Dr Simon W Jones PhD, BSc

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Institute of Inflammation and Ageing
Senior Lecturer in Musculoskeletal Ageing Research

Contact details

Address
Institute of Inflammation and Ageing
MRC-ARUK Centre for Musculoskeletal Ageing Research
Queen Elizabeth Hospital
The University of Birmingham
Edgbaston
Birmingham B15 2WB

Dr Jones is a Senior Lecturer at the MRC-ARUK Centre for Musculoskeletal Ageing Research. His research focuses on understanding the role of obesity-associated inflammation in musculoskeletal disease including sarcopenia and osteoarthritis, and on identifying intrinsic mediators of osteoblast phenotype in bone diseases, including scoliosis.  His group has a particular focus on understanding the functional role of non-coding RNAs, including miRNAs and lncRNAs in mediating inflammation.

Qualifications

  • PhD in Biochemistry, School of Biosciences, University of Nottingham (1999)
  • PGCE in secondary education, University of Nottingham (1995)
  • BSc (Hons) Biochemistry and Biological Chemistry, University of Nottingham (1994)

Teaching

  • MSc Musculoskeletal Ageing (Co-Director)
    • Musculoskeletal Systems Across The Lifespan (Module Lead & Lecturer)
  • SciPhy (EPSRC)
    • Rebuilding The Ageing & Diseased Body (Sub-Module Lead & Lecturer)

Postgraduate supervision

Simon Jones's research interests include the inflammatory and metabolic mechanisms that drive osteoarthritis pathology, the role of skeletal muscle dysfunction and atrophy in chronic disease and understanding the functional role of non-coding RNAs in mediating inflammatory responses.

Dr Jones's current research projects include:

The functional role of long non-coding RNAs (lncRNAs) in mediating joint inflammation in osteoarthritis (in collaboration with Prof Mark Lindsay, University of Bath)
Adiposity and skeletal muscle growth and differentiation: understanding sarcopenic obesity (in collaboration with Dr Kostas Tsintzas, University of Nottingham)
Development and characterisation of novel biomimetic scaffolds for cartilage and bone repair (in collaboration with Prof Liam Grover, University of Birmingham)
The role of adipose-secreted cytokines in mediating osteoarthritis joint pathology

Other activities

Chief Investigator on several NIHR clinical studies

Publications

Recent publications

Article

Nanus, D, Wijesinghe, S, Pearson, M, Hadjicharalambous, M, Rosser, A, Davis, E, Lindsay, MA & Jones, S 2019, 'Obese osteoarthritis patients exhibit an inflammatory synovial fibroblast phenotype, which is regulated by the long non coding RNA MALAT1', Arthritis and Rheumatology.

Hurley, P, Alnajjar, FAQ, Wijesinghe, S, Nanus, D, Davis, E & Jones, S 2019, 'The combination of local infiltration analgesia reagents increases their detrimental effect on human hip OA patient osteoblast viability and function', Journal of Orthopaedics, vol. 16, no. 5, pp. 434-439. https://doi.org/10.1016/j.jor.2019.06.014

Fenton, C, Webster, J, Martin, C, Fareed, S, Wehmeyer, C, Mackie, H, Jones, R, Seabright, A, Lewis, J, Lai, Y-C, Goodyear, CS, Jones, S, Cooper, MS, Lavery, G, Langen, R, Raza, K & Hardy, R 2019, 'Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis', Arthritis Research & Therapy, vol. 21, no. 1, 182. https://doi.org/10.1186/s13075-019-1962-3

Pearson, M, Philip, AM, Nicholson, T, Cooke, M, Grover, L, Newton Ede, M & Jones, S 2019, 'Evidence of intrinsic impairment of osteoblast phenotype at the curve apex in girls with adolescent idiopathic scoliosis', Spine Deformity, vol. 7, no. 4, pp. 533-542. https://doi.org/10.1016/j.jspd.2018.11.016

Macfadyen, M, Parr, T, Brameld, J, Murton, A & Jones, S 2019, 'The commercial pig as a model of spontaneously-occurring osteoarthritis', BMC Musculoskeletal Disorders, vol. 20, 70. https://doi.org/10.1186/s12891-019-2452-0

Nicholson, T, Church, C, Tsintzas, K, Jones, R, Breen, L, Davis, E, Baker, D & Jones, S 2019, 'Vaspin promotes insulin sensitivity of elderly muscle and is upregulated in obesity', Journal of Endocrinology. https://doi.org/10.1530/JOE-18-0528

Murphy, D, Nicholson, T, Jones, S & O'Leary, M 2019, 'MyoCount: a software tool for the automated quantification of myotube surface area and nuclear fusion index', Wellcome Open Research, vol. 4, 6. https://doi.org/10.12688/wellcomeopenres.15055.1

O'Leary, M, Wallace, G, Davis, E, Murphy, DP, Nicholson, T, Bennett, AJ, Tsintzas, K & Jones, S 2018, 'Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB.', Scientific Reports, vol. 8, no. 1, 15360 . https://doi.org/10.1038/s41598-018-33840-x

Cooke, ME, Lawless, BM, Jones, SW & Grover, LM 2018, 'Matrix degradation in osteoarthritis primes the superficial region of cartilage for mechanical damage', Acta Biomaterialia, vol. 78, pp. 320-328. https://doi.org/10.1016/j.actbio.2018.07.037

Pearson, M, Bik, M, Ospelt, C, Naylor, A, Wehmeyer, C, Jones, S, Buckley, C, Gay, S, Filer, A & Lord, J 2018, 'Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts', Scientific Reports, vol. 8, 12887. https://doi.org/10.1038/s41598-018-31173-3

Abstract

Philp, AM, Pearson, M, O'Leary, M & Jones, S 2018, 'Association of chemerin levels in serum and synovial fluid with the severity of hip osteoarthritis', Osteoarthritis and Cartilage, vol. 26, no. Supplement 1, pp. S182. https://doi.org/10.1016/j.joca.2018.02.391

Cooke, M, Lawless, BM, Jones, S & Grover, L 2018, 'Loss of proteoglycan content primes articular cartilage for mechanically induced damage', Osteoarthritis and Cartilage, vol. 26, no. Supplement 1, pp. S371. https://doi.org/10.1016/j.joca.2018.02.731

Pearson, M, Nanus, D, Davis, ET, Lindsay, MA & Jones, S 2018, 'The differential expression and functional role of long non coding RNAs in inflamed synovial tissue from patients with hip osteoarthritis', Osteoarthritis and Cartilage, vol. 26, no. Supplement 1, pp. S161. https://doi.org/10.1016/j.joca.2018.02.350

Review article

Al-Tarrah, K, Jones, S, Moiemen, N & Lord, J 2019, 'Potential role of adipose tissue and its hormones in burns and critically ill patients', Burns. https://doi.org/10.1016/j.burns.2019.01.012

Nicholson, T, Church, C, Baker, D & Jones, S 2018, 'The role of adipokines in skeletal muscle inflammation and insulin sensitivity', Journal of Inflammation, vol. 15, 9. https://doi.org/10.1186/s12950-018-0185-8

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