Foster MA, Bentley C, Hazeldine J, Acharjee A, Nahman O, Shen-Orr SS, Lord JM and Duggal NA (2022), Traumatic injury induces a prematurely aged immune phenotype with increased risk of sepsis. Immunity and Ageing. 19 (1):60.
Belchamber KBR*, Thein OS*, Hazeldine J, Grudzinska FS, Faniyi A, Hughes MJ, Jasper AE, Crowley L, Yip KP, Lugg S, Sapey E, Parekh D, Thickett DR and Scott A (2022), Dysregulated neutrophil phenotype and function in hospitalised non-ICU COVID-19 pneumonia. Cells. 11 (18):2901.
Altarrah K, Tan P, Acharjee A, Hazeldine J, Torlinska B, Wilson Y, Torlinski T, Moiemen N and Lord JM, (2022). Differential benefits of steroid therapies in adults following major burn injury. Journal of Plastic, Reconstructive and Aesthetic Surgery. 75 (8):2616-2624.
Acharjee A*, Hazeldine J*, Bazarova A, Deenadayalu L, Zhang J, Bentley C, Russ D, Lord JM, Gkoutos GV, Young SP, Foster MA (2021), Integration of metabolomic and clinical data improves the prediction of intensive care unit length of stay following major traumatic injury. Metabolites. 12 (1):29.
Hazeldine J, McGee K, Altarrah K, Hassouna T, Patel K, Imran R, Bishop JRB, Bamford A, Barnes D, Wilson Y, Harrison P, Lord JM and Moiemen NS (2021), Multicentre, Prospective Study to Examine the Relationship between Neutrophil Function and Sepsis in Adults and Children with Severe Thermal Injuries: a protocol for the Scientific Investigation of the Biological Pathways Following Thermal Injury-2 (SIFTI-2) study. BMJ Open. 11 (10) e052035.
Cato LD, Bailiff B, Price J, Ermogeneous C, Hazeldine J, Lester W, Lowe G, Wearn C, Bishop JRB, Lord JM and Harrison P (2021), Heparin resistance in severe thermal injury: A prospective cohort study. Burns and Trauma.
Bentley C, Potter C, Yakoub KM, Brock K, Homer V, Toman E, Taylor AE, Shaheen F, Gilligan LC, Athwal A, Barton D, Carrera R, Young K, Desai A, McGee K, Ermogenous C, Sur G, Grieg C, Hazeldine J, Arlt W, Lord JM and Foster MA (2021), . A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT. BMJ Open. 11 (7):e040823.
Hazeldine J, Dinsdale RJ, Naumann DN, Acharjee A, Bishop JRB, Lord JM and Harrison P (2021), Traumatic injury is associated with reduced DNase activity and dysregulation of the actin scavenging system. Burns and Trauma.
Chimen M, Evryviadou A, Box CL, Harrison MJ, Hazeldine J, Dib LH, Kuravi SJ, Payne H, Price JMJ, Kavanagh D, Lax S, Kalia N, Brill A, Thomas SG, Belli A, Crombie N, Adams RA, Evans SA, Deckmyn H, Lord JM, Harrison P, Watson SP, Nash GB and Rainger GE (2020), Appropiation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation. Haematologica. 105 (5):1248-1261.
Bravo-Merodio L*, Acharjee A*, Hazeldine J, Bentley C, Foster M, Gkoutos GV and Lord JM (2019), Machine learning for the detection of early immunological markers as predictors of multi organ dysfunction. Nature Scientific Data. 6 (1):328.
Sapey E, Patel JM, Greenwood H, Walton GM, Grudzinkas F, Parekh D, Mahida RY, Dancer RCA, Lugg ST, Howells P, Hazeldine J, Newby P, Scott A, Nightingale P, Hill AT, McAuley DF, Thicket DR (2019), Simvastatin improves neutrophil function and clinical outcomes in pneumonia: a pilot randomized controlled trial. Am. J. Respir. Crit. Care Med. 200 (10):1282-1293.
Hazeldine J, Dinsdale RJ, Harrison P and Lord JM (2019), Traumatic injury and exposure to mitochondrial-derived damage associated molecular patterns suppresses neutrophil extracellular trap formation. Frontiers in Immunology. 10:685.
Naumann DN, Hazeldine J, Bishop J, Midwinter MJ, Harrison P, Nash G and Hutchings SD (2019), Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: a prospective observational study. Clin. Hemorheol. Microcirc. 71 (1):71-82.
Dinsdale RJ, Hazeldine J, Al Tarrah K, Hampson P, Devi A, Ermogenous C, Bamford AL, Bishop J, Watts S, Kirkman E, Dalle Lucca JJ, Midwinter M, Woolley T, Foster M, Lord JM, Moiemen N and Harrison P (2019), Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury. Br. J. Surg. 107 (4):391-401.
Naumann DN*, Hazeldine J*, Davies D, Bishop JRB, Midwinter MJ, Belli A, Harrison P and Lord JM (2018), Endotheliopathy of trauma is an on-scene phenomenon and is associated with multiple organ dysfunction syndrome: a prospective observational study. Shock. 49 (4):420-428.
Naumann DN, Hazeldine J, Midwinter MJ, Hutchings SD and Harrison P (2018), Poor microcirculatory flow dynamics are associated with endothelial damage and glycocalyx shedding following traumatic haemorrhagic shock. J. Trauma Acute Care Surg. 84 (1):81-88.
Naumann DN*, Hazeldine J*, Dinsdale RJ, Bishop JRB, Midwinter MJ, Harrison P, Hutchings SD and Lord JM (2017), Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study. PLoS One. 12 (12):E0189870.
