Recent publications
Article
Grudzinska, F, Faniyi, AA, Belchamber, KBR, Chen, C, Stockley, R, Jasper, A, Parekh, D, Sapey, E, Scott, A & Thickett, DR 2025, 'Hospitalised older adults with community-acquired pneumonia and sepsis have dysregulated neutrophil function but preserved glycolysis', Thorax, vol. 80, no. 2, pp. 97-104. https://doi.org/10.1136/thorax-2024-222215
Fennell, É, Taylor, GS, Leahy, CI, Ross, AM, Reynolds, G, Perry, T, Youd, E, Skidmore, J, Ramzi, R, Darwish, R, Hunter, KJ, Willcox, BE, Jermann, P, Arif Jahangir, C, Rahman, A, Gallagher, WM, Nikulina, N, Ben Cheikh, B, Braubach, O, Mayer, AT, Young, LS, Grammatopoulos, D, Faustini, S, Richter, A, Dowell, AC, Venith, T, Thein, OS, Parekh, D, Belchamber, KBR, Thickett, DR, Scott, A, Attanoos, R, Mundo, L, Lazzi, S, Leoncini, L, Leopold, G, Steven, N, Marie, J, Sand, B, Karsdal, MA, Julie Leeming, D, Dojcinov, S, Culhane, A, Murray, PG & Pugh, MR 2025, 'Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19', The European respiratory journal. https://doi.org/10.1183/13993003.01699-2023
STARSurg Collaborative, Kathir Kamarajah, S, Bhangu, A, Glasbey, J, Morton, D, Nepogodiev, D, Kouli, O, Jakaitytė, I, Ooi, SZY, El-Boghdadly, K, Farley, A, Nirantharakumar, K, Pinkney, T, Thickett, D & Yeung, J 2025, 'Prevalence, trends and outcomes from smoking in elective surgical systems: a secondary analysis of a prospective observational cohort study across 442 hospitals from 29 countries across Europe', The Lancet Regional Health - Europe, vol. 53, 101282. https://doi.org/10.1016/j.lanepe.2025.101282
Mahida, RY, Yuan, Z, Kolluri, KK, Scott, A, Parekh, D, Hardy, RS, Matthay, MA, Perkins, GD, Janes, SM & Thickett, DR 2024, '11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis', Frontiers in Bioengineering and Biotechnology, vol. 12, 1422761. https://doi.org/10.3389/fbioe.2024.1422761
Jasper, A, Faniyi, A, Davis, L, Grudzinska, F, Halston, R, Hazeldine, J, Parekh, D, Sapey, E, Thickett, D & Scott, A 2024, 'E-cigarette vapor renders neutrophils dysfunctional due to filamentous actin accumulation', Journal of Investigational Allergology and Clinical Immunology, vol. 153, no. 1, pp. 320-329.e8. https://doi.org/10.1016/j.jaci.2023.08.025
Quarton, S, Livesey, A, Jeff, C, Hatton, C, Scott, A, Parekh, D, Thickett, D, McNally, A & Sapey, E 2024, 'Metagenomics in the Diagnosis of Pneumonia: Protocol for a Systematic Review', JMIR Research Protocols, vol. 13, e57334. https://doi.org/10.2196/57334
Patel, A, Caruana, EJ, Hodson, J, Morrison, R, Khor, B, Gysling, S, Trevis, J, Mangel, T, Benson, R, Zakeri, R, Manders, J, Vaja, R, Rogers, L, Baker, P, Pournaras, DJ, Thickett, D, Hewison, M, Naidu, B & Lim, E 2024, 'Role of vitamin D supplementation in modifying outcomes after surgery: a systematic review of randomised controlled trials', BMJ open, vol. 14, no. 1, e073431. https://doi.org/10.1136/bmjopen-2023-073431
Quarton, S, McGee, K, Cumley, N, Behruznia, M, Jeff, C, Belchamber, K, Cox, M, Thickett, D, Scott, A, Parekh, D, McNally, A & Sapey, E 2024, 'Towards personalised anti-microbial and immune approaches to infections in acute care. Can real-time genomic-informed diagnosis of pathogens, and immune-focused therapies improve outcomes for patients? An observational, experimental study protocol', PLoS ONE, vol. 19, no. 3, e0298425. https://doi.org/10.1371/journal.pone.0298425
Chadda, KR, Roberts, SA, Lugg, ST, Faniyi, AA, Faustini, SE, Webster, C, Duffy, JE, Hewison, M, Shields, A, Richter, AG, Parekh, D, Scott, A & Thickett, DR 2024, 'Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers', Frontiers in Medicine, vol. 11, 1494129. https://doi.org/10.3389/fmed.2024.1494129
Mahida, RY, Lax, S, Bassford, CR, Scott, A, Parekh, D, Hardy, RS, Naidu, B, Matthay, MA, Stewart, PM, Cooper, MC, Perkins, GD & Thickett, DR 2023, 'Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS', Frontiers in immunology, vol. 14, 1159831. https://doi.org/10.3389/fimmu.2023.1159831
Grudzinska, FS, Faniyi, AA, Scott, A, Sapey, E & Thickett, DR 2023, 'Observational cohort study protocol: neutrophil function and energetics in adults with pneumonia and sepsis: Pneumonia Metabolism in Ageing (PUMA)', BMJ Open Respiratory Research, vol. 10, no. 1, e001806. https://doi.org/10.1136/bmjresp-2023-001806
Abstract
Thein, OS, Belchamber, K, Hazeldine, J, Faniyi, A, Grudzinska, F, Hughes, M, Jasper, A, Yip, KP, Crowley, L, Lugg, S, Sapey, E, Parekh, D, Thickett, D & Scott, A 2024, 'Dysfunctional neutrophil response in COVID-19 infection vary by subtype', Clinical Medicine, vol. 23, no. 6, pp. 69-70. https://doi.org/10.7861/clinmed.23-6-s69
Letter
PHOSP-COVID Collaborative Group & ISARIC investigators 2024, 'Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease', Nature Immunology, vol. 25, no. 4, pp. 607-621. https://doi.org/10.1038/s41590-024-01778-0
Review article
Jeff, C, Quarton, S, Hatton, C, Parekh, D, Thickett, D, McNally, A & Sapey, E 2025, 'Metagenomics in the diagnosis and treatment of urinary tract infections: A systematic review and meta-analysis', Diagnostic Microbiology and Infectious Disease, vol. 113, no. 3, 116995. https://doi.org/10.1016/j.diagmicrobio.2025.116995
Crowley, LE, Stockley, RA, Thickett, DR, Dosanjh, D, Scott, A & Parekh, D 2024, 'Neutrophil dynamics in pulmonary fibrosis: pathophysiological and therapeutic perspectives', European Respiratory Review, vol. 33, no. 174, 240139. https://doi.org/10.1183/16000617.0139-2024
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