Professor David J. Hodson BVSc (Hons) PhD FRCVS

David Hodson

Institute of Metabolism and Systems Research
Honorary Senior Research Fellow

Contact details

Institute of Metabolism and Systems Research (IMSR)
Institute of Biomedical Research
University of Birmingham
B15 2TT

David is an Honorary Senior Research Fellow and ERC Starting Grant holder.  He has particular interest in using multidisciplinary and innovative approaches (e.g. biophotonics, mouse genetics, modelling, chemical biology) to tackle challenging research questions in metabolism. The overall objective of his work is to identify new mechanisms through which pancreatic alpha-, beta- and delta-cells fail during type 1 diabetes and type 2 diabetes. Further details can be found at


  • Fellow of the Royal College of Veterinary Surgeons (FRCVS), London, 2018
  • Doctor of Philosophy (PhD), University of Bristol, 2008
  • Bachelor of Veterinary Science with Honours (BVSc Hons), University of Bristol, 2005


David Hodson - Next generation tools to understand endocrine function in health and disease
Dr David Hodson: Diabetes research breakthrough
Being a Birmingham Fellow

David Hodson completed a degree in Veterinary Science before undertaking doctoral studies in reproductive physiology and circadian biology at the University of Bristol with Dr Domingo Tortonese. Subsequently, in 2008, he moved to the laboratory of Dr. Patrice Mollard at the Institut de Genomique Fonctionnelle in Montpellier France (CNRS), where, supported by a Fellowship from the Fondation de la Recherche Medicale (FRM), he pursued postdoctoral studies focused on understanding how endocrine cells residing within the mammalian pituitary gland function as three-dimensional networks to generate hormone release. Following award of a Diabetes UK RD Lawrence Fellowship in 2012, David moved to the Department of Medicine at Imperial College London, where he set up a research group devoted to understanding islet cell heterogeneity in health and disease. In 2016, David moved to the nascent Institute of Metabolism and Systems Research (IMSR) at the University of Birmingham where he led the Islet Biology Group.


Postgraduate supervision

Currently supervisor to two PhD students and two MSc students.


Research in the Islet Biology Lab tackles challenging questions concerning the regulation of hormone release from pancreatic islets in health and disease. The major aims of the group are to develop novel tools and imaging approaches to understand how alpha, beta and delta cells, which reside within the islet, release hormone to maintain normal glucose. Importantly, we use tissue from individuals with type 1 and type 2 diabetes, as well as animal models, to understand what goes wrong in relevant pathologies. The group is highly inter-disciplinary, and with colleagues in Europe and North America, we combine chemistry, biology and genetics to open up new avenues of exploration in islet biology.

Other activities

  • Senior Birmingham Fellow, University of Birmingham, 2016-2018
  • Non-Clinical Lecturer in Cell Biology, Imperial College London, 2012-2016
  • FRM Postdoctoral Fellow, CNRS Montpellier, 2010-2012
  • ANR Postdoctoral Fellow, CNRS Montpellier, 2008-2012
  • Locum Veterinary Surgeon, Bristol, 2005-2008


Recent publications


Cuozzo, F, Viloria, K, Shilleh, AH, Nasteska, D, Frazer-Morris, C, Tong, J, Jiao, Z, Boufersaoui, A, Marzullo, B, Rosoff, DB, Smith, HR, Bonner, C, Kerr-Conte, J, Pattou, F, Nano, R, Piemonti, L, Johnson, PRV, Spiers, R, Roberts, J, Lavery, GG, Clark, A, Ceresa, CDL, Ray, DW, Hodson, L, Davies, AP, Rutter, GA, Oshima, M, Scharfmann, R, Merrins, MJ, Akerman, I, Tennant, DA, Ludwig, C & Hodson, DJ 2024, 'LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells', Cell Reports, vol. 43, no. 4, 114047.

Xu, W, Qadir, MMF, Nasteska, D, Mota de Sa, P, Gorvin, CM, Blandino-Rosano, M, Evans, CR, Ho, T, Potapenko, E, Veluthakal, R, Ashford, FB, Bitsi, S, Fan, J, Bhondeley, M, Song, K, Sure, VN, Sakamuri, SSVP, Schiffer, L, Beatty, W, Wyatt, R, Frigo, DE, Liu, X, Katakam, PV, Arlt, W, Buck, J, Levin, LR, Hu, T, Kolls, J, Burant, CF, Tomas, A, Merrins, MJ, Thurmond, DC, Bernal-Mizrachi, E, Hodson, DJ & Mauvais-Jarvis, F 2023, 'Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells', Cell Reports, vol. 42, no. 5, 112529.

