Dr Amy Naylor PhD, MSc, BSc

Amy Naylor

Institute of Inflammation and Ageing
Senior Research Fellow

Contact details

Address
Institute of Inflammation and Ageing (IIA)
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Naylor’s research group studies the bone remodelling process to identify aspects that can be targeted therapeutically to reverse the bone loss seen as a result of inflammation and ageing, both of which represent a significant clinical burden in terms of cost and patient quality of life.

We use models of bone turnover and healing, which are analysed using cutting-edge imaging techniques including the Diamond Light Source facility and novel in silico methods that we have developed in collaboration with the Computer Sciences at the University of Birmingham. To make a positive impact in reducing animal usage as part of our commitment to the practice of the 3Rs, we actively collaborate with chemical and tissue engineers to develop complex in vitro models that mimic the in vivo microenvironment, something that is currently lacking in the field of bone research. To this core research we are adding systems biology approaches (transcript profiling and metabolomics) to further enhance our modelling and mechanistic understanding of the cellular, tissue and whole organism phenotypes that we encounter, with clear translational potential.

Amy has received grant funding from Versus Arthritis (in the form of Foundation and Career Development Fellowships), AstraZeneca, EPSRC and NC3Rs amongst others.

Qualifications

  • PhD, Rheumatology (Oliver Bird Foundation): University of Newcastle, 2008
  • MRes, Medical and Molecular Biosciences: University of Newcastle, 2005
  • BSc (Hons International), Biology: University of Leeds, 2004

Biography

Amy Naylor completed an MSc and PhD in the Musculoskeletal Research Group at the University of Newcastle as part of the Oliver Bird Rheumatism Scheme.

She moved to the University of Birmingham to work for Professor Chris Buckley and was awarded a Foundation Fellowship from Arthritis Research UK to investigate the role of stromal cell-specific markers in inflammation and repair. Since completing the fellowship she has remained at the University of Birmingham in the Institute for Inflammation and Ageing and in 2018 was awarded a prestigious 5 year Career Development Fellowship from Versus Arthritis.

Teaching

Postgraduate

Undergraduate

  • 2012 to date: Tutor, Research taster - MBChB
  • 2013 to date: Lecturer and small group tutor, Intercalated BMedSci - Rheumatology and Orthopaedics module
  • 2019 to date: Lecturer and small group tutor, MPharm - Health, Disease and Therapeutics module
  • 2020 to date: Lecturer, BMedSc - Immunity and Inflammatory Disease

Research projects

Previous summer student, undergraduate student and MSc student research projects include:

  • Developing an analysis assay to assess ossification rate in an organotypic model of the bone remodelling process
  • Using Avizo software to analyse synchrotron-generated super high resolution 3D images of bone
  • In vitro manipulation of a novel endothelial cell-osteoblast interaction
  • The role of the CLEC14A-MMRN2-CD248 mechanism in bone formation: A potential therapeutic target
  • Establishing the role of CD248 in influencing PDGF signalling during angiogenesis
  • The role of CD248 in mesenchymal stem cell differentiation into adipocytes
  • Establishing the role of CD248 in angiogenesis in skeletal muscle
  • Characterising the role of the CD248-MMRN2-CLEC14A protein complex in bone formation
  • Assessing the role of CD248 in the ageing bone

Postgraduate supervision

Amy currently supervisors doctoral researchers undertaking the following projects:

  • An organotypic model of the bone remodelling process
  • Targeting the novel CD248-MMRN2-CLEC14A signalling pathway in age-related bone loss
  • The ageing bone – a novel peptide as an inducer of bone repair
  • Formulation of a novel suspending medium for immobilised culture and tissue processing
  • Characterising the therapeutic potential of a novel peptide in age-related bone loss, skeletal remodelling and repair
  • Development of 3D cell cultures for synthetic bone models

Researchers who are considering undertaking PhD in Life Sciences at Birmingham and have secured funding, or are eligible for funding from local sources, please contact idtp@contacts.bham.ac.uk

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Research themes

Bone remodelling in inflammation and ageing, stromal cell differentiation and migration, stromal cell-osteoclast interactions.

