Recent publications
Article
Southam, AD, Higginson, JA, Lloyd, GR, Smith, MJ, Cruchley-Fuge, LE, Spruce, R, Edbali, O, Weber, RJM, Mehanna, H & Batis, N 2026, 'Regional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues', British Journal of Cancer. https://doi.org/10.1038/s41416-026-03410-4
Payne, KFB, Brotherwood, P, Suriyanarayanan, H, Brooks, JM, Batis, N, Beggs, AD, Gendoo, DMA, Mehanna, H & Nankivell, P 2024, 'Circulating tumour DNA detects somatic variants contributing to spatial and temporal intratumural heterogeneity in head and neck squamous cell carcinoma', Frontiers in Oncology, vol. 14, 1374816. https://doi.org/10.3389/fonc.2024.1374816
Mehanna, H, Rapozo, D, Zeidler, SVV, Harrington, K, Winter, S, Hartley, A, Nankivell, P, Schache, A, Sloan, P, Odell, E, Thavaraj, S, Hunter, K, Shah, K, Thomas, G, Long, A, Amel-Kashipaz, R, Brown, R, Conn, B, Hall, G, Matthews, P, Weir, J, Yeo, Y, Pring, M, West, C, McCaul, J, Golusinski, P, Sitch, A, Spruce, R, Batis, N, Bryant, J, Brooks, J, Jones, TM, Buffa, F, Haider, S & Robinson, M 2024, 'Developing and validating a multivariable prognostic-predictive classifier for treatment escalation of oropharyngeal squamous cell carcinoma: the PREDICTR-OPC study', Clinical Cancer Research, vol. 30, no. 2, pp. 356–367. https://doi.org/10.1158/1078-0432.CCR-23-1013
von Buchwald, C, Jakobsen, KK, Carlander, A-LF, Tous, S, Grønhøj, C, Rasmussen, JH, Brooks, J, Taberna, M, Mena, M, Morey, F, Bruni, L, Batis, N, Brakenhoff, RH, René Leemans, C, Jong, RJBD, Klussmann, JP, Wuerdemann, N, Wagner, S, Dalianis, T, Marklund, L, Mirghani, H, Schache, A, James, JA, Huang, SH, O'Sullivan, B, Nankivell, P, Broglie, MA, Hoffmann, M, Quabius, ES, Anderson, LA, Craig, SG, Alemany, L, Mehanna, H & HNCIG-EPIC group 2024, 'TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma', European Journal of Cancer, vol. 211, 114329. https://doi.org/10.1016/j.ejca.2024.114329
Payne, K, Brooks, J, Batis, N, Khan, N, El-Asrag, M, Nankivell, P, Mehanna, H & Taylor, G 2023, 'Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenotyping', British Journal of Cancer, vol. 129, no. 10, pp. 1590-1598. https://doi.org/10.1038/s41416-023-02428-2
Califano, J, Yousef, A, Mostafa, H, Valsamakis, A, Zhang, X, Batis, N, Varghese, C, Parish, J, Forman, M, Jarrett, J, Messer, K & Mehanna, H 2023, 'Lead Time to Recurrence After Posttreatment Plasma and Saliva HPV DNA Testing in Patients With Low-Risk HPV Oropharynx Cancer', JAMA Otolaryngology - Head and Neck Surgery, vol. 149, no. 9, pp. 812-819. https://doi.org/10.1001/jamaoto.2023.1730
Mehanna, H, Nankivell, P, Batis, N & Brooks, J 2023, 'Prognostic Implications of p16 and HPV discordance in oropharyngeal cancer: a multicenter, multinational (HNCIG-EPIC-OPC) individual patient data analysis', The Lancet Oncology, vol. 24, no. 3, pp. 239-251. https://doi.org/10.1016/S1470-2045(23)00013-X
Shaban, M, Raza, SEA, Hassan, M, Jamshed, A, Mushtaq, S, Loya, A, Batis, N, Brooks, J, Nankivell, P, Sharma, N, Robinson, M, Mehanna, H, Khurram, SA & Rajpoot, N 2022, 'A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma', Journal of Pathology, vol. 256, no. 2, pp. 174-185. https://doi.org/10.1002/path.5819
Payne, K, Brooks, J, Batis, N, Taylor, G, Nankivell, P & Mehanna, H 2022, 'Characterising the epithelial-mesenchymal transition status of circulating tumour cells in head and neck squamous cell carcinoma', Head & Neck, vol. 44, no. 11, pp. 1-10. https://doi.org/10.1002/hed.27167
Payne, K, Brooks, J, Taylor, G, Batis, N, Noyvert, B, Pan, Y, Nankivell, P & Mehanna, H 2021, 'Immediate sample fixation increases Circulating Tumour Cell (CTC) capture and preserves phenotype in head and neck squamous cell carcinoma: towards a standardised approach to microfluidic CTC biomarker discovery', Cancers, vol. 13, no. 21, 5519. https://doi.org/10.3390/cancers13215519
Batis, N, Brooks, J, Payne, K, Sharma, N, Nankivell, P & Mehanna, H 2021, 'Lack of predictive tools for conventional and targeted cancer therapy: barriers to biomarker development and clinical translation', Advanced Drug Delivery Reviews, vol. 176, 113854. https://doi.org/10.1016/j.addr.2021.113854
Swiderska, A, Coney, AM, Alzahrani, AA, Aldossary, HS, Batis, N, Ray, CJ, Kumar, P & Holmes, AP 2021, 'Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the rat', Antioxidants, vol. 10, no. 6, 840. https://doi.org/10.3390/antiox10060840
Gleneadie, HJ, Baker, AH, Batis, N, Bryant, J, Jiang, Y, Clokie, SJH, Mehanna, H, Garcia, P, Gendoo, DMA, Roberts, S, Burley, M, Molinolo, AA, Gutkind, JS, Scheven, BA, Cooper, PR, Parish, JL, Khanim, FL & Wiench, M 2021, 'The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress', Cancer Letters, vol. 501, pp. 172-186. https://doi.org/10.1016/j.canlet.2020.12.029
Abstract
Payne, K, Taylor, G, Brooks, J, Kahn, N, Batis, N, Nankivell, P & Mehanna, H 2021, 'Mass cytometry based multiparameter characterisation of Parsortix-enriched circulating tumour cells in head and neck squamous cell carcinoma: A step towards clinical translation', Annals of Oncology, vol. 32, no. supplement 5, pp. S802. https://doi.org/10.1016/J.ANNONC.2021.08.1310
Preprint
Shaban, M, Raza, SEA, Hassan, M, Jamshed, A, Mushtaq, S, Loya, A, Batis, N, Brooks, J, Nankivell, P, Sharma, N, Robinson, M, Mehanna, H, Khurram, SA & Rajpoot, N 2021 'A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma' arXiv. <https://arxiv.org/abs/2104.12862>
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