Dr Patricia Lalor (Trish) PhD, BSc

Patricia Lalor

Institute of Immunology and Immunotherapy
Reader in Experimental Hepatology

Contact details

Address
Centre for Liver and Gastroenterology Research
Institute of Biomedical Research
Institute of Immunology and Immunotherapy
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Lalor is a Senior Investigator in the Centre for Liver and Gastroenterology Research and an Academic with roles as a tutor and module lead on courses within the Medical School. Trish has a research group studying the molecular regulation of human liver disease and supervise postgraduate students and fellows working in this area and related cross-disciplinary schemes.

Qualifications

  • Fellow of the Higher Education Academy
  • Postgraduate Certificate in Academic Practice (2014)
  • Foundation of Learning and Teaching in Higher Education, 2012
  • PhD in Immunology, 1998
  • BSc Hons Applied Biology, 1994

Biography

Dr Lalor's undergraduate degree included a year in research hosted in the laboratory of Professor Nash which developed her interest in the processes of inflammatory cell recruitment across the vasculature. This was enhanced by Trish's PhD studies in Professor Nash’s group where she investigated the contribution that platelets play in white blood cell adhesion and migration under physiological shear. Dr Lalor was able to advance these studies in her postdoctoral projects to understand the unique phenotype of human hepatic sinusoidal endothelial cell and how these cells participate in the cellular regulation of human liver inflammation and fibrosis during liver disease. She now continues to work closely with clinical colleagues in the Centre for Liver and Gastroenterology Research to use the well validated cohorts of human samples available in our unit to develop human cell and tissue based models to understand the regulation of both acute and chronic liver injury. Trish remains particularly interested in the contribution of sinusoidal endothelial cells and platelets to hepatic inflammation. Dr Lalor also has cross-disciplinary programmes of research that use novel biophysical and chemical tools to understand and potentially treat complex liver disease. She has a particular interest in metabolic liver disease and fibrosis.

Dr Lalor has funding from MRC and Wellcome schemes, BBSRC and The European Union to support her research and she also works with major pharmaceutical companies on collaborative projects. Her team is composed of both scientific and clinical researchers and she supervises PhD students funded on national and international schemes.

Teaching

  • Module co-ordinator for Liver Cell Biology in BMedSc year 3 with responsibility for delivering teaching and designing and marking assessments. Trish also teaches on the Stem cell module for year 2 and is  a personal tutor on this course.  Medical Science BMedSc
  • Clinical Science Bmedsci, supervisor for intercalating student projects and lecturing on the lier and GI module for this course Clinical Science BMedSc - Intercalated Degree
  • Supervisor for BMedSc3, research student projects and dissertation
  • Birmingham Foundation Academy, tutor for lectures and practical sessions for students enrolled on the Medical Sciences pathway Medical Sciences Pathway
  • Medicine and Surgery MBChB: student tutor, lecturer and mentor for SSA activities
  • PSIBS : lecturing and project supervision – Physical Sciences for Health

Postgraduate supervision

Dr Lalor has several current students on clinical, academic and industry funded programmes.

For any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.   

Research

Research interests

  • Inflammation
  • Cell adhesion
  • Endothelial biology
  • Fibrogenesis
  • Liver metabolism
  • Alcohol-related liver injury
  • NAFLD
  • Toxic liver injury

Current projects

  • Marie Curie ITN – DeLiver
  • MRC CiC and WT ISSF – new therapeutic options in acute liver injury
  • BBSRC/ GSK Collaborative Training Partnership : human liver models to investigate hepatic clearance mechanisms
  • MRC Stratified Medicine Initiative – Minimising mortality in alcoholic hepatitis
  • Novo Nordisk: Research collaboration in NAFLD pathogenesis
  • Takeda : Collaborative research project in NASH

Other activities

  • Dr Lalor is a peer reviewer for major high impact, disciplinary journals including: Gastroenterology, PLosOne, Cell Transplantation, Gut, Hepatology, Journal of Leukocyte Biology, The American Journal of Transplantation, Inflammation Research, American Journal of Pathology, Liver International and Liver Transplantation.
  • NC3Rs Fellowship Grant committee member
  • Dr Lalor also also a peer reviews for funding applications (eg BHF Intermediate Fellowships, MRC Training Fellowships, MRC New Investigators Research Grants, Netherlands Organization for Scientific Research (NWO) grants, Austrian Science Fund (FWF) project grants, Agency for Science, Technology and Research (A*STAR) Singapore project grants)
  • Dr Lalor has run public engagement events for Think Tank, The Big Bang Fair and The QEHB showcase days

Publications

Recent publications

Article

Chauhan, A, Sheriff, L, Hussain, MT, Webb, GJ, Patten, DA, Shepherd, EL, Shaw, R, Weston, CJ, Haldar, D, Bourke, S, Bhandari, R, Watson, S, Adams, DH, Watson, SP & Lalor, PF 2020, 'The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure', Nature Communications, vol. 11, no. 1, 1939. https://doi.org/10.1038/s41467-020-15584-3

