Dr Amy Naylor PhD

Dr Amy Naylor

Institute of Inflammation and Ageing
Research Fellow

Contact details

Address
Institute of Inflammation and Ageing (IIA)
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Amy Naylor is a Postdoctoral Research Fellow.

Her main interest is the regulation of bone remodelling in the context of inflammation and ageing. Specifically, the contribution of stromal cell interactions with endothelial cells and osteoclasts.

Qualifications

  • PhD, Rheumatology (Oliver Bird Foundation): University of Newcastle, 2008
  • MRes, Medical and Molecular Biosciences: University of Newcastle, 2005
  • BSc (Hons International), Biology: University of Leeds, 2004

Biography

Amy Naylor completed an MSc and PhD in the Musculoskeletal Research Group at the University of Newcastle as part of the Oliver Bird Rheumatism Scheme.

She moved to the University of Birmingham to work for Professor Chris Buckley and was awarded a Foundation Fellowship from Arthritis Research UK to investigate the role of stromal cell-specific markers in inflammation and repair. Since completing the fellowship she has remained at the University of Birmingham in the Institute for Inflammation and Ageing and her research now centres on the role of the stroma and endothelium in orchestrating bone remodelling during inflammation and ageing.

Teaching

2013 - 2016 Lecturer on BMedSci Intercalated Rheumatology and Orthopaedics module

Postgraduate supervision

Amy has particular experience and interest in supervising students on cross-disciplinary schemes, for example the Research and Training Centre in Physical Sciences for Health

Amy is interested in supervising doctoral research students in the following areas:

• Bone remodelling in the context of inflammation

If you are interested in studying any of these subject areas please contact Amy on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Research themes:

Bone remodelling in inflammation and ageing, stromal cell differentiation and migration, stromal cell-osteoclast interactions 

Publications

Recent publications

Article

Fenton, C, Doig, C, Fareed, S, Naylor, A, Morrell, AP, Addison, O, Wehmeyer, C, Buckley, C, Cooper, MS, Lavery, G, Raza, K & Hardy, R 2019, '11β-HSD1 Plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy', Arthritis Research & Therapy, vol. 21, no. 1, 188. https://doi.org/10.1186/s13075-019-1972-1

Croft, AP, Campos, J, Jansen, K, Turner, JD, Marshall, J, Attar, M, Savary, L, Wehmeyer, C, Naylor, AJ, Kemble, S, Begum, J, Dürholz, K, Perlman, H, Barone, F, Mcgettrick, HM, Fearon, DT, Wei, K, Raychaudhuri, S, Korsunsky, I, Brenner, MB, Coles, M, Sansom, SN, Filer, A & Buckley, CD 2019, 'Distinct fibroblast subsets drive inflammation and damage in arthritis', Nature, vol. 570, no. 7760, pp. 246–251 . https://doi.org/10.1038/s41586-019-1263-7

Pearson, M, Bik, M, Ospelt, C, Naylor, A, Wehmeyer, C, Jones, S, Buckley, C, Gay, S, Filer, A & Lord, J 2018, 'Endogenous Galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts', Scientific Reports, vol. 8, 12887. https://doi.org/10.1038/s41598-018-31173-3

Hardy, R, Fenton, C, Croft, A, Naylor, A, Begum, R, Desanti, G, Buckley, C, Lavery, G, Cooper, MS & Raza, K 2018, '11beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis', Journal of Autoimmunity, vol. 92, pp. 104-113. https://doi.org/10.1016/j.jaut.2018.05.010, https://doi.org/10.1016/j.jaut.2018.05.010

Brown, JM, Ross, E, Desanti, G, Saghir, A, Clark, A, Buckley, C, Filer, A, Naylor, A & Claridge, E 2017, 'Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models', Medical Image Analysis, vol. 40, pp. 30-43. https://doi.org/10.1016/j.media.2017.05.006

Khan, K, Naylor, A, Khan, A, Noy, P, Mambretti, M, Lodhia, P, Athwell, J, Korzystka, A, Buckley, C, Willcox, B, Mohammed, F & Bicknell, R 2017, 'Multimerin-2 is a ligand for group14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface: MMRN2 binds three group 14 family C-type lectins', Oncogene. https://doi.org/10.1038/onc.2017.214

Naylor, A, Desanti, G, Saghir, A & Hardy, R 2017, 'TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding', Laboratory Animals. https://doi.org/10.1177/0023677217707985

Buckley, C & Naylor, A 2017, 'The role of stromal cells in inflammatory bone loss', Clinical & Experimental Immunology. https://doi.org/10.1111/cei.12979

Naylor, A, O'Neil, J, Crowley, T, Ridley, M, Tang, JT, Turner, J, Filer, A, Buckley, C & Clark, A 2017, 'Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression', Annals of the Rheumatic Diseases, vol. 76, pp. 612-619. https://doi.org/10.1136/annrheumdis-2016-209424

Croft, A, Naylor, A, Marshall, J, Turner, J, Desanti, G, Adams, H, Yemm, A, Filer, A & Buckley, C 2016, 'Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage', Arthritis Research & Therapy, vol. 18, 270. https://doi.org/10.1186/s13075-016-1156-1

Smith, S, Croft, A, Morris, HL, Naylor, A, Huso, DL, Isacke, CM, Savage, C & Buckley, C 2015, 'Genetic Deletion of the Stromal Cell Marker CD248 (Endosialin) Protects against the Development of Renal Fibrosis', Nephron, vol. 131, no. 4. https://doi.org/10.1159/000438754

Wilhelm, A, Aldridge, V, Haldar, D, Naylor, AJ, Weston, CJ, Garg, A, Fear, J, Reynolds, GM, Croft, AP, Henderson, NC, Buckley, CD & Newsome, PN 2015, 'CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism', Gut. https://doi.org/10.1136/gutjnl-2014-308325

Chapter

Turner, JD, Naylor, AJ, Buckley, C, Filer, A & Tak, P-P 2018, Fibroblasts and Osteoblasts in Inflammation and Bone Damage. in BMJ Owens & MA Lakins (eds), Stromal Immunology. vol. 1060, Advances in Experimental Medicine and Biology, Springer, pp. 37-54. https://doi.org/10.1007/978-3-319-78127-3_3

Conference contribution

Glinton, S, Naylor, A & Claridge, E 2017, Diagnosing hypoxia in murine models of Rheumatoid Arthritis from reflectance multispectral images. in Proceedings of the 2017 European Conference on Biomedical Optics (ECBO). European Conference on Biomedical Optics Proceedings, OSA Publishing, 2017 European Conferences on Biomedical Optics (ECBO), Munich, Germany, 25/06/17.

Glinton, S, Naylor, A & Claridge, E 2016, Spectral characterization of murine arthritis models. in Optical Tomography and Spectroscopy 2016 . Optical Society of America (OSA), pp. JMA3A.6, Optical Tomography and Spectroscopy, Fort Lauderdale, Florida, United States, 25/04/16. https://doi.org/10.1364/CANCER.2016.JM3A.6

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