Dr Ioannis Gallos DMS MD MRCOG

Dr Ioannis Gallos

Institute of Metabolism and Systems Research
Hoffenberg Clinician Scientist in Gynaecology and Reproductive medicine

Contact details

Address
3rd Floor, Birmingham Women's Hospital
Mindelsohn Way
Edgbaston
Birmingham
B15 2TG

Ioannis has carried out the first network meta-analysis in O&G within Cochrane with cost-effectiveness analysis for identifying the most effective and cost-effective uterotonic agents for preventing postpartum haemorrhage in collaboration with the World Health Organisation. The World Health Organisation updated their international guideline based on this research. This project was funded by NIHR, see the report.  

Ioannis is embarking on further work where similar impact is expected and has published Cochrane protocols for reviews with network meta-analysis for identifying the best method of management of miscarriage and evaluation of controlled ovarian stimulation protocols for assisted reproduction.

Ioannis is the National Clinical Co-ordinator for the “Letrozole or Clomifene, with or without metformin, for ovulation induction in women with polycystic ovary syndrome: a 2x2 factorial design randomised trial (The LOCI trial)” funded by the NIHR HTA programme and is expected to roll out in 50 hospitals across the UK.   

Ioannis is a consultant for the Tommy's National Centre for Miscarriage Research based at Birmingham Women’s Hospital. He runs a weekly clinic along Professor Arri Coomarasamy for couples that have suffered recurrent miscarriages. He is also the principal investigator for Tommy’s Net, a platform that will help us to collect and store information from many different centres. By sharing information, hospitals will be able to work together to carry out more effective research.    

Qualifications

  • MD June 2014
  • MRCOG May 2014
  • DMS October 2005

Biography

Ioannis qualified M.D. cum laude from the University of Rome, Italy in 2005. During his undergraduate studies he received a number of travel research scholarships and distinctions.

He subsequently completed a Wellbeing of Women funded research training scholarship investigating the management and prognosis of endometrial hyperplasia, for which he has submitted his MD thesis and authored a Green top guideline on “The management of endometrial hyperplasia”. He then undertook a year of combined clinical training and academic work as academic clinical fellow in Oxford and John Radcliffe hospital before returning to University of Birmingham as a Clinical Lecturer and then as a Sub-specialist trainee in Reproductive Medicine and Surgery. He is working as a Clinician Scientist in University of Birmingham and Honorary Consultant for Birmingham Women’s Hospital since February 2018.

Teaching

  •  MBChB course
  • 2nd year RED module
  • 5th year Obstetrics and Gynaecology module

Postgraduate supervision

Currently, Ioannis is supervising three PhD students. Has previously supervised students for BMedSc and electives and his students achieved outstanding success with publications in acclaimed academic journals such as the BMJ.

Research

Ioannis’ research interests are primarily early pregnancy and reproduction, and global maternal health.

Benign Gynaecology: Common gynaecological conditions can compromise the quality of life and reproductive ability of affected women. This research has focussed on the prognosis and management of endometrial hyperplasia. Ioannis found that fertility-sparing therapy is a feasible option for women of reproductive age. The findings were based on the largest described cohort of women with endometrial hyperplasia (UKCRN ID 6956) and evidence synthesis funded by Wellbeing of Women. Following this work he was the lead author for the Green top guideline from the RCOG on “The management of endometrial hyperplasia”.

Early pregnancy & Reproduction: Ioannis has published meta-analyses of diagnostic accuracy of tests used to predict early pregnancy complications, such as USS signs, DNA fragmentation and progesterone testing. Ioannis has registered Cochrane reviews with network meta-analysis for methods of management of miscarriage and evaluation of controlled ovarian stimulation protocols for assisted reproduction. Has also studied the effects of tubal surgery for women with hydrosalpinx. He is currently analysing a large database from CARE IVF provider to evaluate the association of the maximum endometrial thickness during IVF treatment with early miscarriage. He also collaborated in a project examining vitamin D levels and IVF outcomes.

