Professor Karim Raza BA, BMBCh, FRCP, PhD

Karim Raza

Institute of Inflammation and Ageing
Professor of Rheumatology supported by Versus Arthritis

Contact details

Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
University of Birmingham
Queen Elizabeth Hospital
Birmingham
B15 2WB

Karim Raza is Professor of Rheumatology at the University of Birmingham and Honorary Consultant Rheumatologist at Sandwell and West Birmingham Hospitals NHS Trust

He qualified from Oxford in 1993 and achieved Membership of the Royal College of Physicians in 1996. From 2000-2003 he worked as an Arthritis Research UK clinical training fellow studying the regulation of leukocyte apoptosis in early inflammatory arthritis. Following the award of a PhD, he was appointed as Senior Lecturer and Honorary Consultant in Rheumatology in 2004. In 2009 he was made a Fellow of the Royal College of Physicians and was awarded the prestigious Michael Mason Prize by the British Society for Rheumatology. He was promoted to Reader in 2011 and Professor in 2013.

Qualifications

  • FRCP 2009
  • PhD, University of Birmingham, 2004
  • BMBCh, Oxford University, 1993
  • BA (Physiological Sciences), Oxford University, 1990

Teaching

  • Co-lead for clinical Rheumatology teaching for Year 4 medical students at the University of Birmingham
  • At a postgraduate level, he teaches on several postgraduate courses and supervises doctors on the Academic Clinical Training program.

Postgraduate supervision

  • Professor Raza has supervised many clinical and non-clinical research fellows through to successful completion of their PhDs

Research

Professor Raza’s research focuses on rheumatoid arthritis, the most common of the chronic inflammatory joint diseases. Within this disease area, his research addresses pathogenic mechanisms, biomarker development and strategies to enhance clinical outcomes for patients with a new onset of disease. Specifically he is interested in:

  1. Mechanisms driving the molecular basis for the switch to disease persistence and the timing of this switch in early arthritis.
  2. Predictors of outcome in patients with early inflammatory arthritis.
  3. Novel anti-inflammatory mechanisms that may be useful in the control of persistent inflammation, including vitamin D and endogenously generated glucocorticoids.
  4. Management pathways for patients with early rheumatoid arthritis, including the development of strategies to facilitate rapid patient assessment.
  5. Perspectives of patients and members of the public about RA and the concept of ‘risk’ in relation to RA to facilitate informed engagement with predictive and early treatment strategies.

Other activities

Positions of responsibility include

  1. Director of Research and Development at Sandwell and West Birmingham Hospitals NHS Trust (2014-2018).
  2. Co-chair of the EULAR Study Group on Risk Factors for Rheumatoid Arthritis rheumatoid arthritis (2011-2018).
  3. Co-lead for Outputs for Unit of Assessment 1 for the Research Excellence Framework (REF) 2021 at the University of Birmingham.

Committee membership

  1. Member of the Arthritis Research UK Clinical Studies Central Progress Review Committee (2009- 2013) and of the Arthritis Research UK Research sub-committee (2013-2017).
  2. Member of the following EULAR taskforces:
    1. ‘EULAR recommendations for the standardised content and structure of minimum data collection to harmonise observational research in rheumatoid arthritis’ (2015-16).
    2. ‘EULAR classification criteria for arthralgia that is clinically suspect for progression to rheumatoid arthritis’ (2015-16).
    3. ‘Update of the 2007 EULAR recommendations for the management of early arthritis’ (2015-16).
    4. EULAR Points to Consider for conducting clinical trials in individuals at-risk of rheumatoid arthritis (current).
    5. EULAR Recommendations for the use and interpretation of laboratory diagnostic tests for the management of systemic autoimmune rheumatic diseases (current).
  3. Member of the British Society for Rheumatology’s Research Committee (2014-2018). 

Editorial Board membership

Member of the Editorial board for Rheumatology (2011-2015) and for RMD Open (2017-present)

Patient and Public involvement in research

Patients and members of the public play an important role in the development, delivery and dissemination of Professor Raza’s research, enhancing its relevance and impact. Professor Raza has been instrumental in establishing the Birmingham Rheumatology Research Patient Partnership (R2P2) which has 40 active members and provides crucial input into clinical and translational studies across the Rheumatology Research Group.

Publications

Recent publications

Article

Buckley, C & Raza, K 2020, 'Cardiovascular risk factors and outcomes in early rheumatoid arthritis: a population-based study', Heart.

