Dr Ioannis D Gallos DMS MD MRCOG

Dr Ioannis D Gallos

Institute of Metabolism and Systems Research
Senior Lecturer in Global Women's Health
Joint Director of WHO Collaborating Centre for Global Women's Health
Clinical Lead for Postgraduate Research

Contact details

Address
WHO Collaborating Centre for Women's Health
Institute of Translational Medicine
Heritage Building
Mindelsohn Way
Birmingham
B15 2TH

Ioannis’ research work focusses on health issues affecting women and families living in resource-constrained settings, particularly targeting on ways to stop mothers dying from excessive bleeding during childbirth.

Every six minutes, a mother dies from losing too much blood while giving birth. The tragedy is that this is almost always preventable.

Oxytocin is the standard medicine for the prevention of bleeding, recommended for all women giving birth, but requires cold storage, which is unavailable in many countries. Ioannis led the evidence synthesis research at the University of Birmingham, which found that a heat-stable drug carbetocin is more effective, equally safe, and more cost-effective than oxytocin for preventing excessive bleeding after childbirth. Based on this work, the World Health Organization (WHO):

As a result, carbetocin has obtained regulatory approval and adoption of carbetocin into national guidelines and practice has begun in India, Kenya, and Nigeria.

Despite an effective prevention medicine, millions of women will still bleed excessively after childbirth. Women often go on to bleed excessively before the complication is recognised and treated.

Sparked by this global public health challenge, Ioannis is coordinating a global effort to tackle bleeding after childbirth, called the E-MOTIVE programme. The aim is to implement an early detection strategy and a ‘first response’ bundle of care for cutting down deaths and complications related to excessive bleeding by 25%. The E-MOTIVE team will work with international partners and coordinating centres in Kenya, Tanzania, Nigeria, South Africa, and Sri Lanka to test the E-MOTIVE intervention in a large randomised trial across 80 health facilities, involving over 300,000 women. The E-MOTIVE study is supported by the Institute of Global Innovation of the University of Birmingham and a $10.9M grant from the Bill & Melinda Gates Foundation.

For most women, if healthcare providers detect the problem early and treat it efficiently, the bleeding will stop and the mother will be safe. If, however, the treatment does not succeed and a woman continues to bleed despite the first response treatment, then her life is at risk. Ioannis is coordinating a team for developing, with funding from the Medical Research Council in the UK, a provisional management package for these women who continue to bleed despite first response treatment. This programme is due to be field-tested and piloted in five health facilities in Kenya.

Qualifications

  • CCT & SST (Certificate of Completion of Training in Obstetrics & Gynaecology with Sub-specialty in Reproductive Medicine) General Medical Council, October 2018
  • MD (Doctor of Medicine, University of Birmingham, UK), June 2014
  • MRCOG, May 2014
  • DMS (Degree in Medicine & Surgery cum laude, University of Rome ‘La Sapienza’, Italy), October 2005

Biography

Ioannis qualified M.D. cum laude from the University of Rome, Italy in 2005. During his undergraduate studies he received a number of travel research scholarships and distinctions.

He subsequently completed a Wellbeing of Women funded research training scholarship investigating the management and prognosis of endometrial hyperplasia, for which he has submitted his MD thesis and authored a Green top guideline on “The management of endometrial hyperplasia”. He then undertook a year of combined clinical training and academic work as academic clinical fellow in Oxford and John Radcliffe hospital before returning to University of Birmingham as a Clinical Lecturer and then as a sub-specialist trainee in Reproductive Medicine and Surgery. He started working as a Clinician Scientist in University of Birmingham and Honorary Consultant for Birmingham Women’s Hospital since February 2018. In July 2019, he was appointed as a senior lecturer in global women’s health and Joint Director for the WHO Collaborating Centre in Global Women’s Health at the University of Birmingham.

Teaching

  •  MBChB course
  • 2nd year RED module
  • 5th year Obstetrics and Gynaecology module

Postgraduate supervision

Currently, Ioannis is supervising eight PhD students. Has previously supervised students for BMedSc and electives and his students achieved outstanding success with publications in acclaimed academic journals such as the BMJ.

Research

Evidence synthesis 

Ioannis has significant expertise in effectiveness and test accuracy data meta-analysis techniques, including advanced data synthesis approaches such as network meta-analysis, meta-regression and bivariate meta-analysis. He has been funded by the National Institute for Health Research and the World Health Organisation to carry out evidence synthesis that inform national and international guidelines.

Clinical trials

Ioannis is coordinating and is an investigator in several national and international trials.

