Recent publications
Article
Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Belchamber, KBR, Hardy, RS, Matthay, MA, Naidu, B & Thickett, DR 2021, 'Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome', Frontiers in Medicine, vol. 8, 737859. https://doi.org/10.3389/fmed.2021.737859
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P, Gates, S & CATALYST Trial Investigators 2021, 'CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults', BMJ open, vol. 11, no. 11, e050202. https://doi.org/10.1136/bmjopen-2021-050202
Roberts, A, Tang, T, Stewart, F, Pallini, C, Wallace, G, Cooper, A, Scott, A, Thickett, D, Lugg, S, Pinkney, T, Taylor, G, Brock, K, Stamataki, Z, Brady, CA, Curnow, J, Gordon, J, Qureshi, O, Barnes, N, Bentley, L, Juvvanapudi, J, Bancroft, H, Hemming, B, Ferris, C, Langman, G, Robinson, A, Chapman, J & Naidu, B 2021, 'Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation', Scientific Reports, vol. 11, no. 1, 4030. https://doi.org/10.1038/s41598-021-83612-3
Faniyi, AA, Lugg, ST, Faustini, SE, Webster, C, Duffy, JE, Hewison, M, Shields, A, Nightingale, P, Richter, AG & Thickett, DR 2021, 'Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19', The European respiratory journal, vol. 57, no. 5, 2100653. https://doi.org/10.1183/13993003.00653-2021
CATALYST investigators, Fisher, B, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, M, Cooke, G, Morley, N, Gabriel, Z, Wise, M, Porter, J, McShane, H, Ho, L-P, Newsome, P, Rowe, A, Sharpe, R, Thickett, D, Bion, J, Gates, S, Richards, D & Kearns, P 2021, 'Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial', The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(21)00460-4
Wright, WA, Crowley, LE, Parekh, D, Crawshaw, A, Dosanjh, DP, Nightingale, P & Thickett, DR 2021, 'Real-world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis', BMJ Open Respiratory Research, vol. 8, no. 1, e000782. https://doi.org/10.1136/bmjresp-2020-000782
Mahida, RY, Chotalia, M, Alderman, J, Patel, C, Hayden, A, Desai, R, Beesley, E, Crowley, LE, Soltan, M, Bangash, M, Parekh, D, Patel, J & Thickett, DR 2020, 'Characterisation and outcomes of ARDS secondary to pneumonia in patients with and without SARS-CoV-2: a single-centre experience', BMJ Open Respiratory Research, vol. 7, no. 1, e000731. https://doi.org/10.1136/bmjresp-2020-000731
EME-TIPAC team 2020, 'Effect of co-trimoxazole (trimethoprim-sulfamethoxazole) vs placebo on death, lung transplant, or hospital admission in patients with moderate and severe idiopathic pulmonary fibrosis: the EME-TIPAC randomized clinical trial', JAMA The Journal of the American Medical Association, vol. 324, no. 22, pp. 2282-2291. https://doi.org/10.1001/jama.2020.22960
Letter
Jasper, AE, Sapey, E, Thickett, D & Scott, A 2020, 'Comment on “E-cigarette use increases susceptibility to bacterial infection by impairment of human neutrophil chemotaxis, phagocytosis, and NET formation”', American Journal of Physiology - Cell Physiology, vol. 318, no. 3, pp. C704-C705. https://doi.org/10.1152/ajpcell.00554.2019
Preprint
Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P & Gates, S 2021 'CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults' medRxiv, pp. 1-15. https://doi.org/10.1101/2021.02.10.21251478
Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2021 'CD14 positive extracellular vesicles in broncho-alveolar lavage fluid as a new biomarker of acute respiratory distress syndrome' medRxiv. https://doi.org/10.1101/2021.09.25.21264053
Fisher, BA, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, MS, Cooke, G, Morley, N, Gabriel, Z, Wise, MP, Porter, J, McShane, H, Ho, L-P, Newsome, PN, Rowe, A, Sharpe, R, Thickett, DR, Bion, J, Gates, S, Richards, D & Kearns, P 2021 'Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial' medRxiv, pp. 1-26. https://doi.org/10.1101/2021.06.02.21258204
Review article
Lugg, ST, Scott, A, Parekh, D, Naidu, B & Thickett, DR 2021, 'Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease', Thorax. https://doi.org/10.1136/thoraxjnl-2020-216296
Llibre, A, Grudzinska, FS, O'Shea, MK, Duffy, D, Thickett, DR, Mauro, C & Scott, A 2021, 'Lactate cross-talk in host-pathogen interactions', The Biochemical journal, vol. 478, no. 17, pp. 3157-3178. https://doi.org/10.1042/BCJ20210263
Jasper, A, Sapey, E, Thickett, D & Scott, A 2021, 'Understanding potential mechanisms of harm: the drivers of electronic cigarette-induced changes in alveolar macrophages, neutrophils and lung epithelial cells', American journal of physiology. Lung cellular and molecular physiology, vol. 321, no. 2, pp. L336-L348. https://doi.org/10.1152/AJPLUNG.00081.2021
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