Dr Aqfan Jamaluddin

Dr Aqfan Jamaluddin

Department of Metabolism and Systems Science
Research Fellow

Contact details

Telephone
+44 (0)7576971423
Email
a.jamaluddin@bham.ac.uk
Twitter
@aq_fun
View my research portal
Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Jamaluddin research is focused on in vitro and in vivo GPCR pharmacology and the therapeutic potential of targeting GPCRs to treat metabolic diseases. He is currently a postdoctoral researcher working with Dr Caroline Gorvin to study metabolic GPCRs involved in appetite regulation.

Qualifications

  • PhD in Biological Sciences, University of Auckland, 2020
  • MSc, University of Auckland, 2015
  • PGDip in Science, University of Auckland, 2014
  • BSc in Biomedical Sciences, University of Auckland, 2013

Biography

Dr Jamaluddin research is primarily focused on GPCR pharmacology with a background in drug candidate development and screening. Earlier research includes the development of adrenomedullin and calcitonin gene-related peptide receptor small molecule and peptide ligands, exploring their potential to modulate the respective targeted GPCR activity and physiological effects. Targeting these receptors oftemn.

Research

How metabolic GPCRs crosstalk and interact to regulate appetite (funded Caroline Gorvin’s Wellcome Trust & Royal Society Sir Henry Dale Fellowship).

Publications

Recent publications

Article

Wallis, NJ, McClellan, A, Mörseburg, A, Kentistou, KA, Jamaluddin, A, Dowsett, GKC, Schofield, E, Morros-Nuevo, A, Saeed, S, Lam, BYH, Sumanasekera, NT, Chan, J, Kumar, SS, Zhang, RM, Wainwright, JF, Dittmann, M, Lakatos, G, Rainbow, K, Withers, D, Bounds, R, Ma, M, German, AJ, Ladlow, J, Sargan, D, Froguel, P, Farooqi, IS, Ong, KK, Yeo, GSH, Tadross, JA, Perry, JRB, Gorvin, CM & Raffan, E 2025, 'Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans', Science (New York, N.Y.). https://doi.org/10.1126/science.ads2145

Jamaluddin, A, Wyatt, RA, Pasaliu, A, Ruggles, O, Calebiro, D, Gorvin, CM & Ronchi, CL 2025, 'Characterisation of a GNAS variant linked to cortisol-producing adrenocortical adenoma', Endocrine Oncology . https://doi.org/10.1530/EO-25-0009

Wyatt, RA, Jamaluddin, A, Mistry, V, Quinn, C & Gorvin, C 2025, 'Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways', Human Molecular Genetics. https://doi.org/10.1093/hmg/ddaf005

Jamaluddin, A, Chuang, C, Williams, ET, Siow, A, Yang, SH, Harris, PWR, Petersen, JSSM, Bower, RL, Chand, S, Brimble, MA, Walker, CS, Hay, DL & Loomes, KM 2022, 'Lipidated calcitonin gene-related peptide (CGRP) peptide antagonists retain CGRP receptor activity and attenuate CGRP action in vivo', Frontiers in Pharmacology, vol. 13, 832589. https://doi.org/10.3389/fphar.2022.832589

Garelja, ML, Bower, RL, Brimble, MA, Chand, S, Harris, PWR, Jamaluddin, MA, Petersen, J, Siow, A, Walker, CS & Hay, DL 2022, 'Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared to human receptors', British Journal of Pharmacology, vol. 179, no. 3, pp. 416-434. https://doi.org/10.1111/bph.15628

Chapter

Jamaluddin, A 2024, Bioluminescence Resonance Energy Transfer (BRET) Assay to Measure Gq Recruitment to the Ghrelin Receptor. in CM Gorvin (ed.), Calcium Signaling: Methods and Protocols. 1 edn, Methods in Molecular Biology, Humana Press, pp. 57-69. https://doi.org/10.1007/978-1-0716-4164-4_5

Jamaluddin, A 2024, Quantifying Gq Signaling Using the IP1 Homogenous Time-Resolved Fluorescence (HTRF) Assay. in CM Gorvin (ed.), Calcium Signaling: Methods and Protocols. 1 edn, Methods in Molecular Biology, Humana Press, pp. 23-32. https://doi.org/10.1007/978-1-0716-4164-4_2

Abstract

Jamaluddin, A, Wyatt, RA, Lee, J, Dowsett, GKC, Yeo, GSH, Levitz, J, Gorvin, CM & Levitz, J 2025, 'The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signalling', Society for Endocrinology BES 2025, Harrogate, 10/03/25 - 12/03/25.

Jamaluddin, A, Wyatt, RA, Pasaliu, A, Ruggles, O, Calebiro, D, Gorvin, CM & Ronchi, C 2023, 'Identification of a novel constitutively active Gαs variant associated with cortisol-producing adrenocortical adenoma', Society for Endocrinology BES 2023, Glasgow, 13/11/23 - 15/11/23.

Doctoral Thesis

Jamaluddin, A 2020, 'Development of CGRP receptor peptide antagonists as potential therapeutics', ???thesis.qualification.phd???, University of Auckland. <http://hdl.handle.net/2292/53025>

Preprint

Price, ML, Wyatt, RA, Crastin, A, Jamaluddin, A, Hardy, RS, Frost, M & Gorvin, CM 2025 'G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells' bioRxiv. https://doi.org/10.1101/2025.04.21.649743

Wyatt, RA, Jamaluddin, A, Mistry, V, Quinn, C & Gorvin, CM 2024 'Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways' bioRxiv. https://doi.org/10.1101/2024.11.19.622403

Jamaluddin, A, Wyatt, RA, Lee, J, Dowsett, GKC, Tadross, JA, Broichhagen, J, Yeo, GSH, Levitz, J & Gorvin, CM 2024 'The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling' bioRxiv. https://doi.org/10.1101/2024.11.06.622243

Review article

Tasma, Z, Garelja, ML, Jamaluddin, A, Alexander, TI & Rees, TA 2025, 'Where are we now? Biased signalling of Class B G protein-coupled receptor-targeted therapeutics', Pharmacology & Therapeutics, vol. 270, 108846. https://doi.org/10.1016/j.pharmthera.2025.108846

Jamaluddin, A & Gorvin, CM 2023, 'RISING STARS: Targeting G protein-coupled receptors to regulate energy homeostasis', Journal of Molecular Endocrinology, vol. 70, no. 4, e230014. https://doi.org/10.1530/JME-23-0014

View all publications in research portal