Recent publications
Article
Nguyen-Tu, M-S, Martinez-Sanchez, A, Leclerc, I, Rutter, GA & da Silva Xavier, G 2021, 'Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice', Diabetologia, vol. 64, no. 1, pp. 129-141. https://doi.org/10.1007/s00125-020-05292-4
Viloria, KM, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, N, Ashford, F, Da Silva Xavier, G, Jimenez-Gonzalez, M, Hasib, A, Cuozzo, F, Manning Fox, J, MacDonald, P, Akerman, I, Lavery, G, Flaxman, C, Morgan, N, Richardson, S, Hewison, M & Hodson, D 2020, 'Vitamin-D-binding protein contributes to the maintenance of α cell function and glucagon secretion', Cell Reports, vol. 31, no. 11, 107761. https://doi.org/10.1016/j.celrep.2020.107761
Davis, SPX, Kumar, S, Alexandrov, Y, Bhargava, A, da Silva Xavier, G, Rutter, GA, Frankel, P, Sahai, E, Flaxman, S, French, PMW & McGinty, J 2019, 'Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish', Journal of Biophotonics, vol. 12, no. 12, e201900128. https://doi.org/10.1002/jbio.201900128
Nguyen-Tu, MS, da Silva Xavier, G, Leclerc, I & Rutter, GA 2018, 'Correction: Correction: Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion (The Journal of biological chemistry (2018) 293 36 (14178-14189))', Journal of Biological Chemistry, vol. 293, no. 36, 14178. https://doi.org/10.1074/jbc.AAC118.006541
Kimura, T, Obata, A, Shimoda, M, Shimizu, I, Okauchi, S, Hirukawa, H, Kohara, K, Mune, T, Moriuchi, S, Hiraoka, A, Tamura, K, Chikazawa, G, Ishida, A, Yoshitaka, H, Rutter, GA, Kaku, K, Kaneto, H & Da Silva Xavier, G 2018, 'Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity', Scientific Reports, vol. 8, 10644. https://doi.org/10.1038/s41598-018-28849-1
Hodson, D & Da Silva Xavier, G 2018, 'Mouse models of peripheral metabolic disease', Best practice & research. Clinical endocrinology & metabolism. https://doi.org/10.1016/j.beem.2018.03.009
Millership, SJ, da Silva Xavier, G, Choudhury, AI, Bertazzo, S, Chabosseau, P, Pedroni, SM, Irvine, EE, Montoya, A, Faull, P, Taylor, WR, Kerr-Conte, J, Pattou, F, Ferrer, J, Christian, M, John, RM, Latreille, M, Liu, M, Rutter, GA, Scott, J & Withers, DJ 2018, 'Neuronatin regulates pancreatic β cell insulin content and secretion', Journal of Clinical Investigation, vol. 128, no. 8, pp. 3369–3381. https://doi.org/10.1172/JCI120115
Nguyen-Tu, M-S, da Silva Xavier, G, Leclerc, I & Rutter, GA 2018, 'Transcription factor-7-like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion', Journal of Biological Chemistry. https://doi.org/10.1074/jbc.RA118.003613
Fletcher, RS, Ratajczak, J, Doig, CL, Oakey, LA, Callingham, R, Da Silva Xavier, G, Garten, A, Elhassan, YS, Redpath, P, Migaud, ME, Philp, A, Brenner, C, Canto, C & Lavery, GG 2017, 'Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells', Molecular metabolism, vol. 6, no. 8, pp. 819-832. https://doi.org/10.1016/j.molmet.2017.05.011
Da Silva Xavier, G, Mondragon, A, Mourougavelou, V, Cruciani-Guglielmacci, C, Denom, J, Herrera, P-L, Magnan, C & Rutter, GA 2017, 'Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.', Diabetologia, vol. 60, no. 6, pp. 1043-1050. https://doi.org/10.1007/s00125-017-4242-2, https://doi.org/10.1007/s00125-017-4242-2
Editorial
Zhang, Q, Huising, MO, Da Silva Xavier, G & Hauge-Evans, AC 2023, 'Editorial: The pancreatic islet – a multifaceted hub of inter-cellular communication', Frontiers in Endocrinology, vol. 14, 1182897. https://doi.org/10.3389/fendo.2023.1182897
Preprint
Nguyen-Tu, M-S, Martinez-Sanchez, A, Leclerc, I, Rutter, GA & Xavier, GDS 2020 'Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice' bioRxiv. https://doi.org/10.1101/2020.05.18.102384
Review article
Da Silva Xavier, G & Rutter, GA 2019, 'Metabolic and functional heterogeneity in pancreatic β cells', Journal of Molecular Biology. https://doi.org/10.1016/j.jmb.2019.08.005
Da Silva Xavier, G 2018, 'The Cells of the Islets of Langerhans', Journal of Clinical Medicine, vol. 7, no. 3, 54. https://doi.org/10.3390/jcm7030054, https://doi.org/10.3390/jcm7030054
Working paper
Viloria, K, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, NHF, Ashford, FB, Xavier, GDS, Ramos, MJ, Fox, JEM, MacDonald, PE, Akerman, I, Lavery, GG, Flaxman, C, Morgan, NG, Richardson, SJ, Hewison, M & Hodson, DJ 2019 'Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion' bioRxiv. https://doi.org/10.1101/2019.12.19.881185
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