Dr Alan M Jones Ph.D., BSc. (Hons), MRSC, FHEA

Dr Alan Jones

School of Pharmacy
Senior Lecturer in Medicinal Chemistry

Contact details

Address
Institute of Clinical Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Alan is a Senior Lecturer in Medicinal Chemistry, the College of Medical and Dental Sciences Chemical Safety Advisor and Institute of Clinical Sciences Chemical Safety Advisor. He is the MDS lead for the University H&S Advisory Group and serves on the College Safety Executive Committee, and Institute H&S Committee.

His group’s research interest focus on the application of synthetic and medicinal chemistry to solve challenges at the intersection of biology and drug discovery.

He has a wealth of experience of teaching at both undergraduate and postgraduate levels.

Qualifications

  • PG Cert 2016
  • FHEA 2016
  • Member of the Royal Society of Chemistry 2009
  • Ph.D. (St And.) 2009
  • BSc. Hons (Aberd.) 2005

Biography

Alan received his Chemistry B.Sc. (Hons) from the University of Aberdeen (UK), Chemistry Ph.D. from the University of St Andrews (UK) (Supervisor: Prof. Nick J. Westwood). After post-doctoral research in the labs of Prof. S. G. Davies and Prof. A. J. Russell (University of Oxford, UK) and Prof. I. Collins (Institute of Cancer Research, UK), Alan joined the University of Birmingham (UK) in 2017 as a Lecturer. As of 2020, Alan is a Senior Lecturer in Medicinal Chemistry. His research interests include combining electrosynthesis with medicinal chemistry.

Teaching

Postgraduate supervision

Our group research interests include combining electrosynthesis with medicinal chemistry. If you are able to self-fund or have secured funding already, we have PhD and MSc (Res.) opportunities in the following:

  • Synthetic Methodology
  • Medicinal Chemistry and Drug Discovery
  • Electrosynthesis and drug metabolism
  • Using chemistry to predict adverse drug reactions

Research

Our research group develops new synthetic routes to bioactive small molecules. We are investigating the following themes:

New Electro-Synthetic Methodology
We are developing electrosynthetic routes to small molecules required in the pharmaceutical and fine chemical industries to accelerate drug discovery.
See recent work: ChemElectroChem 2019; Org. Biomol. Chem. 2017; ACS Sustain. Chem. Eng. 2020

Medicinal Chemistry
We are investigating the role of small molecules in oncology and cardiovascular disease.
See recent work: Sci. Rep. 2019BBA Gen. Subj. 2017Cell Physiol Biochem 2019Biorxiv 2020 

Adverse Drug Reactions in Pharmacy
Understanding of polypharmacology as a determinant of ADRs and drug toxicity.
See: Pharmacol. Res. Perspect. 2020; J. Prescrib. Pract2019 

Chemical Biological Role of Sulfation
The sulfate group acts as an epigenetic marker in approximately ~1% of all known PTMs and as a metabolic detoxification route for small molecules. We are exploring new methods to install and handle these polar functional groups.
See: ChemBioChem 2020Chem. Commun2019

Other activities

Grant Reviewer

  • British Council Newton Fund, UK
  • EPSRC, UK
  • Rosetrees Trust, UK
  • KidScan Cancer charity, UK
  • Parkinson’s UK
  • University of Sharjah, United Arab Emirates
  • Fondation pour la Recherche Médicale, France

Journal Peer Reviewer

ACS, RSC, Wiley, MDPI and Elsevier journal titles including:

  • Chemical Communications
  • Advanced Synthesis & Catalysis
  • ChemSusChem
  • Journal of Organic Chemistry
  • ACS Sustainable Chemistry & Engineering

Editorial roles

  • Molecules MDPI – Organic Chemistry section editor
  • Molecules MDPI – Guest Editor

External PhD examiner

  • University of Nottingham (UK)
  • University of Cardiff (UK)

Consultancy

Novartis

Publications

Recent publications

Article

Alshehri, JA, Benedetti, AM & Jones, AM 2020, 'A novel exchange method to access sulfated molecules', Scientific Reports, vol. 10, no. 1, 16559. https://doi.org/10.1038/s41598-020-72500-x

