Recent publications
Article
Prorok, P, Forouzanfar, F, Murugarren, N, Peiffer, I, Charton, R, Akerman, I & Méchali, M 2023, 'Loss of Ezh2 function remodels the DNA replication initiation landscape', Cell Reports, vol. 42, no. 4, 112280. https://doi.org/10.1016/j.celrep.2023.112280
Akerman, I, Maestro, MA, De Franco, E, Grau, V, Flanagan, S, Garcia-Hurtado, J, Mittler, G, Ravassard, P, Piemonti, L, Ellard, S, Hattersley, AT & Ferrer, J 2021, 'Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene', Cell Reports, vol. 35, no. 2, 108981. https://doi.org/10.1016/j.celrep.2021.108981
Nasteska, D, Fine, N, Ashford, F, Cuozzo, F, Viloria, K, Smith, G, Dahir, A, Dawson, PWJ, Lai, Y-C, Bastidas-Ponce, A, Bakhti, M, Rutter, G, Fiancette, R, Nano, R, Piemonti, L, Lickert, H, Zhou, Q, Akerman, I & Hodson, D 2021, 'PDX1LOW MAFALOW β-cells contribute to islet function and insulin release', Nature Communications, vol. 12, no. 1, 674. https://doi.org/10.1038/s41467-020-20632-z
Schiffer, L, Bossey, A, Kempegowda, P, Taylor, A, Akerman, I, Scheel-Toellner, D, Storbeck, K-H & Arlt, W 2021, 'Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens', European Journal of Endocrinology, vol. 184, no. 3, pp. 353–363. https://doi.org/10.1530/EJE-20-1077
Nasteska, D, Cuozzo, F, Viloria, K, Johnson, E, Thakker, A, Bakar, RB, Westbrook, R, Barlow, J, Hoang, M, Joseph, J, Lavery, G, Akerman, I, Cantley, J, Hodson, L, Tennant, D & Hodson, D 2021, 'Prolyl-4-hydroxylase 3 maintains β-cell glucose metabolism during fatty acid excess in mice', JCI Insight, vol. 6, no. 16, e140288. https://doi.org/10.1172/jci.insight.140288
Westgate, C, Botfield, H, Alimajstorovic, Z, Yiangou, A, Walsh, M, Smith, G, Singhal, R, Mitchell, J, Grech, O, Markey, K, Hebenstreit, D, Tennant, D, Tomlinson, J, Mollan, S, Ludwig, C, Akerman, I, Lavery, G & Sinclair, A 2021, 'Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension', JCI Insight, vol. 6, no. 10, e145346. https://doi.org/10.1172/jci.insight.145346
Akerman, I, Kasaai, B, Bazarova, A, Sang, PB, Peiffer, I, Artufel, M, Derelle, R, Smith, G, Rodriguez-Martinez, M, Romano, M, Kinet, S, Tino, P, Theillet, C, Taylor, N, Ballester, B & Méchali, M 2020, 'A predictable conserved DNA base composition signature defines human core DNA replication origins', Nature Communications, vol. 11, no. 1, 4826 . https://doi.org/10.1038/s41467-020-18527-0
Viloria, KM, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, N, Ashford, F, Da Silva Xavier, G, Jimenez-Gonzalez, M, Hasib, A, Cuozzo, F, Manning Fox, J, MacDonald, P, Akerman, I, Lavery, G, Flaxman, C, Morgan, N, Richardson, S, Hewison, M & Hodson, D 2020, 'Vitamin-D-binding protein contributes to the maintenance of α cell function and glucagon secretion', Cell Reports, vol. 31, no. 11, 107761. https://doi.org/10.1016/j.celrep.2020.107761
Bazarova, A, Nieduszynski, CA, Akerman, I & Burroughs, NJ 2019, 'Bayesian inference of origin firing time distributions, origin interference and licensing probabilities from NGS data', Nucleic Acids Research, vol. 47, no. 5, pp. 2229–2243. https://doi.org/10.1093/nar/gkn000
Ganier, O, Prorok, P, Akerman, I & Méchali, M 2019, 'Metazoan DNA replication origins', Current Opinion in Cell Biology, vol. 58, pp. 134-141.
Elhassan, YS, Kluckova, K, Fletcher, RS, Schmidt, MS, Garten, A, Doig, CL, Cartwright, DM, Oakey, L, Burley, CV, Jenkinson, N, Wilson, M, Lucas, SJE, Akerman, I, Seabright, A, Lai, Y, Tennant, DA, Nightingale, P, Wallis, GA, Manolopoulos, KN, Brenner, C, Philp, A & Lavery, GG 2019, 'Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures', Cell Reports, vol. 28, no. 7, pp. 1717-1728.e6. https://doi.org/10.1016/j.celrep.2019.07.043
Akerman, I, Tu, Z, Beucher, A, Rolando, DMY, Sauty-Colace, C, Benazra, M, Nakic, N, Yang, J, Wang, H, Pasquali, L, Moran, I, Garcia-Hurtado, J, Castro, N, Gonzalez-Franco, R, Stewart, AF, Bonner, C, Piemonti, L, Berney, T, Groop, L, Kerr-Conte, J, Pattou, F, Argmann, C, Schadt, E, Ravassard, P & Ferrer, J 2017, 'Human pancreatic β cell lncRNAs control cell-specific regulatory networks', Cell Metabolism, vol. 25, no. 2, pp. 400-411. https://doi.org/10.1016/j.cmet.2016.11.016
Arnes, L, Akerman, I, Balderes, DA, Ferrer, J & Sussel, L 2016, 'βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function', Genes & Development, vol. 30, no. 5, pp. 502-507. https://doi.org/10.1101/gad.273821.115
Other contribution
Schiffer, L, Bossey, A, Taylor, AE, Akerman, I, Scheel-Toellner, D, Storbeck, K-H & Arlt, W 2020, Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens.. https://doi.org/10.1101/2020.09.08.288316
Working paper
Viloria, K, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, NHF, Ashford, FB, Xavier, GDS, Ramos, MJ, Fox, JEM, MacDonald, PE, Akerman, I, Lavery, GG, Flaxman, C, Morgan, NG, Richardson, SJ, Hewison, M & Hodson, DJ 2019 'Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion' bioRxiv. https://doi.org/10.1101/2019.12.19.881185
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