Professor Janet M Lord FMedSci

Image of Professor Janet Lord

Institute of Inflammation and Ageing
Director of the Institute of Inflammation and Ageing Director of the MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research

Contact details

Address
Institute of Inflammation and Ageing
Birmingham University Research labs.
Queen Elizabeth Hospital
Mindelsohn Way,
Birmingham
B15 2WB

Janet Lord is Director of the Institute of Inflammation and Ageing, a multidisciplinary research institute which brings together fundamental scientists and clinicians to translate understanding of the process of inflammation in to new treatments for chronic age-related inflammatory disease and the consequences of major trauma.

Her own research focusses on the dysregulation of immunity in old age, in particular the decline in neutrophil function and how this compromises the response to infection and tissue injury. She aims to understand the mechanism involved and to develop novel therapies to improve immunity in older adults.

Qualifications

  • Professor of Immune Cell Biology
  • Fellow of the Academy of Medical Sciences 2015
  • PhD Biological Sciences 1983
  • BSc (Hons) Human Biology 1979

Teaching

Module lead, Biology of Ageing, BSc Medical Science

Lecturer, Immunology and Haematology module, MBChB

Postgraduate supervision

Professor Lord supervises doctoral research in the following areas:

The mechanisms underlying reduced neutrophil function in ageing
Lifestyle factors (exercise, diet, sleep) influencing immune function in old age
Stress and immunity

Other activities

  • Section editor for the Journal Ageing Cell

Publications

Recent publications

Article

Dinsdale, R, Hazeldine, J, Al-Tarrah, K, Hampson, P, Devi, A, Ermogenous, C, Bamford, A, Bishop, J, watts, S, kirkman, E, dalle lucca, J, midwinter, M, woolley, T, Foster, M, Lord, J, Moiemen, N & Harrison, P 2019, 'Dysregulation of the actin scavenging system and inhibition of DNAse activity following severe thermal injury' British Journal of Surgery.

Hazeldine, J, Harrison, P, Dinsdale, R & Lord, J 2019, 'Traumatic injury and exposure to mitochondrial-derived damage associated molecular patterns suppresses neutrophil extracellular trap formation' Frontiers in immunology. https://doi.org/10.3389/fimmu.2019.00685

Welch, C, Greig, CA, Hassan-Smith, ZK, Pinkney, TD, Lord, JM & Jackson, TA 2019, 'A pilot observational study measuring acute sarcopenia in older colorectal surgery patients' BMC Research Notes, vol. 12, no. 1, 24. https://doi.org/10.1186/s13104-019-4049-y

Wilson, D, Breen, L, Lord, JM & Sapey, E 2018, 'The challenges of muscle biopsy in a community based geriatric population' BMC Research Notes, vol. 11, no. 1, 830. https://doi.org/10.1186/s13104-018-3947-8

Prete, A, Yan, Q, Al-Tarrah, K, Akturk, H, Prokop, L, Alahdab, F, Foster, MA, Lord, J, Karavitaki, N, Wass, J, Murad, M, Arlt, W & Bancos, I 2018, 'The cortisol stress response induced by surgery: a systematic review and meta-analysis' Clinical Endocrinology, pp. 554-567. https://doi.org/10.1111/cen.13820

Pearson, M, Bik, M, Ospelt, C, Naylor, A, Wehmeyer, C, Jones, S, Buckley, C, Gay, S, Filer, A & Lord, J 2018, 'Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts' Scientific Reports, vol. 8, 12887. https://doi.org/10.1038/s41598-018-31173-3

Duggal, NA, Snelson, C, Shaheen, U, Pearce, V & Lord, JM 2018, 'Innate and adaptive immune dysregulation in critically ill ICU patients' Scientific Reports, vol. 8, no. 1, 10186. https://doi.org/10.1038/s41598-018-28409-7, https://doi.org/10.1038/s41598-018-28409-7

Rushton, AB, Evans, DW, Middlebrook, N, Heneghan, NR, Small, C, Lord, J, Patel, JM & Falla, D 2018, 'Development of a screening tool to predict the risk of chronic pain and disability following musculoskeletal trauma: Protocol for a prospective observational study in the United Kingdom' BMJ open, vol. 8, no. 4, e017876. https://doi.org/10.1136/bmjopen-2017-017876

Borgognone, A, Shantsila, E, Worrall, S, Prompunt, E, Loka, T, Loudon, BL, Chimen, M, Rainger, GE, Lord, JM, Turner, A, Nightingale, P, Feelisch, M, Kirchhof, P, Lip, G, Watson, SP, Frenneaux, MP & Madhani, M 2018, 'Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation' Cardiovascular Research, vol. 114, pp. 1313–1323. https://doi.org/10.1093/cvr/cvy087

Naumann, DN, Hazeldine, J, Davies, DJ, Bishop, J, Midwinter, MJ, Belli, A, Harrison, P & Lord, JM 2018, 'Endotheliopathy of trauma is an on-scene phenomenon, and is associated with multiple organ dysfunction syndrome: a prospective observational study' Shock, vol. 49, no. 4, pp. 420-428. https://doi.org/10.1097/SHK.0000000000000999

Duggal, NA, Pollock, RD, Lazarus, NR, Harridge, S & Lord, JM 2018, 'Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood' Aging Cell, vol. 17, no. 2, e12750. https://doi.org/10.1111/acel.12750

Chapter (peer-reviewed)

Whittaker, A, Duggal, N, Oyebode, JR & Lord, J 2018, Understanding Immunesenescence. in A Walker (ed.), The New Dynamics of Ageing Vol II: Biological Perspectives: Biological Perspectives. 1 edn, vol. 2, Policy Press, Bristol, pp. 107-130.

Review article

Duggal, N, Niemiro, G, Simpson, R, Harridge, S & Lord, J 2019, 'Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?' Nature Reviews Immunology. https://doi.org/10.1038/ s41577-019-0177-9

Al-Tarrah, K, Jones, S, Moiemen, N & Lord, J 2019, 'Potential role of adipose tissue and its hormones in burns and critically ill patients' Burns. https://doi.org/10.1016/j.burns.2019.01.012

Sullivan, J, Mirbahai, L & Lord, J 2018, 'Major trauma and acceleration of the ageing process' Ageing Research Reviews, vol. 48, pp. 32-39. https://doi.org/10.1016/j.arr.2018.10.001

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