Dr Jorge Caamaňo PhD

Image of Jorge Caamaño

Institute of Immunology and Immunotherapy
Reader in Cellular Immunology

Contact details

Telephone
+44 (0)121 414 4077
Fax
+44 (0)121 414 3599
Email
j.caamano@bham.ac.uk
Address
Institute of Immunology and Immunotherapy
IBR - College of Medical and Dental Sciences
University of Birmingham
Vincent Dr.
Edgbaston, Birmingham
B15 2TT
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Jorge Caamaño is Reader in Cellular Immunology. He heads the Stroma-Immune Cell Interaction Group.

Jorge’s research focuses on secondary and tertiary lymphoid tissue development and function during immune responses and inflammation.

He has published over seventy articles in peer-reviewed scientific journals in the field of immunology, cell and developmental biology and signal transduction. His research has received funding from the European Union, BBSRC, The Wellcome Trust, The Royal Society and MRC.

He is a member of the International Engagement College Group and the Brazil Working Group of the University of Birmingham in charge of promoting collaborations, fostering student exchanges and attracting funding with Brazil and South America. 

Qualifications

  • PhD Biochemistry 1992
  • MSc Biochemistry 1987

Biography

Jorge received a MSc degree in Biochemistry from the University of Buenos Aires, Argentina. In 1988 he moved to the Fox Chase Cancer Center in Philadelphia, USA to carry out his PhD studies on the function of the P53 tumour suppressor gene in head and neck tumours as part of a joint program with the University of Buenos Aires.

After graduating, he was awarded a postdoctoral scholarship at the Laboratory of Transcriptional Regulation in the Dept. of Oncology at the Bristol-Myers Squibb Pharmaceutical Research Institute in Princeton, USA. During the tenure of his postdoctoral position, he generated a series of genetically modified animal strains to study the role of the Nuclear Factor kappa B (NF-kB) family of transcription factors. He continued his work on NF-kB in immune responses to infection at the School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.

In 2000, Jorge was recruited at the University of Birmingham to set up a Stroma-Immune Cell Interaction Group within the School of Immunity and Infection of the College of Medical and Dental Sciences. 

He has received funding from the BBSRC, MRC, the European Union, The Wellcome Trust, and The Royal Society.

Jorge is a member of the editorial board of the Immunity and Infection section of the Journal of Visualized Experiments (JoVE). He has organized national and international research conferences in Immunology, and was a member of the advisory board of Unit of Molecular Immunology and Signal Transduction, GIGA-Research at the University of Liege, Belgium (2009).

Teaching

Teaching Programmes

- Lecturer of Immunology and Hematology to MBChB students.

- Module coordinator of the Molecular Mechanisms of Immune Cell Differentiation module of the MSc Course in Immunology and Immunotherapy.

- Personal mentor for 1st and 2nd year medical students at the College of Medicine.

- Project supervision and laboratory training of PhD students.

Postgraduate supervision

Jorge supervises doctoral research students in the following areas:

  • Signalling pathways involved in the development of secondary lymphoid organs and inflammation.
  • Induction of gene expression by members of theTumour Necrosis Factor Receptor family (TNF-R) and the NF-kB transcription factors during immune responses and disease.
  • The role of the NF-kB transcription factors during cell transformation.

In the last few years three PhD students have successfully completed a PhD under his supervision. They have moved on to pursue careers in academia and in the pharmaceutical industry.

If you are interesting in studying any of these subject areas please contact Jorge on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings

Research

RESEARCH THEMES

- Development and function of secondary and tertiary lymphoid tissues. Immune responses in lymphoid tissues

- The role of immune cells in adipose tissues

- Innate lymphoid cells and stromal cells

RESEARCH ACTIVITY

Stromal-Immune Cell Interaction Group

The immune system protects us against infectious diseases by mounting immune responses that aim to ultimately eliminate pathogens that invade our bodies. In order to exert this protection the different cell types of the immune system need to communicate with each other using cell-cell contact mediated by a range of cell surface molecules or by producing soluble factors that act on other cells. These interactions between immune cells are facilitated by their recruitment to specific micro-environments in lymphoid tissues distributed around our bodies such as lymph nodes, Peyer’s patches, bronchial and gut associated lymphoid tissues, fat associated lymphoid clusters, etc.

The main research interests of the team are the interactions between immune and stromal cells that underlie lymphoid tissue formation during embryogenesis and immune responses and inflammation in adults. The team uses in vivo and in vitro approaches combining biochemistry and molecular biology techniques with genetic models and imaging technologies to unravel the cellular and molecular events regulating these processes. Jorge’s team has demonstrated the function of the Lymphotoxin beta receptor and NF-kB signalling in stromal cells during lymph node development (Carragher et al. 2004, White et al. 2007, Benezech et al. 2010).  The team has also shown that interactions between adipocyte progenitor cells from fat pads and immune cells leads to the reprogramming of the former to become lymph node stromal cells that support T cell survival ex vivo (Benezech et al., 2012).