Quevedo, CE, J. R. Bataille, C, Byrne, S, Durbin, M, Elkins, J, Guillermo, A, Jones, AM, Knapp, S, Nadali, A, Walker, RG, Wilkinson, I, Wynne, GM, Davies, SG & Russell, AJ 2020, 'Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family', Bioorganic & Medicinal Chemistry. https://doi.org/10.1016/j.bmc.2020.115724

Benedetti, AM, Gill, D, Tsang, C & Jones, AM 2020, 'Chemical methods for N- and O-sulfation of small molecules, amino acids and peptides', ChemBioChem, vol. 21, no. 7, pp. 938-942. https://doi.org/10.1002/cbic.201900673

Law, JP, Price, AM, Pickup, L, Radhakrishnan, A, Weston, C, Jones, AM, McGettrick, HM, Chua, W, Steeds, RP, Fabritz, L, Kirchhof, P, Pavlovic, D, Townend, JN & Ferro, CJ 2020, 'Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy', Journal of the American Heart Association, vol. 9, no. 7, e016041. https://doi.org/10.1161/JAHA.120.016041

Jones, AM 2020, 'Dialling-In New Reactivity into the Shono-type anodic oxidation reaction', The Chemical Record.

Wetzel, A & Jones, AM 2020, 'Electrically Driven N(sp 2)- C(sp 2/3) Bond Cleavage of Sulfonamides', ACS Sustainable Chemistry & Engineering, vol. 8, no. 8, pp. 3487-3493. https://doi.org/10.1021/acssuschemeng.0c00387

Benedetti, AM, Male, L & Jones, AM 2020, 'Phenylmethanaminium benzylsulfamate', CSD Communication.

Ferro, C, Solkhon, F, Jalal, Z, Al Hamid, A & Jones, AM 2020, 'Relevance of physicochemical properties and functional pharmacology data to predict the clinical safety profile of direct oral anticoagulants', Pharmacology Research and Perspectives, vol. 8, no. 3, e00603. https://doi.org/10.1002/prp2.603, https://doi.org/10.1002/prp2.603

Zazeri, G, Povinelli, APR, Duff, CSL, Tang, B, Cornelio, ML & Jones, AM 2020, 'Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1β and NF-κB Proteins', Molecules. https://doi.org/10.3390/molecules25122841

Benedetti, AM, Male, L & Jones, AM 2020, 'Tributylammonium benzylsulfamate', CSD Communication.

Jones, AM 2020, 'Tributylsulfoammonium betaine', Electronic Encyclopedia of Reagents for Organic Synthesis.

Fuchigami, H, Bal, MK, Brownson, DAC, Banks, CE & Jones, AM 2020, 'Voltammetric Behaviour of Drug Molecules as a Predictor of Metabolic Liabilities', Scientia Pharmaceutica. https://doi.org/10.3390/scipharm88040046

Abstract

Zahid, M, Jones, AM & Jalal, Z 2020, 'A systematic review of the effectiveness of Coenzyme Q10 in reducing mortality in patients with heart failure', International Journal of Pharmacy Practice, vol. 28, no. S1, pp. 76-77. https://doi.org/10.1111/ijpp.12607

Review article

Chopra, V, Sangarappillai, R, Romero-Canelón, I & Jones, AM 2020, 'Lysyl oxidase like-2 (LOXL2): an emerging oncology target', Advanced Therapeutics, vol. 3, no. 2, 1900119. https://doi.org/10.1002/adtp.201900119

Working paper

Stanulović, VS, Reed, MAC, Patani, H, Potluri, S, Georgiadou, E, Roberts, J, Sarkar, S, Pratt, G, Jones, AM, Günther, U, Ludwig, C & Hoogenkamp, M 2020 'Proliferation and survival of T-cell acute lymphoblastic leukaemia depends on mTOR-regulated glutamine uptake and EAAT1-dependent conversion of glutamine to aspartate and nucleotides' bioRxiv. https://doi.org/10.1101/2020.02.08.939694

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