Recent publications
Article
Bryant, J, Batis, N, Franke, AC, Clancey, G, Hartley, M, Ryan, G, Brooks, J, Southam, AD, Barnes, N, Parish, J, Roberts, S, Khanim, F, Spruce, R & Mehanna, H 2019, 'Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma', OncoTarget, vol. 10, no. 50, pp. 5229-5244. https://doi.org/10.18632/oncotarget.27156
Abdullah, MI, Abed, MN, Khanim, F & Richardson, A 2019, 'Screening a library of approved drugs reveals that prednisolone synergizes with pitavastatin to induce ovarian cancer cell death', Scientific Reports, vol. 9, no. 1, 9632. https://doi.org/10.1038/s41598-019-46102-1
Drayson, M, Murray, J, Pratt, G, Jacob, A, Clark, F, Blundred, R, Fox, S, Bishop, R, Wheatley, K, Khanim, F & Bunce, C 2019, 'Single arm phase II trial assessing the safety, compliance with and activity of bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers', Contemporary Clinical Trials Communications, vol. 14, 100361. https://doi.org/10.1016/j.conctc.2019.100361
Barini, E, Miccoli, A, Tinarelli, F, Mulholland, K, Kadri, H, Khanim, F, Stojanovski, L, Read, KD, Burness, K, Blow, JJ, Mehellou, Y & Muqit, MMK 2018, 'The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1', ChemBioChem, vol. 19, no. 5, pp. 425-429. https://doi.org/10.1002/cbic.201700500
Denbigh, JL, Perez-Guaita, D, Vernooij, RR, Tobin, MJ, Bambery, KR, Xu, Y, Southam, AD, Khanim, FL, Drayson, MT, Lockyer, NP, Goodacre, R & Wood, BR 2017, 'Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques', Scientific Reports, vol. 7, 2649. https://doi.org/10.1038/s41598-017-02069-5
Calamita, P, Miluzio, A, Russo, A, Pesce, E, Ricciardi, S, Khanim, F, Cheroni, C, Alfieri, R, Mancino, M, Gorrini, C, Rossetti, G, Peluso, I, Pagani, M, Medina, DL, Rommens, J & Biffo, S 2017, 'SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention', PLoS Genetics, vol. 13, no. 1, e1006552. https://doi.org/10.1371/journal.pgen.1006552
Clarke, K, Ricciardi, S, Pearson, T, Bharudin, I, Davidsen, PK, Bonomo, M, Brina, D, Scagliola, A, Simpson, DM, Beynon, RJ, Khanim, F, Ankers, J, Sarzynski, MA, Ghosh, S, Pisconti, A, Rozman, J, Hrabe de Angelis, M, Bunce, C, Stewart, C, Egginton, S, Caddick, M, Jackson, M, Bouchard, C, Biffo, S & Falciani, F 2017, 'The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks', Cell Reports, vol. 21, no. 6, pp. 1507-1520. https://doi.org/10.1016/j.celrep.2017.10.040
Doig, CL, Battaglia, S, Khanim, FL, Bunce, CM & Campbell, MJ 2016, 'Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells', The Journal of Steroid Biochemistry and Molecular Biology, vol. 155 , no. Part A, pp. 47-55. https://doi.org/10.1016/j.jsbmb.2015.09.037
Thompson, M, Ludwig, C, Bunce, C, Khanim, F & Gunther, U 2016, 'Malonate as a ROS product is associated with pyruvate carboxylase activity in Acute Myeloid Leukaemia cells', Cancer & Metabolism, vol. 4, 15. https://doi.org/10.1186/s40170-016-0155-7
Koczula, KM, Ludwig, C, Hayden, R, Cronin, L, Pratt, G, Parry, H, Tennant, D, Drayson, M, Bunce, CM, Khanim, FL & Günther, UL 2016, 'Metabolic plasticity in CLL: adaptation to the hypoxic niche', Leukemia, vol. 30, no. 1, pp. 65–73. https://doi.org/10.1038/leu.2015.187
Carrigan, J, Reed, MA, Ludwig, C, Khanim, F, Bunce, C & Gunther, U 2016, 'Tracer-based metabolic NMR-based flux analysis in a leukaemia cell line', ChemPlusChem, vol. 81, no. 5, pp. 453–459. https://doi.org/10.1002/cplu.201500549
Southam, A, Khanim, F, Hayden, R, Constantinou, J, Koczula, K, Michell, R, Viant, M, Drayson, M & Bunce, C 2015, 'Drug redeployment to kill leukemia and lymphoma cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids: Antilipogenic Leukemia Therapy Targets SCD1', Cancer Research, vol. 75, no. 12, pp. 2530-40. https://doi.org/10.1158/0008-5472.CAN-15-0202
Chapter
Gunther, U, Chong, MG, Volpari, T, Koczula, K, Atkins, K, Bunce, CM & Khanim, F 2015, Metabolic Fluxes in Cancer Metabolism: Pathways Regulation and Biology. in S Mazurek & M Shoshan (eds), Tumor Cell Metabolism. Springer, pp. 315-348.
Review article
Bunce, CM & Khanim, FL 2018, 'The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins', Laboratory investigation. https://doi.org/10.1038/s41374-017-0012-5
Lilly, AJ, Khanim, FL & Bunce, CM 2015, 'The case for extracellular Nm23-H1 as a driver of acute myeloid leukaemia (AML) progression', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 388, no. 2, pp. 225-33. https://doi.org/10.1007/s00210-014-1027-8
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