Research groups and centres

Other activities

Ioannis is a consultant for the Tommy's National Centre for Miscarriage Research based at Birmingham Women’s Hospital. He runs a weekly clinic alongside Professor Arri Coomarasamy for couples that have suffered recurrent miscarriages.

Publications

Recent publications

Article

Okeke Ogwulu, D, Williams, E, Chu, J, Devall, A, Beeson, L, Hardy, P, Cheed, V, Sun, Y, Jones, L, La Fontaine, J, Bender Atik, R, Brewin, J, Hinshaw, K, Choudhary, M, Ahmed, A, Naflalin , J, Nunes, N, Oliver, A, Izzat, F, Bhatia, K, Hassan, I, Jeve, Y, Hamilton, J, Shilpa, D, Bottomley, C, Ross, J, Watkins, L, Underwood, M, Cheong, Y, Kumar, CS, Gupta, P, Small, R, Pringle, S, Hodge, F, Shahid, A, Horne, AW, Quenby, S, Gallos, I, Coomarasamy, A & Roberts, T 2021, 'Cost-effectiveness of mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage: an economic evaluation based on the MifeMiso Trial', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.16737

Hemming, K, Martin, J, Gallos, I, Coomarasamy, A, Middleton, L & E-MOTIVE study group 2021, 'Interim data monitoring in cluster randomised trials: practical issues and a case study', Clinical Trials. https://doi.org/10.1177/17407745211024751

Quenby, S, Gallos, I, Dhillon-smith, R, Podesek, M, Stephenson, MD, Fisher, J, Brosens, JJ, Brewin, J, Ramhorst, R, Lucas, ES, McCoy, RC, Anderson, R, Daher, S, Regan, L, Al-Memar, M, Bourne, T, MacIntyre, DA, Rai, R, Christiansen, OB, Sugiura-Ogasawara, M, Odendaal, J, Devall, A, Bennett, PR, Petrou, S & Coomarasamy, A 2021, 'Miscarriage matters: the epidemiological, physical, psychological and economic burden of early pregnancy loss', The Lancet, vol. 397, pp. 1658–1667. https://doi.org/10.1016/S0140-6736(21)00682-6

Devall, A, Papadopoulou, A, Podesek, M, Haas , DM, Price, MJ, Coomarasamy, A & Gallos, I 2021, 'Progestogens for preventing miscarriage: a network meta-analysis (Review)', Cochrane Database of Systematic Reviews, vol. 2021, no. 4, CD013792. https://doi.org/10.1002/14651858.CD013792.pub2

Coomarasamy, A, Dhillon-smith, R, Papadopoulou, A, Al-Memar, M, Brewin, J, Abrahams, VM, Maheshwari, A, Christiansen, OB, Stephenson, MD, Goddijn, M, Oladapo, OT, Wijeyaratne, CN, Bick, D, Shehata, H, Small, R, Bennett, PR, Regan, L, Rai, R, Bourne, T, Kaur, R, Pickering, O, Brosens, JJ, Devall, A, Gallos, I & Quenby, S 2021, 'Recurrent miscarriage: evidence to accelerate action', The Lancet, vol. 397, no. 10285, pp. 1675-1682. https://doi.org/10.1016/S0140-6736(21)00681-4

Melo, P, Chung, Y, Pickering, O, Price, M, Fishel, S, Khairy, M, Kingsland, C, Lowe, P, Petsas, G, Rajkhowa, M, Sephton, V, Tozer, A, Wood, S, Labarta, E, Wilcox, M, Devall, A, Gallos, I & Coomarasamy, A 2021, 'Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis', Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2021.07.002

Coomarasamy, A, Gallos, I, Papadopoulou, A, Dhillon-smith, R, Al-Memar, M, Brewin, J, Christiansen, OB, Stephenson, MD, Oladapo, OT, Wijeyaratne, CN, Small, R, Bennett, PR, Regan, L, Goddijn, M, Devall, A, Bourne, T, Brosens, JJ & Quenby, S 2021, 'Sporadic miscarriage: evidence to provide effective care', The Lancet, vol. 397, no. 10285, pp. 1668-1674. https://doi.org/10.1016/S0140-6736(21)00683-8

Cheshire, J, Jones, L, Munthali, L, Kamphinga, C, Liyaya, H, Phiri, T, Parry‐Smith, W, Dunlop, C, Makwenda, C, Devall, AJ, Tobias, A, Nambiar, B, Merriel, A, Williams, H, Gallos, I, Wilson, A, Coomarasamy, A & Lissauer, D 2021, 'The FAST‐M complex intervention for the detection and management of maternal sepsis in low‐resource settings: a multi‐site evaluation', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.16658

