Professor Iain Chapple PhD, BDS, FDSRCPS, FDSRCS, CCST (Rest Dent)

Iain Chapple

School of Dentistry
Professor of Periodontology and Consultant in Restorative Dentistry
Head of Research for Institute of Clinical Sciences

Contact details

Address
The School of Dentistry
5 Mill Pool Way
Edgbaston
Birmingham
B5 7EG
United Kingdom

Iain Chapple was Head of the School of Dentistry 2016-2020. He continues to be Head of Research for the Institute of Clinical Sciences and REF2021 lead for Unit of Assessment 3. He is also Professor and Head of Periodontology within the School, and Honorary Consultant in Restorative Dentistry with Birmingham Community Health Trust. He has honorary consultant contracts with University Hospital Birmingham Foundation Trust, Birmingham Women's and Children’s NHS Foundation Trust, and the Office of the Chief Dental officer.

Iain has published over 240 research papers in the peer reviewed scientific literature, and written and edited 10 textbooks and authored 23 book chapters in the field of Periodontology, Periodontal Medicine and Surgery, Nutrition and Molecular Methods. Iain has received major grants from the Medical Research Council, European Union, Charities and Industry.

Iain is a committed an enthusiastic teacher of undergraduate and postgraduate students within Birmingham, nationally and internationally on various graduate programs across Europe, North America and the Asia-Pacific rim.

Iain is former Scientific Editor of the British Dental Journal, former Associate Editor of Journal of Periodontal Research and the Journal of Clinical Periodontology, and current Associate Editor of Periodontology 2000.

Iain was awarded the Charles Tomes medal of the Royal College of Surgeons of England in 2012; the Distinguished Scientist Award of the International Association for Dental Research (Periodontal Research) in 2018; the Special Citation Award of the American Academy of Periodontology in 2018; and the Eminence Award of the European Federation of Periodontology in 2022.

Iain was President of the International Association for Dental Research (IADR) Periodontal Research Group (PRG-2006-7), Treasurer (2007-2013) and Secretary General (2016-2019) of the European Federation of Periodontology (EFP) and is currently Treasurer of the UK Oral and Dental Research Trust. He co-chairs the annual EFP workshops (research and education).

Iain is clinical lead for a hospital regional specialist periodontal service (referral base of 6-million) and a national oral care service for adult Epidermolysis Bullosa patients.

Iain was awarded an MBE in the 2022 Queen’s honours list for services to Oral and Dental Health.

Qualifications

  • Honorary fellow of the Royal College of Surgeons of Edinburgh (Dental Surgery) 2004.
  • Certificate of completion of specialist training (Rest Dent) – joint Royal Colleges 1996.
  • PhD (University of Birmingham) – 1993.
  • Fellow of the Royal College of Physicians and Surgeons of Glasgow (Dental Surgery) 1989.
  • Bachelor of Dental Surgery (Newcastle) 1986.

Teaching

Postgraduate supervision

Iain Chapple has research and doctoral supervision interests in the fields of periodontology, periodontal medicine and surgery, nutrition and molecular methods. He has received major grants from the Medical Research Council, the European Union and industry. Professor Chapple leads the periodontal research group, whose interests include:

Innate immunity in the pathobiology of periodontitis
Diagnostic biomarkers for periodontitis and associated systemic diseases
Periodontal inflammation and systemic inflammatory conditions
Periodontitis and immunesenescence
Micronutritional modulation of inflammation
Clinical trials in periodontal therapy

Professor Chapple also established the clinical trials team at Birmingham, which runs clinical studies on disease pathogenesis as well as diagnosis and therapy to international GCP standards. He welcomes applications from potential doctoral researchers in his areas of interest.

Other activities

  • European Workshop Committee and co-chair Federation of Periodontology.
  • Treasurer of UK Oral and Dental Research Trust.
  • Specialist advisor to the Office of the Chief Dental Officer in Periodontology.
  • Associate Editor of Journal of Clinical Periodontology.
  • Editorial Board member of Periodontology 2000.
  • Global Expert Panel – Unilever Oral Care Research.
  • Expert advisor for Philips Oral Healthcare.
  • Expert advisor for Johnson & Johnson.
  • Expert advisor for GSK
  • Consultant to PreViser.co.uk – spin out company of The University of Birmingham.
  • Executive Board member of European Nutraceutical Association.
  • Consultant to PreViser.co.uk – spin out company of The University of Birmingham.
  • Executive Board member of European Nutraceutical Association.

Publications

Recent publications

Article

Grant, M, Pasha, S, Inui, T, Chapple, I, Harris, S & Holcombe, L 2022, 'A mass spectrometric approach to the proteomic profiling of the Canis lupus familiaris acquired enamel pellicle on hydroxyapatite discs', Journal of Veterinary Dentistry, vol. 39, no. 3, pp. 241-249. https://doi.org/10.1177/08987564221097188

Hashai, K, Chapple, I, Shapira, L, Assadi, W, Dadon, S & Polak, D 2022, 'CD18 mediates neutrophil imperviousness to the Aggregatibacter actinomycetemcomitans JP2 clone in molar-incisor pattern periodontitis', Frontiers in immunology, vol. 13, 847372. https://doi.org/10.3389/fimmu.2022.847372

Yonel, Z, Kuningas, K, Sharma, P, Dutton, M, Jalal, Z, Cockwell, P, Webber, J, Narendran, P, Dietrich, T & Chapple, I 2022, 'Concordance of three point of care testing devices with clinical chemistry laboratory standard assays and patient-reported outcomes of blood sampling methods', BMC Medical Informatics and Decision Making, vol. 22, 248. https://doi.org/10.1186/s12911-022-01999-z