Rückert, AK, Ast, J, Hasib, A, Nasteska, D, Viloria, K, Broichhagen, J & Hodson, DJ 2023, 'Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca 2+ fluxes', Diabetic Medicine, vol. 40, no. 12, e15220.

Viloria, K, Nasteska, D, Ast, J, Hasib, A, Cuozzo, F, Heising, S, Briant, LJB, Hewison, M & Hodson, DJ 2023, 'GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic α-Cell Adaptation to Metabolic Stress', Diabetes, vol. 72, no. 2, pp. 275-289.

Pezhman, L, Hopkin, S, Begum, J, Heising, S, Nasteska, D, Wahid, M, Rainger, E, Hodson, D, Iqbal, AJ, Chimen, M & McGettrick, H 2023, 'PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation', Clinical & Experimental Immunology.

Ast, J, Nasteska, D, Fine, NHF, Nieves, DJ, Koszegi, Z, Lanoiselée, Y, Cuozzo, F, Viloria, K, Bacon, A, Luu, NT, Newsome, PN, Calebiro, D, Owen, DM, Broichhagen, J & Hodson, DJ 2023, 'Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling', Nature Communications, vol. 14, no. 1, 301.

Galvis, D, Hodson, DJ & Wedgwood, KCA 2023, 'Spatial distribution of heterogeneity as a modulator of collective dynamics in pancreatic beta-cell networks and beyond', Frontiers in network physiology, vol. 3, 1170930.

Ast, J, Novak, AN, Podewin, T, Fine, NHF, Jones, B, Tomas, A, Birke, R, Roßmann, K, Mathes, B, Eichhorst, J, Lehmann, M, Linnemann, AK, Hodson, DJ & Broichhagen, J 2022, 'Expanded LUXendin color palette for GLP1R detection and visualization in vitro and in vivo', JACS Au, vol. 2, no. 4, pp. 1007-1017.

Pauza, AG, Thakka, P, Tasic, T, Felippe, I, Bishop, P, Greenwood, MP, Rysevaite-Kyguoliene, K, Ast, J, Broichhagen, J, Hodson, D, Salgado, HC, Pauza, DH, Japundzic-Zigon, N, Paton, JFR & Murphy, D 2022, 'GLP1R attenuates sympathetic response to high glucose via carotid body inhibition', Circulation, vol. 130, no. 5, pp. 694-707.

Hoang, M, Jentz, E, Janssen, S, Nasteska, D, Cuozzo, F, Hodson, D, Tupling, R, Fong, G-H & Joseph, J 2022, 'Isoform-specific roles of prolyl hydroxylases in the regulation of pancreatic β-cell function', Endocrinology, vol. 163, no. 1, bqab226, pp. 1-17.

Karsai, M, Zuellig, RA, Lehmann, R, Cuozzo, F, Nasteska, D, Luca, E, Hantel, C, Hodson, D, Spinas, GA, Rutter, G & Gerber, PA 2022, 'Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine induced cell death', Journal of Endocrinology, vol. 253, no. 1, pp. 1-11.

Westbrook, R, Bridges, E, Roberts, J, Escribano Gonzalez, C, Eales, K, Vettore, L, Walker, P, Vera-Siguenza, E, Rana, H, Cuozzo, F, Eskla, K-L, Vellama, H, Shaaban, A, Nixon, C, Luuk, H, Lavery, G, Hodson, D, Harris, AL & Tennant, D 2022, 'Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions', Cell Reports, vol. 38, no. 5, 110320.

Birke, R, Ast, J, Roosen, DA, Lee, J, Roßmann, K, Huhn, C, Mathes, B, Lisurek, M, Bushir, D, Sun, H, Jones, B, Lehmann, M, Levitz, J, Haucke, V, Hodson, D & Broichhagen, J 2022, 'Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins', Organic and Biomolecular Chemistry, vol. 20, no. 30, pp. 5967-5980.

Allen, SL, Seabright, AP, Quinlan, JI, Dhaliwal, A, Williams, FR, Fine, NHF, Hodson, DJ, Armstrong, MJ, Elsharkaway, AM, Greig, CA, Lai, Y-C, Lord, JM, Lavery, GG & Breen, L 2022, 'The effect of ex vivo human serum from liver disease patients on cellular protein synthesis and growth', Cells, vol. 11, no. 7, 1098.

Lucey, M, Ashik, T, Marzook, A, Wang, Y, Goulding, J, Oishi, A, Broichhagen, J, Hodson, DJ, Minnion, J, Elani, Y, Jockers, R, Briddon, SJ, Bloom, SR, Tomas, A & Jones, B 2021, 'Acylation of the incretin peptide exendin-4 directly impacts glucagon-like peptide-1 receptor signaling and trafficking', Molecular Pharmacology, vol. 100, no. 4, pp. 319-334.

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