Dr Josefine Hirschfeld Dr. med. dent, FDS(Rest Dent)RCPS, FHEA

Dr Josefine Hirschfeld

School of Dentistry
Associate Professor & Honorary Consultant in Restorative Dentistry
Senior Tutor for Dentistry, Dental Hygiene & Therapy, Biomedical Materials Science

Contact details

The School of Dentistry
5 Mill Pool Way
B5 7EG
United Kingdom

Josefine Hirschfeld is a specialist in Restorative Dentistry and delivers clinical care to patients with complex needs in this field. Because of her research, she has a special interest in periodontology, a discipline concerned with diseases of the gums.

Josefine forms part of the Periodontal Research Group at the School of Dentistry. She supervises PhD students conducting research in the fields of oral and systemic immunology and oral microbiology, focussing on the causes and possible new treatments for periodontitis.

She is particularly interested in neutrophils, a key immune cell, and their interactions with microorganisms and other host cells. She also investigates these cells’ role in diseases like Covid-19 and Epidermolysis Bullosa.

Josefine also teaches dentistry to under- and postgraduate students of all 5 years of the BDS programme and beyond, and is responsible for student welfare and personal academic tutoring within the School of Dentistry.


  • ISFE and CCST in Restorative Dentistry
  • Doctor medicinae dentariae, University of Würzburg, Germany
  • State Examination in Dentistry, University of Würzburg, Germany


  • Clinical and academic teaching of BDS students in subdisciplines of Restorative Dentistry, particularly Periodontology Specialty Teaching
  • Personal Tutoring of 1st – 5th year BDS students


Recent publications


Hirschfeld, J & Chapple, I (eds) 2021, Periodontitis and systemic diseases: clinical evidence and biological plausibility. 1st edn, Quintessence Publishing. <https://www.quintessence-publishing.com/gbr/en/product/periodontitis-and-systemic-diseases>


Kelk, P, Moghbel, NS, Hirschfeld, J & Johansson, A 2022, 'Aggregatibacter actinomycetemcomitans leukotoxin activates the NLRP3 inflammasome and cell-to-cell communication', Pathogens, vol. 11, no. 2, 159. https://doi.org/10.3390/pathogens11020159

Muchová, M, Balacco, D, Grant, M, Chapple, I, Kuehne, S & Hirschfeld, J 2022, 'Fusobacterium nucleatum subspecies differ in biofilm forming ability in vitro', Frontiers in Oral Health, vol. 3, 853618. https://doi.org/10.3389/froh.2022.853618

Thandi, BS, Ip, H & Hirschfeld, J 2022, 'Multiple external root resorptions in a patient with Stage IV, Grade C periodontitis and autoimmune diseases: A case report', Clinical advances in periodontics, pp. 1-6. https://doi.org/10.1002/cap.10232

Raindi, D, Rees, J, Hirschfeld, J, Wright, H, Dobbs, P, Moittie, S, White, K, Stahl, W, Martin, M, Redrobe, S, Hughes, F, Liptovszky, M, Baiker, K & Grant, M 2022, 'Periodontal health, neutrophil activity and cardiovascular health in captive chimpanzees', Archives of Oral Biology, vol. 134, 105342. https://doi.org/10.1016/j.archoralbio.2021.105342

Shields, A, Faustini, S, Kristunas, C, Cook, A, Backhouse, C, Dunbar, L, Ebanks, D, Emmanuel, B, Crouch, E, Kroeger, A, Hirschfeld, J, Sharma, P, Jaffery, R, Nowak, S, Gee, S, Drayson, M, Richter, A, Dietrich, T & Chapple, I 2021, 'COVID 19: Seroprevalence and vaccine responses in UK dental care professionals', Journal of Dental Research, vol. 100, no. 11, pp. 1220-1227. https://doi.org/10.1177/00220345211020270

Hirschfeld, J, Reichardt, E, Sharma, P, Hilber, A, Meyer‐marcotty, P, Stellzig‐eisenhauer, A, Schlagenhauf, U & Sickel, FE 2019, 'Interest in orthodontic tooth alignment in adult patients affected by periodontitis: a questionnaire-based cross-sectional pilot study', Journal of Periodontology, vol. 90, no. 9, pp. 957-965. https://doi.org/10.1002/JPER.18-0578

Moonen, CG, Hirschfeld, J, Cheng, L, Chapple, I, Loos, BG & Nicu, EA 2019, 'Oral neutrophils characterized: chemotactic, phagocytic, and Neutrophil Extracellular Trap (NET) formation properties', Frontiers in immunology, vol. 10, 635. https://doi.org/10.3389/fimmu.2019.00635

Hirschfeld, J, Higham, J, Blair, F, Richards, A & Chapple, I 2019, 'Systemic disease or periodontal disease? Distinguishing causes of gingival inflammation: a guide for dental practicioners: PART II: cancer related, infective, and other causes of gingivial pathology', British Dental Journal, vol. 227, pp. 1029-1034. https://doi.org/10.1038/s41415-019-1053-5

Hirschfeld, J, Higham, J, Chatzistavrianou, D, Blair, F, Richards, A & Chapple, I 2019, 'Systemic disease or periodontal disease? Distinguishing causes of gingival inflammation: a guide for dental practicioners: PART I: immune mediated, autoinflammatory, and hereditary lesions', British Dental Journal, vol. 227, no. 11, pp. 961–966. https://doi.org/10.1038/s41415-019-1050-8

Dommisch, H, Skora, P, Hirschfeld, J, Olk, G, Hildebrandt, L & Jepsen, S 2019, 'The guardians of the periodontium - sequential and differential expression of antimicrobial peptides during gingival inflammation. Results from in vivo and in vitro studies', Journal of Clinical Periodontology, vol. 46, no. 3, pp. 276-285. https://doi.org/10.1111/jcpe.13084

Hirschfeld, J, Milward, MR, Cooper, PR, Wright, HJ, Matthews, JB, Chapple, I & White, P 2018, 'Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response‐related gene expression', Journal of Periodontal Research. https://doi.org/10.1111/jre.12542

Seren, S, Rashed Abouzaid, M, Eulenberg-Gustavus, C, Hirschfeld, J, Nasr Soliman, H, Jerke, U, N'Guessan, K, Dallet-Choisy, S, Lesner, A, Lauritzen, C, Schacher, B, Eickholz, P, Nagy, N, Szell, M, Croix, C, Viaud-Massuard, M-C, Al Farraj Aldosari, A, Ragunatha, S, Ibrahim Mostafa, M, Giampieri, F, Battino, M, Cornillier, H, Lorette, G, Stephan, J-L, Goizet, C, Pedersen, J, Gauthier, F, Jenne, DE, Marchand-Adam, S, Chapple, IL, Kettritz, R & Korkmaz, B 2018, 'Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis', Journal of Biological Chemistry, vol. 293, no. 32, pp. 12415-12428. https://doi.org/10.1074/jbc.RA118.001922

Review article

Hirschfeld, J 2020, 'Neutrophil subsets in periodontal health and disease: a mini review', Frontiers in immunology, vol. 10, 3001. https://doi.org/10.3389/fimmu.2019.03001

Jepsen, S, Gennai, S, Hirschfeld, J, Kalemaj, Z, Buti, J & Graziani, F 2020, 'Regenerative surgical treatment of furcation defects: a systematic review and Bayesian network meta-analysis of randomized clinical trials', Journal of Clinical Periodontology, vol. 47, no. S22, pp. 352-374. https://doi.org/10.1111/jcpe.13238

View all publications in research portal