Professor Alex Richter MBChB, MRCP, FRCPath, MD

Alex Richter

Institute of Immunology and Immunotherapy
Professor and Honorary Consultant in Clinical Immunology

Contact details

Telephone
+44(0)121 414 4069
Fax
+44(0)121 414 3069
Email
a.g.richter@bham.ac.uk
View my research portal
Address
Institute of Immunology and Immunotherapy
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Alex has been leading a team of experts from the University of Birmingham to develop a SARS-CoV-2 antibody test focussed on improving detection in individuals with mild COVID-19 disease. In collaboration with The Binding Site this is being commercialised.

In collaboration with University Hospitals Birmingham NHS Foundation Trust and Birmingham Women’s and Children’s NHS Foundation Trust and Birmingham Dental Hospital this test has been used to investigate seroprevalence in NHS medical and dental staff, determine antibody status for Oxford vaccine study and determine COVID -19 to be the cause of a newly emerged multi-system inflammatory syndrome in children.

Qualifications

  • MBChB (Birmingham)
  • MRCP (London)
  • FRCPath
  • MD (Birmingham)

Biography

Professor Alex Richter earned her undergraduate medical degree from the University of Birmingham (UoB) and undertook her junior doctor training within the British Army. After 10 years military service she returned to Birmingham to undertake a doctorate exploring the immunology of pulmonary vasculitis and interstitial lung disease. She undertook specialist training in Clinical Immunology and was appointed Clinical Lecturer at UoB to complete her training. She established clinical immunology and allergy services at University Hospitals Birmingham, where she is now a Consultant Clinical Immunologist and won a Best in Care award in 2018.

She is Professor of Clinical Immunology and Director of the Clinical Immunology Service. Her research interests are focussed around secondary immunodeficiency and understanding vaccination responses.

Teaching

Alex undertakes regular teaching at the University and clinical teaching and lecturing on her research areas.

  • Awarded the 2019 REME Teaching Award (Recognising Excellence in Medical Education).
  • Examiner for the Royal College of Pathologists.
  • MBChB
    • 2nd year Immunity, infection and haematology – module lead
    • 3rd year Allergy Lecturer
  • BMedSc
    • Clinical Pathology - Lecturer for Year 2 and Year 3
    • Clinical Sciences - Lecturer

Postgraduate supervision

Doctorates

  • MD – Prevalence of MGUS in acute admissions
  • PhD – Role of B cells in HIV
  • PhD - The role of B cells in non small cell lung cancer (current)
  • PhD - The Immunology of recurrent miscarriage (current)
  • DClinSci - Prevalence of secondary immunodeficiency in stem cell transplant recovery (current)

Other

  • Regularly supervisors masters and batchelor degree projects
  • Educational supervisor for clinical lecturer and academic clinical fellow

If you are interesting in studying any of these subject areas please contact Professor Alex Richter directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Research interests include the emerging field of secondary immunodeficiency; developing diagnostics, exploring vaccination responses and management of patients with an immunodeficiency secondary to either malignancy or prolonged immunosuppression for an inflammatory disorder. For many cancers and inflammatory conditions, infection is one of the most significant causes of death and optimising and supporting the immune system can potentially reduce this risk.

During the SARS-CoV 2 pandemic Alex lead a team that developed a high sensitivity antibody test that was commercialised by The Binding Site. This assay was used to establish seroprevalence in a large staff cohort study at UHB (COCO), a Birmingham dental cohort and a haemodialysis cohort. Alex has helped establish the Birmingham Turnkey laboratory to contribute to the pillar 2 testing effort.