Yonel, Z, Kocher, T, Chapple, I, Dietrich, T, Völzke, H, Nauck, M, Collins, G, Gray, LJ & Holtfreter, B 2022, 'Development and External Validation of a Multivariable Prediction Model to Identify Nondiabetic Hyperglycemia and Undiagnosed Type 2 Diabetes: Diabetes Risk Assessment in Dentistry Score (DDS)', Journal of Dental Research. https://doi.org/10.1177/00220345221129807

Grant, M, Taylor, JJ, Creese, A, Gowland, C, Burke, B, Doudin, K, Patel, U, Weston, P, Milward, M, Bissett, SM, Cooper, H, Kooijman, G, Rmaile, A, de Jager, M, Preshaw, PM & Chapple, I 2022, 'Discovery, validation, and diagnostic ability of multiple protein-based biomarkers in saliva and gingival crevicular fluid to distinguish between health and periodontal diseases', Journal of Clinical Periodontology, vol. 49, no. 7, pp. 622-632. https://doi.org/10.1111/jcpe.13630

Muchová, M, Balacco, D, Grant, M, Chapple, I, Kuehne, S & Hirschfeld, J 2022, 'Fusobacterium nucleatum subspecies differ in biofilm forming ability in vitro', Frontiers in Oral Health, vol. 3, 853618. https://doi.org/10.3389/froh.2022.853618

Roberts, HM, Yonel, Z, Kantarci, A, Grant, MM & Chapple, ILC 2022, 'Impact of Gingivitis on Circulating Neutrophil Reactivity and Gingival Crevicular Fluid Inflammatory Proteins', International Journal of Environmental Research and Public Health, vol. 19, no. 10, 6339. https://doi.org/10.3390/ijerph19106339

Heaney, J, Faustini, S, Evans, L, Rapson, A, Collman, E, Emery, A, Campbell, JP, Moore, S, Goodall, M, Afzal, Z, Chapple, I, Pratt, G & Drayson, M 2022, 'Investigating the utility of saliva immunoglobulins for the detection of myeloma and using myeloma proteins to clarify partition between oral and systemic immunity', European journal of haematology. https://doi.org/10.1111/ejh.13758

De Pablo, P, Serban, S, Lopez-oliva, I, Rooney, J, Hill, K, Raza, K, Filer, A, Chapple, I & Dietrich, T 2022, 'Outcomes of Periodontal therapy in Rheumatoid Arthritis: the OPERA feasibility randomised trial.', Journal of Clinical Periodontology.

Lamerton, R, Marcial-Juarez, E, Faustini, S, Perez-Toledo, M, Goodall, M, Jossi, S, Newby, ML, Chapple, I, Dietrich, T, Veenith, T, Shields, A, Harper, L, Henderson, I, Rayes, J, Wraith, D, Watson, S, Crispin, M, Drayson, M, Richter, A & Cunningham, A 2022, 'SARS-CoV-2 spike- and nucleoprotein-specific antibodies induced after vaccination or infection promote classical complement activation', Frontiers in immunology, vol. 13, 838780. https://doi.org/10.3389/fimmu.2022.838780

Herrera, D, Sanz, M, Kebschull, M, Jepsen, S, Sculean, A, Berglundh, T, Papapanou, PN, Chapple, I & Tonetti, MS 2022, 'Treatment of stage IV periodontitis: the EFP S3 level clinical practice guideline', Journal of Clinical Periodontology, vol. 49, no. S24, pp. 4-71. https://doi.org/10.1111/jcpe.13639

Cunha de Medeiros, TC, Areas e Souza, A, Coelho Prates, R, Chapple, I & Steffens, JP 2021, 'Association between tooth loss, chronic conditions and common risk factors – results from the 2019 Brazilian Health Survey', Journal of Periodontology. https://doi.org/10.1002/JPER.21-0433

Shields, A, Faustini, S, Kristunas, C, Cook, A, Backhouse, C, Dunbar, L, Ebanks, D, Emmanuel, B, Crouch, E, Kroeger, A, Hirschfeld, J, Sharma, P, Jaffery, R, Nowak, S, Gee, S, Drayson, M, Richter, A, Dietrich, T & Chapple, I 2021, 'COVID 19: Seroprevalence and vaccine responses in UK dental care professionals', Journal of Dental Research, vol. 100, no. 11, pp. 1220-1227. https://doi.org/10.1177/00220345211020270

Conference contribution

Dawood, H, Kroeger, A, Chavda, V, Chapple, I & Kebschull, M 2022, Under pressure - mechanisms and risk factors for orthodontically induced inflammatory root resorption: a systematic review. in Under Pressure - Mechanisms and Risk Factors for Orthodontically Induced Inflammatory Root Resorption: A Systematic Review . Europerio 10, Copenhagen, Denmark, 14/06/22.

Preprint

Lamerton, RE, Juarez, EM, Faustini, SE, Perez-Toledo, ME, Goodall, M, Jossi, SE, Newby, ML, Chapple, I, Dietrich, T, Veenith, T, Shields, AM, Harper, L, Henderson, IR, Rayes, J, Wraith, DC, Watson, SP, Crispin, M, Drayson, MT, Richter, AG & Cunningham, AF 2021 'In vitro, classical complement activation differs by disease severity and between SARS-CoV-2 antigens' medRxiv. https://doi.org/10.1101/2021.11.22.21266681

View all publications in research portal

Expertise

Periodontal Diseases