More recently the team has identified the signals and cells required for the formation of a novel type of lymphoid tissues called Fat Associated Lymphoid Clusters (FALCs) located in the mesenteries, myocardium, and mediastinum. Specifically, FALCs respond to inflammatory signals by increasing the size and number of clusters, in particular through the recruitment of macrophages, B1 and B2 cells (Benezech et al., 2015).

By dissecting the molecular interactions between stromal and immune cells during lymphoid tissue formation Jorge’s team aims to understand how to either prevent the ectopic formation of these tissues during autoimmune diseases or to induce their development to support local immune responses against tumours. This knowledge will aid in the development of therapies against inflammation, uncontrolled immune responses and cancer.

 

OTHER ACTIVITIES

- Jorge is a member of the editorial board of the Immunity and Infection section of the Journal of Visualized Experiments (JoVE). 

- Jorge is review editor for the e-journal “Frontiers in Immunology”

- He has organized the “17th Germinal Centre Conference on Lymphatic Tissues and Immune Reactions” together with Kai Toellner. 4th-8th of September 2011. The Belfry, West Midlands, UK. 170 participants.

- He has also organized the “Microanatomy of Immune Responses in Health and Disease Conference” together with Peter Lane and Graham Anderson. 5th-8th of September 2009. University of Birmingham, UK. 150 participants.

- He was a member of the advisory board of Unit of Molecular Immunology and Signal Transduction, GIGA-Research at the University of Liege, Belgium (2009).

Other activities

  • Jorge is a member of the editorial board of the Immunity and Infection section of the Journal of Visualized Experiments (JoVE)
  • He has organised the "17th Germinal Centre Conference on Lymphatic Tissues and Immune Reactions" together with Kai Toellner, 4th - 8th September 2011, The Belfry, West Midlands, UK (170 participants)
  • He has also organised the "Microanatomy of Immune Responses in Health and Disease Conference" together with Peter Lane and Graham Anderson, 5th - 8th September 2009, University of Birmingham, UK (150 participants)
  • He was a member of the advisory board of Unit of Molecular Immunology and Signal Transduction, GIGA-Research at the University of Liege, Belgium, 2009

Publications

- Duchene J, Novitzky-Basso I, Thiriot A, Casanova-Acebes M, Bianchini M, Etheridge SL, Hub E, Nitz K, Artinger K, Eller K, Caamaño J, Rülicke T, Moss P, Megens RTA, von Andrian UH, Hidalgo A, Weber C, Rot A. (2017). Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol. 18:753-761. doi: 10.1038/ni.3763. PMID:28553950

Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M, Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie AN and Caamaño J (2015) Inflammation-induced formation of fat-associated lymphoid clusters. Nat Immunol 16(8):819-28

Buckley CD, Barone F, Nayar S, Bénézech C and Caamaño J (2015) Stromal cells in chronic inflammation and tertiary lymphoid organ formation. Annu Rev Immunol 33:715-45

Bénézech C, Nayar S, Finney BA, Withers DR, Lowe K, Desanti GE, Marriot CL, Watson SP, Caamaño J, Buckley CD and Barone F (2014) CLEC-2 is required for development and maintenance of lymph nodes. Blood 123(2):3200-7

Furtado GC, Pacer ME, Bongers G, Bénézech C, He Z, Chen L, Berin MC, Kollias G, Caamaño J and Lira SA (2013) TNFα-dependent development of lymphoid tissue in the absence of RORγt+ lymphoid tissue inducer cells. Mucosal Immunol 7(3):602-14

Bénézech C and Caamaño J (2013) Generation of lymph node-fat pad chimeras for the study of lymph node stromal cell origin. J Vis Exp Dec 16(82):e50952

Cowan JE, Parnell SM, Nakamura K, Caamaño J, Lane PJ, Jenkinson EJ, Jenkinson WE and Anderson G (2013) The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J Exp Med 210(4):675-81

Bénézech C, Mader E, Khan M, Nakamura K, White A, Ware C, Anderson G and Caamaño J (2012) Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells. Immunity 37(4):721-34

Bénézech C, White A, Madder E, Serre K, Parnell S, Pfeffer K, Ware C, Anderson G and Caamaño J (2010) Ontogeny of stromal organizer cells during lymph node development. J Immunol 184(8):4521-30