 2022, 'GPVI and collagen: the final word?', Blood, vol. 139, no. 20, pp. 3005–3007. https://doi.org/10.1182/blood.2022015962
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