Dr Josefine Hirschfeld Dr. med. dent, FHEA

Dr Josefine Hirschfeld

School of Dentistry
Academic Clinical Lecturer in Restorative Dentistry
Senior Tutor for Dentistry, Dental Hygiene & Therapy, Biomedical Materials Science

Contact details

The School of Dentistry
5 Mill Pool Way
B5 7EG
United Kingdom

Josefine Hirschfeld is currently an Academic Clinical Lecturer in Restorative Dentistry. She started her specialty training in Restorative Dentistry at the Birmingham Dental Hospital in April 2016 and has a special interest in periodontology, a discipline concerned with diseases of the gums.

Apart from her clinical work, she undertakes research in the fields of oral immunology and oral microbiology, focussing on the causes and possible new treatments of periodontitis.

 She also takes part in teaching BDS students in clinical Restorative Dentistry.


  • Doctor medicinae dentariae, University of Würzburg, Germany
  • Dentistry, University of Würzburg, Germany


  • Clinical teaching of BDS students in Restorative Dentistry
  • Tutoring of 1st – 5th year BDS students


Recent publications


Shields, A, Faustini, S, Kristunas, C, Cook, A, Backhouse, C, Dunbar, L, Ebanks, D, Emmanuel, B, Crouch, E, Kroeger, A, Hirschfeld, J, Sharma, P, Jaffery, R, Nowak, S, Gee, S, Drayson, M, Richter, A, Dietrich, T & Chapple, I 2021, 'COVID 19: Seroprevalence and vaccine responses in UK dental care professionals', Journal of Dental Research.

Hirschfeld, J, Reichardt, E, Sharma, P, Hilber, A, Meyer‐marcotty, P, Stellzig‐eisenhauer, A, Schlagenhauf, U & Sickel, FE 2019, 'Interest in orthodontic tooth alignment in adult patients affected by periodontitis: a questionnaire-based cross-sectional pilot study', Journal of Periodontology, vol. 90, no. 9, pp. 957-965. https://doi.org/10.1002/JPER.18-0578

Moonen, CG, Hirschfeld, J, Cheng, L, Chapple, I, Loos, BG & Nicu, EA 2019, 'Oral neutrophils characterized: chemotactic, phagocytic, and Neutrophil Extracellular Trap (NET) formation properties', Frontiers in immunology, vol. 10, 635. https://doi.org/10.3389/fimmu.2019.00635

Hirschfeld, J, Higham, J, Blair, F, Richards, A & Chapple, I 2019, 'Systemic disease or periodontal disease? Distinguishing causes of gingival inflammation: a guide for dental practicioners: PART II: cancer related, infective, and other causes of gingivial pathology', British Dental Journal, vol. 227, pp. 1029-1034. https://doi.org/10.1038/s41415-019-1053-5

Hirschfeld, J, Higham, J, Chatzistavrianou, D, Blair, F, Richards, A & Chapple, I 2019, 'Systemic disease or periodontal disease? Distinguishing causes of gingival inflammation: a guide for dental practicioners: PART I: immune mediated, autoinflammatory, and hereditary lesions', British Dental Journal, vol. 227, no. 11, pp. 961–966. https://doi.org/10.1038/s41415-019-1050-8

Dommisch, H, Skora, P, Hirschfeld, J, Olk, G, Hildebrandt, L & Jepsen, S 2019, 'The guardians of the periodontium - sequential and differential expression of antimicrobial peptides during gingival inflammation. Results from in vivo and in vitro studies', Journal of Clinical Periodontology, vol. 46, no. 3, pp. 276-285. https://doi.org/10.1111/jcpe.13084

Hirschfeld, J, Milward, MR, Cooper, PR, Wright, HJ, Matthews, JB, Chapple, I & White, P 2018, 'Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response‐related gene expression', Journal of Periodontal Research. https://doi.org/10.1111/jre.12542

Seren, S, Rashed Abouzaid, M, Eulenberg-Gustavus, C, Hirschfeld, J, Nasr Soliman, H, Jerke, U, N'Guessan, K, Dallet-Choisy, S, Lesner, A, Lauritzen, C, Schacher, B, Eickholz, P, Nagy, N, Szell, M, Croix, C, Viaud-Massuard, M-C, Al Farraj Aldosari, A, Ragunatha, S, Ibrahim Mostafa, M, Giampieri, F, Battino, M, Cornillier, H, Lorette, G, Stephan, J-L, Goizet, C, Pedersen, J, Gauthier, F, Jenne, DE, Marchand-Adam, S, Chapple, IL, Kettritz, R & Korkmaz, B 2018, 'Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis', Journal of Biological Chemistry, vol. 293, no. 32, pp. 12415-12428. https://doi.org/10.1074/jbc.RA118.001922

Korkmaz, B, Caughey, GH, Chapple, I, Gauthier, F, Hirschfeld, J, Jenne, DE, Kettritz, R, Lalmanach, G, Lamort, A-S, Lauritzen, C, Łȩgowska, M, Lesner, A, Marchand-Adam, S, McKaig, SJ, Moss, C, Pedersen, J, Roberts, H, Schreiber, A, Seren, S & Thakker, NS 2018, 'Therapeutic targeting of cathepsin C: from pathophysiology to treatment', Pharmacology & Therapeutics, vol. 190, pp. 202-236. https://doi.org/10.1016/j.pharmthera.2018.05.011

Hirschfeld, J, Howait, M, Movila, A, Parčina, M, Bekeredjian-Ding, I, Deschner, J, Jepsen, S & Kawai, T 2017, 'Assessment of the involvement of the macrophage migration inhibitory factor (MIF)-glucocorticoid regulatory dyad in MMP-2 expression during periodontitis', European Journal of Oral Sciences, vol. 125, no. 5, pp. 345–354. https://doi.org/10.1111/eos.12363

Hirschfeld, J, Akinoglu, EM, Wirtz, DC, Hoerauf, A, Bekeredjian-Ding, I, Jepsen, S, Haddouti, E-M, Limmer, A & Giersig, M 2017, 'Long-term release of antibiotics by carbon nanotube-coated titanium alloy 2 surfaces diminish biofilm formation by Staphylococcus epidermidis', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 13, no. 4, pp. 1587–1593. https://doi.org/10.1016/j.nano.2017.01.002

Hirschfeld, J, White, P, Milward, M, Cooper, P & Chapple, I 2017, 'Modulation of neutrophil extracellular trap and reactive oxygen species release by periodontal bacteria', Infection and Immunity, vol. 85, no. 12, pp. e00297-17. https://doi.org/10.1128/IAI.00297-17

Matsuda, S & Hirschfeld, J 2016, 'A novel method of sampling gingival crevicular fluid from a mouse model of periodontitis', Journal of Immunological Methods, vol. 438, pp. 21-25. https://doi.org/10.1016/j.jim.2016.08.008

Review article

Hirschfeld, J 2020, 'Neutrophil subsets in periodontal health and disease: a mini review', Frontiers in immunology, vol. 10, 3001. https://doi.org/10.3389/fimmu.2019.03001

Jepsen, S, Gennai, S, Hirschfeld, J, Kalemaj, Z, Buti, J & Graziani, F 2020, 'Regenerative surgical treatment of furcation defects: a systematic review and Bayesian network meta-analysis of randomized clinical trials', Journal of Clinical Periodontology, vol. 47, no. S22, pp. 352-374. https://doi.org/10.1111/jcpe.13238

View all publications in research portal