Current grants

  • 2020: Confidence in Concept MRC: Development of an annual influenza serotype antibody ELISA
  • 2020: COPE-Birmingham: The contribution of occupational exposures to risk of COVID-19 and approaches to control among healthcare workers. DHSC/UKRI COVID-19 Rapid Response Initiative
  • 2020: Development of antibody-based testing for SARS-CoV-2. Proximity to Discovery, MRC
  • 2020: Developing a point of care diagnostic tool for COVID-19 for use in LMIC settings. Institute for Global Innovation (IGI)
  • 2019: Investigating immunity in post-transplant LPD in a clinical trial cohort. Rosetree foundation. Co-investigator.
  • 2019: Treating plagues – public engagement grant from BSI. Co-investigator
  • 2018: Does hospitalisation of older patients with severe community acquired pneumonia and sepsis lead to long term immunoparesis? MRC (MR/S002782/1): Co- investigator

Other activities

University of Birmingham

External appointments

  • Myeloma UK -  Early Diagnosis Steering Committee
  • UK Primary Immunodeficiency Network UKPIN – Trustee
  • NIHR CRF specialist advisory committee at UHB

Publications

Recent publications

Article

Reynolds, JA, Faustini, SE, Tosounidou, S, Plant, T, Ubhi, M, Gilman, R, Richter, AG & Gordon, C 2023, 'Anti-SARS-CoV-2 antibodies following vaccination are associated with lymphocyte count and serum immunoglobulins in SLE', Lupus, vol. 32, no. 3, pp. 431-437. https://doi.org/10.1177/09612033231151603

Shields, AM, Faustini, SE, Young, S, Terjesen, S, McCarthy, NI, Anderson, RL, Drayson, MT & Richter, AG 2023, 'Clinical and laboratory characteristics of patients with symptomatic secondary immunodeficiency following the treatment of haematological malignancies', EJHaem, vol. 4, no. 2, pp. 339-349. https://doi.org/10.1002/jha2.683

Patel, AJ, Khan, N, Richter, A, Naidu, B, Drayson, MT & Middleton, GW 2023, 'Deep immune B and plasma cell repertoire in non-small cell lung cancer', Frontiers in immunology, vol. 14, 1198665. https://doi.org/10.3389/fimmu.2023.1198665

PITCH Consortium, Jenner, MW, Owen, RG, Pratt, D, Cook, G, Richter, A, Drayson, M & Kaiser, MF 2023, 'Immune responses to COVID-19 booster vaccinations in intensively anti-CD38 antibody treated patients with ultra-high-risk multiple myeloma: results from the Myeloma UK (MUK) nine OPTIMUM trial', British Journal of Haematology, vol. 201, no. 5, pp. 845-850. https://doi.org/10.1111/bjh.18714

Hornsby, H, Nicols, AR, Longet, S, Liu, C, Tomic, A, Angyal, A, Kronsteiner, B, Tyerman, JK, Tipton, T, Zhang, P, Gallis, M, Supasa, P, Selvaraj, M, Abraham, P, Neale, I, Ali, M, Barratt, NA, Nell, JM, Gustafsson, L, Strickland, S, Grouneva, I, Rostron, T, Moore, SC, Hering, LM, Dobson, SL, Bibi, S, Mongkolsapaya, J, Lambe, T, Wootton, D, Hall, V, Hopkins, S, Dong, T, Barnes, E, Screaton, G, Richter, A, Turtle, L, Rowland-Jones, SL, Carroll, M, Duncan, CJA, Klenerman, P, Dunachie, SJ, Payne, RP & de Silva, TI 2023, 'Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history', Nature Communications, vol. 14, no. 1, 5065. https://doi.org/10.1038/s41467-023-40592-4

Ward, KE, Steadman, L, Karim, AR, Reynolds, GM, Pugh, M, Chua, W, Faustini, SE, Veenith, T, Thwaites, RS, Openshaw, PJM, Drayson, MT, Shields, AM, Cunningham, AF, Wraith, DC & Richter, AG 2023, 'SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection', Clinical and Experimental Immunology, vol. 213, no. 2, pp. 243-251. https://doi.org/10.1093/cei/uxad046

PITCH Consortium, CONSENSUS & OCTAVE Collaborative Group 2023, 'SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease', Nature Medicine. https://doi.org/10.1038/s41591-023-02414-4