Publications

Recent publications

Article

Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2021, 'Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 250-260. https://doi.org/10.1136/annrheumdis-2020-218493

Armitage, EG, Barnes, A, Patrick, K, Bechar, J, Harrison, MJ, Lavery, GG, Rainger, GE, Buckley, CD, Loftus, NJ, Wilson, ID & Naylor, AJ 2021, 'Metabolic consequences for mice lacking endosialin: LC-MS/MS-based metabolic phenotyping of serum from C56Bl/6J control and CD248 knock-out mice', Metabolomics, vol. 17, no. 2, 14. https://doi.org/10.1007/s11306-020-01764-1

Neag, G, Finlay, M & Naylor, A 2021, 'The cellular choreography of osteoblast angiotropism in bone development and homeostasis', International Journal of Molecular Sciences, vol. 22, no. 14, 7253. https://doi.org/10.3390/ijms22147253

Fenton, C, Doig, C, Fareed, S, Naylor, A, Morrell, AP, Addison, O, Wehmeyer, C, Buckley, C, Cooper, MS, Lavery, G, Raza, K & Hardy, R 2019, '11β-HSD1 Plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy', Arthritis Research & Therapy, vol. 21, no. 1, 188. https://doi.org/10.1186/s13075-019-1972-1

Croft, AP, Campos, J, Jansen, K, Turner, JD, Marshall, J, Attar, M, Savary, L, Wehmeyer, C, Naylor, AJ, Kemble, S, Begum, J, Dürholz, K, Perlman, H, Barone, F, Mcgettrick, HM, Fearon, DT, Wei, K, Raychaudhuri, S, Korsunsky, I, Brenner, MB, Coles, M, Sansom, SN, Filer, A & Buckley, CD 2019, 'Distinct fibroblast subsets drive inflammation and damage in arthritis', Nature, vol. 570, no. 7760, pp. 246–251 . https://doi.org/10.1038/s41586-019-1263-7

Hardy, R, Fenton, C, Croft, A, Naylor, A, Begum, R, Desanti, G, Buckley, C, Lavery, G, Cooper, MS & Raza, K 2018, '11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis', Journal of Autoimmunity, vol. 92, pp. 104-113. https://doi.org/10.1016/j.jaut.2018.05.010

Pearson, M, Bik, M, Ospelt, C, Naylor, A, Wehmeyer, C, Jones, S, Buckley, C, Gay, S, Filer, A & Lord, J 2018, 'Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts', Scientific Reports, vol. 8, 12887. https://doi.org/10.1038/s41598-018-31173-3

Brown, JM, Ross, E, Desanti, G, Saghir, A, Clark, A, Buckley, C, Filer, A, Naylor, A & Claridge, E 2017, 'Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models', Medical Image Analysis, vol. 40, pp. 30-43. https://doi.org/10.1016/j.media.2017.05.006

Khan, K, Naylor, A, Khan, A, Noy, P, Mambretti, M, Lodhia, P, Athwell, J, Korzystka, A, Buckley, C, Willcox, B, Mohammed, F & Bicknell, R 2017, 'Multimerin-2 is a ligand for group14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface: MMRN2 binds three group 14 family C-type lectins', Oncogene, vol. 36, pp. 6097–6108. https://doi.org/10.1038/onc.2017.214

Naylor, A, Desanti, G, Saghir, A & Hardy, R 2017, 'TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding', Laboratory Animals. https://doi.org/10.1177/0023677217707985

Buckley, C & Naylor, A 2017, 'The role of stromal cells in inflammatory bone loss', Clinical & Experimental Immunology. https://doi.org/10.1111/cei.12979

Chapter

Turner, JD, Naylor, AJ, Buckley, C, Filer, A & Tak, P-P 2018, Fibroblasts and Osteoblasts in Inflammation and Bone Damage. in BMJ Owens & MA Lakins (eds), Stromal Immunology. vol. 1060, Advances in Experimental Medicine and Biology, Springer, pp. 37-54. https://doi.org/10.1007/978-3-319-78127-3_3

Conference contribution

Glinton, S, Naylor, A & Claridge, E 2017, Diagnosing hypoxia in murine models of Rheumatoid Arthritis from reflectance multispectral images. in Proceedings of the 2017 European Conference on Biomedical Optics (ECBO). European Conference on Biomedical Optics Proceedings, OSA Publishing, 2017 European Conferences on Biomedical Optics (ECBO), Munich, Germany, 25/06/17.

Patent

Naylor, A & Bicknell, R Apr. 15 2021, Treatment of osteopenia and osteoporosis.

Review article

Lewis, J, Edwards, J, Naylor, A & McGettrick, H 2021, 'Adiponectin signalling in bone homeostasis, with age and in disease', Bone Research, vol. 9, 1. https://doi.org/10.1038/s41413-020-00122-0

View all publications in research portal