Professor Christopher A Green BMedSci(Hons), MBBS, DTM&H, FRCP, DPhil(Oxon)

Dr Chris Green

School of Chemical Engineering
Clinical Professor & Consultant Physician in Infectious Diseases

Contact details

Email
c.a.green.2@bham.ac.uk
View my research portal
Address
School of Chemical Engineering
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Christopher Green divides his time between the NHS and as an academic researcher with University of Birmingham. His main research interests are in translational medicine, vaccines development, understanding the immune response to infection/vaccination, and the problem of antimicrobial resistance.

Qualifications

  • Fellow of the Royal College of Physicians (FRCP), Royal College of Physicians 2024
  • Certificate of Completion of Training (CCT) in Infectious Diseases and General (Internal) Medicine 2018
  • Doctor of Philosophy (DPhil), University of Oxford 2017
  • Diploma in Tropical Medicine & Hygiene (DTMH), Royal College of Physicians 2008
  • Bachelor of Medicine and Bachelor of Surgery (MBBS), University of Newcastle upon Tyne 2004
  • Bachelor of Medical Science (BMedSci) with 2:1 honours in Visual Neuroscience, University of Newcastle upon Tyne 2002

Biography

Christopher Green is a Professor and Consultant Physician in Infectious Diseases & Global Health. As well as being a front-line NHS clinician, his main work and research interests focus on the development of new experimental vaccines for infectious diseases and in optimising vaccine impact in African settings. His DPhil at the University of Oxford was in leading the first-in-world clinical trials of viral-vectored vaccine technology for respiratory syncytial virus (RSV), which was directly relevant to COVID-19 vaccines needed to safely end the pandemic. He led many vaccine trials and other high-priority projects in this time and was a member of SAGE to UK government on hospital disease epidemiology. Today, his team works on clinical trials of experimental vaccines and is one of only a few global sites undertaking human challenge studies (deliberate infection) as part of an accelerated evaluation of vaccines for enteric fever. However, vaccine innovation needs to have impact. His global health research programmes are based in Rwanda, and this work includes (1) designing ‘next-generation’ vaccine deployment systems for equitable and sustainable vaccine policy implementation and future resilience to climate change and disease outbreaks, (2) the development of novel immune diagnostics for vaccine prioritisation, (3) clinical vaccine trials and (4) the development of ‘over the horizon’ public health threats detection systems.

Teaching

  • Research-led teaching on various undergraduate and postgraduate courses.

Postgraduate supervision

Vaccines, infectious diseases

Research

Research areas

  • Translational clinical research
  • Experimental vaccine research – special interest in early-phase clinical trials and controlled human infection models
  • Applied vaccine research – special interest in vaccine deployment and impact in African and other LMIC settings
  • Artificial intelligence – special interest in antimicrobial stewardship and antimicrobial resistance

Other activities

  • Principal Investigator for clinical trials of investigational medicinal products (CTIMPs) at the NIHR/Wellcome Clinical Research Facility at University Hospitals Birmingham NHS Foundation Trust; early-stage vaccine candidates and use of controlled human challenge models for accelerated vaccine evaluation
  • Consultant Physician in Infectious Diseases and General (internal) Medicine, Dept of Infectious Diseases & Tropical Medicine, University Hospitals Birmingham NHS Foundation Trust
  • Co-Chair of the national NIHR Infectious Diseases Vaccine Research Forum (UKID-VRF)
  • Faculty member of the UK Clinical Vaccine Network (UKCVN)
  • Member of the data safety monitoring committee (DMSC) for several early-phase vaccine CTIMPs

Key recent posts

  • Clinical Research Specialty Lead for Infection & Immunology for NIHR West Midlands Regional Research Delivery Network (2020 - 2025)
  • Member of the COVID Clinical Information Network member (Clinical Characterisation of Covid-19 admitted to hospitals in the UK committee) subgroup of the Scientific Advisory Group of Emergencies (SAGE) (2020-2023)
  • NIHR Academy – Lead for Infection (2019-2023)
  • Member of the ISARIC 4C consortium (2020-2023)
  • Member of the NIHR task and finish group on aerosol generating procedures for COVID-19 (2020-2021)