Faustini, SE, Cook, A, Hill, H, Al-Taei, S, Heaney, J, Efstathiou, E, Tanner, C, Townsend, N, Ahmed, Z, Dinally, M, Hoque, M, Goodall, M, Stamataki, Z, Plant, T, Chapple, I, Cunningham, AF, Drayson, MT, Shields, AM & Richter, AG 2023, 'Saliva antiviral antibody levels are detectable but correlate poorly with serum antibody levels following SARS-CoV-2 infection and/or vaccination', Journal of Infection, vol. 87, no. 4, pp. 328-335. https://doi.org/10.1016/j.jinf.2023.07.018

Wang, L, Nicols, A, Turtle, L, Richter, A, Duncan, CJA, Dunachie, SJ, Klenerman, P & Payne, RP 2023, 'T cell immune memory after covid-19 and vaccination', BMJ Medicine, vol. 2, no. 1, e000468. https://doi.org/10.1136/bmjmed-2022-000468

Ferentinos, P, Koivula, F, Faustini, S, Nicholson-Little, A, Stacey, M, Cunningham, AF, Woods, D, Richter, A, O'Shea, MK, Snape, D, Gifford, RM, Parsons, IT, Lamb, LEM, Greeves, J & O'Hara, JP 2023, 'Validation of dried blood spot sampling for detecting SARS-CoV-2 antibodies and total immunoglobulins in a large cohort of asymptomatic young adults', Journal of Immunological Methods, vol. 518, 113492. https://doi.org/10.1016/j.jim.2023.113492

The COVID-19 Genomics U. K. (COG-UK) Consortium, Modat, M, Hammers, A, Spector, TD, Steves, CJ, Sudre, CH, Ourselin, S & Duncan, EL 2022, 'COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study', Scientific Reports, vol. 12, no. 1, 10904. https://doi.org/10.1038/s41598-022-14016-0

Vivaldi, G, Jolliffe, DA, Faustini, S, Shields, AM, Holt, H, Perdek, N, Talaei, M, Tydeman, F, Chambers, ES, Cai, W, Li, W, Gibbons, JM, Pade, C, McKnight, Á, Shaheen, SO, Richter, AG & Martineau, AR 2022, 'Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study', The Journal of Infectious Diseases, vol. 226, no. 11, pp. 1903-1908. https://doi.org/10.1093/infdis/jiac321

Letter

Elhaj, MO, Richter, AG, Goddard, S & Shields, AM 2023, 'Dose reductions in immunoglobulin replacement are associated with increased antibiotic usage in patients with antibody deficiency', British Journal of Haematology, vol. 202, no. 4, pp. 900-903. https://doi.org/10.1111/bjh.18910

Parry, H, Bruton, R, Roberts, T, Mcilroy, G, Damery, S, Sylla, P, Dowell, AC, Tut, G, Lancaster, T, Bone, D, Willett, B, Logan, N, Scott, S, Hulme, S, Jadir, A, Amin, U, Nicol, S, Stephens, C, Faustini, S, Al-taei, S, Richter, A, Blakeway, D, Verma, K, Margielewska-davies, S, Pearce, H, Pratt, G, Zuo, J, Paneesha, S & Moss, P 2022, 'COVID-19 vaccines elicit robust cellular immunity and clinical protection in chronic lymphocytic leukemia', Cancer Cell, vol. 40, no. 6, pp. 584-586. https://doi.org/10.1016/j.ccell.2022.05.001

Faustini, S, Shields, A, Banham, G, Wall, N, Al-Taei, S, Tanner, C, Ahmed, Z, Efstathiou, E, Townsend, N, Goodall, M, Plant, T, Perez-Toledo, M, Jasiulewicz, A, Price, R, Mclaughlin, J, Farnan, J, Moore, J, Robertson, L, Nesbit, A, Curry, G, Black, A, Cunningham, A, Harper, L, Moore, T, Drayson, M & Richter, A 2022, 'Cross reactivity of spike glycoprotein induced antibody against Delta and Omicron variants before and after third SARS-CoV-2 vaccine dose in healthy and immunocompromised individuals', Journal of Infection, vol. 84, no. 4, pp. 579-613. https://doi.org/10.1016/j.jinf.2022.01.002

View all publications in research portal