Global Health: Ioannis is engaged in evidence synthesis of interventions to reduce the global burden of maternal mortality and morbidity. He has evaluated the effectiveness of strategies incorporating traditional birth attendants and has carried out the first network meta-analysis in O&G within Cochrane with cost-effectiveness analysis for identifying the most effective and cost-effective uterotonic for reducing postpartum haemorrhage. The World Health Organisation updated their international guideline based on this research.

Research groups and centres

Tommy’s National Centre for Miscarriage Research

Publications

Gallos I.D, Williams HM, Price M.J, Merriel A, Gee H, Lissauer D, Moorthy V, Tobias A, Deeks J.J, Widmer M, Tunçalp Ö, Gülmezoglu A.M, Hofmeyr GJ, Coomarasamy A (2018) Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis. Cochrane Database Syst Rev. 4: CD011689. doi: 10.1002/14651858.CD011689.pub2.

Chu J, Gallos I.D, Tobias A, Tan B, Robinson L, Kirkman-Brown J, Harb H, Rajkhowa M, Coomarasamy A (2017) Vitamin D and assisted reproductive treatment outcome: A meta-analysis. Hum Reprod. 33: 65-80.

Gallos I.D, Eapen A, Price M.J, Sunkara S.K, Macklon N.S, Bhattacharya S, Khalaf Y, Tobias A, Deeks J.J, Rajkhowa M, Coomarasamy A (2017) Controlled ovarian stimulation protocols for assisted reproduction: a network meta-analysis (Protocol). Cochrane Database of Systematic Reviews Issue 3. Art. No.: CD012586. DOI: 10.1002/14651858.CD012586.

De Silva P.M, Chu J.J, Gallos I.D, Vidyasagar A.T, Robinson L, Coomarasamy A (2017) Fallopian tube catheterization in the treatment of proximal tubal obstruction: a systematic review and meta-analysis. Hum Reprod. 10: 1-17. doi: 10.1093/humrep/dex022.   

Gallos I.D, Williams H.M, Price M.J, Eapen A, Eyo M.M, Tobias A, Deeks J.J, Tunçalp Ö, Gülmezoglu A.M, Coomarasamy A (2017) Methods for managing miscarriage: a network meta-analysis (Protocol). Cochrane Database of Systematic Reviews Issue 3. Art. No.: CD012602. DOI: 10.1002/14651858.CD012602

Parry Smith W.R, Gallos I.D, Williams H.M, Widmer M, Angolkar M, Tobias A, Price M.J, Alfirevic Z, Weeks A, Hofmeyr G.J, Gülmezoglu A.M, Coomarasamy A (2017) First-line uterotonics for treating postpartum haemorrhage: a systematic review and network meta-analysis. (Protocol) Cochrane Database of Systematic Reviews. Issue 8. Art. No.: CD012754. DOI:  10.1002/14651858.CD012754

Robinson L, Gallos I.D, Conner S.J, Rajkhowa M, Miller D, Lewis S, Kirkman-Brown J, Coomarasamy A (2012) The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Hum Reprod. 27: 2908-17

Gallos I.D, Yap J, Rajhkowa M, Coomarasamy A, Luesley D.M, Gupta J.K (2012) Regression, relapse and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis. Am J Obstet Gynecol. 204:266.e1-266.e12

Verhaegen J, Gallos I.D, Abdel-Aziz M, Harb H, Takwoingi Y, Deeks J.J, Mol B.W, Coomarasamy A (2012) Accuracy of a single progesterone test to predict early pregnancy outcome in women with pain or bleeding: a meta-analysis of cohort studies. BMJ. 345:e6077.

Wilson A, Gallos I.D, Plana N, Lissauer D, Khan KS, Zamora J, MacArtur C, Coomarasamy A (2011) Effectiveness of strategies incorporating training and support of traditional birth attendants on perinatal and maternal mortality: meta-analysis. BMJ ;343:d7102. 

For a full list of Dr Gallos's publications

View all publications in research portal