Publications

Recent publications

Article

Gokani, K, Faustini, SE, Tanner, C, Kwok, HF, Agarwal, R, Takwoingi, Y, Semukunzi, H, Umuhoza, C, Richter, A, Nyombayire, J, Muvunyi, CM, Heaney, J & Green, CA 2026, 'A clinical accuracy study protocol for a saliva-based point-of-care lateral flow test to assess protective immunity to tetanus (TETANUS study)', BMJ Open, vol. 16, e119202. https://doi.org/10.1136/bmjopen-2026-119202

MpoxCARE Study Team, Clarke, J, Semukunzi, H, Faustini, SE, Heaney, JLJ, Kwok, HF, Uwimana, JMV, Gokani, K, Rukundo, G, Musabyimana, JP, Ingabire, P, Bitunguhari, L, de Dieu Harelimana, J, Richter, AG, Muvunyi, CM & Green, CA 2026, 'A combined ELISA for infection-induced and vaccine-induced mpox antibodies during the clade Ib outbreak in Rwanda: an observational, cross-sectional, clinical validation study', The Lancet Infectious Diseases, vol. 26, no. 6, pp. 581-589. https://doi.org/10.1016/S1473-3099(26)00006-X

Ebrahimi, N, de Whalley, P, Kanji, N, Ramasamy, MN, Aley, PK, Bibi, S, Clutterbuck, EA, Collins, AM, Darton, TC, Duncan, CJA, Faust, SN, Feng, ES, Goodman, AL, Green, CA, Heath, PT, Kwok, J, Lazarus, R, Libri, V, Lillie, PJ, McGregor, A, Mujadidi, YF, Owino, N, Plested, E, Pollock, KM, Robinson, H, Sutherland, RK, Thomson, EC, Toshner, M, Turner, DPJ, Williams, CJ, Hirsch, I, Villafana, TL, Lambe, T, Voysey, M & Pollard, AJ 2026, 'ChAdOx1 nCoV-19 coronavirus vaccine: Long-term safety and immunological responses', Vaccine, vol. 88, 128951. https://doi.org/10.1016/j.vaccine.2026.128951

Leroux-Roels, I, Huang, G, Ferguson, M, Kohli, A, Clark, R, Bickel, M, Soens, M, Du, E, Pucci, A, Hicks, B, Eschen, C, Das, R, Wilson, E & Fluent Trial Investigators 2026, 'Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults', The New England Journal of Medicine, vol. 394, no. 18, pp. 1803-1813. https://doi.org/10.1056/NEJMoa2516491

Mugisha, JC, Daba, TM, Ndahimana, R, Musabyimana, JP, Gashegu, M, Green, CA, Muvunyi, CM & Mutesa, L 2026, 'Mapping wastewater pathogens and their associated environmental and public health risk factors: a systematic review and meta-analysis', International Journal of Infectious Diseases , vol. 172, 109097. https://doi.org/10.1016/j.ijid.2026.109097

Gokani, K, Semukunzi, H, Rukundo, G, Clarke, J, Faustini, SE, Musabyimana, JP, Roche, S, Jones, S, Otter, AD, Richter, A, Muvunyi, C, Heaney, J, Green, CA & MpoxCARE Study Group 2026, 'Mpox comprehensive assessment for responsive immunisation in emergency outbreaks (MpoxCARE): study protocol', BMC Infectious Diseases, vol. 26, no. 1, 590. https://doi.org/10.1186/s12879-026-12809-6

