Dr Jessie Gew

Dr Jessie Gew

Department of Metabolism and Systems Science
PhD student

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Jessie Gew is a PhD researcher in the Department of Metabolism and Systems Science. Her research focuses on improving the understanding, diagnosis, and management of idiopathic intracranial hypertension (IIH) through clinical research and disease phenotyping. She is particularly interested in the relationship between visual dysfunction and headache, as well as the mechanisms underlying neuro-ophthalmic disorders. Dr Gew also has a research interest in space medicine and spaceflight-associated neuro-ocular syndrome (SANS), aiming to advance understanding of neuro-ophthalmic adaptations in extreme environments.

Qualifications

  • Postgraduate certificate in Clinical Neurology with Distinction
  • Postgraduate certificate in Clinical Education with Merit
  • MRCP (UK)
  • MBChB

Biography

Dr Jessie Gew earned her MBChB from the University of Edinburgh in 2017. She subsequently completed foundation and internal medicine training, gaining broad exposure to a wide range of medical specialties. During this period, she also undertook postgraduate studies in Clinical Education and Clinical Neurology, further enhancing her academic and clinical expertise.

Dr Gew progressed into Neurology Specialty Training, where she deepened her interest in complex neurological conditions. Her clinical experiences sparked a strong research focus, particularly in the fields of neuro-ophthalmology and headache disorders.

Alongside her clinical and research pursuits, Dr. Gew is an enthusiastic educator. She has delivered lectures, facilitated tutorials, and presented at conferences, contributing actively to the development of medical education.

Committed to integrating clinical practice with academic inquiry, Dr. Gew continues to seek opportunities that advance neurological care through research, education, and innovation.

Doctoral research

PhD title
Exploring the role of OCT and blood biomarkers in predicting the need for surgical intervention in Idiopathic Intracranial Hypertension (IIH).

Research

Idiopathic intracranial hypertension (IIH) is a condition characterised by raised intracranial pressure in the absence of secondary causes. IIH predominantly affects women of reproductive age and has a well-established association with obesity. The prevalence of IIH is rising, parallel to the rise in global obesity rates, posing growing challenges for healthcare systems. The majority of patients are managed through weight loss and medical therapy. However, in cases of sight-threatening IIH, timely escalation to surgical intervention is important to prevent permanent visual loss. There is currently no international recognised consensus on definition of sight-threatening IIH requiring surgical intervention. Additionally, there is lack of robust evidence on precise timing of surgical intervention.

The main objective of Jessie's study is to identify Optical Coherence Tomography (OCT) and blood biomarkers that indicate sight-threatening IIH requiring surgical intervention. 

Jessie's PhD supervisors are Professor Alexandra Sinclair and Professor Lisa Hill.

Publications

Recent publications

Article

Gew, J, Tsermoulas, G, Berman, G, Dinkin, M, Hill, LJ, John, S, Lange, MG, McHugh, JA, Mollan, SP, Takeshima, T, Winters, S, Yiangou, A & Sinclair, AJ 2026, 'Cerebrospinal Fluid Shunting and Venous Sinus Stenting in Sight-threatening Idiopathic Intracranial Hypertension: A Practical Review of Current Evidence', Journal of Neurology, Neurosurgery and Psychiatry.

Tsermoulas, G, Mollan, SP, Homer, V, Kristunas, C, White, P, Wakerley, BR, Toma, AK, Robertson, F, Berman, G, Ahmed, F, Atan, D, Bandyopadhyay, S, Barton, D, Booth, T, Bremner, F, Denton, A, Downer, J, Edwards, R, Frew, E, Gew, JJY, Hill, LJ, Hughes, T, Lax, S, Macdonald, J, Maxwell, G, McHugh, J, Shah, P, Taleti, E, Tasker, R, Thomas, S, Joannides, AJ & Sinclair, A 2026, 'Cerebrospinal fluid shunting or dural venous sinus stenting to preserve vision in idiopathic intracranial hypertension (IIH Intervention): protocol for an open-label, multicentre, randomised controlled phase IIb trial', BMJ Open, vol. 16, no. 8, e111013. https://doi.org/10.1136/bmjopen-2025-111013

Yiangou, A, Phu Do, T, Grech, O, Mugo, CW, Thomas, CN, Gew, J, Lange, MG, Gee, M, Mollan, SP, Hill, LJ, Lucas, SJE, Ashina, M & Sinclair, AJ 2026, 'CGRP-provoked headache is associated with a neuroimmune signature in idiopathic intracranial hypertension', The Journal of Headache and Pain, vol. 27, no. 1, 159. https://doi.org/10.1186/s10194-026-02385-0

Comment/debate

Gew, J, Berman, G, Sinclair, A & Mollan, SP 2026, 'Letter to the Editor. Enhancing comparability in idiopathic intracranial hypertension research through standardized outcome measures', Neurosurgical Focus, vol. 61, no. 1, E15. https://doi.org/10.3171/2026.2.FOCUS2681

Review article

Kennedy, G, Watson, DPB, Davies, B, Bahra, A, Fisher, C, Ghadiri-Sani, M, Kamourieh, S, Gew, JJY, Long, M, Weatherall, M, Wakerley, B, Anderson, JM & Sinclair, AJ 2026, 'Migraine-advanced preventative treatments: the British Association for the Study of Headache Clinical Practice Recommendations and Consensus Guidance ', Journal of Neurology Neurosurgery and Psychiatry. https://doi.org/10.1136/jnnp-2026-339062

Gew, J, Hyder, YF, Grech, O, Brunstetter, T, Tarver, W, Mason, SS, Gibson, CR, Polk, JD, Schneider, VS, van Baalen, M, Mitchell, JL, Yiangou, A, Mollan, SP & Sinclair, AJ 2026, 'Spaceflight-associated neuro-ocular syndrome (SANS): expert consensus on diagnosis and management', Eye. https://doi.org/10.1038/s41433-026-04651-6

View all publications in research portal