Dr Naylor’s research group studies the bone remodelling process to identify aspects that can be targeted therapeutically to reverse the bone loss that occurs because of inflammation and ageing, both of which represent a significant clinical burden in terms of cost and patient quality of life.
To make a positive impact in reducing and replacing animal models as part of our commitment to the practice of the 3Rs, we actively collaborate with chemical and tissue engineers to develop complex in vitro models that mimic the physiological microenvironment, something that is currently lacking in the field of bone research. To this core research we are adding systems biology approaches (transcript and protein expression profiling and metabolomics) to further enhance our modelling and mechanistic understanding of the cellular, tissue and whole organism phenotypes that we encounter, with clear translational potential.
Amy has received grant funding from Versus Arthritis (in the form of Foundation and Career Development Fellowships), AstraZeneca, the EPSRC, Wellcome Trust, MRC, NC3Rs and the Chernajovsky Foundation amongst others.