Kuravi SJ, Yates C, Foster M, Harrison P, Hazeldine J, Hampson P, Watson C, Belli A, Midwinter M and Nash GB (2017), Changes in the pattern of plasma extracellular vesicles after severe trauma. PLoS One. 12 (8):e0183640.
Hazeldine J, Naumann DN, Toman E, Davies D, Bishop JRB, Su Z, Hampson P, Dinsdale RJ, Crombie N, Duggal NA, Harrison P, Belli A and Lord JM (2017), Pre-hospital immune responses and development of Multiple Organ Dysfunction Syndrome following traumatic injury: A Prospective Cohort Study. PLoS Medicine. 14 (7):e1002338.
Sapey E, Patel JM, Greenwood HL, Walton GM, Hazeldine J, Sadhra C, Parekh D, Dancer RCA, Nightingale P, Lord JM and Thickett DR (2017), Pulmonary infections in the elderly lead to prolonged impairment of neutrophil targeting, improved by simvastatin. Am. J. Respir. Crit. Care Med. 196 (10):1325-1336.
Hill LJ*, Di Pietro V*, Hazeldine J, Davies D, Toman E, Logan A and Belli A (2017), Cystatin D: An ultra-early inflammatory biomarker of traumatic brain injury. Scientific Reports. 7 (1):5002.
Dinsdale RJ, Devi A, Hampson P, Wearn CM, Bamford AL, Hazeldine J, Bishop JRB, Ahmed S, Watson C, Lord JM, Moiemen N and Harrison P (2017), Changes in novel haematological parameters following thermal injury. Scientific Reports. 7 (1):3211.
Di Pietro V, Ragusa M, Lazzarino G, Davies D, Su Z, Hazeldine J, Hill LJ, Crombie N, Purrello M, Logan A and Belli A (2017), MicroRNAs as novel biomarkers for the diagnosis and prognosis of mild and severe traumatic brain injury. J. Neurotrauma. 34 (11):1948-1956.
Bancos I*, Hazeldine J*, Chortis V, Hampson P, Taylor AE, Lord JM and Arlt W (2017), Primary adrenal insufficiency is associated with impaired natural killer cell function – a potential link to increased mortality. Eur. J. Endocrinol. 176 (4):471-480.
Hampson P*, Dinsdale RJ*, Wearn CM, Bamford A, Bishop JB, Hazeldine J, Moiemen NS, Harrison P and Lord JM (2016), Neutrophil dysfunction, immature granulocytes and cell-free DNA are early biomarkers of sepsis in burn-injured patients: A prospective observational cohort study. Annals of Surgery. 265 (6):1241-1249.
Hazeldine J*, Hampson P*, Adeusi Opoku F, Foster M and Lord JM (2015), N-formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP Kinase signalling pathways. J.Injury. 46 (6):975-984.
Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E and Lord JM (2014), Impaired neutrophil extracellular trap (NET) formation: a novel defect in the innate immune system of aged individuals. Aging Cell. 13 (4):690-698.
Hazeldine J, Hampson P and Lord JM (2012), Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity. Aging Cell. 11 (5):751-759.
Wang K, Hampson P, Hazeldine J, Krystof V, Strnad M and Pechan PMJ (2012), Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis. PLoS One. 7 (1):e30128.
Hazeldine J and Lord JM (2021), Neutrophils and COVID-19: Active participants and rational therapeutic targets. Frontiers in Immunology. 12:680134.
Hazeldine J and Lord JM (2020), Immunesenescence: a predisposing risk factor for the development of COVID-19? Frontiers in Immunology. 11:573662.
Bentley C, Hazeldine J, Grieg C, Lord JM and Foster M (2019). Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient. Burns and Trauma. 7:26.
Hazeldine J, Hampson P and Lord JM (2016), The diagnostic and prognostic value of systems biology research on major traumatic and thermal injury: a review. Burns and Trauma. 4:33.
Hazeldine J, Lord JM and Belli A (2015), Traumatic brain injury and peripheral immune suppression: primer and prospectus. Frontiers in Neurology. 6:235.
Hazeldine J, Lord JM and Hampson P (2015), Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient. Ageing Res. Rev. 24 (Pt B):349-357.
Hazeldine J*, Hampson P* and Lord JM (2014), The impact of trauma on neutrophil function. J. Injury. 45 (12):1824-1833.
Hazeldine J and Lord JM (2014), Innate Immunesenescence: Underlying mechanisms and clinical relevance. J. Biogerontology. 16 (2): 187-201.
Hazeldine J and Lord JM. (2021). Immunesenescence and compromised removal of senescent cells: implications for health in old age. In: Bueno V., Pawelec G. (eds) Healthy Longevity and Immune System. Springer, Cham. DOI: https://doi.org/10.1007/978-3-030-87532-9. eBook ISBN: 978-3-030-87532-9.
Hazeldine J and Lord JM. (2018). The Impact of Age on Neutrophil Extracellular Trap formation. In: Fulop T., Franceschi C., Hirokawa K., Pawelec G. (eds) Handbook of Immunosenescence. Springer, Cham. DOI:10.1007/978-3-319-64597-1_102-1. Online ISBN: 978-3-319-64597-1.
Tariq MA*, Hazeldine J* and Lord JM. (2017). Innate Immunosenescence and Its Impact on Health in Old Age. In: Bueno V., Lord JM., Jackson T. (eds) The Ageing Immune System and Health. Springer, Cham. DOI:10.1007/978-3-319-43365-3_1. Online ISBN: 978-3-319-43365-3.
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