Dr James A. Roberts BSc, MRes, PhD

Dr James A. Roberts

Department of Biomedical Sciences
Post-doctoral Research Fellow

Contact details

Address
Robert Aitken Institute for Clinical Research
Department of Biomedical Sciences
College of Medicine and Health
University of Birmingham
B15 2TT

Dr James Roberts is a post-doctoral research fellow within the Department of Biomedical Sciences. His research spans neurodegeneration, in particular brain and eye health, bridging molecular discovery, therapeutic intervention and cutting-edge drug delivery approaches for better patient outcomes. 

Dr Roberts completed his PhD at the University of Liverpool in 2024 exploring how oxidative stress contributes to drug-induced cardiovascular toxicity and the potential mitigation through activation of the NRF2 pathway. This research facilitated his interests into the contribution of oxidative stress, inflammation and other degenerative pathways to diseases such as age-related macular degeneration (AMD).

His current research investigates the mechanisms underpinning AMD, glaucoma, brain injury and other neurodegenerative disorders. He also has a keen interest in novel therapeutic interventions in combination with delivery strategies and technologies. His research crosses preclinical (in vitro, ex vivo and in vivo) and clinical applications, providing a comprehensive translational research pathway.

Dr Roberts teaches on undergraduate Biomedical Sciences programmes, supervises BSc and MSci project students and is a PhD supervisor. He is passionate about mentoring the next generation of scientists and advancing translational neurodegenerative research for the wider public and patient benefit.

Qualifications

  • PhD in Cellular and Molecular Physiology, 2024
  • MRes in Cellular and Molecular Physiology, 2020
  • BSc in Pharmacology, 2019

Biography

Dr James Roberts has a background in cellular and molecular physiology, acquiring a PhD at the University of Liverpool in 2024 exploring how the cytoprotective transcription factor NRF2 can mitigate the cardiotoxicity induced by chemotherapeutics. In his role as a post-doctoral research fellow, Dr Roberts investigates novel therapeutics and drug delivery strategies for neurodegenerative diseases such as age-related macular degeneration and glaucoma in a variety of preclinical models. This research supports the neuroscience and ophthalmology team led by Professor Lisa Hill and Dr Hannah Botfield.

Dr Roberts is also integrated within a portfolio of traumatic brain injury (TBI) clinical studies including mTBI-Predict, a major international project funded by The U.S. Department of Defense, specifically within the biofluids workstream. This clinical aspect of neurodegeneration is a key aspect of his research. 

Dr Roberts is passionate about translating research into tangible impact for patients through a variety of pathways including collaboration and commercialisation. Moreover, he is dedicated to advancing the next generation of researchers by providing supervision (including BSc and MSci projects), laboratory training and comprehensive support for their personal and professional development.

Research

Research interests

  • Developing preclinical models of neurodegenerative and ophthalmological disorders (including glaucoma and age-related macular degeneration)
  • Investigating pathophysiological mechanisms contributing to neurodegenerative diseases including oxidative stress, extracellular matrix dynamics, and inflammation
  • Developing and re-purposing therapies for age-related macular degeneration and glaucoma
  • Advancing therapeutic delivery strategies for disorders of the eye and brain
  • Identifying biomarkers for neurological and neurodegenerative diseases including traumatic brain injury