Professor Paul Moss

Paul Moss

Institute of Immunology and Immunotherapy
Deputy Head of College of Medical and Dental Sciences
Professor of Haematology

Contact details

Address
Institute of Immunology and Immunotherapy
University of Birmingham
Cancer Sciences Building
Edgbaston
Birmingham
B15 2TT

Professor Moss is Professor of Haematology at the University of Birmingham and Deputy Head of the College of Medical and Dental Sciences. He is an NIHR Senior Investigator and was previously Chair of the Infection and Immunity Board at the Medical Research Council and the Clinical and Translational Research Committee at Cancer Research UK.

Professor Moss is leading the UK Coronavirus Immunology Consortium (UK-CIC), bringing together leading immunologists from 17 UK Universities to understand the immune response to SARS-CoV-2. UK-CIC launched on 28 August 2020 with £6.5 million funding from UKRI and NIHR. The Consortium aims to determine the mechanisms of virus-specific immunity and how these relate to clinical outcome in different patient groups. The programme will also investigate the maintenance of long-term immunity and inform the development of vaccines and new therapies.

In this video Professor Moss describes his career to date, his passion for his research and how it is helping to change the world, and how he enjoys working with postgraduate researchers from the UK and abroad.

Qualifications

  • M.A. Medical Sciences (University of Cambridge)
  • B.M. B.S. (University of Oxford)
  • Member of Royal College of Physicians UK
  • Fellow of Royal College of Pathologists
  • Ph.D
  • Fellow of the Academy of Medical Sciences

Teaching

Teaching Programmes

Teaching Activity

Professor Moss makes substantial contributions to teaching both within the University of Birmingham and beyond. He was previously Programme Director of the Intercalated Bachelor in Medical Sciences (Clinical Sciences) which offers medical students the opportunity to undertake an 8 month research project during their undergraduate degree.

Research

Research Themes

Haematology and Translational Immunology 

Research Activity

Professor Moss’s research is focussed around the application of translational immunological research in the study of human disease. His current research group includes clinical and non-clinical research scientists working on a range of different projects:

The immune response to cancer

The group study the innate, adaptive and stromal response in several human cancers including leukaemia & lymphoma as well as pancreatic, ovarian and testicular cancer. Important technologies include flow sorting, CyTOF and single cell RNA-Seq.

Immune control of chronic human viral infection

With over 20 years of contribution within cytomegalovirus infection, the team continue to investigate the mechanisms and impact of chronic viral infection on human health.

Mechanisms of graft-versus-leukaemia following stem cell transplantation

Stem cell (bone marrow) transplantation can cure chemo-resistant cancer and the team are working with colleagues within the Department of Haematology to uncover the mechanisms of this effect

The Immunology of pregnancy

Pregnancy offers a major immunological challenge to the mother and several disorders of pregnancy may arise from a heightened fetal-specific ‘rejection’. In collaboration with Professor Kilby, the team investigate the underlying mechanisms of immune homeostasis.

Additional research is undertaken with Professor Stankovic on the genetics of Chronic Lymphocytic Leukaemia and with colleagues within UHBFT on research using Clinical Informatics.

His work is supported by four research Programme Grants and collaborations with Industry. Several of his discoveries have been taken into clinical trials.

He has been appointed as a member of the UoA1 panel (Clinical Medicine) in REF 2021.

He is on the Scientific Advisory Board for the MATWIN cancer open-innovation platform in France. 

Other activities

Clinical Activity/NHS Affiliation

Professor Moss is an honorary Consultant at the University Hospitals Birmingham NHS Foundation Trust. His primary interests are in haemato-oncology and general haematology and he is the Clinical Service Lead for Chronic Lymphocytic Leukaemia. He became an NIHR Senior Investigator in 2018.

He is currently Chair of the UK Regenerative Medicine Platform, the Grants Advisory Panel at Prostate Cancer UK and the Epidemic Technical Advisory Panel at the Wellcome Trust. He is also Chair of the Innovate/MRC Biomedical Catalyst Major Awards Panel.

In addition he has previously held a number of important academic appointments:

  • Chair of the Infections and Immunity Board and member of Strategy Board at the Medical Research Council
  • Chair of the Cancer Research UK (CRUK) Clinical and Translational Research Committee (2008-2012)
  • Member of the Wellcome Trust Clinical Interview Committee
  • Deputy Chair of the MRC Infections and Immunity Board 2009-2013
  • Output assessor for Clinical Medicine Panel of Research Excellence Framework 2014 (REF2014)

Publications

Recent publications

Article

Moss, P 2020, '"The ancient and the new": is there an interaction between cytomegalovirus and SARS-CoV-2 infection?', Immunity & Ageing, vol. 17, 14. https://doi.org/10.1186/s12979-020-00185-x

Wilkie, M, Satti, I, Minhinnick, A, Harris, S, Riste, M, Ramon, RL, Sheehan, S, Thomas, Z-RM, Wright, D, Stockdale, L, Hamidi, A, O'Shea, MK, Dwivedi, K, Behrens, HM, Davenne, T, Morton, J, Vermaak, S, Lawrie, A, Moss, P & McShane, H 2020, 'A phase I trial evaluating the safety and immunogenicity of a candidate tuberculosis vaccination regimen, ChAdOx1 85A prime - MVA85A boost in healthy UK adults', Vaccine, vol. 38, no. 4, pp. 779-789. https://doi.org/10.1016/j.vaccine.2019.10.102

