Dr Geoffrey Brown BSc, PhD

Dr Geoffrey Brown

Institute of Clinical Sciences
Reader in Cellular Immunology
Associate Member Institute of Immunology and Immunotherapy

Contact details

Address
Institute of Clinical Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Geoffrey Brown is Lead for Postgraduate Taught, College of Medical Sciences and Director of Graduate Studies, Institute of Clinical Sciences. He is also Director of the EU-funded Marie Curie FP7 Initial Training Network and consortium DECIDE (Decision-making within cells and differentiation entity therapies) which is based in the Institute of Immunology and Immunotherapy.

Geoffrey has published over 150 original research papers in scientific journals and 16 reviews/book chapters in the fields of blood cell development and leukaemia. In 2009, he edited the book entitled ‘Cell Determination during Hematopoiesis’ which included contributions from principle workers in this field from around the world. He is co-author with Isidro Sanchez-Garcia of the book entitled “Diversity, Versatility and Leukaemia”.

Qualifications

  • MA (status) Oxford 1975
  • PhD Tumour Immunology London 1975
  • BSc (Hons) Microbiology London 1972

Teaching

Teaching Programmes

Postgraduate supervision

Dr Brown is interested in supervising doctoral research in the following areas:

The development of blood cells
The use of retinoids to modulate the behaviour of normal and malignant cells

Other activities

  • 1998-2004 Consultant to Allergan Pharmaceuticals, Irvine, California
  • A founder member of the Rotary Club of Edgbaston Convention

Publications

Recent publications

Article

Brown, G, Sánchez, L & Sanchez-Garcia, I 2020, 'Lineage decision-making within normal haematopoietic and leukemic stem cells', International Journal of Molecular Sciences, vol. 21, no. 6, 2247. https://doi.org/10.3390/ijms21062247

Brown, G, Kutner, A & Marcinkowska, E 2020, 'Vitamin D and haematopoiesis', Current Tissue Microenvironment Reports, pp. 1-11. https://doi.org/10.1007/s43152-020-00001-0

Brown, G, Vicente-Dueñas, C & Sanchez-Garcia, I 2020, 'Editorial: epigenetic reprogramming and cancer development', Frontiers in cell and developmental biology, vol. 8, no. 12. https://doi.org/10.3389/fcell.2020.00012

Brown, G, Sánchez, L & Sanchez-Garcia, I 2019, 'Are leukaemic stem cells restricted to a single cell lineage?', International Journal of Molecular Sciences, vol. 21, no. 1, 45. https://doi.org/10.3390/ijms21010045

Kutner, A & Brown, G 2018, 'Vitamins D: The Relationships between Structure and Biological Activity', International Journal of Molecular Sciences, vol. 19, no. 7, 2119. https://doi.org/10.3390/ijms19072119

Brown, G, Tsapogas, P & Ceredig, R 2018, 'The changing face of haematopoiesis: A spectrum of options is available to stem cells', Immunology and Cell Biology. https://doi.org/10.1111/imcb.12055

Brown, G 2017, 'A case of AML characterized by a novel t(4;15)(q31;q22) translocation that confers a growth-stimulatory response to retinoid-based therapy', International Journal of Molecular Sciences.

Tsapogas, P, Mooney, C, Brown, G & Rolink, A 2017, 'The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis', International Journal of Molecular Sciences, vol. 18, no. 6, pp. 1115. https://doi.org/10.3390/ijms18061115

Mooney, C, Cunningham, A, Tsapogas, P, Toellner, K-M & Brown, G 2017, 'Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment', International Journal of Molecular Sciences, vol. 18, no. 5, pp. 1037. https://doi.org/10.3390/ijms18051037

Chapter (peer-reviewed)

Brown, G 2018, The role of interleukin-7 during haematopoiesis. in Advances in Medicine and Biology. Nova Science Publishers, Inc.

Editorial

Brown, G & Ceredig, R 2018, 'Cell lineage choice during hematopoiesis: in honor of Professor Antonius Rolink', International Journal of Molecular Sciences, vol. 19, no. 9, 2798. https://doi.org/10.3390/ijms19092798

Brown, G & Marcinkowska, E 2017, 'Acute Myeloid Leukaemia: New Targets and Therapies', International Journal of Molecular Sciences, vol. 18, no. 12, 2577. https://doi.org/10.3390/ijms18122577

Review article

Brown, G 2020, 'Towards a new understanding of decision-making by hematopoietic stem cells', International Journal of Molecular Sciences, vol. 21, no. 7, 2362. https://doi.org/10.3390/ijms21072362

Brown, G & Ceredig, R 2019, 'Modeling the Hematopoietic Landscape', Frontiers in cell and developmental biology, vol. 7, 104. https://doi.org/10.3389/fcell.2019.00104

Brown, G, Ceredig, R & Tsapogas, P 2018, 'The making of hematopoiesis: Developmental ancestry and environmental nurture', International Journal of Molecular Sciences, vol. 19, no. 7, 2122. https://doi.org/10.3390/ijms19072122

View all publications in research portal

Expertise

How blood stem cells are able to generate the many different types of cells that exist in the blood; hematopietic cells; blood cell development in leukaemia

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