Dr Simon W Jones PhD, BSc

Simon Jones

Institute of Inflammation and Ageing
Reader in Musculoskeletal Ageing

Contact details

Address
Institute of Inflammation and Ageing
MRC-Versus Arthritis Centre
Queen Elizabeth Hospital
The University of Birmingham
Edgbaston
Birmingham B15 2WB

Dr Jones is a Reader in Musculoskeletal Ageing within the Institute of Inflammation and Ageing. His research is focused on understanding the inflammatory and metabolic mechanisms that mediate joint and musculoskeletal pathological disorders including Osteoarthritis, Sarcopenia, Type II Diabetes and Scoliosis. He has a particular research focus on the role of non-coding RNAs (including miRNAs and long non coding RNAs) in mediating inflammatory responses and in understanding how obesity affects the pathology of diseased joint and musculoskeletal tissues.

Teaching

Dr Jones is Head of Education for the Institute of Inflammation and Ageing. He also teaches on the following modules and programmes.

Module Leader

  • MPharm, Health, Disease and Therapeutics 3.1

Lecturer

  • BMedSci, Biology of Ageing
  • BMedSci, Immunity and Inflammatory Disease
  • MBChB, Infection, Immunity and Haematology

Postgraduate supervision

Simon Jones's research interests include the inflammatory and metabolic mechanisms that drive osteoarthritis pathology, the role of skeletal muscle dysfunction and atrophy in chronic disease and understanding the functional role of non-coding RNAs in mediating inflammatory responses.

Dr Jones's current research projects include:

The functional role of long non-coding RNAs (lncRNAs) in mediating joint inflammation in osteoarthritis (in collaboration with Prof Mark Lindsay, University of Bath)
Adiposity and skeletal muscle growth and differentiation: understanding sarcopenic obesity (in collaboration with Dr Kostas Tsintzas, University of Nottingham)
Development and characterisation of novel biomimetic scaffolds for cartilage and bone repair (in collaboration with Prof Liam Grover, University of Birmingham)
The role of adipose-secreted cytokines in mediating osteoarthritis joint pathology

Other activities

Chief Investigator on several NIHR clinical studies

Publications

Recent publications

Article

Pandey, P, Yang, J-H, Tsitsipatis, D, Panda, A, Kim, K, Noh, JH, Munk, R, Nicholson, T, Hanniford, D, Argibay, D, Yang, X, Martindale, J, Chang, M-W, Jones, S, Hernando, E, De, S, Abdelmohsen, K & Gorospe, M 2020, 'CircSamd4 represses myogenic transcriptional activity of PUR proteins', Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa035

Davies, O, Cox, S, Azoidis, I, McGuinness, A, Cooke, M, Heaney, LM, Davis, E, Jones, S & Grover, L 2019, 'Corrigendum: Osteoblast-derived vesicle protein content Is temporally regulated during osteogenesis: implications for regenerative therapies', Frontiers in Bioengineering and Biotechnology, vol. 7, 392, pp. 1-2. https://doi.org/10.3389/fbioe.2019.00392

Mountcastle, SE, Allen, P, Mellors, BOL, Lawless, BM, Cooke, ME, Lavecchia, CE, Fell, NLA, Espino, DM, Jones, SW & Cox, SC 2019, 'Dynamic viscoelastic characterisation of human osteochondral tissue: understanding the effect of the cartilage-bone interface', BMC Musculoskeletal Disorders, vol. 20, no. 1, 575, pp. 1-13. https://doi.org/10.1186/s12891-019-2959-4

Nanus, D, Wijesinghe, S, Pearson, M, Hadjicharalambous, M, Rosser, A, Davis, E, Lindsay, MA & Jones, S 2019, 'Obese osteoarthritis patients exhibit an inflammatory synovial fibroblast phenotype, which is regulated by the long non coding RNA MALAT1', Arthritis and Rheumatology, pp. 1-29. https://doi.org/10.1002/art.41158

Hurley, P, Alnajjar, FAQ, Wijesinghe, S, Nanus, D, Davis, E & Jones, S 2019, 'The combination of local infiltration analgesia reagents increases their detrimental effect on human hip OA patient osteoblast viability and function', Journal of Orthopaedics, vol. 16, no. 5, pp. 434-439. https://doi.org/10.1016/j.jor.2019.06.014

Fenton, C, Webster, J, Martin, C, Fareed, S, Wehmeyer, C, Mackie, H, Jones, R, Seabright, A, Lewis, J, Lai, Y-C, Goodyear, CS, Jones, S, Cooper, MS, Lavery, G, Langen, R, Raza, K & Hardy, R 2019, 'Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis', Arthritis Research & Therapy, vol. 21, no. 1, 182. https://doi.org/10.1186/s13075-019-1962-3

Pearson, M, Philip, AM, Nicholson, T, Cooke, M, Grover, L, Newton Ede, M & Jones, S 2019, 'Evidence of intrinsic impairment of osteoblast phenotype at the curve apex in girls with adolescent idiopathic scoliosis', Spine Deformity, vol. 7, no. 4, pp. 533-542. https://doi.org/10.1016/j.jspd.2018.11.016, https://doi.org/10.1016/j.jspd.2018.11.016

Macfadyen, M, Parr, T, Brameld, J, Murton, A & Jones, S 2019, 'The commercial pig as a model of spontaneously-occurring osteoarthritis', BMC Musculoskeletal Disorders, vol. 20, 70. https://doi.org/10.1186/s12891-019-2452-0

Nicholson, T, Church, C, Tsintzas, K, Jones, R, Breen, L, Davis, E, Baker, D & Jones, S 2019, 'Vaspin promotes insulin sensitivity in elderly muscle and is upregulated in obesity', Journal of Endocrinology, vol. 241, no. 1, pp. 31-43. https://doi.org/10.1530/JOE-18-0528

Murphy, D, Nicholson, T, Jones, S & O'Leary, M 2019, 'MyoCount: A software tool for the automated quantification of myotube surface area and nuclear fusion index [version 1; referees: 2 approved]', Wellcome Open Research, vol. 4, 6, pp. 6. https://doi.org/10.12688/wellcomeopenres.15055.1

O'Leary, M, Wallace, G, Davis, E, Murphy, DP, Nicholson, T, Bennett, AJ, Tsintzas, K & Jones, S 2018, 'Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB.', Scientific Reports, vol. 8, no. 1, 15360 . https://doi.org/10.1038/s41598-018-33840-x

Cooke, ME, Lawless, BM, Jones, SW & Grover, LM 2018, 'Matrix degradation in osteoarthritis primes the superficial region of cartilage for mechanical damage', Acta Biomaterialia, vol. 78, pp. 320-328. https://doi.org/10.1016/j.actbio.2018.07.037

Pearson, M, Bik, M, Ospelt, C, Naylor, A, Wehmeyer, C, Jones, S, Buckley, C, Gay, S, Filer, A & Lord, J 2018, 'Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts', Scientific Reports, vol. 8, 12887. https://doi.org/10.1038/s41598-018-31173-3

Review article

Al-Tarrah, K, Jones, S, Moiemen, N & Lord, J 2019, 'Potential role of adipose tissue and its hormones in burns and critically ill patients', Burns. https://doi.org/10.1016/j.burns.2019.01.012

Nicholson, T, Church, C, Baker, D & Jones, S 2018, 'The role of adipokines in skeletal muscle inflammation and insulin sensitivity', Journal of Inflammation, vol. 15, 9. https://doi.org/10.1186/s12950-018-0185-8

View all publications in research portal