Llibre, A, Siddiqui, H, Burel, JG, Pillaye, J, Jones, C, Hill, H, Faustini, SE, Windle, EF, Karim, H, Sherry, E, Green, CA, Dedicoat, M, Stamataki, Z, Cunningham, AF & O'Shea, MK 2025, 'Differential control of mycobacterial growth ex vivo by COVID-19 patients is associated with CD8+ CD28+ T cells', Clinical Immunology, vol. 279, 110539. https://doi.org/10.1016/j.clim.2025.110539

Taylor, AE, Millard, G, Packham, A, Semuto Ngabonziza, JC, Mambo Muvunyi, C & Green, CA 2025, 'Ethnicity and sub-Saharan African representation in the emergency development of covid-19 vaccines', BMJ Medicine, vol. 4, no. 1, e000780. https://doi.org/10.1136/bmjmed-2023-000780

the COV-BOOST study group 2025, 'Heterologous COVID-19 vaccine schedule with protein-based prime (NVX-CoV2373) and mRNA boost (BNT162b2) induces strong humoral responses: Results from COV-BOOST trial', Journal of Infection, vol. 91, no. 3, 106576. https://doi.org/10.1016/j.jinf.2025.106576

RECOVERY Collaborative Group 2025, 'Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial', The Lancet Infectious Diseases, vol. 25, no. 9, pp. 1000-1010. https://doi.org/10.1016/S1473-3099(25)00093-3

Gokani, K, Taylor, AE, Packham, A, Musabyimana, JP, Shema, H, Mutabaruka, A, Roche, S, Takwoingi, Y, Umuhoza, C, Nyombayire, J, Muvunyi, C & Green, CA 2025, 'Safety and immunogenicity of rVSVΔG-ZEBOV-GP vaccination when dosed concurrent with mRNA COVID-19 vaccine booster doses in healthy African adults (EbolaCov): protocol for a phase IV, single-centre, single-blinded, randomised controlled trial', BMJ Open, vol. 15, no. 9, e102898. https://doi.org/10.1136/bmjopen-2025-102898

VASP Study Team, McCann, N, Vicentine, MP, Ebrahimi, N, Greenland, M, Angus, B, Collins, AM, Darton, T, Emary, K, Faust, SN, Flaxman, A, Maria, N, Green, CA, Molina, CJ, Paidisetti, R, Lazarus, R, Macaulay, GC, McLean, F, Mohan, VK, Naidu, MG, Ramasamy, MN, Rao, DY, Singh, N, Vernon, S, Kim, YC, Levine, MM, Liu, X & Pollard, AJ 2025, 'Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine', New England Journal of Medicine, vol. 393, no. 17, pp. 1704-1714. https://doi.org/10.1056/NEJMoa2502992

Letter

Faustini, SE, Jones, S, Green, CA, Otter, AD, Richter, AG & Heaney, JLJ 2025, 'Developing accessible and affordable tests to support mpox immunosurveillance and vaccine studies', Emerging Microbes and Infections, vol. 14, no. 1, 2576581. https://doi.org/10.1080/22221751.2025.2576581

Callaby, H, Olver, J, Emery, K, Richards, KS, Killip, M, Groves, N, Beadsworth, MBJ, Price, DA, Cooke, GS, Collini, P, Cole, J, Dunning, J, Semple, MG, Baillie, JK, ISARIC4C Investigators, Rampling, T & Houlihan, CF 2025, 'Monkeypox virus isolation from longitudinal samples in 11 hospitalised patients', The Lancet Infectious Diseases, vol. 25, no. 1, pp. e4-e5. https://doi.org/10.1016/S1473-3099(24)00735-7

Review article

Rukundo, G, Moore, M, Semukunzi, H, Chatterjee, S, Musabyimana, JP, Mambo Muvunyi, C & Green, CA 2026, 'Vaccine cold chain and understanding what underpins vaccine security for vaccine preventable diseases', BMJ Medicine, vol. 5, no. 1, e001835. https://doi.org/10.1136/bmjmed-2025-001835

View all publications in research portal