Dr Jake Mann is a clinician–scientist specialising in paediatric hepatology, with a focus on the mechanisms of fibrosis and inflammation in childhood liver disease. His research programme studies rare, severe conditions (particularly biliary atresia) to identify conserved pathways that may represent therapeutic targets in more common diseases such as metabolic dysfunction–associated steatotic liver disease (MASLD).
His laboratory uses advanced molecular approaches, including single-cell and spatial transcriptomics in human liver tissue, to interrogate processes of liver injury and repair. He has a particular interest in the ductular reaction and its role across cholestatic and metabolic liver diseases.
Clinically, Dr Mann has led the development of a specialist paediatric MASLD service, establishing a coordinated, networked model of care that supports clinicians across the UK.
Alongside his mechanistic work, Dr Mann contributes to shaping clinical practice and policy in paediatric MASLD. He led the 2026 European paediatric MASLD guideline development and has a strong interest in how evidence is translated into real-world care. His clinical research includes studies of long-term outcomes in children with MASLD and the use of non-invasive imaging tools for risk stratification.
Dr Mann is committed to supporting the development of clinical academic trainees, particularly in paediatrics. He runs a regular webinar programme, writes an active blog (https://jakepmann.com/), and mentors several trainees.
He is keen to support motivated paediatric clinical trainees interested in pursuing research careers, particularly those preparing applications for funded PhD fellowships. Opportunities are available across paediatric MASLD and fibro-inflammatory liver disease, spanning clinical, translational, and data-driven research. Please get in touch to discuss potential projects and mentorship.