Birch, B, Simons, G, Buckley, C, Raza, K & Falahee, M 2020, 'Development and formative evaluation of patient research partner involvement in a multi-disciplinary European translational research project', Research Involvement and Engagement, vol. 6, 6. https://doi.org/10.1186/s40900-020-0178-7

Chandan, JS, Thomas, T, Raza, K, Bradbury-jones, C, Taylor, J, Bandyopadhyay, S & Nirantharakumar, K 2019, 'Intimate Partner Violence and the Risk of Developing Fibromyalgia and Chronic Fatigue Syndrome', Journal of Interpersonal Violence, pp. 088626051988851. https://doi.org/10.1177/0886260519888515

Wei, K, Korsunsky, I, Marshall, J, Major, T, Croft, A, Filer, A, Raza, K & Buckley, C 2019, 'Synovial fibroblast positional identity controlled by inductive Notch signaling underlies pathologic damage in inflammatory arthritis', Nature.

Hider, S, Muller, S, Helliwell, T, Prior, JA, Scott, I, Lawton, SA, Zwierska, I, van Schaardenburg, D, van der Helm-van Mil, A, Raza, K & Mallen, CD 2019, 'Symptoms associated with inflammatory arthritis are common and persistent in the primary care population: results from the Joint Symptoms Survey', Rheumatology, vol. 58, no. 11, pp. 2009–2014. https://doi.org/10.1093/rheumatology/kez184

Nikiphorou, E, De Lusignan, S, Mallen, C, Roberts, J, Khavandi, K, Bedarida, G, Buckley, CD, Galloway, J & Raza, K 2019, 'Prognostic value of comorbidity indices and lung diseases in early rheumatoid arthritis: a UK population-based study', Rheumatology (Oxford, England). https://doi.org/10.1093/rheumatology/kez409

Serban, S, Dietrich, T, Lopez-Oliva, I, De Pablo, P, Raza, K, Filer, A, Chapple, I & Hill, K 2019, 'Attitudes towards oral health in patients with rheumatoid arthritis: a qualitative study nested within a randomized controlled trial', JDR Clinical & Translational Research, vol. 4, no. 4, pp. 360-370. https://doi.org/10.1177/2380084419833694

Nikiphorou, E, de Lusignan, S, Malen, C, Khavandi, K, Roberts, J, Buckley, C, Galloway, J & Raza, K 2019, 'Haematological abnormalities in new onset rheumatoid arthritis and risk of common infections: a population-based study', Rheumatology (Oxford, England). https://doi.org/10.1093/rheumatology/kez344

Fenton, C, Doig, C, Fareed, S, Naylor, A, Morrell, AP, Addison, O, Wehmeyer, C, Buckley, C, Cooper, MS, Lavery, G, Raza, K & Hardy, R 2019, '11β-HSD1 Plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy', Arthritis Research & Therapy, vol. 21, no. 1, 188. https://doi.org/10.1186/s13075-019-1972-1

Fenton, C, Webster, J, Martin, C, Fareed, S, Wehmeyer, C, Mackie, H, Jones, R, Seabright, A, Lewis, J, Lai, Y-C, Goodyear, CS, Jones, S, Cooper, MS, Lavery, G, Langen, R, Raza, K & Hardy, R 2019, 'Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis', Arthritis Research & Therapy, vol. 21, no. 1, 182. https://doi.org/10.1186/s13075-019-1962-3

Burgers, LE, Raza, K & Van Der Helm - Van Mil, AH 2019, 'Window of opportunity in rheumatoid arthritis – definitions and supporting evidence: from old to new perspectives', RMD Open, vol. 5, no. 1, e000870. https://doi.org/10.1136/rmdopen-2018-000870, https://doi.org/10.1136/rmdopen-2018-000870

Review article

Pucino, V, Certo, M, Varricchi, G, Marone, G, Ursini, F, Rossi, FW, de Paulis, A, Mauro, C, Raza, K & Buckley, C 2020, 'Metabolic checkpoints in rheumatoid arthritis', Frontiers in Physiology, vol. 11, 347. https://doi.org/10.3389/fphys.2020.00347

Raza, K, Hardy, R & Cooper, MS 2020, 'Therapeutic glucocorticoids mechanisms of actions in rheumatic diseases', Nature Reviews Rheumatology, vol. 16, no. 3, pp. 133-144. https://doi.org/10.1038/s41584-020-0371-y, https://doi.org/https://www.nature.com/articles/s41584-020-0371-y#article-info

Harrison, SR, Li, D, Jeffery, LE, Raza, K & Hewison, M 2019, 'Vitamin D, Autoimmune Disease and Rheumatoid Arthritis', Calcified Tissue International. https://doi.org/10.1007/s00223-019-00577-2

Special issue

Falahee, M, Finckh, A, Raza, K & Harrison, M 2019, 'Preferences of patients and at risk individuals for preventive approaches to rheumatoid arthritis', Clinical Therapeutics, vol. 41, no. 7, pp. 1346-1354. https://doi.org/10.1016/j.clinthera.2019.04.015

View all publications in research portal

Expertise

Rheumatoid Arthritis