Malehmir, M, Pfister, D, Gallage, S, Szydlowska, M, Inverso, D, Kotsiliti, E, Leone, V, Peiseler, M, Surewaard, BGJ, Rath, D, Ali, A, Wolf, MJ, Drescher, H, Healy, ME, Dauch, D, Kroy, D, Krenkel, O, Kohlhepp, M, Engleitner, T, Olkus, A, Sijmonsma, T, Volz, J, Deppermann, C, Stegner, D, Helbling, P, Nombela-Arrieta, C, Rafiei, A, Hinterleitner, M, Rall, M, Baku, F, Borst, O, Wilson, CL, Leslie, J, O'Connor, T, Weston, CJ, Adams, DH, Sheriff, L, Teijeiro, A, Prinz, M, Bogeska, R, Anstee, N, Bongers, MN, Notohamiprodjo, M, Geisler, T, Withers, DJ, Ware, J, Mann, DA, Augustin, HG, Vegiopoulos, A, Milsom, MD, Rose, AJ, Lalor, PF, Llovet, JM, Pinyol, R, Tacke, F, Rad, R, Matter, M, Djouder, N, Kubes, P, Knolle, PA, Unger, K, Zender, L, Nieswandt, B, Gawaz, M, Weber, A & Heikenwalder, M 2019, 'Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer', Nature Medicine, vol. 25, no. 4, pp. 641-655. https://doi.org/10.1038/s41591-019-0379-5, https://doi.org/10.1038/s41591-019-0379-5

Saborano, R, Lalor, P & Gunther, U 2019, 'A framework for tracer-based metabolism in mammalian cells by NMR', Scientific Reports, vol. 9, no. 1, 2520 (2019), pp. 2520. https://doi.org/10.1038/s41598-018-37525-3

Rahman, H-U, Bhogal, R & Lalor, P 2018, 'Models for predicting risk of acute kidney injury after liver surgery', OBM Hepatology and Gastroenterology, vol. 2, no. 2, 007. https://doi.org/10.21926/obm.hg.1802007

Dufton, NP, Peghaire, CR, Osuna-Almagro, L, Raimondi, C, Kalna, V, Chuahan, A, Webb, G, Yang, Y, Birdsey, GM, Lalor, P, Mason, JC, Adams, DH & Randi, AM 2017, 'Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis', Nature Communications, vol. 8, 895. https://doi.org/10.1038/s41467-017-01169-0

Schofield, Z, Reed, MAC, Newsome, P, Adams, D, Gunther, U & Lalor, P 2017, 'Changes in human hepatic metabolism in steatosis and cirrhosis', World Journal of Gastroenterology, vol. 23, no. 15, pp. 2685-2695. https://doi.org/10.3748/wjg.v23.i15.2685

Chauhan, A, Adams, DH, Watson, SP & Lalor, PF 2016, 'Platelets: no longer bystanders in liver disease', Hepatology, vol. 64, no. 5, pp. 1774–1784. https://doi.org/10.1002/hep.28526

Chen, Y-Y, Jeffery, HC, Hunter, S, Bhogal, R, Birtwistle, J, Kaur Braitch, M, Roberts, S, Ming, M, Hannah, J, Thomas, C, Adali, G, Hubscher, S, Syn, W-K, Afford, S, Lalor, PF, Adams, DH & Oo, YH 2016, 'Human intrahepatic tregs are functional, require IL-2 from effector cells for survival and are susceptible to fas ligand mediated apoptosis', Hepatology, vol. 64, no. 1, pp. 138–150. https://doi.org/10.1002/hep.28517

Chapter (peer-reviewed)

Wiggins, BG, Aliazis, K, Davies, SP, Hirschfield, G, Lalor, PF, Reynolds, G & Stamataki, Z 2017, In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma. in GE Rainger & HM Mcgettrick (eds), T-Cell Trafficking: Methods and Protocols. vol. 1591, Methods in Molecular Biology, Springer, pp. 195-214. https://doi.org/10.1007/978-1-4939-6931-9_14

Lalor, PF & Hepburn, EA 2017, Introduction to Lymphocyte Trafficking in Disease. in GE Rainger & HM Mcgettrick (eds), T-Cell Trafficking: Methods and Protocols. vol. 1591, Methods in Molecular Biology , Springer, pp. 169-176. https://doi.org/10.1007/978-1-4939-6931-9_12

Wiggins, BG, Stamataki, Z & Lalor, PF 2017, Using Ex Vivo Liver Organ Cultures to Measure Lymphocyte Trafficking. in GE Rainger & HM Mcgettrick (eds), T-Cell Trafficking: Methods and Protocols. vol. 1591, Methods in Molecular Biology, Springer, pp. 177-194. https://doi.org/10.1007/978-1-4939-6931-9_13

Abstract

Dufton, N, Peghaire, C, Osuna-Almagro, L, Raimondi, C, Kalna, V, Chuahan, A, Webb, G, Yang, Y, Birdsey, G, Lalor, P, Mason, J, Adams, D & Randi, A 2017, 'Dynamic Regulation of Canonical TGF beta-Signalling by the Endothelial Transcription Factor ERG Protects from Liver Fibrogenesis', Journal of Vascular Research, vol. 54, no. S1, pp. 6-7. https://doi.org/10.1159/000471944

Chauhan, A, Bourke, S, Adams, DH, Watson, SP & Lalor, PF 2016, 'Blocking platelet activation dramatically accelerates liver recovery from acetaminophen induced sterile liver injury', Hepatology, vol. 64, no. S1, 29, pp. 15A. https://doi.org/10.1002/hep.28796

Editorial

Adams, DH, Shepherd, EL & Lalor, PF 2018, 'Could endothelial TGFβ signaling be a promising new target for liver disease?', Expert review of gastroenterology & hepatology, vol. 12, no. 7, pp. 637-639. https://doi.org/10.1080/17474124.2018.1477587

Review article

Shetty, S, Lalor, PF & Adams, DH 2018, 'Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity', Nature Reviews. Gastroenterology & Hepatology. https://doi.org/10.1038/s41575-018-0020-y

View all publications in research portal