Dr Amy Naylor PhD

Dr Amy Naylor

Institute of Inflammation and Ageing
Research Fellow

Contact details

Address
Institute of Inflammation and Ageing (IIA)
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Amy Naylor is a Postdoctoral Research Fellow.

Her main interest is the regulation of bone remodelling in the context of inflammation and ageing. Specifically, the contribution of stromal cell interactions with endothelial cells and osteoclasts.

Qualifications

  • PhD, Rheumatology (Oliver Bird Foundation): University of Newcastle, 2008
  • MRes, Medical and Molecular Biosciences: University of Newcastle, 2005
  • BSc (Hons International), Biology: University of Leeds, 2004

Biography

Amy Naylor completed an MSc and PhD in the Musculoskeletal Research Group at the University of Newcastle as part of the Oliver Bird Rheumatism Scheme.

She moved to the University of Birmingham to work for Professor Chris Buckley and was awarded a Foundation Fellowship from Arthritis Research UK to investigate the role of stromal cell-specific markers in inflammation and repair. Since completing the fellowship she has remained at the University of Birmingham in the Institute for Inflammation and Ageing and her research now centres on the role of the stroma and endothelium in orchestrating bone remodelling during inflammation and ageing.

Teaching

2013 - 2016 Lecturer on BMedSci Intercalated Rheumatology and Orthopaedics module

Postgraduate supervision

Amy has particular experience and interest in supervising students on cross-disciplinary schemes, for example the Research and Training Centre in Physical Sciences for Health

Amy is interested in supervising doctoral research students in the following areas:

• Bone remodelling in the context of inflammation

If you are interested in studying any of these subject areas please contact Amy on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Research themes:

Bone remodelling in inflammation and ageing, stromal cell differentiation and migration, stromal cell-osteoclast interactions 

Publications

Rheumatoid synovial fibroblasts differentiate into distinct functional subsets in the presence of cytokines and cartilage. A.J. Naylor*, A.P. Croft*, J.L. Marshall, D.L. Hardie, B. Zimmermann, J. Turner, G. Desanti, H. Adams, A.I. Yemm, U. Muller-Ladner, J-M. Dayer, E. Neumann, A. Filer, C.D Buckley. (2016) Arthritis Research and Therapy. 18. 27

Spectral characterization of murine arthritis models. S. Glinton. A. Naylor, E. Claridge. Optical Tomography and Spectroscopy 2016. (2016) Optical Society of America (OSA). JMA3A.6

11β-hydroxysteroid dehydrogenase within muscle protects against the adverse effects of local inflammation. R.S. Hardy, Z. Hussain, C. Doig, S. Morgan, M.J. Pearson, A. Naylor, S.W. Jones, A. Filer, P.M. Stewart, C.D. Buckley, G.G. Lavery, M.S. Cooper, K. Raza. (2016) Journal of Pathology. 240: 472-83

Treatment of Inflammatory Arthritis via Targeting of Tristetraprolin, a Master Regulator of Pro-inflammatory Gene Expression. E. Ross, A. Naylor, J O'Neil, T. Smallie, J. Crowe, T. Tang, J. Turner, L. Norling, S. Dominguez, H. Perlman, N. Verrills, G. Kollias, M. Vitek, A. Filer, C. Buckley, J. Dean. (2016) Annals of the Rheumatic Diseases. doi:10.1136/annrheumdis-2016-209424

Genetic deletion of the stromal cell marker CD248 (endosialin) protects against the development of renal fibrosis. S. Smith, A. Croft, H. Morris, A.J. Naylor, D. Huso, C. Isacke, C. Savage, C. Buckley. (2015) Nephron. DOI: 10.1159/000438754

CD248/Endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism. A. Wilhelm, V. Aldridge, D. Haldar, A.J. Naylor, C. Weston, A. Garg, J. Fear, G.M. Reynolds, A.P. Croft, N.C. Henderson, C.D. Buckley, P.N. Newsome. (2015) Gut. 65:1175-85

A differential role for CD248 (Endosialin) in PDGF-mediated skeletal muscle angiogenesis. A.J. Naylor*, H.M. McGettrick*, W.D. Maynard, P. May, F. Barone, A.P. Croft, S. Egginton, C.D. Buckley. (2014) PLOS One 9: e107146

3D Articulated Registration of the Mouse Hind Limb for Bone Morphometric Analysis in Rheumatoid Arthritis. J.M. Brown, A. Naylor, C. Buckley, A. Filer, E. Claridge. (2014) Biomedical Image Registration, Springer. 8545: 41-50

Differential Expression of CD148 on leucocyte subsets in inflammatory arthritis. R.K. Dave, A.J. Naylor, S.P. Young, R. Bayley, D.L. Hardie, O. Haworth, D.A. Rider, A.D. Cook, C.D. Buckley, S. Kellie. (2013) Arthritis Research and Therapy. 15: R108 

The role of stromal cells in the persistence of chronic inflammation. A.J. Naylor, A. Filer, C.D. Buckley. (2013) Clinical and Experimental Immunology. 171:30-56

Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis. R. Hardy, M. Juarez, A. Naylor, J. Tu, E.H Rabbitt, A. Filer, P.M. Stewart, C.D Buckley, K.Raza, M.S. Cooper. (2012) Arthritis Research and Therapy. 14: R226

The MSC marker CD248 (Endosialin) is a negative regulator of bone formation in mice. A.J. Naylor, E. Azzam, S. Smith, A. Croft, C. Poyser, J.S. Duffield, D.L. Huso, S. Gay, C. Ospelt, M.S. Cooper, C. Isacke, S. Goodyear, M.J. Rogers, C.D. Buckley. (2012) Arthritis and Rheumatism 64:3334-43

The stromal cell antigen CD248 (endosialin) is expressed on naive CD8(+) human T cells and regulates proliferation. D.L. Hardie, M.J. Baldwin, A. Naylor, O.J. Haworth, T.Z. Hou, S. Lax, S.J. Curnow, N. Willcox, J. Macfadyen, C.M. Isacke, C.D. Buckley. (2011) Immunology 133:288-95

The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. S. Lax, D.L. Hardie, A. Wilson, M.R. Douglas, G. Anderson, D. Huso, C.M. Isacke, C.D. Buckley. (2010) European Journal of Immunology. 40: 1884-9

Evc is a positive mediator of Ihh-regulated bone growth that localizes at the base of chondrocyte cilia. V.L. Ruiz-Perez, H.J. Blair, M.E. Rodriguez-Andres, M.J. Blanco,A. Wilson,Y-N, Liu, C. Miles, H. Peters, J.A. Goodship. (2007) Development. 134: 2903-12

Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. T.E. Cawston, A.J. Wilson. (2006)Best Practice and Research: Clinical Rheumatology. 20:983-10

A pragmatic andreadily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis. T. Sangster, H. Major, R. Plumb, A.J. Wilson, I.D. Wilson. (2006) The Analyst. 131: 1075-8

A metabonomic analysis of plasma from Zucker rat strains using GC-MS and pattern recognition. H.J. Major, R. Williams, A.J. Wilson, I.D. Wilson. (2006) Rapid Communications in Mass Spectroscopy. 20: 3295-30

A multi-analytical platform approach to the metabolic analysis of plasma from normal and zucker (fa/fa) obese rats. R. Williams, E.M. Lenz, A.J. Wilson, J. Granger, I.D. Wilson, H. Major, C. Stumpf, R. Plumb. (2006) Molecular Biosystems. 2: 174-83