Recent publications
Article
Cumberland, M, Riebel, LL, Roy, A, O'Shea, C, Holmes, A, Denning, C, Kirchhof, P, Rodriguez, B & Gehmlich, K 2022, 'Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond', Frontiers in Physiology, vol. 13, 806366. https://doi.org/10.3389/fphys.2022.806366
O’Shea, C, Winter, J, Kabir, SN, O’Reilly, M, Wells, SP, Baines, O, Sommerfeld, LC, Correia, J, Lei, M, Kirchhof, P, Holmes, AP, Fabritz, L, Rajpoot, K & Pavlovic, D 2022, 'High resolution optical mapping of cardiac electrophysiology in pre-clinical models', Scientific Data, vol. 9, no. 1, 135. https://doi.org/10.1038/s41597-022-01253-1
O'Brien, S-M, Holmes, A, Johnson, D, Kabir, SN, O'Shea, C, O'Reilly, M, Avezzu, A, Reyat, J, Hall, AW, Apicella, C, Ellinor, PT, Niederer, S, Tucker, NR, Fabritz, L, Kirchhof, P & Pavlovic, D 2022, 'Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels', Journal of Molecular and Cellular Cardiology, vol. 166, pp. 23-35. https://doi.org/10.1016/j.yjmcc.2022.01.009
MacMillan, S, Holmes, AP, Dallas, ML, Mahmoud, AD, Shipston, MJ, Peers, C, Hardie, DG, Kumar, P & Evans, AM 2022, 'LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response', Communications Biology, vol. 5, no. 1, 642. https://doi.org/10.1038/s42003-022-03583-7
Swiderska, A, Coney, AM, Alzahrani, AA, Aldossary, HS, Batis, N, Ray, CJ, Kumar, P & Holmes, AP 2021, 'Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the rat', Antioxidants, vol. 10, no. 6, 840. https://doi.org/10.3390/antiox10060840
Holmes, AP, Saxena, P, Kabir, SN, O'Shea, C, Kuhlmann, SM, Gupta, S, Fobian, D, Apicella, C, O'Reilly, M, Syeda, F, Reyat, JS, Smith, GL, Workman, AJ, Pavlovic, D, Fabritz, L & Kirchhof, P 2021, 'The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone', Heart Rhythm, vol. 2021, no. 00, pp. 1-37. https://doi.org/10.1016/j.hrthm.2021.03.016
Alzahrani, AA, Cao, LL, Aldossary, HS, Nathanael, D, Fu, J, Ray, CJ, Brain, KL, Kumar, P, Coney, AM & Holmes, AP 2021, 'β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia', Pfluegers Archiv: European journal of physiology , vol. 473, no. 1, pp. 37-51. https://doi.org/10.1007/s00424-020-02492-0
Holmes, AP, Ray, CJ, Kumar, P & Coney, AM 2020, 'A student practical to conceptualize the importance of Poiseuille’s law and flow control in the cardiovascular system', Advances in Physiology Education. https://doi.org/10.1152/advan.00004.2019
Holmes, AP 2020, 'Damage control: carotid body activation and remodelling in response to aseptic tissue injury', Experimental Physiology, vol. 105, no. 9, pp. 1467-1469. https://doi.org/10.1113/EP088923
Cao, L, Holmes, A, Marshall, J, Fabritz, L & Brain, K 2020, 'Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: a novel fluorescence imaging method', Autonomic Neuroscience, vol. 223, 102611. https://doi.org/10.1016/j.autneu.2019.102611
Reyat, JS, Chua, W, Cardoso, VR, Witten, A, Kastner, PM, Kabir, SN, Sinner, MF, Wesselink, R, Holmes, AP, Pavlovic, D, Stoll, M, Kääb, S, Gkoutos, GV, de Groot, JR, Kirchhof, P & Fabritz, L 2020, 'Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation', JCI Insight, vol. 5, no. 16, e139179. https://doi.org/10.1172/jci.insight.139179
O’shea, C, Holmes, AP, Winter, J, Correia, J, Ou, X, Dong, R, He, S, Kirchhof, P, Fabritz, L, Rajpoot, K & Pavlovic, D 2019, 'Cardiac optogenetics and optical mapping – overcoming spectral congestion in all-optical cardiac electrophysiology', Frontiers in Physiology, vol. 10, 182. https://doi.org/10.3389/fphys.2019.00182
Review article
Holmes, AP, Swiderska, A, Nathanael, D, Aldossary, HS, Ray, CJ, Coney, AM & Kumar, P 2022, 'Are multiple mitochondrial related signalling pathways involved in carotid body oxygen sensing?', Frontiers in Physiology, vol. 13, 908617. https://doi.org/10.3389/fphys.2022.908617
Aldossary, HS, Alzahrani, AA, Nathanael, D, Alhuthail, EA, Ray, CJ, Batis, N, Kumar, P, Coney, AM & Holmes, AP 2020, 'G-protein-coupled receptor (GPCR) signaling in the carotid body: roles in hypoxia and cardiovascular and respiratory disease', International Journal of Molecular Sciences, vol. 21, no. 17, 6012. https://doi.org/10.3390/ijms21176012
Short survey
O'Shea, C, Kabir, SN, Holmes, AP, Lei, M, Fabritz, L, Rajpoot, K & Pavlovic, D 2020, 'Cardiac optical mapping – state-of-the-art and future challenges', International Journal of Biochemistry and Cell Biology, vol. 126, 105804. https://doi.org/10.1016/j.biocel.2020.105804
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