Wilson, A, Hodgetts-Morton, VA, Marson, EJ, Markland, AD, Larkai, E, Papadopoulou, A, Coomarasamy, A, Tobias, A, Chou, D, Oladapo, OT, Price, MJ, Morris, K & Gallos, ID 2021, 'Tocolytics for delaying preterm birth: a network meta-analysis', Cochrane Database of Systematic Reviews, vol. 2021, no. 4, CD014978. https://doi.org/10.1002/14651858.CD014978

Chu, J, Devall, A, Beeson, L, Hardy, P, Cheed, V, Sun, Y, Roberts, T, Okeke Ogwulu, D, Williams, E, Jones, L, La Fontaine, J, Bender Atik, R, Brewin, J, Hinshaw, K, Choudhary, M, Ahmed, A, Naftalin, J, Nunes, N, Oliver, A, Izzat, F, Bhatia, K, Hassan, I, Jeve, Y, Hamilton, J, Deb, S, Bottomley, C, Ross, J, Watkins, L, Underwood, M, Cheong, Y, Kumar, CS, Gupta, P, Small, R, Pringle, S, Hodge, F, Shahid, A, Gallos, I, Horne, AW, Quenby, S & Coomarasamy, A 2020, 'Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial', The Lancet, vol. 396, no. 10253, pp. 770-778. https://doi.org/10.1016/S0140-6736(20)31788-8

Coomarasamy, A, Harb, HM, Devall, AJ, Cheed, V, Roberts, TE, Goranitis, I, Ogwulu, CB, Williams, HM, Gallos, ID, Eapen, A, Daniels, JP, Ahmed, A, Bender-Atik, R, Bhatia, K, Bottomley, C, Brewin, J, Choudhary, M, Crosfill, F, Deb, S, Duncan, WC, Ewer, A, Hinshaw, K, Holland, T, Izzat, F, Johns, J, Lumsden, MA, Manda, P, Norman, JE, Nunes, N, Overton, CE, Kriedt, K, Quenby, S, Rao, S, Ross, J, Shahid, A, Underwood, M, Vaithilingham, N, Watkins, L, Wykes, C, Horne, AW, Jurkovic, D & Middleton, LJ 2020, 'Progesterone to prevent miscarriage in women with early pregnancy bleeding: The PRISM RCT', Health Technology Assessment, vol. 24, no. 33, pp. 1-70. https://doi.org/10.3310/hta24330

Review article

Ghosh, J, Papadopoulou, A, Devall, AJ, Jeffery, HC, Beeson, LE, Do, V, Price, MJ, Tobias, A, Tunçalp, Ö, Lavelanet, A, Gülmezoglu, AM, Coomarasamy, A & Gallos, ID 2021, 'Methods for managing miscarriage: a network meta-analysis', Cochrane Database of Systematic Reviews, vol. 2021, no. 6, CD012602. https://doi.org/10.1002/14651858.CD012602.pub2

Laios, A, Duarte Portela, S, Papadopoulou, A, Gallos, ID, Otify, M & Ind, T 2021, 'Ovarian transposition and cervical cancer', Best Practice & Research: Clinical Obstetrics & Gynaecology. https://doi.org/10.1016/j.bpobgyn.2021.01.013

Oladapo, OT, Okusanya, BO, Abalos, E, Gallos, I & Papadopoulou, A 2020, 'Intravenous versus intramuscular prophylactic oxytocin for the third stage of labour (Review)', Cochrane Library, no. 11, CD009332. https://doi.org/10.1002/14651858.CD009332.pub4

Coomarasamy, A, Devall, AJ, Brosens, JJ, Quenby, S, Stephenson, MD, Sierra, S, Christiansen, OB, Small, R, Brewin, J, Roberts, TE, Dhillon-Smith, R, Harb, H, Noordali, H, Papadopoulou, A, Eapen, A, Prior, M, Di Renzo, GC, Hinshaw, K, Mol, BW, Lumsden, MA, Khalaf, Y, Shennan, A, Goddijn, M, van Wely, M, Al-Memar, M, Bennett, P, Bourne, T, Rai, R, Regan, L & Gallos, ID 2020, 'Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence', American journal of obstetrics and gynecology, vol. 223, no. 2, pp. 167-176. https://doi.org/10.1016/j.ajog.2019.12.006

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