Dr Jason D. Turner BSc (Hons) PhD

Dr Jason Turner

Institute of Inflammation and Ageing
Research Fellow

Contact details

Address
Rheumatology Research Group
Institute of Inflammation and Ageing
University of Birmingham
Queen Elizabeth Hospital
Birmingham
B15 2WB

Dr. Turner is a postdoctoral research fellow working in the lab of Prof. Andrew Filer. He currently provides bioinformatic support for the lab along with performing wet lab experiments generating RNA-sequencing datasets and validating findings from this work. His work spans several autoimmune diseases including rheumatoid arthritis, Sjögren’s disease, and systemic lupus erythematosus.

Google Scholar Profile

ResearchGate Profile

Qualifications

The Carpentries Instructor Training Program, 2020.

PhD by Research in Immunity and Infection, University of Birmingham, 2017.

BSc (Hons) Biological science, Plymouth University (Class I), 2012.

Biography

Dr. Turner completed his undergraduate studies in Biological Sciences at Plymouth University in 2011. He began working as a research technician in the lab of Prof. Filer before beginning his doctoral studies which he successfully completed in 2017. Since then, he has continued to work as a postdoctoral research fellow in the Filer lab whilst developing his own research interests.

Teaching

• BSc Biomedical Science Year 3: Immunity and Inflammatory Disease
• ICS Rheumatology & Orthopaedics
• R Software Carpentry

Research

  • Stratification of immune disorders using process modules common/private to disorders
  • Stromal immunology, in particular the role of stromal subsets in the healthy immune response and disease and how stromal responses and subsets vary across tissues
  • Transcriptomics data analysis, particularly single-cell RNA sequencing and leading-edge developments, and working in the R programming language
  • Platforms and methods for easing access and interpretation of big data by colleagues without computational ability
  • Merging transcriptomic data with wet-lab validation and spatial assignment of transcriptomic data

Publications

Recent publications

Article

Pucino, V, Turner, JD, Nayar, S, Kollert, F, Rauz, S, Richards, A, Higham, J, Poveda-Gallego, A, Bowman, SJ, Barone, F & Fisher, BA 2022, 'Sjögren's and non-Sjögren's sicca share a similar symptom burden but with a distinct symptom-associated proteomic signature', RMD Open, vol. 8, no. 1, e002119. https://doi.org/10.1136/rmdopen-2021-002119

Friščić, J, Böttcher, M, Reinwald, C, Bruns, H, Writh, B, Popp, S-J, Walker, KI, Ackermann, JA, Chen, X, Turner, J, Zhu, H, Seyler, L, Euler, M, Kirchner, P, Krüger, R, Ekici, AB, Major, T, Aust, O, Weidner, D, Fischer, A, Andes, FT, Stanojevic, Z, Trajkovic, V, Hermann, M, Korb-Pap, A, Wank, I, Hess, A, Winter, J, Wixler, V, Distler, J, Steiner, G, Kiener, HP, Frey, B, Kling, L, Raza, K, Frey, S, Kleyer, A, Bäuerle, T, Grüneboom, A, Steffen, U, Krönke, G, Croft, A, Filer, A, Köhl, J, Klein, K, Buckley, CD, Schett, G, Mougiakakos, D & Hoffmann, MH 2021, 'The complement system drives local inflammatory tissue priming by metabolic reprogramming of articular fibroblasts', Immunity, vol. 2021, no. 00, pp. 1-31. https://doi.org/10.1016/j.immuni.2021.03.003

Korsunsky, I, Wei, K, Pohin, M, Kim, E, Turner, J, Nayar, S, Fisher, B, Raza, K, Friedrich, M, Marshall, J, Croft, A, Coles, M, Frei, A, Filer, A, Barone, F, Lassen, K, Powrie, F, Buckley, C, Brenner, M & Raychaudhuri, S 2020, 'A Single Cell Stromal Atlas Identifies Conserved Fibroblast Phenotypes Expanded in the Inflamed Synovium, Lung, Intestine, and Salivary Gland', Arthritis & Rheumatology.

Carr, H, Sahbudin, I, Maybury, M, Dyke, B, Turner, J, Gullick, N, Raza, K, Scheel-Toellner, D & Filer, A 2020, 'Development of a Tool to Assess Synovial Tissue Infiltrates and Derive Histological Pathotype in Inflammatory Arthritis: Relationship to Clinical and Ultrasound Variables', Arthritis & Rheumatology.

Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Turner, J, Filer, A & Buckley, C 2019, 'Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry', Nature Immunology, vol. 20, no. 7, pp. 928-942. https://doi.org/10.1038/s41590-019-0378-1

Croft, AP, Campos, J, Jansen, K, Turner, JD, Marshall, J, Attar, M, Savary, L, Wehmeyer, C, Naylor, AJ, Kemble, S, Begum, J, Dürholz, K, Perlman, H, Barone, F, Mcgettrick, HM, Fearon, DT, Wei, K, Raychaudhuri, S, Korsunsky, I, Brenner, MB, Coles, M, Sansom, SN, Filer, A & Buckley, CD 2019, 'Distinct fibroblast subsets drive inflammation and damage in arthritis', Nature, vol. 570, no. 7760, pp. 246–251 . https://doi.org/10.1038/s41586-019-1263-7

Nayar, S, Dias De Campos, J, Smith, C, Iannizzotto, V, Gardner, D, Mourcin, F, Roulois, D, Turner, J, Sylvestre, M, Asam, S, Glaysher, B, Bowman, SJ, Fearon, DT, Filer, A, Tarte, K, Luther, SA, Fisher, B, Buckley, C, Coles, MC & Barone, F 2019, 'Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology', Proceedings of the National Academy of Sciences, vol. 116, no. 27, pp. 13490-13497. https://doi.org/10.1073/pnas.1905301116

Mizoguchi, F, Slowikowski, K, Wei, K, Marshall, J, Rao, DA, Chang, SK, Nguyen, HN, Noss, EH, Turner, J, Earp, BE, Blazar, PE, Wright, J, Simmons, BP, Donlin, LT, Kalliolias, GD, Goodman, SM, Bykerk, VP, Ivashkiv, LB, Lederer, JA, Hacohen, N, Nigrovic, PA, Filer, A, Buckley, C, Raychaudhuri, S & Brenner, MB 2018, 'Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis', Nature Communications, vol. 9, no. 1, 789 . https://doi.org/10.1038/s41467-018-02892-y

Donlin, LT, Rao, DA, Wei, K, Slowikowski, K, McGeachy, MJ, Turner, JD, Meednu, N, Mizoguchi, F, Gutierrez-Arcelus, M, Lieb, DJ, Keegan, J, Muskat, K, Hillman, J, Rozo, C, Ricker, E, Eisenhaure, TM, Li, S, Browne, EP, Chicoine, A, Sutherby, D, Noma, A, Accelerating Medicines Partnership RA/SLE Network, Nusbaum, C, Kelly, S, Pernis, AB, Ivashkiv, LB, Goodman, SM, Robinson, WH, Utz, PJ, Lederer, JA, Gravallese, EM, Boyce, BF, Hacohen, N, Pitzalis, C, Gregersen, PK, Firestein, GS, Raychaudhuri, S, Moreland, LW, Holers, VM, Bykerk, VP, Filer, A, Boyle, DL, Brenner, MB & Anolik, JH 2018, 'Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue', Arthritis Research and Therapy, vol. 20, 139. https://doi.org/10.1186/s13075-018-1631-y

Choi, IY, Karpus, ON, Turner, J, Hardie, D, Marshall, J, de Hair, MJH, Maijer, KI, Tak, PP, Raza, K, Hamann, J, Buckley, C, Gerlag, DM & Filer, A 2017, 'Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis', PLoS ONE, vol. 12, no. 8, e0182751. https://doi.org/10.1371/journal.pone.0182751

Ross, E, Naylor, A, O'Neil, J, Crowley, T, Ridley, M, Crowe, J, Smallie, T, Tang, JT, Turner, J, Norling, LV, Dominguez, S, Perlman, H, Verrills, NM, Kollias, G, Vitek, MP, Filer, A, Buckley, C, Dean, JL & Clark, A 2017, 'Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression', Annals of the Rheumatic Diseases, vol. 76, no. 3, pp. 612-619. https://doi.org/10.1136/annrheumdis-2016-209424

Croft, A, Naylor, A, Marshall, J, Hardie, DL, Zimmermann, B, Turner, J, Desanti, G, Adams, H, Yemm, A, Müller-Ladner, U, Dayer, J-M, Neumann, E, Filer, A & Buckley, C 2016, 'Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage', Arthritis Research & Therapy, vol. 18, no. 1, 270. https://doi.org/10.1186/s13075-016-1156-1

Chapter

Turner, JD, Naylor, AJ, Buckley, C, Filer, A & Tak, P-P 2018, Fibroblasts and Osteoblasts in Inflammation and Bone Damage. in BMJ Owens & MA Lakins (eds), Stromal Immunology. vol. 1060, Advances in Experimental Medicine and Biology, Springer, pp. 37-54. https://doi.org/10.1007/978-3-319-78127-3_3

Letter

Kollert, F, Pucino, V, Nayar, S, Turner, J, Rauz, S, Richards, A, Higham, J, Poveda Gallego, A, Brown, R, Bates, T, Bowman, S, Barone, F & Fisher, B 2022, 'History of tonsillectomy is associated with glandular inflammation in Sjögren's disease', Rheumatology (Oxford). https://doi.org/10.1093/rheumatology/keac096

Review article

Carr, HL, Turner, JD, Major, T, Scheel-Toellner, D & Filer, A 2020, 'New developments in transcriptomic analysis of synovial tissue', Frontiers in Medicine, vol. 7, 21. https://doi.org/10.3389/fmed.2020.00021

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