Dr Chris McConville BSc, MSc, PhD

Dr Chris McConville

School of Pharmacy
Senior Lecturer in Pharmaceutics, Formulation and Drug Delivery

Contact details

Address
School of Pharmacy
Institute of Clinical Sciences
Sir Robert Aitken Institute for Medical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Chris McConville is a Senior Lecturer in Pharmaceutics, Formulation and Drug Delivery. His previous experience within the pharmaceutical industry and academia has provided him with expertise in preformulation, dosage form design, drug delivery and analysis.

He believes that for most diseases we currently have some excellent drug candidates; but in some cases we just choose to administer them incorrectly.  Therefore, there is a need to improve the way in which we deliver certain drugs to the body. 

His research is focused on the design, formulation and characterisation of novel dosage forms and delivery devices to improve therapeutic outcomes for patients, while reducing systemic toxicities and improving their quality of life during treatment. 

Qualifications

  • Postgraduate Certificate in Higher Education Teaching and Learning (2013)
  • PhD in Pharmaceutics, Queen’s University of Belfast (2008)
  • MSc in Biomolecular Structure and Function, Queen’s University of Belfast (2005)
  • BSc in Applied Biochemical Sciences, University of Ulster (2003)

Teaching

Chris holds a Postgraduate Certificate in Higher Education Teaching and Learning and has experience in lecturing to both undergraduate and postgraduate students.

He currently teaches on the MPharm programme at the University of Birmingham.

Postgraduate supervision

Dr McConville is interested in supervising research projects in the following areas:

The development of implantable drug delivery devices for the localised treatment of brain tumours
The use of 3D printing to manufacture multi-layered tablets
HIV Microbicides and Multipurpose Prevention Technology
Solubility enhancement of poorly water soluble drugs

Other activities

Chris is currently a reviewer for a number of leading pharmaceutical and drug delivery journals.

Publications

Recent publications

Article

Mahmoud, BS & McConville, C 2021, 'Development and Optimization of Irinotecan-Loaded PCL Nanoparticles and Their Cytotoxicity against Primary High-Grade Glioma Cells', Pharmaceutics, vol. 13, no. 4, 541. https://doi.org/10.3390/pharmaceutics13040541

Gawley, M, Almond, L, Daniel, S, Lastakchi, S, Kaur, S, Detta, A, Cruickshank, G, Miller, R, Hingtgen, S, Sheets, K & McConville, C 2020, 'Development and in vivo evaluation of Irinotecan-loaded Drug Eluting Seeds (iDES) for the localised treatment of recurrent glioblastoma multiforme', Journal of Controlled Release, vol. 324, pp. 1-16. https://doi.org/10.1016/j.jconrel.2020.05.012

Mahmoud, B, AlAmri, AH & McConville, C 2020, 'Polymeric Nanoparticles for the Treatment of Malignant Gliomas', Cancers, vol. 12, no. 1, 175, pp. 1. https://doi.org/10.3390/cancers12010175

Kalisvaart, M, Broadhurst, D, Marcon, F, Pande, R, Schlegel, A, Sutcliffe, R, Marudanayagam, R, Mirza, D, Chatzizacharias, N, Abradelo, M, Muiesan, P, Isaac, J, Ma, YT, Mcconville, C & Roberts, K 2020, 'Recurrence patterns of pancreatic cancer after pancreatoduodenectomy: systematic review and a single-centre retrospective study', HPB : the official journal of the International Hepato Pancreato Biliary Association. https://doi.org/10.1016/j.hpb.2020.01.005

Matos, RL, Lu, T, Leeke, G, Prosapio, V, McConville, C & Ingram, A 2020, 'Single-step coprecipitation and coating to prepare curcumin formulations by supercritical fluid technology', Journal of Supercritical Fluids, vol. 159, 104758. https://doi.org/10.1016/j.supflu.2020.104758

Garrett, A-M, Lastakchi, S & McConville, C 2020, 'The Personalisation of Glioblastoma Treatment Using Whole Exome Sequencing: A Pilot Study', Genes, vol. 11, no. 2, 173. https://doi.org/10.3390/genes11020173

Fuenmayor, E, Forde, M, Healy, AV, Devine, DM, Lyons, JG, McConville, C & Major, I 2019, 'Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets', International Journal of Pharmaceutics, vol. 558, pp. 328-340. https://doi.org/10.1016/j.ijpharm.2019.01.013

Lessa Matos, R, Lu, T, Prosapio, V, McConville, C, Leeke, G & Ingram, A 2019, 'Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process', Journal of CO2 Utilization, vol. 30, pp. 48-62. https://doi.org/10.1016/j.jcou.2019.01.005

Lessa Matos, R, Lu, T, McConville, C, Leeke, G & Ingram, A 2018, 'Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process', Journal of Supercritical Fluids, vol. 141, pp. 143-156. https://doi.org/10.1016/j.supflu.2017.12.013

Butcher, K, Kannappan, V, Kilari, RS, Morris, MR, McConville, C, Armesilla, AL & Wang, W 2018, 'Investigation of the key chemical structures involved in the anticancer activity of disulfiram in A549 non-small cell lung cancer cell line', BMC Cancer, vol. 18, no. 1, pp. 753. https://doi.org/10.1186/s12885-018-4617-x

Fuenmayor, E, Forde, M, Healy, AV, Devine, DM, Lyons, JG, McConville, C & Major, I 2018, 'Material Considerations for Fused-Filament Fabrication of Solid Dosage Forms', Pharmaceutics, vol. 10, no. 2. https://doi.org/10.3390/pharmaceutics10020044

Najlah, M, Ahmed, Z, Iqbal, M, Wang, Z, Tawari, P, Wang, W & McConville, C 2017, 'Development and Characterisation of Disulfiram-loaded PLGA Nanoparticles for the Treatment of Non-Small Cell Lung Cancer', European Journal of Pharmaceutics and Biopharmaceutics, vol. 112, EJPB 12367, pp. 224-233. https://doi.org/10.1016/j.ejpb.2016.11.032

Wang, Z, Tan, J, Mcconville, C, Kannappan, V, Tawari, PE, Brown, J, Ding, J, Armesilla, AL, Irache, JM, Mei, Q, Tan, Y, Liu, Y, Jiang, W, Bian, X & Wang, W 2017, 'Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 13, no. 2, pp. 641-657. https://doi.org/10.1016/j.nano.2016.08.001

Major, I & Mcconville, C 2017, 'Vaginal drug delivery for the localised treatment of cervical cancer', Drug delivery and translational research, vol. 7, no. 6, pp. 817–828. https://doi.org/10.1007/s13346-017-0395-2

Shergill, M, Patel, M, Khan, S, Bashir, A & McConville, C 2016, 'Development and characterisation of sustained release solid dispersion oral tablets containing the poorly water soluble drug disulfiram', International Journal of Pharmaceutics, vol. 497, no. 1-2, pp. 3-11. https://doi.org/10.1016/j.ijpharm.2015.11.029

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