Frumento, G, Verma, K, Croft, W, White, A, Zuo, J, Nagy, Z, Kissane, S, Anderson, G, Moss, P & Chen, FE 2020, 'Homeostatic Cytokines Drive Epigenetic Reprogramming of Activated T Cells into a "Naive-Memory" Phenotype', iScience, vol. 23, no. 4, 100989. https://doi.org/10.1016/j.isci.2020.100989

Kwok, MCK, Oldreive, C, Rawstron, AC, Goel, A, Papatzikas, G, Jones, R, Drennan, S, Agathanggelou, A, Sharma-Oates, A, Evans, P, Smith, E, Dalal, S, Mao, J, Hollows, R, Gordon, N, Hamada, M, Davies, N, Parry, H, Beggs, A, Munir, T, Moreton, P, Paneesha, S, Pratt, G, Taylor, M, Forconi, F, Baird, D, Cazier, J-B, Moss, P, Hillmen, P & Stankovic, T 2020, 'Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL: natural history and mechanism of spontaneous CLL regression', Blood, vol. 135, no. 6, pp. 411-428. https://doi.org/10.1182/blood.2019001262

Karangizi, AHK, Chanouzas, D, Fenton, A, Moss, P, Cockwell, P, Ferro, CJ & Harper, L 2020, 'Response to: Cytomegalovirus seropositivity is independently associated with cardiovascular disease in non-dialysis dependent chronic kidney disease', QJM: An International Journal of Medicine, vol. 113, no. 9, pp. 702-703. https://doi.org/10.1093/qjmed/hcaa195

Khakwani, M, Srinath, S, Pratt, G & Moss, P 2019, 'A rare complication of bone marrow aspiration and trephine biopsy: staphylococcus aureus osteomyelitis and septicaemia', British Journal of Haematology, vol. 184, no. 1, pp. 7. https://doi.org/10.1111/bjh.15630

Frumento, G, Zuo, J, Verma, K, Croft, W, Ramagiri, P, Chen, FE & Moss, P 2019, 'CD117 (c-Kit) is expressed during CD8+ T cell priming and stratifies sensitivity to apoptosis according to strength of TCR engagement', Frontiers in immunology, vol. 10, 468. https://doi.org/10.3389/fimmu.2019.00468

Miles, DJC, Shumba, F, Pachnio, A, Begum, J, Corbett, EL, Heyderman, RS & Moss, P 2019, 'Early T cell differentiation with well-maintained function across the adult life course in sub-Saharan Africa', Journal of Immunology, vol. 203, no. 5, pp. 1160-1171. https://doi.org/10.4049/jimmunol.1800866

Parry, HM, Mirajkar, N, Cutmore, N, Zuo, J, Long, H, Kwok, M, Oldrieve, C, Hudson, C, Stankovic, T, Paneesha, S, Kelly, M, Begum, J, McSkeane, T, Pratt, G & Moss, P 2019, 'Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia', Frontiers in immunology, vol. 10, 2832. https://doi.org/10.3389/fimmu.2019.02832

Kinsella, FAM, Zuo, J, Inman, CF, Pearce, H, Maggs, L, Eldershaw, SE, Chan, YLT, Nunnick, J, Nagra, S, Griffiths, M, Craddock, C, Malladi, R & Moss, P 2019, 'Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells', Blood Advances, vol. 3, no. 5, pp. 734-743. https://doi.org/10.1182/bloodadvances.2018025502

Murray, D, McMurray, JL, Eldershaw, S, Pearce, H, Davies, N, Scarisbrick, JJ & Moss, P 2019, 'Progression of mycosis fungoides occurs through divergence of tumor immunophenotype by differential expression of HLA-DR', Blood Advances, vol. 3, no. 4, pp. 519-530. https://doi.org/10.1182/bloodadvances.2018025114

Kinsella, FAM, Inman, CF, Gudger, A, Chan, YT, Murray, DJ, Zuo, J, McIlroy, G, Nagra, S, Nunnick, J, Holder, K, Wall, K, Griffiths, M, Craddock, C, Nikolousis, E, Moss, P & Malladi, R 2019, 'Very early lineage-specific chimerism after reduced intensity stem cell transplantation is highly predictive of clinical outcome for patients with myeloid disease', Leukemia Research, vol. 83, 106173. https://doi.org/10.1016/j.leukres.2019.106173, https://doi.org/10.1016/j.leukres.2019.106173

Letter

Oldreive, CE, Byrd, PJ, Stewart, GS, Taylor, AJ, Farhat, S, Skowronska, A, Smith, E, Raghavan, M, Janic, D, Dokmanovic, L, Clokie, S, Davies, N, Kwok, M, Pratt, G, Paneesha, S, Moss, P, Stankovic, T & Taylor, AJ 2019, 'PALB2 variant status in hematological malignancies - a potential therapeutic target?', Leukemia and Lymphoma, vol. 60, no. 7, pp. 1823-1826. https://doi.org/10.1080/10428194.2018.1551539

Review article

Moss, P 2019, ''From immunosenescence to immune modulation': a re-appraisal of the role of cytomegalovirus as major regulator of human immune function', Medical Microbiology and Immunology, vol. 208, no. 3-4, pp. 271-280. https://doi.org/10.1007/s00430-019-00612-x

Loke, J, Malladi, R, Moss, P & Craddock, C 2019, 'The role of allogeneic stem cell transplantation in the management of acute myeloid leukaemia: a triumph of hope and experience', British Journal of Haematology, vol. 188, no. 1, pp. 129-146. https://doi.org/10.1111/bjh.16355

View all publications in research portal

Expertise

Cancer – especially immune response to cancer; immunity to viruses and related health problems; evolution in clinical medicine

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Expertise

Haematology