Dr Maria Lange

Dr Maria Lange

Department of Metabolism and Systems Science
PhD student

Contact details

Address
Department of Metabolism and Systems Science
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Maria's passion for academic medicine began during a medical school elective in Endocrinology
at the National Institute of Health, USA. She subsequently undertook an Academic Foundation
programme post in Medical Education and was awarded an NIHR Academic Clinical
Fellowship in Endocrinology at the University of Warwick. During this time, she balanced clinical
and research training. Her projects ranged from lab-based epigenetic projects, cohort studies
in the weight management service, to rapid reviews and meta-analysis. MSc degrees in
Health Research and Nutritional Sciences further strengthened her research skills in various
methodologies.

Maria is also an Endocrinology trainee (ST5) in the West Midlands. She previously completed Internal
Medicine Training (IMT) and MRCP (UK). Her clinical practice has provided her with a deeper
understanding of the lived experience of obesity, enriching her research perspective. She is
passionate about medicine and research that unites diverse specialities. She believes that patients do not live within the boundaries of medical specialities and that collaborative, inter-disciplinary research is crucial for driving meaningful, real-world impact.

Qualifications

  • MSc (Distinction) in Nutritional Sciences, University of Nottingham
  • MSc (Distinction) in Health Research, University of Warwick
  • MRCP (UK)
  • MBChB (Commendation), University of Glasgow

Doctoral research

PhD title
An interdisciplinary exploration of Tirzepatide’s therapeutic role in Idiopathic Intracranial Hypertension.

Research

At an early stage of her career, Maria developed a research interest in obesity, pursuing research projects
that would allow her to explore the breadth of this condition from diverse perspectives. Sustainable
weight management is the only disease modifying therapy in Idiopathic Intracranial hypertension (IIH),
a disease widely accepted to have a metabolic aetiology. GLP1 receptor agonists have transformed the
management of non-IIH obesity with promising data for their use in IIH, with evidence of improvement
in IIH outcomes dependent and independent of weight loss. Her central research question is: What
are the effects of GLP-1/GIP receptor agonist tirzepatide on patient attitudes, sleep parameters and
glucocorticoid phenotype in an IIH cohort?

Maria's PhD supervisors are Professor Alexandra Sinclair, Professor Lisa Hill, and Dr Jonathan Hazelhurst.

Publications

Lange, M.G., Kalidindi, S. Bariatric Metabolic Surgery Instead of or In Addition to Obesity Pharmacotherapy: Perspectives on the Evolving and Emerging Concept of a Medical Bypass. OBES SURG (2025). https://doi.org/10.1007/s11695-025-07704-z

Lange, M.G., Neophytou, C., Cappuccio, F.P., Barber, T.M., Johnson, S., & Chen, Y.F. Sex differences in the association between short sleep duration and obesity: A systematic-review and meta-analysis. Nutr Metab Cardiovasc Dis (2024), 34(10), 2227-2239. doi:10.1016/j.numecd.2024.06.008

Lange M.G., Coffey A.A., Coleman P.C., Barber T.M., Van Rens T., Oyebode O., Abbott S., Hanson P. Metabolic changes following intermittent fasting: A rapid review of systematic reviews. J Hum Nutr Diet. 2023 Oct 2. doi: 10.1111/jhn.13253. Epub ahead of print. PMID: 37786321.

Hanson P., Lange M., Oduro-Donkor D., Shuttlewood E., Weickert M.O., Randeva H.S., Menon V., Alexander R.T., Basset P., Shankar R., Barber T.M. The role of mindfulness training in sustaining weight reduction: retrospective cohort analysis. BJPsych Open. 2022 Nov 15;8(6):e198. doi: 10.1192/bjo.2022.602. PMID: 36377522

Hanson P, Summers C., Panesar A., Oduro-Donkor D., Lange M.., Menon V., Barber T.M. Low Carb Program Health App Within a Hospital-Based Obesity Setting: Observational Service Evaluation. JMIR Form Res. 2021 Sep 23;5(9):e29110. doi: 10.2196/29110. PMID: 34449405

Klubo-Gwiezdzinska, J., Lange, M., Cochran, E., Semple, R., Gewert, C., Brown, R. and Gorden, P. (2018). Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study. Diabetes Care, 41(11), pp. 2353-2360. PMID: 30201849

MG Lange, S Coats, L Cobain, R Ignao, A Lindsay, B McKee, A McLaren, S Sinclair, DM Carty and JG Boyle. (2017). Benefit of a primary/secondary care virtual clinic interface on glycaemic control in Type 2 diabetes. Novel approaches to treatment. Diabetic Medicine, 34, pp.29